{"id":5608,"date":"2024-08-04T20:07:31","date_gmt":"2024-08-04T20:07:31","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5608"},"modified":"2024-08-04T20:07:31","modified_gmt":"2024-08-04T20:07:31","slug":"olibanum","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/olibanum\/","title":{"rendered":"A t\u00f6mj\u00e9n akut vesek\u00e1rosod\u00e1s kezel\u00e9s\u00e9re szolg\u00e1l\u00f3 mechanizmus\u00e1nak felt\u00e1r\u00e1sa h\u00e1l\u00f3zati farmakol\u00f3giai \u00e9s in vitro sejtk\u00eds\u00e9rletek alapj\u00e1n"},"content":{"rendered":"

A t\u00f6mj\u00e9n akut vesek\u00e1rosod\u00e1s kezel\u00e9s\u00e9re szolg\u00e1l\u00f3 mechanizmus\u00e1nak felt\u00e1r\u00e1sa h\u00e1l\u00f3zati farmakol\u00f3giai \u00e9s in vitro sejtk\u00eds\u00e9rletek alapj\u00e1n
\nAz akut vesek\u00e1rosod\u00e1s (AKI) a vesefunkci\u00f3 hirtelen \u00e9s folyamatos cs\u00f6kken\u00e9s\u00e9re utal, amelyet k\u00fcl\u00f6nb\u00f6z\u0151 okok \u00e9s patogenezisek okoznak. A klinikai gyakorlatban az egyik leggyakoribb kritikus betegs\u00e9g, amelynek magas az el\u0151fordul\u00e1si ar\u00e1nya, a ki\u00fajul\u00e1si ar\u00e1nya \u00e9s a mortalit\u00e1sa. A statisztik\u00e1k szerint vil\u00e1gszerte \u00e9vente k\u00f6r\u00fclbel\u00fcl 13 milli\u00f3 megbeteged\u00e9s fordul el\u0151, \u00e9s a kezel\u00e9si gy\u00f3gyszerek \u00e9s strat\u00e9gi\u00e1k hi\u00e1nya miatt \u00e9vente k\u00f6r\u00fclbel\u00fcl 1,7 milli\u00f3 beteg hal meg, a betegek 85% r\u00e9sze a fejl\u0151d\u0151 orsz\u00e1gokban. A v\u00e9rnyom\u00e1s stabiliz\u00e1l\u00e1sa \u00e9s a hat\u00e9kony kering\u0151 v\u00e9rmennyis\u00e9g n\u00f6vel\u00e9se kulcsfontoss\u00e1g\u00fa az AKI megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben. Ez\u00e9rt az AKI megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re szolg\u00e1l\u00f3 gy\u00f3gyszerek megtal\u00e1l\u00e1sa nagy jelent\u0151s\u00e9ggel b\u00edr az ebben a betegs\u00e9gben szenved\u0151 betegek \u00e9let\u00e9nek megment\u00e9s\u00e9ben. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s t\u00f6bb \u00f6sszetev\u0151 \u00e9s c\u00e9lpont jellemz\u0151ivel rendelkezik, \u00e9s jelent\u0151s el\u0151rel\u00e9p\u00e9st \u00e9rt el az AKI megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben.<\/p>\n

Az olibanum az olajbogy\u00f3f\u00e9l\u00e9k csal\u00e1dj\u00e1ba tartoz\u00f3 Boswellia carterii Birdw \u00e9s a B Bhaw dajiana Birdw nemzets\u00e9gb\u0151l sz\u00e1rmazik. A k\u00e9regb\u0151l sziv\u00e1rg\u00f3 gyanta. Meleg term\u00e9szet\u0171, cs\u00edp\u0151s \u00e9s keser\u0171 \u00edz\u0171, \"v\u00e9rkering\u00e9st el\u0151seg\u00edt\u0151 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3, duzzanatcs\u00f6kkent\u0151 \u00e9s izomn\u00f6veked\u00e9st el\u0151seg\u00edt\u0151\" hat\u00e1s\u00fa. A t\u00f6mj\u00e9n f\u0151 \u00f6sszetev\u0151je a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a f\u00e1jdalom enyh\u00edt\u00e9s\u00e9re a t\u00f6mj\u00e9nsavvegy\u00fcletek. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a t\u00f6mj\u00e9n antibakteri\u00e1lis, r\u00e1kellenes, gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns \u00e9s egy\u00e9b hat\u00e1s\u00fa. Funkcion\u00e1lis jellemz\u0151i alapj\u00e1n tov\u00e1bbi kutat\u00e1sokra van sz\u00fcks\u00e9g a t\u00f6mj\u00e9n AKI-ra gyakorolt hat\u00e1smechanizmus\u00e1nak vizsg\u00e1lat\u00e1hoz.<\/p>\n

Ebben a tanulm\u00e1nyban a t\u00f6mj\u00e9n hat\u00f3anyagokat h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1val vizsg\u00e1lt\u00e1k, fel\u00e9p\u00edtettek egy gy\u00f3gyszerhat\u00f3anyag-betegs\u00e9gc\u00e9lh\u00e1l\u00f3zatot, \u00e9s azt in vitro sejtk\u00eds\u00e9rletekkel igazolt\u00e1k. A t\u00f6mj\u00e9nnek az AKI megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben j\u00e1tszott szerep\u00e9t tiszt\u00e1ztuk, megb\u00edzhat\u00f3 elm\u00e9leti alapot biztos\u00edtva az akut vesek\u00e1rosod\u00e1s elleni gy\u00f3gyszerk\u00e9nt val\u00f3 kifejleszt\u00e9s\u00e9hez.<\/p>\n

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\nA nyugati orvosl\u00e1s \u00fagy v\u00e9li, hogy az AKI el\u0151fordul\u00e1sa szorosan \u00f6sszef\u00fcgg a vese iszk\u00e9mi\u00e1val \u00e9s a hipoxi\u00e1val. Jelenleg m\u00e9g mindig hi\u00e1nyoznak a klinikai gyakorlatban a hat\u00e9kony kezel\u00e9si m\u00f3dszerek \u00e9s beavatkoz\u00e1si int\u00e9zked\u00e9sek, f\u0151k\u00e9nt a beteg betegs\u00e9g\u00e1llapot\u00e1nak jav\u00edt\u00e1s\u00e1ra ir\u00e1nyul\u00f3 t\u00fcneti kezel\u00e9ssel. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s az AKI klinikai jellemz\u0151it olyan kateg\u00f3ri\u00e1kba sorolja, mint a \"Longbi\", a \"Guange\", az \"\u00f6d\u00e9ma\" \u00e9s a \"fullad\u00e1sos m\u00e9reg\". Ez\u00e9rt a kezel\u00e9s alapelvei k\u00f6z\u00e9 tartozik a h\u0151tiszt\u00edt\u00e1s \u00e9s a m\u00e9regtelen\u00edt\u00e9s, a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9se \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9se, a h\u0151 kitiszt\u00edt\u00e1sa \u00e9s a v\u00edz elt\u00e1vol\u00edt\u00e1sa, valamint a szervek kering\u00e9s\u00e9nek el\u0151seg\u00edt\u00e9se \u00e9s a zavaross\u00e1g megsz\u00fcntet\u00e9se. A Frankincense hat\u00e1sa az izomn\u00f6veked\u00e9s el\u0151seg\u00edt\u00e9se, a v\u00e9rz\u00e9s el\u00e1ll\u00edt\u00e1sa, a v\u00e9rkering\u00e9s aktiv\u00e1l\u00e1sa, a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9se, a duzzanat cs\u00f6kkent\u00e9se \u00e9s a f\u00e1jdalom enyh\u00edt\u00e9se. A klinikai gyakorlatban gyakran haszn\u00e1lj\u00e1k v\u00e9r pang\u00e1s vagy reuma kezel\u00e9s\u00e9re. Ez\u00e9rt a v\u00e9rkering\u00e9st aktiv\u00e1l\u00f3 \u00e9s a pang\u00e1st megsz\u00fcntet\u0151 gy\u00f3gyszerek hozz\u00e1ad\u00e1sa az akut vesek\u00e1rosod\u00e1s korai \u00e9s k\u00f6z\u00e9ps\u0151 szakasz\u00e1ban fontos megel\u0151z\u0151 \u00e9s ter\u00e1pi\u00e1s hat\u00e1ssal van a betegek vesefunkci\u00f3j\u00e1nak jav\u00edt\u00e1s\u00e1ra, a klinikai t\u00fcnetek, p\u00e9ld\u00e1ul a hematuria cs\u00f6kkent\u00e9s\u00e9re \u00e9s a betegs\u00e9g progresszi\u00f3j\u00e1nak lass\u00edt\u00e1s\u00e1ra.
\nEz a tanulm\u00e1ny szisztematikusan elemezte a t\u00f6mj\u00e9n \"t\u00f6bbkomponens\u0171, t\u00f6bb c\u00e9lpont\u00fa, t\u00f6bb \u00fatvonal\u00fa\" kezel\u00e9s\u00e9nek anyagi alapjait \u00e9s hat\u00e1smechanizmus\u00e1t az AKI eset\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3giai m\u00f3dszerek alkalmaz\u00e1s\u00e1val. Sz\u00e1mos k\u00eds\u00e9rlet kimutatta, hogy a t\u00f6mj\u00e9nsavat a t\u00f6mj\u00e9n legbiol\u00f3giailag akt\u00edvabb komponens\u00e9nek tekintik. A legjelent\u0151sebbek a gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s daganatellenes tulajdons\u00e1gok, valamint sz\u00e1mos m\u00e1s farmakol\u00f3giai tev\u00e9kenys\u00e9g, mint p\u00e9ld\u00e1ul fek\u00e9lyellenes, immunszab\u00e1lyoz\u00f3, lipidcs\u00f6kkent\u0151, vesev\u00e9d\u0151, antibakteri\u00e1lis hat\u00e1sok stb. A kutat\u00e1si eredm\u00e9nyek azt mutatj\u00e1k, hogy az AK-BA, az \u03b1 - BA \u00e9s m\u00e1s hat\u00f3anyagok a f\u0151 hat\u00f3anyagok az AKI kezel\u00e9s\u00e9ben. Vannak irodalmi jelent\u00e9sek arr\u00f3l, hogy az \u03b1 - BA k\u00e9pes g\u00e1tolni az LPS \u00e1ltal stimul\u00e1lt pro-inflammatorikus citokinek (TNF - \u03b1 \u00e9s IL-1 \u03b2) termel\u00e9s\u00e9t U937 makrof\u00e1gokban, ami meger\u0151s\u00edti gyullad\u00e1scs\u00f6kkent\u0151 tulajdons\u00e1gait in vitro. A t\u00f6mj\u00e9n bioakt\u00edv komponense, a pentaciklusos triterpenoidok g\u00e1tolj\u00e1k a leukotri\u00e9nek bioszint\u00e9zis\u00e9t az 5-lipoxigen\u00e1zon kereszt\u00fcl, \u00e9s kifejtik gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sukat. Vizsg\u00e1latok kimutatt\u00e1k, hogy a t\u00f6mj\u00e9nsav antioxid\u00e1ns \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1n kereszt\u00fcl h\u00fagy\u00fati v\u00e9d\u0151hat\u00e1st fejt ki ciklofoszfamid \u00e1ltal kiv\u00e1ltott cisztitiszes patk\u00e1nyokon.
\nA PPI-h\u00e1l\u00f3zat szerint a MAPK3, a PPARG, a PTGS2, a HIF1 \u03b1 \u00e9s az ESR1 a t\u00f6mj\u00e9n k\u00f6zponti c\u00e9lpontjai az akut vesek\u00e1rosod\u00e1s kezel\u00e9s\u00e9ben. A MAPK3 a mitog\u00e9n aktiv\u00e1lt feh\u00e9rje kin\u00e1z MAPK csal\u00e1dba tartozik. A MAPK kaszk\u00e1d aktiv\u00e1l\u00e1sa sz\u00e1mos olyan fiziol\u00f3giai folyamatokban r\u00e9szt vev\u0151 jel\u00e1tviteli \u00fatvonal k\u00f6zpontja, mint a sejtn\u00f6veked\u00e9s, differenci\u00e1l\u00f3d\u00e1s \u00e9s apopt\u00f3zis. A PPARG a nukle\u00e1ris transzkripci\u00f3s faktorok szupercsal\u00e1dj\u00e1ba tartozik. K\u00eds\u00e9rletek bizony\u00edtott\u00e1k, hogy a PPARG-hi\u00e1nyos egerekn\u00e9l fokozott glikozuria \u00e9s albuminuria figyelhet\u0151 meg. Az \u00e9letkor n\u00f6veked\u00e9s\u00e9vel az egerekn\u00e9l veseel\u00e9gtelens\u00e9g \u00e9s a 2-es t\u00edpus\u00fa cukorbetegs\u00e9g tov\u00e1bbi s\u00falyosbod\u00e1sa k\u00f6vetkezett be. A jelent\u00e9sek szerint a PPARG agonist\u00e1k v\u00e9dik a ves\u00e9ket az I\/R s\u00e9r\u00fcl\u00e9ssel szemben az\u00e1ltal, hogy g\u00e1tolj\u00e1k az I\/R s\u00e9r\u00fcl\u00e9s \u00e1ltal kiv\u00e1ltott diff\u00faz tubul\u00e1ris nekr\u00f3zist \u00e9s akut gyullad\u00e1st, valamint cs\u00f6kkentik a nitrog\u00e9n-oxid plazmaszintj\u00e9t \u00e9s az ED-1+ sejtek infiltr\u00e1ci\u00f3j\u00e1t. A PPAR-agonist\u00e1k jelent\u0151s potenci\u00e1lt mutattak az AKI kezel\u00e9s\u00e9ben. A PTGS2 egy kulcsfontoss\u00e1g\u00fa enzim, amely az arachidonsavat gyullad\u00e1sos medi\u00e1tor prosztaglandinn\u00e1 alak\u00edtja, \u00e9s els\u0151sorban a nukle\u00e1ris membr\u00e1non oszlik el. Expresszi\u00f3j\u00e1t olyan ingerek induk\u00e1lj\u00e1k, mint a gyullad\u00e1sos faktorok \u00e9s a tumor n\u00f6veked\u00e9si faktorok. A kutat\u00e1sok kimutatt\u00e1k, hogy az Aranycsontl\u00f3tusz kivonata d\u00f3zisf\u00fcgg\u0151en szab\u00e1lyozza le a PTGS2\/COX-2 mRNS expresszi\u00f3j\u00e1t, ez\u00e1ltal gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st fejt ki. A HIF1 \u03b1 a hipoxi\u00e1ra adott adapt\u00edv v\u00e1lasz f\u0151 szab\u00e1lyoz\u00f3 t\u00e9nyez\u0151je, \u00e9s a vese iszk\u00e9mia-reperf\u00fazi\u00f3val kiv\u00e1ltott AKI modellben a HIF1 \u03b1 expresszi\u00f3ja jelent\u0151sen megn\u00f6vekedett a vese tubulusokban.
\nA GO d\u00fas\u00edt\u00e1si elemz\u00e9s sor\u00e1n els\u0151sorban olyan biol\u00f3giai folyamatokat foglal mag\u00e1ban, mint a hipoxi\u00e1ra adott v\u00e1lasz, az apopt\u00f3zis, a gyullad\u00e1sos v\u00e1lasz, a molekul\u00e1ris funkci\u00f3k, p\u00e9ld\u00e1ul a mitokondriumok \u00e9s a sejtkomponensek, p\u00e9ld\u00e1ul az endopeptid\u00e1z aktivit\u00e1s, ami azt jelzi, hogy a t\u00f6mj\u00e9n biol\u00f3giai \u00fatjai az AKI kezel\u00e9s\u00e9ben gazdagok \u00e9s \u00f6sszetettek. A KEGG \u00fatvonalak gazdagod\u00e1si elemz\u00e9se szerint a t\u00f6mj\u00e9n AKI kezel\u00e9s\u00e9ben a t\u00f6mj\u00e9n jel\u00e1tviteli \u00fatvonala a Toll-szer\u0171 receptor jel\u00e1tviteli \u00fatvonalhoz, a TNF jel\u00e1tviteli \u00fatvonalhoz \u00e9s az NF - \u03ba B jel\u00e1tviteli \u00fatvonalhoz kapcsol\u00f3dik. K\u00f6z\u00fcl\u00fck a Toll-szer\u0171 receptor (TLR) egy membr\u00e1nfeh\u00e9rje-receptor, \u00e9s a TLR4 fontos molekula, amely AKI gyullad\u00e1sos v\u00e1laszt okoz. K\u00fcl\u00f6nb\u00f6z\u0151 citokineket \u00e9s gyullad\u00e1sos medi\u00e1torokat k\u00e9pes \u00e1t\u00edrni \u00e9s felszabad\u00edtani, kiv\u00e1ltva ezzel az immunrendszer gyullad\u00e1sos v\u00e1lasz\u00e1t. Vizsg\u00e1latok kimutatt\u00e1k, hogy az akut vesek\u00e1rosod\u00e1s s\u00falyoss\u00e1ga szorosan \u00f6sszef\u00fcgg a TLR4 \u00e9s az NF - \u03ba B sz\u00e9rumszintj\u00e9vel. A TLR4 NF - \u03ba B jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1sa enyh\u00edtheti az akut vesek\u00e1rosod\u00e1s s\u00falyoss\u00e1g\u00e1t. A tumor nekr\u00f3zis faktor (TNF) egy olyan citokin, amelynek sz\u00e1mos biol\u00f3giai hat\u00e1sa van. \u00c1ltal\u00e1ban a TNF a makrof\u00e1gok \u00e1ltal termelt TNF - \u03b1-ra utal. Aktiv\u00e1l\u00f3d\u00e1s ut\u00e1n els\u0151sorban a sejtn\u00f6veked\u00e9s, differenci\u00e1l\u00f3d\u00e1s, apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9ben \u00e9s a gyullad\u00e1s kiv\u00e1lt\u00e1s\u00e1ban j\u00e1tszik fontos szerepet. Az AKI aktiv\u00e1lja a TLR4 NF - \u03ba B jel\u00e1tviteli \u00fatvonalat, ami a pro-inflammatorikus citokin TNF - \u03b1 felszabadul\u00e1s\u00e1t induk\u00e1lja. Ez\u00e9rt a TLR4, az NF - \u03ba B \u00e9s a TNF - \u03b1 szintek ellen\u0151rz\u00e9s\u00e9nek er\u0151s\u00edt\u00e9se enyh\u00edtheti az akut vesek\u00e1rosod\u00e1st \u00e9s el\u0151seg\u00edtheti a betegek progn\u00f3zis\u00e1nak javul\u00e1s\u00e1t.
\nA t\u00f6mj\u00e9n f\u0151 hat\u00f3anyagainak MAPK3-hoz \u00e9s PPARG-hoz val\u00f3 k\u00f6t\u0151d\u00e9si energi\u00e1it molekul\u00e1ris dokkol\u00e1si m\u00f3dszerrel hat\u00e1roztuk meg. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az AKBA \u00e9s az \u03b1 - BA j\u00f3 k\u00f6t\u0151d\u00e9si k\u00e9pess\u00e9ggel rendelkezik a MAPK3-hoz \u00e9s a PPARG-hoz.
\nV\u00e9gezet\u00fcl, ez a tanulm\u00e1ny sejtkult\u00far\u00e1n kereszt\u00fcl szimul\u00e1lta a vese I\/R s\u00e9r\u00fcl\u00e9s\u00e9t, hogy megvizsg\u00e1lja az \u03b1-BA hat\u00e1smechanizmus\u00e1t. A kutat\u00e1si eredm\u00e9nyek azt mutatj\u00e1k, hogy az \u03b1 - BA-nak nincs toxikus hat\u00e1sa a HK-2 sejtekre, \u00e9s d\u00f3zisf\u00fcgg\u0151en n\u00f6veli a sejtek \u00e9letk\u00e9pess\u00e9g\u00e9t az I\/R s\u00e9r\u00fcl\u00e9s modellben, ami vesev\u00e9d\u0151 hat\u00e1sra utal. A Ho-echst 33258 fest\u00e9s azt mutatta, hogy az I\/R kezel\u00e9s jelent\u0151sen megn\u00f6velte az apoptotikus sejtek ar\u00e1ny\u00e1t, m\u00edg az \u03b1 - BA koncentr\u00e1ci\u00f3f\u00fcgg\u0151 m\u00f3don jelent\u0151sen cs\u00f6kkentette az apoptotikus sejtek ar\u00e1ny\u00e1t. Az \u03b1 - BA jelent\u0151sen g\u00e1tolni tudja az I\/R \u00e1ltal induk\u00e1lt HK-2 sejtek \u00e1ltal termelt gyullad\u00e1sos faktorokat. Ek\u00f6zben a val\u00f3s idej\u0171 fluoreszcens kvantitat\u00edv RT-PCR kimutat\u00e1s azt mutatta, hogy az \u03b1 - BA le tudja szab\u00e1lyozni a kulcsfontoss\u00e1g\u00fa c\u00e9lpontok MAPK3 \u00e9s PPARG g\u00e9nek expresszi\u00f3j\u00e1t az AKI folyamat\u00e1ban, ami \u00f6sszhangban van a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e1ltal megj\u00f3solt eredm\u00e9nyekkel.
\nEz a tanulm\u00e1ny a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1j\u00e1t haszn\u00e1lta fel a t\u00f6mj\u00e9n akt\u00edv \u00f6sszetev\u0151inek \u00e9s potenci\u00e1lis c\u00e9lpontjainak, valamint az AKI kapcsol\u00f3d\u00f3 c\u00e9lpontjainak keres\u00e9s\u00e9re. \u00d6sszesen 72 metsz\u00e9spontot kaptunk a hat\u00f3anyagok \u00e9s a betegs\u00e9g c\u00e9lpontjai k\u00f6z\u00f6tt. A GO \u00e9s KEGG jel\u00e1tviteli \u00fatvonalak gazdagod\u00e1si elemz\u00e9s\u00e9t ezut\u00e1n elv\u00e9gezt\u00fck ezeken a c\u00e9lpontokon, hogy megj\u00f3soljuk a f\u0151 hat\u00f3anyagokat AKBA, \u03b1 - BA, stb. Az AKI kezel\u00e9s\u00e9t els\u0151sorban olyan c\u00e9lpontok szab\u00e1lyoz\u00e1s\u00e1val \u00e9rt\u00e9k el, mint a MAPK3, PPARG, PTGS2, Toll-like receptorok, TNF \u00e9s NF - \u03ba B jel\u00e1tviteli \u00fatvonalak, hogy enyh\u00edts\u00e9k az iszk\u00e9mia, a hipoxia s\u00e9r\u00fcl\u00e9s\u00e9t \u00e9s szab\u00e1lyozz\u00e1k a sejt apopt\u00f3zist. Ek\u00f6zben az in vitro sejtk\u00eds\u00e9rletek el\u0151zetesen meger\u0151s\u00edtett\u00e9k az el\u0151rejelz\u00e9s pontoss\u00e1g\u00e1t \u00e9s megb\u00edzhat\u00f3s\u00e1g\u00e1t, referenciaalapot biztos\u00edtva a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s k\u00e9s\u0151bbi kutat\u00e1s\u00e1hoz \u00e9s klinikai prom\u00f3ci\u00f3j\u00e1hoz. De m\u00e9g mindig vannak bizonyos korl\u00e1tai, \u00e9s tov\u00e1bbi ellen\u0151rz\u00e9sre van sz\u00fcks\u00e9g \u00e1llatk\u00eds\u00e9rleteken kereszt\u00fcl.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism of frankincense in treating acute kidney injury based on network pharmacology and in vitro cell experiments Acute kidney injury (AKI) refers to the sudden and continuous decline of renal function caused by a variety of causes and pathogenesis. It is one of the common critical diseases in clinical practice, with a high […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of frankincense in treating acute kidney injury based on network pharmacology and in vitro cell experiments - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/olibanum\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of frankincense in treating acute kidney injury based on network pharmacology and in vitro cell experiments - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of frankincense in treating acute kidney injury based on network pharmacology and in vitro cell experiments Acute kidney injury (AKI) refers to the sudden and continuous decline of renal function caused by a variety of causes and pathogenesis. 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