{"id":5501,"date":"2024-08-04T19:27:28","date_gmt":"2024-08-04T19:27:28","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5501"},"modified":"2024-08-04T19:27:28","modified_gmt":"2024-08-04T19:27:28","slug":"three-volatile-oils","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/three-volatile-oils\/","title":{"rendered":"A kakukkf\u0171b\u0151l sz\u00e1rmaz\u00f3 h\u00e1rom ill\u00f3olaj \u00f6sszetev\u0151inek, antibakteri\u00e1lis aktivit\u00e1s\u00e1nak \u00e9s citotoxicit\u00e1s\u00e1nak vizsg\u00e1lata emberi m\u00e1jr\u00e1kos sejteken"},"content":{"rendered":"

A kakukkf\u0171b\u0151l sz\u00e1rmaz\u00f3 h\u00e1rom ill\u00f3olaj \u00f6sszetev\u0151inek, antibakteri\u00e1lis aktivit\u00e1s\u00e1nak \u00e9s citotoxicit\u00e1s\u00e1nak vizsg\u00e1lata emberi m\u00e1jr\u00e1kos sejteken
\nA kakukkf\u0171 a Lamiaceae csal\u00e1dba tartoz\u00f3, Bels\u0151-Mong\u00f3li\u00e1ban, Heilongjiangban \u00e9s m\u00e1s r\u00e9gi\u00f3kban sz\u00e9les k\u00f6rben elterjedt kis f\u00e9lcserje. A kakukkf\u0171 ill\u00f3olaj a kakukkf\u0171 egyed\u00fcl\u00e1ll\u00f3 ill\u00f3olaja, \u00e9s tartalma a n\u00f6veked\u00e9si k\u00f6rnyezett\u0151l \u00e9s a t\u00edpust\u00f3l f\u00fcgg\u0151en v\u00e1ltozik. Legink\u00e1bb terp\u00e9nekb\u0151l \u00e9s arom\u00e1s vegy\u00fcletekb\u0151l \u00e1ll, a legmagasabb a timol \u00e9s a karvacrol tartalma. A kakukkf\u0171 ill\u00f3olajat kiv\u00e1l\u00f3 antioxid\u00e1ns tulajdons\u00e1gai miatt sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k \u00e9lelmiszer-adal\u00e9kanyagokban, valamint sz\u00e9ps\u00e9g- \u00e9s b\u0151r\u00e1pol\u00e1si term\u00e9kekben. Er\u0151s g\u00e1tl\u00f3 hat\u00e1ssal van a patog\u00e9n bakt\u00e9riumokra is, mint p\u00e9ld\u00e1ul a Streptococcus pneumoniae, Staphylococcus aureus, Candida albicans \u00e9s Salmonella typhimurium. Ez\u00e9rt jelent\u0151s figyelmet kapott az orvostudom\u00e1nyban. B\u00e1r sz\u00e1mos irodalmi jelent\u00e9s sz\u00fcletett a r\u00e1kos sejtek apopt\u00f3zis\u00e1t kiv\u00e1lt\u00f3 n\u00f6v\u00e9nyi ill\u00f3olaj mechanizmus\u00e1r\u00f3l, a kakukkf\u0171 n\u00f6v\u00e9nyek ill\u00f3olaj\u00e1r\u00f3l kev\u00e9s kutat\u00e1si jelent\u00e9s sz\u00fcletett, \u00e9s kev\u00e9s jelent\u00e9s van arr\u00f3l, hogy hogyan vezet a r\u00e1kos sejtek nekr\u00f3zis\u00e1hoz \u00e9s apopt\u00f3zis\u00e1hoz, valamint a szisztematikus kutat\u00e1s hi\u00e1nya.<\/p>\n

Ebben a tanulm\u00e1nyban a Thymus citriodorus, a Thymus mongolicus \u00e9s a Thymus vulgaris volt az alapanyag, amelyb\u0151l h\u00e1rom ill\u00f3olajat vontak ki v\u00edzg\u0151zdesztill\u00e1ci\u00f3val a kakukkf\u0171b\u0151l. K\u00e9miai \u00f6sszetev\u0151ik g\u00e1zkromatogr\u00e1fia-t\u00f6megspektrometri\u00e1s (GC-MS) elemz\u00e9s\u00e9vel kombin\u00e1lva tanulm\u00e1nyoztuk az antibakteri\u00e1lis hat\u00e1st \u00e9s a m\u00e1jr\u00e1ksejtekre gyakorolt toxicit\u00e1st, ami t\u00f6bb alapvet\u0151 elm\u00e9leti alapot biztos\u00edt a kakukkf\u0171 ill\u00f3olajok tov\u00e1bbi \u00e1tfog\u00f3 fejleszt\u00e9s\u00e9hez.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nA n\u00f6v\u00e9nyi ill\u00f3olajok kivon\u00e1sa arom\u00e1s n\u00f6v\u00e9nyekb\u0151l hat\u00e9kony alternat\u00edv\u00e1ja a k\u00e9miai gomba\u00f6l\u0151 szereknek \u00e9s a r\u00e1kellenes szereknek, mivel viszonylag biztons\u00e1gos, alacsony toxicit\u00e1s\u00fa, k\u00f6nnyen leboml\u00f3 \u00e9s k\u00f6rnyezetbar\u00e1t tulajdons\u00e1gokkal rendelkezik. Az ill\u00f3olajok \u00f6sszet\u00e9tele a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00f3gyn\u00f6v\u00e9nyekn\u00e9l elt\u00e9r\u0151, \u00e1ltal\u00e1ban k\u00fcl\u00f6nb\u00f6z\u0151 terpenoidokat, arom\u00e1s vegy\u00fcleteket, alif\u00e1s vegy\u00fcleteket, valamint nitrog\u00e9ntartalm\u00fa \u00e9s k\u00e9ntartalm\u00fa vegy\u00fcleteket tartalmaznak. Jelenleg korl\u00e1tozott kutat\u00e1sok folynak a kakukkf\u0171 ill\u00f3olajban l\u00e9v\u0151 hat\u00f3anyagok daganatellenes hat\u00e1sair\u00f3l. Ebben a tanulm\u00e1nyban hagyom\u00e1nyos v\u00edzg\u0151z-desztill\u00e1ci\u00f3val h\u00e1romf\u00e9le kakukkf\u0171 ill\u00f3olajat nyertek, \u00e9s GC-MS seg\u00edts\u00e9g\u00e9vel elemezt\u00e9k az \u00f6sszet\u00e9tel\u00fckben mutatkoz\u00f3 k\u00fcl\u00f6nbs\u00e9geket. A legszembet\u0171n\u0151bb az volt, hogy a citromos kakukkf\u0171 ill\u00f3olaj k\u00e9t vegy\u00fcletet, citr\u00e1lt \u00e9s izocitr\u00e1lt tartalmazott, m\u00edg a m\u00e1sik k\u00e9t ill\u00f3olaj nem tartalmazta ezt a k\u00e9t anyagot. A k\u00eds\u00e9rletben h\u00e1romf\u00e9le kakukkf\u0171 ill\u00f3olajat haszn\u00e1ltak k\u00fcl\u00f6nb\u00f6z\u0151 n\u00f6v\u00e9nyi k\u00f3rokoz\u00f3k kezel\u00e9s\u00e9re, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy k\u00fcl\u00f6nb\u00f6z\u0151 k\u00e9pess\u00e9geket mutattak az antibakteri\u00e1lis aktivit\u00e1s ter\u00e9n. K\u00f6z\u00fcl\u00fck a citromos kakukkf\u0171 ill\u00f3olajnak volt a legjobb antibakteri\u00e1lis hat\u00e1sa, k\u00fcl\u00f6n\u00f6sen az Escherichia colira. Ezzel szemben a francia kakukkf\u0171 ill\u00f3olaj antibakteri\u00e1lis k\u00e9pess\u00e9ge gyeng\u00e9bb, amelyet a kakukkf\u0171 ill\u00f3olaj k\u00f6vet. A k\u00eds\u00e9rletben a m\u00e1jr\u00e1kos sejtvonalak prolifer\u00e1ci\u00f3j\u00e1ra \u00e9s apopt\u00f3zis\u00e1ra gyakorolt hat\u00e1s\u00e1t is elemezt\u00e9k CCK-8 m\u00f3dszerrel. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a h\u00e1romf\u00e9le kakukkf\u0171 ill\u00f3olaj jelent\u0151sen g\u00e1tolni tudja a HepG2 m\u00e1jr\u00e1ksejt prolifer\u00e1ci\u00f3j\u00e1t \u00e9s apopt\u00f3zist induk\u00e1l, ami bizonyos kutat\u00e1si potenci\u00e1llal rendelkezik a daganatellenes gy\u00f3gyszerek fejleszt\u00e9s\u00e9ben. Ez az antibakteri\u00e1lis \u00e9s r\u00e1kellenes funkci\u00f3 szorosan \u00f6sszef\u00fcgg a kakukkf\u0171 nemzets\u00e9gben tal\u00e1lhat\u00f3 ill\u00f3olajok \u00f6sszet\u00e9tel\u00e9vel. A timol, amely a legmagasabb tartalommal rendelkezik, nemcsak jelent\u0151s ter\u00e1pi\u00e1s hat\u00e1ssal van a n\u00f6v\u00e9nyi gomb\u00e1kra, a dermatofit\u00e1kra \u00e9s az emberi gyullad\u00e1sra, hanem j\u00f3 daganatellenes farmakol\u00f3giai aktivit\u00e1st is mutat. P\u00e9ld\u00e1ul a timol k\u00e9pes apopt\u00f3zist induk\u00e1lni a m\u00e1jr\u00e1kos sejtekben, a prosztatar\u00e1kos sejtekben \u00e9s a gyomorr\u00e1kos sejtekben a mitog\u00e9n aktiv\u00e1lt feh\u00e9rje kin\u00e1z (MAPK), az extracellul\u00e1risan szab\u00e1lyozott feh\u00e9rje kin\u00e1z (ERK) \u00e9s az apoptotikus Bax g\u00e9nb\u0151l, \u00e9s r\u00e1kellenes hat\u00e1st fejt ki a mitokondri\u00e1lis transzmembr\u00e1n ROS indukci\u00f3j\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel, a kaszp\u00e1z expresszi\u00f3 fokoz\u00e1s\u00e1val \u00e9s a Bcl-2 expresszi\u00f3j\u00e1nak leszab\u00e1lyoz\u00e1s\u00e1val. Ezen t\u00falmen\u0151en, a citral k\u00e9pes a leuk\u00e9mi\u00e1s sejtek apopt\u00f3zis\u00e1t kiv\u00e1ltani az\u00e1ltal, hogy oxidat\u00edv stresszreakci\u00f3t induk\u00e1l, n\u00f6veli az intracellul\u00e1ris malondialdehid szintj\u00e9t, cs\u00f6kkenti a reduk\u00e1lt glutationt, \u00e9s a leuk\u00e9mi\u00e1s sejtek apopt\u00f3zis\u00e1t induk\u00e1lja. A BAK pro apoptotikus feh\u00e9rje expresszi\u00f3j\u00e1nak felfel\u00e9 szab\u00e1lyoz\u00e1sa \u00e9s a Bcl xL anti apoptotikus feh\u00e9rje expresszi\u00f3j\u00e1nak lefel\u00e9 szab\u00e1lyoz\u00e1sa r\u00e9v\u00e9n g\u00e1tolhatja a limf\u00f3ma sejtek prolifer\u00e1ci\u00f3j\u00e1t, \u00e9s blokkolhatja a sejtciklust, hogy g\u00e1tolja az eml\u0151r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t. Zhao \u00e9s munkat\u00e1rsai levendula ill\u00f3olajat haszn\u00e1ltak a HepG2 hum\u00e1n m\u00e1jr\u00e1kos sejtvonal n\u00f6veked\u00e9s\u00e9nek g\u00e1tl\u00e1s\u00e1ra. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a levendula ill\u00f3olaj koncentr\u00e1ci\u00f3f\u00fcgg\u0151 m\u00f3don jelent\u0151sen g\u00e1tolni tudja a HepG2 sejtek prolifer\u00e1ci\u00f3j\u00e1t. A kezel\u00e9s ut\u00e1n a levendula ill\u00f3olaj k\u00fcl\u00f6nb\u00f6z\u0151 koncentr\u00e1ci\u00f3i jelent\u0151s apopt\u00f3zist \u00e9s nekr\u00f3zist mutattak a HepG2 sejtekben. Jia \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a limon\u00e9n n\u00f6velheti a Bax \u00e9s a citokr\u00f3m tartalm\u00e1t, cs\u00f6kkentheti a Bcl-2 expresszi\u00f3j\u00e1t, \u00e9s apopt\u00f3zist induk\u00e1lhat az LS174T hum\u00e1n vastagb\u00e9lr\u00e1k sejtvonalban; Jaganathan \u00e9s munkat\u00e1rsai meger\u0151s\u00edtett\u00e9k, hogy a fenol a p53 \u00e9s a kaszp\u00e1z-3 aktiv\u00e1l\u00e1s\u00e1val apopt\u00f3zist induk\u00e1lhat a vastagb\u00e9lr\u00e1ksejtekben.<\/p>\n

A term\u00e9szetes n\u00f6v\u00e9nyi ill\u00f3olajok nagy potenci\u00e1lis biol\u00f3giai er\u0151forr\u00e1st jelentenek. A kakukkf\u0171 ill\u00f3olajok kutat\u00e1s\u00e1nak elm\u00e9ly\u00edt\u00e9s\u00e9vel t\u00f6bb lehet\u0151s\u00e9g ny\u00edlik a klinikai orvosl\u00e1s, a gy\u00f3gyszerell\u00e1t\u00e1s \u00e9s az \u00e9lelmiszerbiztons\u00e1g sz\u00e1m\u00e1ra, \u00faj utakat nyitva az \u00faj term\u00e9szetes antioxid\u00e1nsok \u00e9s daganatellenes gy\u00f3gyszerek kifejleszt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the components, antibacterial activity, and cytotoxicity of three volatile oils from thyme on human liver cancer cells Thyme is a small semi shrub of the Lamiaceae family, widely distributed in Inner Mongolia, Heilongjiang and other regions. Thyme volatile oil is a unique volatile substance of thyme, and its content varies depending on the […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the components, antibacterial activity, and cytotoxicity of three volatile oils from thyme on human liver cancer cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/three-volatile-oils\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the components, antibacterial activity, and cytotoxicity of three volatile oils from thyme on human liver cancer cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the components, antibacterial activity, and cytotoxicity of three volatile oils from thyme on human liver cancer cells Thyme is a small semi shrub of the Lamiaceae family, widely distributed in Inner Mongolia, Heilongjiang and other regions. 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