{"id":5474,"date":"2024-08-04T19:20:51","date_gmt":"2024-08-04T19:20:51","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5474"},"modified":"2024-08-04T19:20:51","modified_gmt":"2024-08-04T19:20:51","slug":"solanum-nigrum","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/solanum-nigrum\/","title":{"rendered":"A Solanum nigrum mechanizmus\u00e1nak felt\u00e1r\u00e1sa az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1si technol\u00f3gia \u00e9s az in vitro k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n."},"content":{"rendered":"<section>A Solanum nigrum mechanizmus\u00e1nak felt\u00e1r\u00e1sa az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1si technol\u00f3gia \u00e9s az in vitro k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n.<br \/>\nAz eml\u0151r\u00e1k az egyik leggyakoribb rosszindulat\u00fa daganat a n\u0151k k\u00f6r\u00e9ben a vil\u00e1gon, \u00e9s ez a r\u00e1k okozta hal\u00e1loz\u00e1sok f\u0151 oka is a n\u0151k k\u00f6r\u00e9ben. Az eml\u0151r\u00e1k kock\u00e1zata sz\u00e1mos t\u00e9nyez\u0151vel f\u00fcgg \u00f6ssze, p\u00e9ld\u00e1ul az \u00e9letkorral, a genetik\u00e1val, a reprodukci\u00f3s t\u00e9nyez\u0151kkel \u00e9s az elh\u00edz\u00e1ssal. Jelenleg a hormonter\u00e1pia, a m\u0171t\u00e9t, a kemoter\u00e1pia \u00e9s a sug\u00e1rter\u00e1pia az eml\u0151r\u00e1k kezel\u00e9s\u00e9nek f\u0151 strat\u00e9gi\u00e1i. Mivel azonban az eml\u0151r\u00e1k \u00f6sszetett \u00e9s rendk\u00edv\u00fcl heterog\u00e9n betegs\u00e9g, a t\u00f6bb gy\u00f3gyszerrel szembeni rezisztencia \u00e9s a s\u00falyos mell\u00e9khat\u00e1sok korl\u00e1tozz\u00e1k e kezel\u00e9si m\u00f3dszerek ter\u00e1pi\u00e1s hat\u00e1s\u00e1t. Ez\u00e9rt s\u00fcrg\u0151sen sz\u00fcks\u00e9g van hat\u00e9konyabb \u00e9s biztons\u00e1gosabb eml\u0151r\u00e1kellenes gy\u00f3gyszerek kifejleszt\u00e9s\u00e9re. A r\u00e1k kezel\u00e9s\u00e9ben a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u00e9s a term\u00e9szetes term\u00e9kek el\u0151nyei a t\u00f6bbszint\u0171, t\u00f6bb \u00fatvonal\u00fa, t\u00f6bb c\u00e9lpont\u00fa, nagy hat\u00e9konys\u00e1g\u00fa \u00e9s minim\u00e1lis mell\u00e9khat\u00e1sok, amelyek j\u00f3 daganatellenes hat\u00e1st mutatnak. M\u00edg a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u00e9s hat\u00f3anyagai a hat\u00e1rozott gy\u00f3gy\u00edt\u00f3 hat\u00e1s, a kis toxikus \u00e9s mell\u00e9khat\u00e1sok, a gazdag c\u00e9lpontok \u00e9s a v\u00e1ltozatos mechanizmusok jellemz\u0151i az eml\u0151r\u00e1k ellen. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1sb\u00f3l sz\u00e1rmaz\u00f3 mellr\u00e1kellenes gy\u00f3gyszerek j\u00f3 fejleszt\u00e9si \u00e9s alkalmaz\u00e1si kil\u00e1t\u00e1sokkal rendelkeznek.<br \/>\nA Solanum nigrum L. a Solanaceae csal\u00e1dba tartoz\u00f3, Eur\u00f3p\u00e1ban, \u00c1zsi\u00e1ban \u00e9s Amerik\u00e1ban sz\u00e9les k\u00f6rben elterjedt gy\u00f3gyn\u00f6v\u00e9ny. A longkui r\u00e1kellenes, gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns, antibakteri\u00e1lis \u00e9s epilepsziaellenes hat\u00e1ssal rendelkezik. F\u0151 bioakt\u00edv \u00f6sszetev\u0151i k\u00f6z\u00e9 tartoznak a szteroid szaponinok, alkaloidok, fenolok \u00e9s poliszacharidok. A modern kutat\u00e1sok azt mutatj\u00e1k, hogy a Solanum nigrum \u00e9s hat\u00f3anyagai (f\u0151k\u00e9nt szteroidok, szerves savak, lign\u00e1nok \u00e9s m\u00e1sok) felhaszn\u00e1lhat\u00f3k k\u00fcl\u00f6nb\u00f6z\u0151 r\u00e1kt\u00edpusok, p\u00e9ld\u00e1ul m\u00e1jr\u00e1k, m\u00e9hnyakr\u00e1k, hasny\u00e1lmirigyr\u00e1k, mellr\u00e1k stb. kezel\u00e9s\u00e9re. A Solanum nigrum metanolos kivonata k\u00e9pes autof\u00e1gi\u00e1t \u00e9s apopt\u00f3zist induk\u00e1lni az MDA-MB-468 mellr\u00e1kos sejtvonalban. A Solanum nigrum vizes \u00e9s etanolos kivonata citotoxikus az MCF-7 eml\u0151r\u00e1kos sejtvonalra, \u00e9s apopt\u00f3zist \u00e9s ciklusmeg\u00e1ll\u00e1st id\u00e9z el\u0151 az MCF-7 sejtvonalban. Ezenk\u00edv\u00fcl a Solanum nigrum epigenetikai modul\u00e1ci\u00f3n kereszt\u00fcl eml\u0151r\u00e1kellenes szerepet is j\u00e1tszhat. A diosgenin egyfajta term\u00e9szetes szteroid szaponin a Dioscorea n\u00f6v\u00e9nyekb\u0151l, amely j\u00f3 daganatellenes aktivit\u00e1ssal rendelkezik. A kutat\u00e1sok azt mutatj\u00e1k, hogy a diosgenin a Vav2 aktivit\u00e1s g\u00e1tl\u00e1s\u00e1val g\u00e1tolhatja az MDA-MB-231 eml\u0151r\u00e1ksejtek migr\u00e1ci\u00f3j\u00e1t, \u00e9s befoly\u00e1solhatja a sejtek migr\u00e1ci\u00f3s viselked\u00e9s\u00e9t, ami azt mutatja, hogy a diosgeninnek \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s-ellenes potenci\u00e1lja lehet. B\u00e1r a fenti kutat\u00e1sok n\u00e9mi el\u0151rel\u00e9p\u00e9st \u00e9rtek el, a Solanum nigrum anyagi alapja, hat\u00e1sc\u00e9ljai \u00e9s r\u00e9szletes molekul\u00e1ris mechanizmusa az eml\u0151r\u00e1k ellen nem teljesen vil\u00e1gos. A h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a molekul\u00e1ris dokkol\u00e1s technikai m\u00f3dszerei alapj\u00e1n ez a tanulm\u00e1ny egy t\u00f6bbszint\u0171 \u00e9s t\u00f6bb sz\u00f6gb\u0151l \u00e1ll\u00f3 \"gy\u00f3gyszerc\u00e9lpont-\u00fatvonal-betegs\u00e9g\" h\u00e1l\u00f3zati kapcsolatot \u00e9p\u00edtett fel, \u00e9s azt in vitro sejtk\u00eds\u00e9rletek kombin\u00e1l\u00e1s\u00e1val ellen\u0151rizte. Egy\u00e9rtelm\u0171 volt, hogy a Solanum nigrum hat\u00e9kony \u00f6sszetev\u0151je g\u00e1tolni tudta az MDA-MB-231 sejtek prolifer\u00e1ci\u00f3j\u00e1t mellr\u00e1kban \u00e9s sejt apopt\u00f3zist induk\u00e1lt, \u00e9s el\u0151zetesen felt\u00e1rta a diosgenin molekul\u00e1ris hat\u00e1smechanizmus\u00e1t, referenci\u00e1t ny\u00fajtva a Solanum nigrum tov\u00e1bbi kutat\u00e1s\u00e1hoz az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5475\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-151.png\" alt=\"\" width=\"1125\" height=\"419\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-151.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-151-768x286.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5476\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-137.png\" alt=\"\" width=\"1125\" height=\"396\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-137.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-137-768x270.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5477\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-130.png\" alt=\"\" width=\"1125\" height=\"734\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-130.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-130-768x501.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-130-1104x720.png 1104w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5478\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-115.png\" alt=\"\" width=\"1125\" height=\"521\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-115.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-115-768x356.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5479\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-102.png\" alt=\"\" width=\"1125\" height=\"545\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-102.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-102-768x372.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5480\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-95.png\" alt=\"\" width=\"1125\" height=\"523\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-95.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-95-768x357.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5481\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-85.png\" alt=\"\" width=\"1125\" height=\"546\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-85.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-85-768x373.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5482\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-79.png\" alt=\"\" width=\"1125\" height=\"430\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-79.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-79-768x294.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5483\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-72.png\" alt=\"\" width=\"1125\" height=\"485\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-72.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-72-768x331.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5484\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-3.jpg\" alt=\"\" width=\"1223\" height=\"805\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-3.jpg 1223w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-3-768x506.jpg 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-3-1094x720.jpg 1094w\" sizes=\"(max-width: 1223px) 100vw, 1223px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5485\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-54.png\" alt=\"\" width=\"1125\" height=\"468\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-54.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-54-768x319.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5486\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-44.png\" alt=\"\" width=\"1125\" height=\"553\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-44.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-44-768x378.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5487\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-39.png\" alt=\"\" width=\"1125\" height=\"706\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-39.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-39-768x482.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5488\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-33.png\" alt=\"\" width=\"1125\" height=\"677\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-33.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-33-768x462.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><br \/>\nA Solanum nigrum hagyom\u00e1nyos k\u00ednai gy\u00f3gyn\u00f6v\u00e9ny. A modern farmakol\u00f3gia meg\u00e1llap\u00edtotta, hogy a Solanum nigrum k\u00fcl\u00f6nb\u00f6z\u0151 biol\u00f3giai aktivit\u00e1sokkal rendelkezik, amelyek t\u00f6bbs\u00e9ge a daganatellenes ter\u00fcletre koncentr\u00e1l\u00f3dik. Vizsg\u00e1latok kimutatt\u00e1k, hogy hat\u00f3anyaga, a diosgenin, k\u00fcl\u00f6nb\u00f6z\u0151 sejtes jel\u00e1tviteli utak szab\u00e1lyoz\u00e1s\u00e1val tumorellenes hat\u00e1st fejthet ki, \u00e9s szorosan kapcsol\u00f3dik sz\u00e1mos fontos molekul\u00e1ris c\u00e9lponthoz, p\u00e9ld\u00e1ul a sejtn\u00f6veked\u00e9shez, a differenci\u00e1l\u00f3d\u00e1shoz \u00e9s az apopt\u00f3zishoz.<br \/>\nA TCMSP h\u00e1l\u00f3zati farmakol\u00f3giai adatb\u00e1zis\u00e1nak elemz\u00e9s\u00e9vel ez a tanulm\u00e1ny h\u00e9t hat\u00e9kony hat\u00f3anyagot, nevezetesen a fraxinolt, a \u03b2-karotint, a szitoszterint, a diosgenint, a szolanin, a koleszterint \u00e9s a kvercetint sz\u0171rte. A metsz\u00e9spontot a Solanum nigrum hat\u00f3anyagainak relev\u00e1ns c\u00e9lpontjainak felt\u00e9rk\u00e9pez\u00e9s\u00e9vel kaptuk a mellr\u00e1k betegs\u00e9g c\u00e9lpont bevezet\u0151 vonal szoftver VENNY 2.1 seg\u00edts\u00e9g\u00e9vel. Ugyanakkor a PPI-h\u00e1l\u00f3zatelemz\u00e9s azt mutatta, hogy szoros kapcsolat van e metsz\u00e9si c\u00e9lpontok k\u00f6z\u00f6tt. Tanulm\u00e1nyok kimutatt\u00e1k, hogy a kvercetin, az ausztr\u00e1l szolanin \u00e9s a szitoszterin farmakol\u00f3giai hat\u00e1sokkal rendelkezik, p\u00e9ld\u00e1ul g\u00e1tolja a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s kiv\u00e1ltja a tumorsejtek apopt\u00f3zis\u00e1t. A diosgenin el\u0151seg\u00edtheti az eml\u0151r\u00e1k MCF-7 sejtek \u00e9s az Skp2 sejtek apopt\u00f3zis\u00e1t. Ebb\u0151l l\u00e1that\u00f3, hogy a Solanum nigrum hat\u00f3anyagai, mint a kvercetin, a szolanin, a szitoszterin \u00e9s a dioszg\u00e9n tumorellenes hat\u00e1st fejthetnek ki.<br \/>\nAz \u00f6sszetett c\u00e9lponth\u00e1l\u00f3zat diagramja szerint a Solanum nigrum \u00e9s a betegs\u00e9g c\u00e9lpontjainak metsz\u00e9spontja ut\u00e1n 110 c\u00e9lpontot kaptunk. A tov\u00e1bbi sz\u0171r\u00e9s meg\u00e1llap\u00edtotta, hogy az ERBB2, EGFR, KIT, SRC, ESR1, AKT1, MAPK1, PIK3CA stb. voltak a Solanum nigrum hat\u00e9kony \u00f6sszetev\u0151inek c\u00e9lfeh\u00e9rjei az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben. K\u00f6z\u00fcl\u00fck a resveratrol, a diosgenin \u00e9s a kvercetin mind az AKT1 \u00e9s az EGFR c\u00e9lpontokra hat, \u00e9s az AKT (szerin\/treonin kin\u00e1z) \u00e9s az EGFR (epiderm\u00e1lis n\u00f6veked\u00e9si faktor receptor) fontos szerepet j\u00e1tszik a sejtprolifer\u00e1ci\u00f3ban, a migr\u00e1ci\u00f3ban \u00e9s az anyagcser\u00e9ben. Ez\u00e9rt az AKT \u00e9s az EGFR c\u00e9lzott kezel\u00e9se nagyon vonz\u00f3 kezel\u00e9si strat\u00e9gia az eml\u0151r\u00e1k eset\u00e9ben. E vizsg\u00e1lat eredm\u00e9nyei azt mutatj\u00e1k, hogy az AKT1 \u00e9s az EGFR, valamint m\u00e1s c\u00e9lpontok fontos szerepet j\u00e1tszanak az eml\u0151r\u00e1k kialakul\u00e1s\u00e1ban, \u00e9s a Solanum nigrum potenci\u00e1lis c\u00e9lpontjai lehetnek az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben. A GO feld\u00fasul\u00e1si elemz\u00e9s azt mutatja, hogy a Solanum nigrum eml\u0151r\u00e1k elleni c\u00e9lg\u00e9njei olyan biol\u00f3giai folyamatokat foglalnak magukban, mint a kin\u00e1z aktivit\u00e1s pozit\u00edv szab\u00e1lyoz\u00e1sa, a k\u00f6t\u0151feh\u00e9rje szerin \/ treonin kin\u00e1z aktivit\u00e1s, a MAPK kaszk\u00e1d pozit\u00edv szab\u00e1lyoz\u00e1sa, a PI3K jel pozit\u00edv szab\u00e1lyoz\u00e1sa, ATP-k\u00f6t\u00e9s stb. Ezek a kulcsfontoss\u00e1g\u00fa folyamatok fontos szerepet j\u00e1tszanak a Solanum nigrum mellr\u00e1k kezel\u00e9s\u00e9ben. A KEGG eredm\u00e9nyek azt mutatt\u00e1k, hogy \u00f6sszesen 137 jel\u00e1tviteli \u00fatvonalat gazdag\u00edtottak, bele\u00e9rtve a r\u00e1kos \u00fatvonalat, a PI3K \/ Akt jel\u00e1tviteli \u00fatvonalat, az EGFR tirozinkin\u00e1z inhibitor rezisztencia jel\u00e1tviteli \u00fatvonalat, az ErbB jel\u00e1tviteli \u00fatvonalat, a MAPK jel\u00e1tviteli \u00fatvonalat, a Ras jel\u00e1tviteli \u00fatvonalat, a Rap1 jel\u00e1tviteli \u00fatvonalat stb.<br \/>\nA molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1t haszn\u00e1lt\u00e1k a Solanum nigrum kulcsfontoss\u00e1g\u00fa akt\u00edv \u00f6sszetev\u0151i \u00e9s a c\u00e9lfeh\u00e9rj\u00e9k k\u00f6z\u00f6tti affinit\u00e1s felt\u00e1r\u00e1s\u00e1ra. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az akt\u00edv komponensek, mint a kvercetin, a szitoszterin \u00e9s a diosgenin j\u00f3 k\u00f6t\u0151d\u00e9si aktivit\u00e1st mutattak a c\u00e9lpont AKT1, EGFR, ESR1, SRC \u00e9s MAPK feh\u00e9rj\u00e9kkel, ami azt t\u00fckr\u00f6zi, hogy a Solanum nigrum f\u0151 akt\u00edv \u00f6sszetev\u0151inek, a szitoszterinnek \u00e9s a kvercetinnek az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben a f\u0151 mechanizmusa szorosan kapcsol\u00f3dhat a fenti akt\u00edv komponensekhez \u00e9s c\u00e9lpontokhoz. A Solanum nigrumnak t\u00f6bb c\u00e9lponton \u00e9s t\u00f6bb jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl bizonyos ter\u00e1pi\u00e1s hat\u00e1sa lehet az eml\u0151r\u00e1kra.<br \/>\nA molekul\u00e1ris dokkol\u00e1si kutat\u00e1sok eredm\u00e9nyei alapj\u00e1n a Solanum nigrum f\u0151 hat\u00f3anyag\u00e1t, a diosgenint v\u00e1lasztott\u00e1k ki a daganatellenes k\u00eds\u00e9rletekhez, \u00e9s igazolt\u00e1k a diosgenin szab\u00e1lyoz\u00f3 hat\u00e1s\u00e1t a megj\u00f3solt c\u00e9lpontokra, az EGFR-re \u00e9s az AKT1-re. A diosgenin mellr\u00e1k elleni potenci\u00e1lis mechanizmus\u00e1nak felt\u00e1r\u00e1sa. A k\u00eds\u00e9rleti eredm\u00e9nyek azt mutatt\u00e1k, hogy a dioszg\u00e9n k\u00e9pes g\u00e1tolni az MDA-MB-231 sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s apopt\u00f3zist induk\u00e1lni az MDA-MB-231 sejtekn\u00e9l. A dioszg\u00e9n k\u00e9pes lefel\u00e9 szab\u00e1lyozni az EGFR feh\u00e9rje expresszi\u00f3j\u00e1t \u00e9s felfel\u00e9 szab\u00e1lyozni az AKT1 feh\u00e9rje expresszi\u00f3j\u00e1t a sejtekben. \u00c9rdemes megjegyezni, hogy a dioszcin k\u00e9pes lefel\u00e9 szab\u00e1lyozni az AKT foszforil\u00e1ci\u00f3s szintj\u00e9t, \u00e9s ezzel egyidej\u0171leg k\u00e9pes felfel\u00e9 szab\u00e1lyozni a Bax pro-apoptotikus feh\u00e9rje expresszi\u00f3j\u00e1t \u00e9s lefel\u00e9 szab\u00e1lyozni a Bcl-2 antiapoptotikus feh\u00e9rje expresszi\u00f3j\u00e1t.<br \/>\n\u00d6sszefoglalva, ez a tanulm\u00e1ny a h\u00e1l\u00f3zati farmakol\u00f3giai adatplatformot alkalmazta a Solanum nigrum f\u0151 hat\u00f3anyagainak elemz\u00e9s\u00e9re \u00e9s sz\u0171r\u00e9s\u00e9re, \u00e9s elemezte a Solanum nigrum t\u00f6bbkomponens\u0171, t\u00f6bb c\u00e9lpont\u00fa, t\u00f6bb \u00fatvonal\u00fa mechanizmus\u00e1t az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben, \u00e9s k\u00eds\u00e9rleti ellen\u0151rz\u00e9st v\u00e9gzett in vitro. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a Solanum nigrum hathat az AKT1-re, az EGFR-re \u00e9s m\u00e1s c\u00e9lpontokra, hogy szerepet j\u00e1tsszon az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben, \u00f6tleteket \u00e9s alapot ny\u00fajtva a Solanum nigrum kapcsol\u00f3d\u00f3 mechanizmus\u00e1nak tov\u00e1bbi m\u00e9lyrehat\u00f3 kutat\u00e1s\u00e1hoz az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben \u00e9s a Solanum nigrum k\u00e9s\u0151bbi klinikai alkalmaz\u00e1si kutat\u00e1s\u00e1hoz.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Explore the mechanism of Solanum nigrum in the treatment of breast cancer based on network pharmacology, molecular docking technology and in vitro experimental verification Breast cancer is one of the most common malignant tumors among women in the world, and it is also the main cause of cancer related deaths among women. 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