{"id":5435,"date":"2024-08-04T18:58:34","date_gmt":"2024-08-04T18:58:34","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5435"},"modified":"2024-08-04T18:58:34","modified_gmt":"2024-08-04T18:58:34","slug":"research-on-non-coumarin-components-in-bai-zhi","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/research-on-non-coumarin-components-in-bai-zhi\/","title":{"rendered":"A Bai Zhi nem kumarin komponenseinek kutat\u00e1sa"},"content":{"rendered":"A Bai Zhi nem kumarin komponenseinek kutat\u00e1sa
\nA Bai Zhi az Umbelliferae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9ny, az Angelica dahurica (Fisch. ex Hoffm.) Benth Et Hook. f. vagy Hangbaizhi A dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan sz\u00e1r\u00edtott gy\u00f6kerei. F\u0171szeres \u00edz, meleg term\u00e9szet. T\u00fcnetold\u00f3, a hideget el\u0171z\u0151, a szelet el\u0171z\u0151 \u00e9s a f\u00e1jdalmat enyh\u00edt\u0151, az orrny\u00edl\u00e1st el\u0151seg\u00edt\u0151, a nedvess\u00e9get sz\u00e1r\u00edt\u00f3 \u00e9s az \u00f6veket meg\u00e1ll\u00edt\u00f3, valamint a duzzanatot \u00e9s a gennyet cs\u00f6kkent\u0151 hat\u00e1s\u00fa. A klinikai gyakorlatban megf\u00e1z\u00e1s, fejf\u00e1j\u00e1s, szem\u00f6ld\u00f6kf\u00e1j\u00e1s, orrdugul\u00e1s, orrfoly\u00e1s, orrdugul\u00e1s, orrmell\u00e9k\u00fcreggyullad\u00e1s, fogf\u00e1j\u00e1s, h\u00fcvelyi foly\u00e1s, f\u00e1jdalmas \u00e9s f\u00e1jdalmas sebek stb. kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k. Az Angelica dahurica az egyik leggyakrabban haszn\u00e1lt \u00f6mlesztett gy\u00f3gy\u00e1szati anyag a klinikai gyakorlatban. A statisztik\u00e1k szerint eddig 565 fajta hagyom\u00e1nyos k\u00ednai szabadalmi gy\u00f3gyszert \u00e9s egyszer\u0171 k\u00e9sz\u00edtm\u00e9nyt, amelyek Angelica dahurica-t tartalmaznak, vettek fel a hagyom\u00e1nyos k\u00ednai szabadalmi gy\u00f3gyszerek \u00e9s egyszer\u0171 k\u00e9sz\u00edtm\u00e9nyek receptadatb\u00e1zis\u00e1ba, \u00e9s 1836 Angelica dahurica-t tartalmaz\u00f3 receptet vettek fel a hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerek receptadatb\u00e1zis\u00e1ba. A farmakol\u00f3giai anyagalapok tiszt\u00e1z\u00e1sa \u00e9rdek\u00e9ben a tud\u00f3sok izol\u00e1ltak \u00e9s azonos\u00edtottak egy sor kumarin-komponenst a Bai Zhi-b\u0151l. Ezen k\u00edv\u00fcl vannak irodalmi jelent\u00e9sek arr\u00f3l, hogy a Bai Zhi b\u0151s\u00e9ges flavonoidokat tartalmaz, de jelenleg nincsenek relev\u00e1ns jelent\u00e9sek a Bai Zhi flavonoid-monomerek izol\u00e1l\u00e1s\u00e1r\u00f3l \u00e9s tiszt\u00edt\u00e1s\u00e1r\u00f3l. Az Angelica dahurica k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek el\u0151zetes szisztematikus vizsg\u00e1lata sor\u00e1n a kutat\u00f3csoport meg\u00e1llap\u00edtotta, hogy a nagy mennyis\u00e9g\u0171 kumarin komponens mellett az Angelica dahurica nem kumarin komponenseket, p\u00e9ld\u00e1ul alkaloidokat \u00e9s flavonoidokat is tartalmazhat. Az LC-MS ir\u00e1ny\u00edtott elv\u00e1laszt\u00e1si technol\u00f3gia alkalmaz\u00e1s\u00e1val sikeresen fedeztek fel t\u00f6bb, szerkezetileg \u00fajszer\u0171 kumarin-dimert az Angelica dahurica-b\u00f3l, \u00e9s tanulm\u00e1nyozt\u00e1k a Hangbai dahurica etanolos kivonat\u00e1nak nagy polarit\u00e1s\u00fa r\u00e9szeit. Tizenhat pirrol-alkaloidot siker\u00fclt izol\u00e1lni \u00e9s azonos\u00edtani. Ez a cikk tov\u00e1bb\u00e1 besz\u00e1mol nem kumarin vegy\u00fcletek izol\u00e1l\u00e1s\u00e1r\u00f3l \u00e9s azonos\u00edt\u00e1s\u00e1r\u00f3l az Angelica dahurica v\u00edzben old\u00f3d\u00f3 r\u00e9szeib\u0151l.<\/p>\n
![\"\"](\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-146.png\")
Az Angelica dahurica k\u00e9miai \u00f6sszet\u00e9tel\u00e9r\u0151l sz\u00f3l\u00f3 szakirodalomban \u00e1ltal\u00e1ban \u00fagy v\u00e9lik, hogy az Angelica dahurica f\u0151 k\u00e9miai \u00f6sszetev\u0151i a kumarinvegy\u00fcletek, m\u00edg az Angelica dahurica dahurica nem kumarinvegy\u00fcleteir\u0151l kev\u00e9s jelent\u00e9s tal\u00e1lhat\u00f3. Lu \u00e9s munkat\u00e1rsai egyszer izol\u00e1ltak \u00e9s azonos\u00edtottak egy pirrolikus alkaloidot, a kumarint, az Angelica dahurica-b\u00f3l. Az Angelica dahurica szisztematikus vizsg\u00e1lata sor\u00e1n kutat\u00f3csoportunk nemcsak nagy mennyis\u00e9g\u0171 kumarint \u00e9s kumarin-dimereket izol\u00e1lt, hanem 16 pirrolikus alkaloidot is izol\u00e1lt az Angelica dahurica-b\u00f3l, gazdag\u00edtva ezzel a k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek meg\u00e9rt\u00e9s\u00e9t. A Bai Zhi k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek tov\u00e1bbi kutat\u00e1sa sor\u00e1n v\u00e1ratlanul izol\u00e1ltak 18 nem kumarin komponenst, amelyekr\u0151l ebben a cikkben sz\u00e1moltunk be. A kor\u00e1bban bejelentett Jin Qian Cao alkaloid mellett a t\u00f6bbi 17 nem kumarin komponens, k\u00f6zt\u00fck 9 flavonoid, 5 lign\u00e1n, 2 egyszer\u0171 fenol\u00e9szter \u00e9s 1-H-imidazo [4,5-d] piridazin-2-amin, mindegyiket a Bai Zhi-b\u0151l izol\u00e1lt\u00e1k el\u0151sz\u00f6r. A 3. \u00e9s 18. vegy\u00fcletek bizonyos g\u00e1tl\u00f3 hat\u00e1ssal vannak a zimoz\u00e1n \u00e1ltal induk\u00e1lt szuperoxid felszabadul\u00e1s\u00e1ra a neutrofilekb\u0151l, m\u00edg az 1. \u00e9s 18. vegy\u00fclet g\u00e1tl\u00f3 hat\u00e1ssal van a RAW 264.7 sejtek NO-aktivit\u00e1s\u00e1nak felszabadul\u00e1s\u00e1ra. \u00c9rdemes megjegyezni, hogy b\u00e1r az Angelica dahurica flavonoidjainak jelenl\u00e9t\u00e9r\u0151l t\u00f6bb irodalmi jelent\u00e9s is sz\u00fcletett, ezek mind el\u0151zetes jelent\u00e9sek az \u00f6sszes flavonoidtartalom meghat\u00e1roz\u00e1s\u00e1r\u00f3l. Jelenleg nincs jelent\u00e9s az Angelica dahurica monomer flavonoidjainak izol\u00e1l\u00e1s\u00e1r\u00f3l. Ebben a tanulm\u00e1nyban azonban el\u0151sz\u00f6r nyertek t\u00f6bbsz\u00f6r\u00f6s flavonoidokat \u00e9s flavonoid-glikozid-monomereket az Angelica dahurica-b\u00f3l, ami nagy meglepet\u00e9st okozott sz\u00e1munkra. K\u00e9telkedt\u00fcnk abban, hogy a gy\u00f3gy\u00e1szati anyagokkal van-e probl\u00e9ma, de az ebben a cikkben izol\u00e1lt \u00e9s k\u00f6z\u00f6lt 1, 6, 7 \u00e9s 8 vegy\u00fcletek tov\u00e1bbi elemz\u00e9se LC-MS seg\u00edts\u00e9g\u00e9vel h\u00e1rom k\u00fcl\u00f6nb\u00f6z\u0151 eredet\u0171, Hangbai, Chuanbai \u00e9s Yubai Angelica dahurica-ban tal\u00e1ltuk. Ez azt jelzi, hogy az 1., 6., 7. \u00e9s 8. vegy\u00fclet kimutathat\u00f3 a k\u00fcl\u00f6nb\u00f6z\u0151 eredet\u0171 Angelica dahurica-ban. A Bai Zhi val\u00f3ban tartalmazhat flavonoidokat. A kutat\u00e1si eredm\u00e9nyek gazdag\u00edtott\u00e1k az Angelica dahurica k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek meg\u00e9rt\u00e9s\u00e9t, \u00e9s fontos referenci\u00e1kat szolg\u00e1ltattak a min\u0151s\u00e9gellen\u0151rz\u00e9shez, valamint a fejleszt\u00e9shez \u00e9s felhaszn\u00e1l\u00e1shoz.<\/p>","protected":false},"excerpt":{"rendered":"
Research on Non coumarin Components in Bai Zhi Bai Zhi is a plant in the Umbelliferae family, Angelica dahurica (Fisch. ex Hoffm.) Benth Et Hook. f. or Hangbaizhi A dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan’s dried roots. Spicy taste, warm nature. It has the effects of relieving […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\n
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