{"id":5410,"date":"2024-08-04T18:48:24","date_gmt":"2024-08-04T18:48:24","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5410"},"modified":"2024-08-04T18:48:24","modified_gmt":"2024-08-04T18:48:24","slug":"study-on-secondary-metabolites-of-marine-fungus-aspergillus-terreus","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/study-on-secondary-metabolites-of-marine-fungus-aspergillus-terreus\/","title":{"rendered":"Az Aspergillus terreus tengeri gomba m\u00e1sodlagos metabolitjainak vizsg\u00e1lata"},"content":{"rendered":"<p>Az Aspergillus terreus tengeri gomba m\u00e1sodlagos metabolitjainak vizsg\u00e1lata<br \/>\nAz elm\u00falt \u00e9vekben a tengeri term\u00e9szetes term\u00e9kek vil\u00e1gszerte felkeltett\u00e9k a vegy\u00e9szek \u00e9s biol\u00f3gusok figyelm\u00e9t. T\u00f6bb mint 16000 tengeri term\u00e9szetes term\u00e9ket izol\u00e1ltak \u00e9s azonos\u00edtottak tengeri szervezetekb\u0151l, \u00e9s a tengeri mikroorganizmusokat \u00e9rt\u00e9kes forr\u00e1snak tekintik \u00faj antibiotikumok, daganatellenes \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 gy\u00f3gyszerek el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz. A tengeri gomb\u00e1k, k\u00fcl\u00f6n\u00f6sen a tengeri alg\u00e1kkal, szivacsokkal, gerinctelen \u00e1llatokkal \u00e9s \u00fcled\u00e9kekkel rokon gomb\u00e1k hat\u00e9kony termel\u0151i a bioakt\u00edv m\u00e1sodlagos anyagcsereterm\u00e9keknek. A h\u0151m\u00e9rs\u00e9klet, a t\u00e1panyagok, a konkurencia \u00e9s a s\u00f3tartalom jellemz\u0151i miatt a sz\u00e1razf\u00f6ldi gomb\u00e1khoz k\u00e9pest saj\u00e1tos m\u00e1sodlagos anyagcsere-utakat alak\u00edtanak ki, \u00e9s b\u0151s\u00e9gesen k\u00e9pesek \u00faj akt\u00edv term\u00e9szetes term\u00e9keket el\u0151\u00e1ll\u00edtani. Ezek az \u00faj szerkezeti m\u00e1sodlagos anyagcsereterm\u00e9kek fontos szerepet j\u00e1tszanak a gy\u00f3gyszerkutat\u00e1sban.<\/p>\n<p>Az Aspergillus gomb\u00e1k a F\u00f6ld egyik legsz\u00e9lesebb k\u00f6rben elterjedt gombafajcsoportja, amely t\u00f6bb mint 300-350 gombafajt foglal mag\u00e1ban. Jelenleg a m\u00e1sodlagos metabolitok k\u00fcl\u00f6nb\u00f6z\u0151 szerkezeti t\u00edpusait fedezt\u00e9k fel az Aspergillus gomb\u00e1kban, mint p\u00e9ld\u00e1ul alkaloidok, terp\u00e9nek, lignin, szteroidok, poliketonok, ciklikus peptidek stb., \u00e9s ezek k\u00fcl\u00f6nb\u00f6z\u0151 biol\u00f3giai aktivit\u00e1sokkal rendelkeznek, mint p\u00e9ld\u00e1ul daganatellenes, antibakteri\u00e1lis, gyullad\u00e1scs\u00f6kkent\u0151, v\u00edrusellenes stb. Az Aspergillus terreus sz\u00e9les k\u00f6rben jelen van a term\u00e9szetben, \u00e9s gyakran izol\u00e1lj\u00e1k a talaj rizoszf\u00e9r\u00e1j\u00e1b\u00f3l, boml\u00f3 szerves anyagokb\u00f3l \u00e9s tengeri k\u00f6rnyezetb\u0151l. Az Aspergillus terreus a lipidcs\u00f6kkent\u0151 lovasztatin \u00e9s k\u00f6ztiterm\u00e9keinek el\u0151\u00e1ll\u00edt\u00e1sa mellett sz\u00e1mos gazdas\u00e1gilag jelent\u0151s m\u00e1sodlagos anyagcsereterm\u00e9ket is k\u00e9pes el\u0151\u00e1ll\u00edtani. Ugyanaz a bakt\u00e9rium a k\u00fcl\u00f6nb\u00f6z\u0151 forr\u00e1sok \u00e9s k\u00f6rnyezetek miatt k\u00fcl\u00f6nb\u00f6z\u0151 metabolitokat termel. Ebben a tanulm\u00e1nyban a Nansha-szigetek tengeri iszapj\u00e1b\u00f3l izol\u00e1lt Aspergillus terreus t\u00f6rzset v\u00e1lasztottuk kutat\u00e1si t\u00e1rgynak, \u00e9s a nagy\u00fczemi ferment\u00e1ci\u00f3hoz rizs szil\u00e1rd k\u00f6zeget haszn\u00e1ltunk. Szekunder metabolitjait izol\u00e1lt\u00e1k, tiszt\u00edtott\u00e1k \u00e9s azonos\u00edtott\u00e1k, \u00e9s \u00e9rt\u00e9kelt\u00e9k a hipoxia\/reoxigeniz\u00e1ci\u00f3 \u00e1ltal s\u00e9r\u00fclt PC12 sejtek in vitro neuroprotekt\u00edv aktivit\u00e1s\u00e1t, hogy \u00faj szerkezet\u0171 \u00e9s j\u00f3 aktivit\u00e1s\u00fa metabolitokat tal\u00e1ljanak, \u00e9s tov\u00e1bb gazdag\u00edts\u00e1k az Aspergillus gomb\u00e1k m\u00e1sodlagos metabolitjait.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5411\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-143.png\" alt=\"\" width=\"779\" height=\"354\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-143.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-143-768x349.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5412\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-130.png\" alt=\"\" width=\"775\" height=\"279\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-130.png 775w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-130-768x276.png 768w\" sizes=\"(max-width: 775px) 100vw, 775px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5413\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-123.png\" alt=\"\" width=\"775\" height=\"263\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-123.png 775w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-123-768x261.png 768w\" sizes=\"(max-width: 775px) 100vw, 775px\" \/>Ebben a tanulm\u00e1nyban a tengeri forr\u00e1sb\u00f3l sz\u00e1rmaz\u00f3 Aspergillus terreus m\u00e1sodlagos metabolitjait makropor\u00f3zus adszorpci\u00f3s gyant\u00e1val, szilikag\u00e9llel, g\u00e9loszlopkromatogr\u00e1fi\u00e1val \u00e9s f\u00e9lig preparat\u00edv folyad\u00e9kos m\u00f3dszerekkel v\u00e1lasztott\u00e1k el \u00e9s tiszt\u00edtott\u00e1k meg. Tizenh\u00e1rom vegy\u00fcletet izol\u00e1ltak \u00e9s azonos\u00edtottak, amelyek k\u00f6z\u00fcl az 1-3 vegy\u00fcletek \u03b3-butilakton-sz\u00e1rmaz\u00e9kok, a 4 vegy\u00fclet a tengeri term\u00e9szetes alkaloidok egy oszt\u00e1ly\u00e1ba tartoz\u00f3 maleimid (2,5-pirrolidon) sz\u00e1rmaz\u00e9kok, az 5 vegy\u00fclet a lovasztatin nev\u0171 sztatin hat\u00f3anyag, a 6 vegy\u00fclet terp\u00e9nvegy\u00fclet, a 7 vegy\u00fclet pedig metil-benzo\u00e1t vegy\u00fclet volt. NMR-adataikr\u00f3l el\u0151sz\u00f6r sz\u00e1moltak be. A 8-12 vegy\u00fclet \u00f6t diketopiperazin volt, amelyek k\u00f6z\u00fcl a 8. \u00e9s 9. vegy\u00fclet tiodiketopiperazin, a 13. vegy\u00fclet pedig benzopiranon vegy\u00fclet. Az el\u0151zetes in vitro neuroprotekt\u00edv aktivit\u00e1si vizsg\u00e1latok azt mutatt\u00e1k, hogy az 1., 3., 5., 6. \u00e9s 7. vegy\u00fcletek jelent\u0151sen cs\u00f6kkentik az oxidat\u00edv stressz \u00e1ltal okozott sejtk\u00e1rosod\u00e1st. Ez a tanulm\u00e1ny a m\u00e1sodlagos metabolitok \u00e9s az Aspergillus oryzae rizsferment\u00e1ci\u00f3s term\u00e9kekben tal\u00e1lhat\u00f3 egyes vegy\u00fcletek neuroprotekt\u00edv aktivit\u00e1s\u00e1t vizsg\u00e1lta, tudom\u00e1nyos hivatkoz\u00e1si alapot ny\u00fajtva az Aspergillus oryzae m\u00e1sodlagos metabolitok k\u00e9miai sokf\u00e9les\u00e9g\u00e9nek tov\u00e1bbi felt\u00e1r\u00e1s\u00e1hoz a j\u00f6v\u0151ben.<\/p>","protected":false},"excerpt":{"rendered":"<p>Study on secondary metabolites of marine fungus Aspergillus terreus In recent years, marine natural products have attracted the attention of chemists and biologists around the world. More than 16000 marine natural products have been isolated and identified from marine organisms, and marine microorganisms are considered a valuable source for producing new antibiotics, anti-tumor and anti-inflammatory [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on secondary metabolites of marine fungus Aspergillus terreus - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/study-on-secondary-metabolites-of-marine-fungus-aspergillus-terreus\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on secondary metabolites of marine fungus Aspergillus terreus - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on secondary metabolites of marine fungus Aspergillus terreus In recent years, marine natural products have attracted the attention of chemists and biologists around the world. 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