{"id":5245,"date":"2024-08-04T18:00:50","date_gmt":"2024-08-04T18:00:50","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5245"},"modified":"2024-08-04T18:00:50","modified_gmt":"2024-08-04T18:00:50","slug":"atherosclerosis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/atherosclerosis\/","title":{"rendered":"A Morinda officinalis ateroszkler\u00f3zis elleni mechanizmus\u00e1nak felt\u00e1r\u00e1sa h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n"},"content":{"rendered":"

A Morinda officinalis ateroszkler\u00f3zis elleni mechanizmus\u00e1nak felt\u00e1r\u00e1sa h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n
\nAz ateroszkler\u00f3zis (AS) gyakori kr\u00f3nikus sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9g, amelyet a nagy \u00e9s k\u00f6z\u00e9ps\u0151 art\u00e9ri\u00e1k intim\u00e1j\u00e1ban ateroszklerotikus plakk vagy rostos plakk k\u00e9pz\u0151d\u00e9se jellemez. A lipidek besziv\u00e1rg\u00e1sa az art\u00e9ri\u00e1s intim\u00e1ba az ateroszkler\u00f3zis f\u0151 patogenezis\u00e9v\u00e9 v\u00e1lt. Az intim\u00e1ban \u00e9s a m\u00e9diumban \u00f6sszegy\u0171lt makrof\u00e1gok a sejtmembr\u00e1non l\u00e9v\u0151 scavenger receptorokon kereszt\u00fcl nagy mennyis\u00e9g\u0171 oxid\u00e1lt alacsony s\u0171r\u0171s\u00e9g\u0171 lipoproteint (ox LDL) nyelnek el, \u00e9s habsejteket k\u00e9peznek, amelyek arra k\u00e9sztetik a sejteket, hogy nagysz\u00e1m\u00fa proinflammatorikus faktor \u00e9s m\u00e1trix metalloprotein\u00e1z felszabaduljon a sejtek k\u00f6z\u00f6tti t\u00e9rben, el\u0151seg\u00edtik a plakk felhalmoz\u00f3d\u00e1s\u00e1t az art\u00e9ri\u00e1s falban, majd instabil plakk\u00e1 alakulnak, \u00e9s v\u00e9g\u00fcl sz\u00edvinfarktushoz vezetnek. Az AS el\u0151rehalad\u00e1s\u00e1nak hat\u00e9kony k\u00e9sleltet\u00e9se azonban mindig is az egyik olyan kih\u00edv\u00e1s volt, amely a tudom\u00e1nyos k\u00f6z\u00f6ss\u00e9get zavarja. Az ut\u00f3bbi \u00e9vekben a n\u00e9pszer\u0171, felt\u00f6rekv\u0151 gy\u00f3gy- \u00e9s \u00e9tkez\u00e9si term\u00e9k, a Morinda officinalis, bizony\u00edtottan j\u00f3 hat\u00e1ssal van a v\u00e9rzs\u00edrok szab\u00e1lyoz\u00e1s\u00e1ra \u00e9s az ateroszkler\u00f3zis jav\u00edt\u00e1s\u00e1ra.
\nA Morinda citrifolia, m\u00e1s n\u00e9ven Noni, a Rubiaceae csal\u00e1dba tartoz\u00f3 Euphorbia nemzets\u00e9gbe tartoz\u00f3 n\u00f6v\u00e9ny. Farmakol\u00f3giai hat\u00e1sai k\u00f6z\u00e9 tartozik a gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns \u00e9s lipidcs\u00f6kkent\u0151. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s elm\u00e9lete szerint a Morinda officinalis savany\u00fa \u00e9s \u00e9des \u00edz\u0171, kiegyens\u00falyozott gy\u00f3gyhat\u00e1s\u00fa, \u00e9s a veseesszencia t\u00e1pl\u00e1l\u00e1s\u00e1ra, a jin \u00e9s jang kiegyens\u00falyoz\u00e1s\u00e1ra, valamint az \u00f6reged\u00e9s k\u00e9sleltet\u00e9s\u00e9re alkalmas. Hat\u00e9konyan megel\u0151zheti a sz\u00edv- \u00e9s \u00e9rrendszeri, valamint az agyi \u00e9rrendszeri betegs\u00e9geket. A Hai Ba Ji konkr\u00e9t mechanizmusa az AS kezel\u00e9s\u00e9ben azonban m\u00e9g mindig nem vil\u00e1gos. Tekintettel a Morinda officinalis \u00f6sszetett k\u00e9miai \u00f6sszet\u00e9tel\u00e9re, amely f\u0151k\u00e9nt antrakinonokb\u00f3l, flavonoidokb\u00f3l, fenilpropanoidokb\u00f3l, fenolsavakb\u00f3l \u00e9s m\u00e1s \u00f6sszetev\u0151kb\u0151l \u00e1ll, a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s t\u00f6bbkomponens\u0171 \u00e9s t\u00f6bb c\u00e9lpontra vonatkoz\u00f3 jellemz\u0151ivel \u00f6sszhangban a h\u00e1l\u00f3zati farmakol\u00f3gia felhaszn\u00e1lhat\u00f3 a Morinda officinalis farmakol\u00f3giai hat\u00e1sainak molekul\u00e1ris mechanizmus\u00e1nak egy\u00e9rtelm\u0171 megvil\u00e1g\u00edt\u00e1s\u00e1ra. Az ut\u00f3bbi \u00e9vekben a h\u00e1l\u00f3zati farmakol\u00f3gia olyan felt\u00f6rekv\u0151 tudom\u00e1ny\u00e1gg\u00e1 v\u00e1lt, amely integr\u00e1lja a sz\u00e1m\u00edt\u00e1stechnik\u00e1t, a bioinformatik\u00e1t \u00e9s az adatb\u00e1ny\u00e1szatot. Ez egy \"gy\u00f3gyszer hat\u00f3anyag betegs\u00e9g c\u00e9lbetegs\u00e9g\" h\u00e1l\u00f3zatot konstru\u00e1l, \u00e9s megmagyar\u00e1zza annak biol\u00f3giai funkci\u00f3it, lehet\u0151v\u00e9 t\u00e9ve az emberek sz\u00e1m\u00e1ra, hogy vil\u00e1gosabban meg\u00e9rts\u00e9k a betegs\u00e9gek gy\u00f3gyszeres ter\u00e1pi\u00e1j\u00e1nak mechanizmusait \u00e9s mechanizmusait. Ez a tanulm\u00e1ny a Morinda officinalis v\u00e1ltozatos hat\u00f3anyagain \u00e9s gazdag c\u00e9lpontjain alapul, \u00e9s a h\u00e1l\u00f3zati farmakol\u00f3giai m\u00f3dszereket k\u00edv\u00e1nja haszn\u00e1lni a Morinda officinalis c\u00e9lpontjainak, biol\u00f3giai folyamatainak \u00e9s jel\u00e1tviteli \u00fatvonalainak el\u0151rejelz\u00e9s\u00e9re \u00e9s elemz\u00e9s\u00e9re az AS kezel\u00e9s\u00e9ben. Ugyanakkor in vitro k\u00eds\u00e9rleteket haszn\u00e1lnak majd az ellen\u0151rz\u00e9shez, hogy farmakol\u00f3giai alapot biztos\u00edtsanak az AS gy\u00f3gyszerfejleszt\u00e9s\u00e9hez \u00e9s kezel\u00e9s\u00e9hez.<\/p>\n

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\"\"\u00e9relmeszesed\u00e9s\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nAz AS gyakori kardiovaszkul\u00e1ris betegs\u00e9g, \u00e9s gyors progresszi\u00f3ja k\u00f6zvetlen\u00fcl rosszindulat\u00fa kardiovaszkul\u00e1ris esem\u00e9nyekhez, p\u00e9ld\u00e1ul sz\u00edvinfarktushoz vezethet a betegekn\u00e9l. A modern orvostudom\u00e1ny \u00fagy v\u00e9li, hogy a lipidelm\u00e9let m\u00e9g mindig az AS el\u0151fordul\u00e1s\u00e1nak f\u0151 mechanizmusa. A sztatinokat, a PCSK9-g\u00e1tl\u00f3kat \u00e9s m\u00e1s lipidcs\u00f6kkent\u0151 gy\u00f3gyszereket a klinikai gyakorlatban gyakran alkalmazz\u00e1k az ateroszkler\u00f3zis progresszi\u00f3j\u00e1nak lass\u00edt\u00e1s\u00e1ra. A ter\u00e1pi\u00e1s d\u00f3zisokban m\u00e9g mindig el\u0151fordul\u00f3 mell\u00e9khat\u00e1sok, p\u00e9ld\u00e1ul izomf\u00e1jdalom \u00e9s m\u00e1jfunkci\u00f3-k\u00e1rosod\u00e1s miatt azonban sok beteg nem toler\u00e1lja ezeket a gy\u00f3gyszereket. Ez\u00e9rt az AS kezel\u00e9s\u00e9re szolg\u00e1l\u00f3 \u00faj, biztons\u00e1gosabb \u00e9s kev\u00e9sb\u00e9 toxikus gy\u00f3gyszerek keres\u00e9se pozit\u00edv jelent\u0151s\u00e9ggel b\u00edr. A Morinda officinalis, mint felt\u00f6rekv\u0151 gy\u00f3gy\u00e1szati \u00e9s ehet\u0151 term\u00e9k, a hat\u00f3anyagok \u00e9s farmakol\u00f3giai hat\u00e1sok sz\u00e9les sk\u00e1l\u00e1j\u00e1val rendelkezik, ami \u00f6sszhangban van a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s jellemz\u0151 jellemz\u0151ivel, a betegs\u00e9gek t\u00f6bb c\u00e9lpont\u00fa \u00e9s t\u00f6bb \u00fatvonalon t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9vel. Ez a tanulm\u00e1ny h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t haszn\u00e1lt a Morinda officinalis hat\u00e9kony \u00f6sszetev\u0151inek \u00e9s c\u00e9lpontjainak el\u0151rejelz\u00e9s\u00e9re az AS kezel\u00e9s\u00e9ben, \u00e9s THP-1 makrof\u00e1g modellt \u00e9p\u00edtett annak igazol\u00e1s\u00e1ra, hogy a Morinda officinalis el\u0151seg\u00edti az intracellul\u00e1ris koleszterin ki\u00e1raml\u00e1st a PPAR \u03b3 jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl.<\/p>\n

A k\u00fcl\u00f6nb\u00f6z\u0151 adatb\u00e1zisok \u00e1tvizsg\u00e1l\u00e1sa sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy 59 vegy\u00fclet, k\u00f6zt\u00fck flavonoidok, fenilpropanoidok \u00e9s fenolsavak, els\u0151sorban ter\u00e1pi\u00e1s szerepet j\u00e1tszanak az AS kezel\u00e9s\u00e9ben. Az elm\u00falt \u00e9vekben t\u00f6bb kutat\u00e1si jelent\u00e9s is kimutatta, hogy a flavonoidok kulcsszerepet j\u00e1tszanak az AS kezel\u00e9s\u00e9ben, \u00e9s a n\u00f6v\u00e9nyi gy\u00f3gyszerek f\u0151 akt\u00edv helyei. Sahib \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a Morinda officinalis gy\u00fcm\u00f6lcs\u00e9ben a katechin, a kvercetin \u00e9s a kaempferol tartalma 53,68 mg\/g, 7,4 mg\/g, illetve 6,4 mg\/g volt, ami a h\u00e1rom legismertebb akt\u00edv flavonoid k\u00f6z\u00e9 tartozik. Ez a h\u00e1rom komponens jelent\u0151s szerepet j\u00e1tszik a v\u00e9rzs\u00edr-rendelleness\u00e9gek szab\u00e1lyoz\u00e1s\u00e1ban \u00e9s az \u00e9relmeszesed\u00e9s k\u00e9sleltet\u00e9s\u00e9ben. A kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a Yixin Tongmai granul\u00e1tum f\u0151 \u00f6sszetev\u0151je, a katechinek, molekul\u00e1ris dokkol\u00e1ssal \u00e9s in vitro \u00e9s in vivo k\u00eds\u00e9rletekkel k\u00f6zvetlen\u00fcl aktiv\u00e1lhatj\u00e1k a PPAR \u03b3 \u00fatvonalat \u00e9s jav\u00edthatj\u00e1k az AS-t. A kvercetin sz\u00e9les k\u00f6rben jelen van k\u00fcl\u00f6nb\u00f6z\u0151 n\u00f6v\u00e9nyekben, jelent\u0151s ar\u00e1nyban a Morinda officinalisban. Jia \u00e9s munkat\u00e1rsai, valamint Li \u00e9s munkat\u00e1rsai arr\u00f3l sz\u00e1moltak be, hogy a kvercetin jelent\u0151sen cs\u00f6kkentheti az Apoe -\/- eg\u00e9r AS modellj\u00e9nek magas zs\u00edrtartalm\u00fa \u00e9trenddel induk\u00e1lt mellkasi aort\u00e1j\u00e1ban a plakkok tartalm\u00e1t. A mechanizmus az ATP-k\u00f6t\u0151 kazett\u00e1s transzporter A1 (ABCA1) fokozott expresszi\u00f3j\u00e1val f\u00fcgg \u00f6ssze. A kutat\u00e1sok meger\u0151s\u00edtett\u00e9k, hogy a kaempferol er\u0151s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1ssal rendelkezik, \u00e9s a PI3K\/AKT\/Nrf2 \u00fatvonal aktiv\u00e1l\u00e1s\u00e1val k\u00e9sleltetheti az ateroszkler\u00f3zis progresszi\u00f3j\u00e1t.<\/p>\n

Ezt k\u00f6vet\u0151en a GO feld\u00fasul\u00e1si elemz\u00e9s felt\u00e1rta, hogy a Morinda officinalis els\u0151sorban olyan biol\u00f3giai funkci\u00f3kat szab\u00e1lyoz, mint a membr\u00e1nreceptorok \u00e9s a nukle\u00e1ris receptorok a sejtekben; A KEGG jel\u00e1tviteli \u00fatvonalak feld\u00fasul\u00e1si elemz\u00e9se felt\u00e1rta, hogy az AS Morinda officinalis-szal t\u00f6rt\u00e9n\u0151 kezel\u00e9se a lipidanyagcser\u00e9vel kapcsolatos jel\u00e1tviteli \u00fatvonalakhoz kapcsol\u00f3dik, amelyek k\u00f6z\u00fcl az egyik a PPAR jel\u00e1tviteli \u00fatvonal. A kutat\u00e1sok kimutatt\u00e1k, hogy a lipidanyagcser\u00e9vel kapcsolatos jel\u00e1tviteli \u00fatvonalak, k\u00fcl\u00f6n\u00f6sen a PPAR jel\u00e1tviteli \u00fatvonal, szorosan kapcsol\u00f3dnak a sejtmembr\u00e1non l\u00e9v\u0151 lipid transzporterekhez \u00e9s a sejtmagban l\u00e9v\u0151 receptorokhoz. Mint tudjuk, a PPAR-ok klasszikus nukle\u00e1ris receptorok, amelyek a sejtmagban helyezkednek el. A m\u00e1sodik h\u00edrviv\u0151 jel\u00e9nek fogad\u00e1sa ut\u00e1n a PPAR-ok a downstream transzkripci\u00f3s faktorok aktiv\u00e1l\u00e1s\u00e1val n\u00f6velik a koleszterin transzporterek expresszi\u00f3j\u00e1t a sejtmembr\u00e1non, ez\u00e1ltal cs\u00f6kkentik a koleszterin felhalmoz\u00f3d\u00e1s\u00e1t a sejtekben, \u00e9s megakad\u00e1lyozz\u00e1k, hogy a makrof\u00e1gok habsejtekk\u00e9 alakuljanak. Ez\u00e9rt a PPAR jel\u00e1tviteli \u00fatvonal fontos szerepet j\u00e1tszik a lipidmagok habsejtek kialakul\u00e1s\u00e1nak cs\u00f6kkent\u00e9s\u00e9ben \u00e9s az AS k\u00e9sleltet\u00e9s\u00e9ben. Ezenk\u00edv\u00fcl a PPARG g\u00e9n ebben a tanulm\u00e1nyban is fontos csom\u00f3pont a komponens c\u00e9lh\u00e1l\u00f3zat\u00e1nak magh\u00e1l\u00f3zat\u00e1ban.<\/p>\n

A fenti h\u00e1l\u00f3zati farmakol\u00f3giai elemz\u00e9s alapj\u00e1n ebben a tanulm\u00e1nyban THP-1 makrof\u00e1gokat \u00e1ll\u00edtottak el\u0151, hogy in vitro szimul\u00e1lj\u00e1k az ateroszklerotikus plakkokban l\u00e9v\u0151 habsejteket. Miut\u00e1n a Morinda officinalis beavatkozott a THP-1 sz\u00e1rmaz\u00e9k makrof\u00e1gokba, azt tal\u00e1lt\u00e1k, hogy az intracellul\u00e1ris koleszterintartalom jelent\u0151sen cs\u00f6kkent, \u00e9s a PPAR \u03b3 expresszi\u00f3ja a sejtekben jelent\u0151sen felszab\u00e1lyoz\u00f3dott. Inada \u00e9s munkat\u00e1rsai, illetve Nerurkar \u00e9s munkat\u00e1rsai \u00e1llatk\u00eds\u00e9rletekkel igazolt\u00e1k a Morinda officinalis lipidcs\u00f6kkent\u0151 hat\u00e1s\u00e1t. Egy klinikai vizsg\u00e1latban meg\u00e1llap\u00edtott\u00e1k, hogy a Morinda officinalis jelent\u0151sen cs\u00f6kkentheti a sz\u00e9rum LDL-szintj\u00e9t \u00e9s n\u00f6velheti a nagy s\u0171r\u0171s\u00e9g\u0171 lipoprotein (HDL) szintj\u00e9t er\u0151sen doh\u00e1nyz\u00f3 alanyokn\u00e1l. Nemr\u00e9giben Chong \u00e9s munkat\u00e1rsai meger\u0151s\u00edtett\u00e9k, hogy a Morinda officinalis jelent\u0151sen cs\u00f6kkentheti a lipid plakkokat a termikusan oxid\u00e1lt p\u00e1lmaolaj di\u00e9t\u00e1val kiv\u00e1ltott AS patk\u00e1ny modell aort\u00e1j\u00e1ban, de a specifikus mechanizmust nem tiszt\u00e1zt\u00e1k. Kor\u00e1bban Lee \u00e9s munkat\u00e1rsai 70% metanollal extrah\u00e1lt\u00e1k a Morinda officinalis gy\u00fcm\u00f6lcs\u00e9nek sz\u00e1r\u00edtott por\u00e1t, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy k\u00e9pes gerjeszteni a PPAR \u03b3 receptorokat a C2C12 v\u00e1zizomsejtekben. Ez a k\u00eds\u00e9rleti jelent\u00e9s \u00f6sszhangban van az eredm\u00e9nyeinkkel. Ebben a tanulm\u00e1nyban tal\u00e1ltuk el\u0151sz\u00f6r, hogy a Morinda officinalis el\u0151seg\u00edtheti a koleszterin ki\u00e1raml\u00e1s\u00e1t a THP-1 sz\u00e1rmaztatott makrof\u00e1gokb\u00f3l, \u00e9s a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1val kombin\u00e1lva el\u0151re jelezte a ford\u00edtott koleszterintranszport (RCT) hat\u00e1s\u00e1t a PPAR \u03b3 jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1s\u00e1val. Az egyik fontos mechanizmus, amellyel az RCT szab\u00e1lyozza a lipid-rendelleness\u00e9geket \u00e9s jav\u00edtja az AS-t in vivo, a koleszterin sejtekb\u0151l t\u00f6rt\u00e9n\u0151 \u00e1tvitele a sejtmembr\u00e1non l\u00e9v\u0151 scavenger-receptorokon kereszt\u00fcl, amely azt\u00e1n a plazm\u00e1ban l\u00e9v\u0151 apolipoprotein A, apoE \u00e9s m\u00e1s feh\u00e9rj\u00e9khez k\u00f6t\u0151dik, \u00e9s metabolizmus c\u00e9lj\u00e1b\u00f3l a m\u00e1jba ker\u00fcl. Ezut\u00e1n epesavakk\u00e1 alakul \u00e1t \u00e9s kiv\u00e1laszt\u00f3dik a szervezetb\u0151l, ez\u00e1ltal jav\u00edtva a lipidanyagcsere-rendelleness\u00e9geket. Az ABCA1-et, mint a makrof\u00e1gok membr\u00e1nj\u00e1n l\u00e9v\u0151 fontos scavenger-receptort, a PPAR \u03b3 upstream nukle\u00e1ris transzkripci\u00f3s faktor finoman szab\u00e1lyozza, \u00e9s az RCT-folyamaton kereszt\u00fcl felel\u0151s az intracellul\u00e1ris koleszterin extracellul\u00e1ris t\u00e9rbe t\u00f6rt\u00e9n\u0151 sz\u00e1ll\u00edt\u00e1s\u00e1\u00e9rt. Ebben a vizsg\u00e1latban az ABCA1 expresszi\u00f3s szintje a PPAR \u03b3 aktiv\u00e1l\u00e1s\u00e1val felfel\u00e9 szab\u00e1lyoz\u00f3dott. Amikor a PPAR \u03b3 g\u00e1tl\u00f3 GW9662-t haszn\u00e1lt\u00e1k, az ABCA1 receptor expresszi\u00f3j\u00e1nak felfel\u00e9 ir\u00e1nyul\u00f3 szab\u00e1lyoz\u00f3d\u00e1si tendenci\u00e1ja a THP-1 sz\u00e1rmaz\u00e9k makrof\u00e1gokban g\u00e1tolt volt, \u00e9s nem volt jelent\u0151s cs\u00f6kken\u00e9s az intracellul\u00e1ris koleszterintartalomban, ami azt jelzi, hogy a PPAR \u03b3 \u00e1ltal k\u00f6zvet\u00edtett ABCA1 az intracellul\u00e1ris koleszterinsz\u00e1ll\u00edt\u00e1s f\u0151 sz\u00e1ll\u00edt\u00f3ja. Hasonl\u00f3k\u00e9ppen, a kvercetin, a baicalin \u00e9s a dihidromiricetin mind el\u0151seg\u00edthetik az RCT-t \u00e9s AS-ellenes hat\u00e1st fejthetnek ki a PPAR \u03b3\/ABCA1 jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1s\u00e1val. Ez\u00e9rt a Morinda officinalis a PPAR \u03b3 jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1s\u00e1val el\u0151seg\u00edtheti a koleszterin ki\u00e1raml\u00e1s\u00e1t a THP-1 sz\u00e1rmaz\u00e9k makrof\u00e1gokb\u00f3l.<\/p>\n

\u00d6sszefoglalva, a Morinda officinalis \u00e9des \u00e9s savany\u00fa \u00edz\u0171, kiegyens\u00falyozott gy\u00f3gyhat\u00e1s\u00fa. T\u00e1pl\u00e1lhatja a vese esszenci\u00e1j\u00e1t, kiegyens\u00falyozhatja a jin \u00e9s a jang egyens\u00faly\u00e1t, \u00e9s megel\u0151zheti a sz\u00edv- \u00e9s \u00e9rrendszeri, valamint az agyi \u00e9rrendszeri betegs\u00e9geket. Ez a tanulm\u00e1ny a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t kombin\u00e1lta in vitro k\u00eds\u00e9rletekkel, hogy felt\u00e1rja a Morinda officinalis mechanizmus\u00e1t az AS kezel\u00e9s\u00e9ben, \u00e9s el\u0151sz\u00f6r mutatta ki, hogy a Morinda officinalis el\u0151seg\u00edtheti a koleszterin ki\u00e1raml\u00e1s\u00e1t a THP-1 sz\u00e1rmaz\u00e1s\u00fa makrof\u00e1gokb\u00f3l \u00e9s el\u0151seg\u00edtheti az RCT-t a PPAR \u03b3 jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1s\u00e1val. Ez\u00e9rt ez a tanulm\u00e1ny \u00faj farmakol\u00f3giai mechanizmust biztos\u00edt az AS hat\u00e9kony megel\u0151z\u00e9s\u00e9hez \u00e9s kezel\u00e9s\u00e9hez a Morinda officinalis seg\u00edts\u00e9g\u00e9vel. A tanulm\u00e1nynak azonban m\u00e9g mindig van n\u00e9h\u00e1ny korl\u00e1toz\u00e1sa: (1) Mivel a TCMSP adatb\u00e1zis nem tartalmazta a Morinda officinalis n\u00f6v\u00e9nyi gy\u00f3gyszert, a CAMUP adatb\u00e1zist \u00e9s a SwissADME adatb\u00e1zist haszn\u00e1ltuk a hat\u00f3anyagok sz\u0171r\u00e9s\u00e9nek seg\u00edt\u00e9s\u00e9re. B\u00e1r voltak olyan tanulm\u00e1nyok, amelyek t\u00f6bb adatb\u00e1zist haszn\u00e1ltak a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat \u00f6sszetev\u0151inek k\u00f6z\u00f6s sz\u0171r\u00e9s\u00e9re, a k\u00fcl\u00f6nb\u00f6z\u0151 adatb\u00e1zisokban a hat\u00f3anyagok sz\u0171r\u00e9si krit\u00e9riumai elt\u00e9r\u0151ek, ez\u00e9rt tov\u00e1bbi ellen\u0151rz\u00e9sre van sz\u00fcks\u00e9g a sz\u0171r\u00e9s megb\u00edzhat\u00f3s\u00e1ga tekintet\u00e9ben; (2) Ez a tanulm\u00e1ny 5 betegs\u00e9ggel kapcsolatos adatb\u00e1zist sz\u0171rte, \u00e9s az eredm\u00e9nyek azt mutatt\u00e1k, hogy az egyes adatb\u00e1zisokban jelent\u0151s k\u00fcl\u00f6nbs\u00e9gek voltak az AS c\u00e9lpontok sz\u00e1m\u00e1ban, ami \u00f6sszef\u00fcgghet az egyes adatb\u00e1zisokban szerepl\u0151 betegs\u00e9gt\u00edpusok k\u00fcl\u00f6nbs\u00e9geivel; (3) Az in vitro k\u00eds\u00e9rletek eredm\u00e9nyei alapj\u00e1n kutat\u00f3csoportunk tov\u00e1bb \u00e9p\u00edti az AS \u00e1llatmodellj\u00e9t, hogy teljesebb k\u00eds\u00e9rleti alapot biztos\u00edtson az RCT el\u0151mozd\u00edt\u00e1s\u00e1ra \u00e9s az AS k\u00e9sleltet\u00e9s\u00e9re a Morinda officinalis \u00e1ltal az in vivo k\u00eds\u00e9rletek szempontj\u00e1b\u00f3l.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism of Morinda officinalis against atherosclerosis based on network pharmacology and experimental verification Atherosclerosis (AS) is a common chronic cardiovascular disease characterized by the formation of atherosclerotic plaque or fibrous plaque in the intima of large and middle arteries. The infiltration of lipids into the arterial intima has become the main pathogenesis of […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of Morinda officinalis against atherosclerosis based on network pharmacology and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/atherosclerosis\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of Morinda officinalis against atherosclerosis based on network pharmacology and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of Morinda officinalis against atherosclerosis based on network pharmacology and experimental verification Atherosclerosis (AS) is a common chronic cardiovascular disease characterized by the formation of atherosclerotic plaque or fibrous plaque in the intima of large and middle arteries. 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