{"id":5203,"date":"2024-08-04T17:48:42","date_gmt":"2024-08-04T17:48:42","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5203"},"modified":"2024-08-04T17:48:42","modified_gmt":"2024-08-04T17:48:42","slug":"mushroom","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/mushroom\/","title":{"rendered":"\u00daj fibrinolitikus enzim hat\u00e9kony elv\u00e1laszt\u00e1sa \u00e9s tiszt\u00edt\u00e1sa a b\u00e1rsony agancsgomba term\u0151test\u00e9b\u0151l"},"content":{"rendered":"

\u00daj fibrinolitikus enzim hat\u00e9kony elv\u00e1laszt\u00e1sa \u00e9s tiszt\u00edt\u00e1sa a b\u00e1rsony agancsgomba term\u0151test\u00e9b\u0151l
\nA tromboemb\u00f3li\u00e1s betegs\u00e9gek magas rokkants\u00e1gi \u00e9s hal\u00e1loz\u00e1si ar\u00e1nnyal j\u00e1rnak. A fibrin a v\u00e9rr\u00f6g\u00f6k f\u0151 \u00f6sszetev\u0151je, ez\u00e9rt a fibrin lebont\u00e1s\u00e1nak el\u0151seg\u00edt\u00e9se a trombotikus betegs\u00e9gek megel\u0151z\u00e9s\u00e9nek \u00e9s kezel\u00e9s\u00e9nek egyik gyakori eszk\u00f6ze. Az exog\u00e9n fibrinolitikus enzimeket, mint p\u00e9ld\u00e1ul az urokin\u00e1zt (UK) \u00e9s a sztreptokin\u00e1zt (SK), sz\u00e9les k\u00f6rben alkalmazz\u00e1k a tromboemb\u00f3li\u00e1s betegs\u00e9gek klinikai kezel\u00e9s\u00e9ben, mivel k\u00f6zvetve vagy k\u00f6zvetlen\u00fcl k\u00e9pesek hidroliz\u00e1lni a fibrint. B\u00e1r jelent\u0151s trombol\u00edtikus hat\u00e9konys\u00e1ggal rendelkeznek, alkalmaz\u00e1suknak vannak bizonyos korl\u00e1tai is, mint p\u00e9ld\u00e1ul a r\u00f6vid felez\u00e9si id\u0151 \u00e9s a jelent\u0151s mell\u00e9khat\u00e1sok. Ez\u00e9rt az er\u0151s specificit\u00e1ssal, j\u00f3 biztons\u00e1ggal \u00e9s alacsony mell\u00e9khat\u00e1sokkal rendelkez\u0151 \u00faj fibrinolitikus enzimek keres\u00e9se a jelenlegi kutat\u00e1sok egyik forr\u00f3 pontj\u00e1v\u00e1 v\u00e1lt.<\/p>\n

Az ehet\u0151 gomb\u00e1k feh\u00e9rj\u00e9kben, poliszacharidokban, terp\u00e9nekben, aminosavakban, szterolokban, nukleozidokban \u00e9s egy\u00e9b anyagokban gazdagok, amelyek k\u00fcl\u00f6nb\u00f6z\u0151 \u00e9lettani funkci\u00f3kkal rendelkeznek, p\u00e9ld\u00e1ul antioxid\u00e1ns, daganatellenes, immunrendszer-szab\u00e1lyoz\u00f3 \u00e9s idegi szab\u00e1lyoz\u00e1ssal. Jelenleg az ehet\u0151 gomb\u00e1kb\u00f3l sz\u00e1rmaz\u00f3 fibrinolitikus enzimek \u00e9s funkcion\u00e1lis tulajdons\u00e1gaik kutat\u00e1sa sz\u00e9les k\u00f6r\u0171 figyelmet kap. Jelentett\u00e9k, hogy fibrinolitikus enzimeket izol\u00e1ltak \u00e9s extrah\u00e1ltak k\u00fcl\u00f6nb\u00f6z\u0151 ehet\u0151 gomb\u00e1kb\u00f3l, p\u00e9ld\u00e1ul Lentinus edodes, Cordyceps Militaris, Agrocybe aegerita, Tricholoma sejunctum, Lepista nuda, Pleurotus ferulae stb.<\/p>\n

A szarvasagancs gomba az \u00e9szaki f\u00e9lteke m\u00e9rs\u00e9kelt \u00e9g\u00f6vi r\u00e9gi\u00f3iban sz\u00e9les k\u00f6rben elterjedt, f\u00e1n boml\u00f3, ehet\u0151 \u00e9s gy\u00f3gyhat\u00e1s\u00fa gomba. Olyan \u00e9lettani funkci\u00f3kkal rendelkezik, mint az antioxid\u00e1ns, immuner\u0151s\u00edt\u0151, tumorelnyom\u00f3 \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151. Az el\u0151zetes k\u00eds\u00e9rletek sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy a b\u00e1rsony agancsgomba term\u0151test\u00e9nek kivonata magas aktivit\u00e1s\u00fa plazmint tartalmazott, amely jelent\u0151sen magasabb volt, mint a m\u00e1s ehet\u0151 gomb\u00e1kb\u00f3l sz\u00e1rmaz\u00f3, bejelentett plazmin. Ez a cikk bemutatja a b\u00e1rsony agancsgomba term\u0151test\u00e9ben l\u00e9v\u0151 fibrinolitikus enzim elv\u00e1laszt\u00e1si \u00e9s tiszt\u00edt\u00e1si m\u00f3dszer\u00e9t, \u00e9s el\u0151zetesen azonos\u00edtja az enzimet. Jelenleg kutat\u00f3csoportunk nem tal\u00e1lkozott m\u00e1s, a b\u00e1rsony agancsgomb\u00e1ban tal\u00e1lhat\u00f3 fibrinolitikus enzimmel kapcsolatos besz\u00e1mol\u00f3kkal. Ez a tanulm\u00e1ny alapot ny\u00fajthat a b\u00e1rsony agancsgomba fibrinolitikus enzim trombol\u00edtikus \u00e9s antitrombotikus funkcion\u00e1lis vizsg\u00e1latainak elv\u00e9gz\u00e9s\u00e9hez, valamint elm\u00e9leti alapot teremthet a funkcion\u00e1lis \u00e9lelmiszerek kifejleszt\u00e9s\u00e9ben val\u00f3 felhaszn\u00e1l\u00e1s\u00e1hoz.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Ebben a tanulm\u00e1nyban egy fibrinolitikus enzimet izol\u00e1ltak \u00e9s tiszt\u00edtottak meg a b\u00e1rsony agancsgomba term\u0151test\u00e9b\u0151l modern kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si technol\u00f3gi\u00e1val. A fibrinolitikus enzim N-termin\u00e1lis tizenk\u00e9t aminosav szekvenci\u00e1ja Gly Ala Val Thr Gln Asn Ala Pro Trp Gly Leu. Az NCBI adatb\u00e1zis\u00e1val val\u00f3 \u00f6sszehasonl\u00edt\u00e1s ut\u00e1n a fibrinolitikus enzimet \u00faj fibrinolitikus enzimk\u00e9nt azonos\u00edtott\u00e1k. A fibrinolitikus enzim specifikus aktivit\u00e1sa 4105,78U\/mg, a tiszt\u00edt\u00e1si t\u00e9nyez\u0151 206,09, az aktivit\u00e1s visszanyer\u00e9si ar\u00e1nya 30,91%. Nat\u00edv PAGE elektrofor\u00e9zis \u00e9s SDS-PAGE elektrofor\u00e9zis kimutat\u00e1s\u00e1val meg\u00e1llap\u00edtott\u00e1k, hogy a fibrinolitikus enzim relat\u00edv molekulat\u00f6mege 30,9 kDa. A fenti eredm\u00e9nyek azt mutatj\u00e1k, hogy a b\u00e1rsony agancsgomba term\u0151test\u00e9b\u0151l sz\u00e1rmaz\u00f3 \u00faj fibrinolitikus enzim j\u00f3 trombol\u00edtikus potenci\u00e1llal rendelkezik, \u00e9s felhaszn\u00e1lhat\u00f3 a trombof\u00edli\u00e1s hajlamot cs\u00f6kkent\u0151 funkcion\u00e1lis \u00e9lelmiszerek kifejleszt\u00e9s\u00e9re.<\/p>","protected":false},"excerpt":{"rendered":"

Efficient separation and purification of novel fibrinolytic enzyme from the fruiting body of velvet antler mushroom Thromboembolic diseases have a high disability and mortality rate. Fibrin is the main component of blood clots, therefore, promoting fibrin degradation is a common means of preventing and treating thrombotic diseases. Exogenous fibrinolytic enzymes, such as urokinase (UK) and […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nEfficient separation and purification of novel fibrinolytic enzyme from the fruiting body of velvet antler mushroom - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/mushroom\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Efficient separation and purification of novel fibrinolytic enzyme from the fruiting body of velvet antler mushroom - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Efficient separation and purification of novel fibrinolytic enzyme from the fruiting body of velvet antler mushroom Thromboembolic diseases have a high disability and mortality rate. 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