{"id":5138,"date":"2024-08-04T17:30:44","date_gmt":"2024-08-04T17:30:44","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5138"},"modified":"2024-08-04T17:30:44","modified_gmt":"2024-08-04T17:30:44","slug":"camel-blood-protein","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/camel-blood-protein\/","title":{"rendered":"A hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00f3 peptidek sz\u00e1m\u00edt\u00f3g\u00e9pes szimul\u00e1ci\u00f3s \u00e9rt\u00e9kel\u00e9se tevev\u00e9rfeh\u00e9rj\u00e9ben"},"content":{"rendered":"<p>A hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00f3 peptidek sz\u00e1m\u00edt\u00f3g\u00e9pes szimul\u00e1ci\u00f3s \u00e9rt\u00e9kel\u00e9se tevev\u00e9rfeh\u00e9rj\u00e9ben<br \/>\nAz elm\u00falt \u00e9vekben az emberek \u00e9letsz\u00ednvonal\u00e1nak javul\u00e1s\u00e1val \u00e9s a t\u00e1pl\u00e1lkoz\u00e1si szok\u00e1sok megv\u00e1ltoz\u00e1s\u00e1val a hiperlipid\u00e9mia (HLP) fokozatosan az emberi eg\u00e9szs\u00e9get vesz\u00e9lyeztet\u0151 \"els\u0151 sz\u00e1m\u00fa gyilkoss\u00e1\" v\u00e1lt. Ezt a betegs\u00e9get a szervezet lipidanyagcser\u00e9j\u00e9nek diszregul\u00e1ci\u00f3ja okozza. Tekintettel a koleszterin felsz\u00edv\u00f3d\u00e1sa \u00e9s a lipidanyagcsere k\u00f6z\u00f6tti szoros kapcsolatra, a koleszterin felsz\u00edv\u00f3d\u00e1si \u00fatvonal fontos beavatkoz\u00e1si c\u00e9lpontt\u00e1 v\u00e1lt a hiperlipid\u00e9mia kezel\u00e9s\u00e9ben, amely a koleszterin felsz\u00edv\u00f3d\u00e1s\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel a b\u00e9lben hat\u00e9konyan megel\u0151zheti a hiperlipid\u00e9mi\u00e1t. A t\u00e1pl\u00e1l\u00e9kkal bevitt lipideket el\u0151sz\u00f6r a hasny\u00e1lmirigy lip\u00e1z hidroliz\u00e1lja, zs\u00edrsavakk\u00e1 \u00e9s monogliceridekk\u00e9 bontja, a koleszterinnel, epes\u00f3kkal stb. micell\u00e1kat k\u00e9pez, \u00e9s v\u00e9g\u00fcl a b\u00e9lben l\u00e9v\u0151 sejtek felsz\u00edvj\u00e1k. Ez\u00e9rt a hasny\u00e1lmirigy-lip\u00e1z (PL) aktivit\u00e1s hat\u00e9kony g\u00e1tl\u00e1sa cs\u00f6kkentheti a lipidek felsz\u00edv\u00f3d\u00e1s\u00e1t a szervezetben, enyh\u00edtheti a forr\u00e1sb\u00f3l sz\u00e1rmaz\u00f3 \u00e1llapotot, \u00e9s megel\u0151zheti a betegs\u00e9geket. A piacon l\u00e9v\u0151 egyes gy\u00f3gyszereknek vannak bizonyos mell\u00e9khat\u00e1sai, amelyek kellemetlens\u00e9geket okozhatnak a betegekn\u00e9l. Ez\u00e9rt s\u00fcrg\u0151s a term\u00e9szetben el\u0151fordul\u00f3 bioakt\u00edv anyagok kifejleszt\u00e9se a hiperlipid\u00e9mia kezel\u00e9s\u00e9nek seg\u00edt\u00e9s\u00e9re.<\/p>\n<p>A bioakt\u00edv peptidek az ut\u00f3bbi \u00e9vekben a kutat\u00e1s egyik forr\u00e1saiv\u00e1 v\u00e1ltak sz\u00e9les k\u00f6r\u0171 forr\u00e1saik \u00e9s magas biztons\u00e1gi t\u00e9nyez\u0151j\u00fck miatt. A tevev\u00e9r magas feh\u00e9rjetartalommal rendelkezik, teljes feh\u00e9rjetartalma 6,80 g\/dl, hemoglobintartalma pedig 141,11 g\/l, ami magasabb, mint m\u00e1s haszon\u00e1llatok\u00e9. Ezenk\u00edv\u00fcl gazdag aminosavv\u00e1laszt\u00e9kkal rendelkezik, amely megfelel a WHO\/FAO\/UNU aj\u00e1nlott \u00e9rt\u00e9keinek, \u00e9s kiv\u00e1l\u00f3 min\u0151s\u00e9g\u0171 bioakt\u00edv peptidek potenci\u00e1lis forr\u00e1sa. A kutat\u00e1sok pedig kimutatt\u00e1k, hogy a tevev\u00e9r prote\u00e1z-hidroliz\u00e1tumok f\u00e1radts\u00e1g elleni, antioxid\u00e1ns \u00e9s v\u00e9rnyom\u00e1scs\u00f6kkent\u0151 hat\u00e1ssal rendelkeznek. Ez\u00e9rt a hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00f3 peptidek el\u0151\u00e1ll\u00edt\u00e1sa tevev\u00e9rfeh\u00e9rj\u00e9b\u0151l bizonyos kutat\u00e1si \u00e9rt\u00e9kkel b\u00edr.<\/p>\n<p>Ebben a tanulm\u00e1nyban semleges prote\u00e1zt haszn\u00e1ltak a tevev\u00e9rfeh\u00e9rje hidroliz\u00e1l\u00e1s\u00e1hoz, \u00e9s a hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00e1si ar\u00e1ny\u00e1t haszn\u00e1lt\u00e1k \u00e9rt\u00e9kel\u00e9si indexk\u00e9nt az enzimatikus hidrol\u00edzis folyamat\u00e1nak optimaliz\u00e1l\u00e1s\u00e1hoz. A tevev\u00e9r peptidek molekulat\u00f6meg-eloszl\u00e1s\u00e1nak meghat\u00e1roz\u00e1s\u00e1hoz m\u00e1trix-assziszt\u00e1lt l\u00e9zer deszorpci\u00f3s\/ioniz\u00e1ci\u00f3s rep\u00fcl\u00e9si idej\u0171 t\u00f6megspektrometri\u00e1t (MALDI-TOF-MS), a tevev\u00e9r peptidek azonos\u00edt\u00e1s\u00e1hoz \u00e9s elemz\u00e9s\u00e9hez pedig folyad\u00e9kkromatogr\u00e1fi\u00e1s t\u00f6megspektrometri\u00e1t (LC-MS) alkalmaztunk. A PepSite2-t a k\u00f6t\u0151helyek modellez\u00e9s\u00e9re \u00e9s el\u0151rejelz\u00e9s\u00e9re haszn\u00e1lt\u00e1k, \u00e9s molekuladinamikai szimul\u00e1ci\u00f3t alkalmaztak a vizsg\u00e1lt peptidek k\u00f6t\u0151helyeinek \u00e9s hat\u00e1sm\u00f3djainak \u00e9rt\u00e9kel\u00e9s\u00e9re, ami alapot szolg\u00e1ltat a tevev\u00e9r peptidek j\u00f6v\u0151beli azonos\u00edt\u00e1s\u00e1hoz \u00e9s elemz\u00e9s\u00e9hez. A lip\u00e1zg\u00e1tl\u00f3 peptidek vizsg\u00e1lata referenci\u00e1t \u00e9s \u00faj \u00f6tleteket ny\u00fajt a tevev\u00e9r fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5139\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-121.png\" alt=\"\" width=\"363\" height=\"250\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5140\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-107.png\" alt=\"\" width=\"775\" height=\"445\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-107.png 775w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-107-768x441.png 768w\" sizes=\"(max-width: 775px) 100vw, 775px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5141\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-101.png\" alt=\"\" width=\"778\" height=\"435\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-101.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-101-768x429.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5142\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-90.png\" alt=\"\" width=\"781\" height=\"187\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-90.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-90-768x184.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5143\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-83.png\" alt=\"\" width=\"781\" height=\"198\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-83.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-83-768x195.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5144\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-75.png\" alt=\"\" width=\"776\" height=\"630\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-75.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-75-768x624.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5145\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-68.png\" alt=\"\" width=\"774\" height=\"410\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-68.png 774w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-68-768x407.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5146\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-63.png\" alt=\"\" width=\"776\" height=\"231\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-63.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-63-768x229.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5147\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-57.png\" alt=\"\" width=\"775\" height=\"277\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-57.png 775w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-57-768x274.png 768w\" sizes=\"(max-width: 775px) 100vw, 775px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5148\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-47.png\" alt=\"\" width=\"771\" height=\"297\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-47.png 771w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-47-768x296.png 768w\" sizes=\"(max-width: 771px) 100vw, 771px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5149\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-42.png\" alt=\"\" width=\"777\" height=\"341\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-42.png 777w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-42-768x337.png 768w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5150\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-36.png\" alt=\"\" width=\"779\" height=\"216\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-36.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-36-768x213.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5151\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-31.png\" alt=\"\" width=\"774\" height=\"291\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-31.png 774w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-31-768x289.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5152\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-26.png\" alt=\"\" width=\"774\" height=\"261\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-26.png 774w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-26-768x259.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5153\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-20.png\" alt=\"\" width=\"761\" height=\"684\" \/><br \/>\nA hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00e1sa a hiperlipid\u00e9mia \u00e9s az elh\u00edz\u00e1s egyik fontos ter\u00e1pi\u00e1s beavatkoz\u00e1s\u00e1nak tekinthet\u0151. Ebben a tanulm\u00e1nyban a tevev\u00e9r hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00f3 peptidek semleges prote\u00e1z hidrol\u00edzissel t\u00f6rt\u00e9n\u0151 el\u0151\u00e1ll\u00edt\u00e1s\u00e1nak folyamat\u00e1t optimaliz\u00e1ltuk a hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00f3 aktivit\u00e1s alapj\u00e1n egyt\u00e9nyez\u0151s \u00e9s v\u00e1laszfel\u00fcleti k\u00eds\u00e9rletekkel. Optim\u00e1lis k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt a tevev\u00e9r peptid hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00e1si ar\u00e1nya 42,13% volt. Az enzimatikus hidrol\u00edzis term\u00e9keinek MALDI-TOF-MS, LC-MS \u00e9s bioinformatikai technol\u00f3gia seg\u00edts\u00e9g\u00e9vel t\u00f6rt\u00e9n\u0151 elemz\u00e9s\u00e9vel h\u00e1rom peptidszegmens, az ALERMFLGF, a GQPAVPVRF \u00e9s a WDPSKVPPR, a hasny\u00e1lmirigy lip\u00e1zhoz val\u00f3 szignifik\u00e1ns k\u00f6t\u0151d\u00e9s\u00e9t azonos\u00edtott\u00e1k. Molekuladinamikai szimul\u00e1ci\u00f3k seg\u00edts\u00e9g\u00e9vel meg\u00e1llap\u00edtott\u00e1k, hogy a h\u00e1rom peptidszegmens f\u0151k\u00e9nt a PL akt\u00edv hely\u00e9nek aminosavmaradv\u00e1nyaihoz k\u00f6t\u0151dik hidrog\u00e9nk\u00f6t\u00e9sen \u00e9s hidrof\u00f3b k\u00f6lcs\u00f6nhat\u00e1sokon kereszt\u00fcl, megzavarva a pankre\u00e1sz lip\u00e1z N-termin\u00e1lis dom\u00e9n szelep\u00e9nek m\u0171k\u00f6d\u00e9s\u00e9t \u00e9s g\u00e1tolva annak aktivit\u00e1s\u00e1t. K\u00f6z\u00fcl\u00fck a GQPAVPVRF magas k\u00f6t\u00e9si szabad energi\u00e1val \u00e9s 100ns-en bel\u00fcl nagysz\u00e1m\u00fa hidrog\u00e9nk\u00f6t\u00e9ssel rendelkezik, ami azt jelenti, hogy szorosan k\u00f6t\u0151dhet az 1ETH-hoz, \u00e9s v\u00e1rhat\u00f3an a hasny\u00e1lmirigy-lip\u00e1z inhibitorok \u00f6sszetev\u0151j\u00e9v\u00e9 v\u00e1lik. A kutat\u00e1si eredm\u00e9nyek arra utalnak, hogy a tevev\u00e9rfeh\u00e9rje a hasny\u00e1lmirigy-lip\u00e1z g\u00e1tl\u00f3 peptidek forr\u00e1sak\u00e9nt szolg\u00e1lhat. A virtu\u00e1lis sz\u0171r\u00e9s eredm\u00e9nyeinek azonban vannak bizonyos korl\u00e1tai, \u00e9s a j\u00f6v\u0151ben optimaliz\u00e1lni kell a peptidszegmensek v\u00edzoldhat\u00f3s\u00e1g\u00e1t \u00e9s em\u00e9szt\u00e9si stabilit\u00e1s\u00e1t. A mesters\u00e9ges szint\u00e9zis ut\u00e1n a hiperlipid\u00e9miaellenes hat\u00e1st in vitro \u00e9s in vivo k\u00eds\u00e9rletekkel kell igazolni.<\/p>","protected":false},"excerpt":{"rendered":"<p>Computer simulation evaluation of pancreatic lipase inhibitory peptides in camel blood protein In recent years, with the improvement of people&#8217;s living standards and changes in dietary habits, hyperlipidemia (HLP) has gradually become the &#8220;number one killer&#8221; that endangers human health. This disease is caused by dysregulation of lipid metabolism in the body. Given the close [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Computer simulation evaluation of pancreatic lipase inhibitory peptides in camel blood protein - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/camel-blood-protein\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Computer simulation evaluation of pancreatic lipase inhibitory peptides in camel blood protein - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Computer simulation evaluation of pancreatic lipase inhibitory peptides in camel blood protein In recent years, with the improvement of people&#8217;s living standards and changes in dietary habits, hyperlipidemia (HLP) has gradually become the &#8220;number one killer&#8221; that endangers human health. This disease is caused by dysregulation of lipid metabolism in the body. 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