{"id":5099,"date":"2024-08-04T17:19:25","date_gmt":"2024-08-04T17:19:25","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5099"},"modified":"2024-08-04T17:19:25","modified_gmt":"2024-08-04T17:19:25","slug":"tumor-cell","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/tumorsejt\/","title":{"rendered":"Fucoidan nano szel\u00e9n el\u0151\u00e1ll\u00edt\u00e1sa \u00e9s a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1nak g\u00e1tl\u00e1sa"},"content":{"rendered":"

Fucoidan nano szel\u00e9n el\u0151\u00e1ll\u00edt\u00e1sa \u00e9s a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1nak g\u00e1tl\u00e1sa
\nJelenleg a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek mellett a r\u00e1k a m\u00e1sodik vezet\u0151 emberi hal\u00e1loz\u00e1si ok. Neh\u00e9z kezelhet\u0151s\u00e9ge, hossz\u00fa kezel\u00e9si ciklusa \u00e9s magas kezel\u00e9si k\u00f6lts\u00e9gei miatt s\u00falyos terhet r\u00f3 az emberek \u00e9let\u00e9re. A kemoter\u00e1pia a modern nyugati orvosl\u00e1sban a r\u00e1k kezel\u00e9s\u00e9nek egyik f\u0151 m\u00f3dszere, de a kemoter\u00e1pi\u00e1s gy\u00f3gyszerek s\u00falyos mell\u00e9khat\u00e1sai \u00e9s gy\u00f3gyszerrezisztenci\u00e1ja miatt a kezel\u00e9s hat\u00e1sa nem ide\u00e1lis. Ez\u00e9rt a nagy hat\u00e9konys\u00e1g\u00fa \u00e9s toxikus mell\u00e9khat\u00e1sok n\u00e9lk\u00fcli, sz\u00e9les spektrum\u00fa daganatellenes gy\u00f3gyszer kifejleszt\u00e9se m\u00e9g mindig s\u00fcrg\u0151s megoldand\u00f3 probl\u00e9ma.
\nA szel\u00e9n (Se) az emberi szervezet sz\u00e1m\u00e1ra n\u00e9lk\u00fcl\u00f6zhetetlen nyomelem, amely fontos szerepet j\u00e1tszik a glutation-peroxid\u00e1z, a tioredoxin-redukt\u00e1z \u00e9s m\u00e1s enzimek szint\u00e9zis\u00e9ben. R\u00e9szt vesz a k\u00fcl\u00f6nb\u00f6z\u0151 \u00e9lettev\u00e9kenys\u00e9gekben, \u00e9s nagy jelent\u0151s\u00e9ggel b\u00edr az emberi eg\u00e9szs\u00e9g szempontj\u00e1b\u00f3l. Ugyanakkor a szel\u00e9nnek k\u00fcl\u00f6nb\u00f6z\u0151 funkcion\u00e1lis tev\u00e9kenys\u00e9gei is vannak, p\u00e9ld\u00e1ul antioxid\u00e1ns \u00e9s daganatellenes. Kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a r\u00e1kos betegek szervezet\u00e9ben szel\u00e9nhi\u00e1ny l\u00e9p fel. A szel\u00e9n megfelel\u0151 bevitele megv\u00e9dheti a norm\u00e1l sejteket \u00e9s cs\u00f6kkentheti a r\u00e1k el\u0151fordul\u00e1s\u00e1t. A szervezetekben haszn\u00e1lhat\u00f3 Se biztons\u00e1gos adagol\u00e1si tartom\u00e1nya azonban nagyon sz\u0171k, \u00e9s a t\u00falzott haszn\u00e1lat miatt k\u00f6nnyen m\u00e9rgez\u00e9st okozhat. Ez\u00e9rt l\u00e9tfontoss\u00e1g\u00fa a Se biztons\u00e1gos form\u00e1inak felt\u00e1r\u00e1sa \u00e9s kifejleszt\u00e9se a toxicit\u00e1s cs\u00f6kkent\u00e9se \u00e9rdek\u00e9ben. A kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a Se hagyom\u00e1nyos form\u00e1ihoz k\u00e9pest a szel\u00e9n nanor\u00e9szecsk\u00e9k (SeNP-k) kisebb toxicit\u00e1ssal \u00e9s jobb biol\u00f3giai hozz\u00e1f\u00e9rhet\u0151s\u00e9ggel rendelkeznek egyedi m\u00e9ret\u00fck \u00e9s fel\u00fcleti hat\u00e1suk miatt. A SeNP-k azonban nagy aktivit\u00e1ssal rendelkeznek, mivel a fel\u00fclet\u00fck\u00f6n nincsenek szomsz\u00e9dos koordin\u00e1l\u00f3 atomok, ami szobah\u0151m\u00e9rs\u00e9kleten rendk\u00edv\u00fcl instabill\u00e1 teszi \u0151ket, \u00e9s hajlamosak aggreg\u00e1l\u00f3dni, hogy toxikusabb elemi Se-t k\u00e9pezzenek. Ez\u00e9rt a SeNP-k el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz \u00e1ltal\u00e1ban diszperg\u00e1l\u00f3szereket haszn\u00e1lnak, hogy n\u00f6velj\u00e9k diszperg\u00e1lhat\u00f3s\u00e1gukat. A poliszacharidok molekulaszerkezet\u00e9ben hidroxilcsoportok tal\u00e1lhat\u00f3k, amelyek intermolekul\u00e1ris hidrog\u00e9nk\u00f6t\u00e9seken kereszt\u00fcl k\u00f6t\u0151dhetnek a Se-hez, \u00edgy megakad\u00e1lyozz\u00e1k a SeNP-k aggreg\u00e1ci\u00f3j\u00e1t. Ez\u00e9rt a poliszacharidokat gyakran haszn\u00e1lj\u00e1k a SeNP-k diszperg\u00e1l\u00e1s\u00e1ra. Jelenleg a nanoszel\u00e9n-m\u00f3dos\u00edt\u00f3k\u00e9nt haszn\u00e1lt poliszacharidok k\u00f6z\u00e9 tartoznak az asztragalusz poliszacharidok, a konjak gl\u00fckomann\u00e1n stb.
\nA fucoidan (FD) egy term\u00e9szetes, v\u00edzben old\u00f3d\u00f3 poliszacharid, amely barna alg\u00e1b\u00f3l sz\u00e1rmazik, \u00e9s szulf\u00e1tozott fucoidanb\u00f3l, mann\u00f3zb\u00f3l, arabin\u00f3zb\u00f3l, gl\u00fckuronsavb\u00f3l \u00e9s m\u00e1s monoszacharidokb\u00f3l \u00e1ll. A kutat\u00f3k meg\u00e1llap\u00edtott\u00e1k, hogy a fucoidan k\u00fcl\u00f6nb\u00f6z\u0151 funkcion\u00e1lis tev\u00e9kenys\u00e9gekkel rendelkezik, p\u00e9ld\u00e1ul tumorellenes, antioxid\u00e1ns \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1ssal. Jelenleg azonban nincsenek jelent\u00e9sek a nano szel\u00e9n fucoid\u00e1nnal t\u00f6rt\u00e9n\u0151 m\u00f3dos\u00edt\u00e1s\u00e1r\u00f3l. Ez\u00e9rt ez a cikk az FD-t stabiliz\u00e1tork\u00e9nt haszn\u00e1lja a fucoidan szel\u00e9n nanor\u00e9szecsk\u00e9k (FD SeNP-k) el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz redoxi reakci\u00f3kon kereszt\u00fcl. Egyt\u00e9nyez\u0151s \u00e9s v\u00e1laszfel\u00fcleti k\u00eds\u00e9rleteket haszn\u00e1lunk az el\u0151\u00e1ll\u00edt\u00e1si folyamat param\u00e9tereinek optimaliz\u00e1l\u00e1s\u00e1ra, valamint a tov\u00e1bbi szerkezeti azonos\u00edt\u00e1st \u00e9s a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1nak g\u00e1tl\u00e1s\u00e1t vizsg\u00e1ljuk, elm\u00e9leti adatokkal al\u00e1t\u00e1masztva az FD SeNP-k tumorsejt-g\u00e1tl\u00f3k\u00e9nt val\u00f3 kifejleszt\u00e9s\u00e9t \u00e9s alkalmaz\u00e1s\u00e1t.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nEz a cikk az FD SeNP-k optim\u00e1lis el\u0151\u00e1ll\u00edt\u00e1si folyamatparam\u00e9tereit egyt\u00e9nyez\u0151s \u00e9s v\u00e1laszfel\u00fclet-optimaliz\u00e1l\u00e1si k\u00eds\u00e9rletekkel kapta meg, amelyek a k\u00f6vetkez\u0151k: 35 \u2103 reakci\u00f3h\u0151m\u00e9rs\u00e9klet, 1 \u00f3ra reakci\u00f3id\u0151, 14:1 aszkorbinsav \u00e9s n\u00e1trium-szelenit mol\u00e1ris ar\u00e1nya, valamint 0,8 mg\/ml FD-koncentr\u00e1ci\u00f3. Ilyen k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt a minim\u00e1lis r\u00e9szecskem\u00e9ret (83,40 \u00b1 0,55) nm-t, a potenci\u00e1l (-31,89 \u00b1 0,47) mV-ot, a szel\u00e9ntartalom pedig 29,93%-t \u00e9rt el. A szerkezet tov\u00e1bbi azonos\u00edt\u00e1sa kimutatta, hogy az FD hidroxiladszorpci\u00f3 r\u00e9v\u00e9n egyenletesen g\u00f6mb alak\u00fa nanor\u00e9szecsk\u00e9ket k\u00e9pez a SeNP-k fel\u00fclet\u00e9n, ami azt jelzi, hogy a poliszacharidok pol\u00e1ros csoportjai hat\u00e9konyan g\u00e1tolhatj\u00e1k a SeNP-k aggreg\u00e1ci\u00f3j\u00e1t.<\/p>\n

A jelenlegi kutat\u00e1s meg\u00e1llap\u00edtotta, hogy a daganatellenes mechanizmusok k\u00f6z\u00e9 tartozik a tumorsejtek n\u00f6veked\u00e9s\u00e9nek g\u00e1tl\u00e1sa, a tumorsejtek \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s\u00e9nek vagy inv\u00e1zi\u00f3j\u00e1nak g\u00e1tl\u00e1sa, valamint a szervezet immunrendszer\u00e9nek szab\u00e1lyoz\u00f3 k\u00e9pess\u00e9g\u00e9nek fokoz\u00e1sa a daganatellenes hat\u00e1sok el\u00e9r\u00e9se \u00e9rdek\u00e9ben. A kutat\u00e1sok kimutatt\u00e1k, hogy a poliszacharidokat sablonk\u00e9nt haszn\u00e1l\u00f3 SeNP-k el\u0151seg\u00edthetik a kapcsol\u00f3d\u00f3 apoptotikus feh\u00e9rj\u00e9k \u00e9s autof\u00e1gia-marker feh\u00e9rj\u00e9k expresszi\u00f3j\u00e1t, ez\u00e1ltal a tumorsejtek apopt\u00f3zis\u00e1t \u00e9s autof\u00e1gi\u00e1j\u00e1t induk\u00e1lj\u00e1k. A jelen tanulm\u00e1ny in vitro daganatellenes k\u00eds\u00e9rlete azt mutatta, hogy az FD m\u00f3dos\u00edtott SeNP-k jelent\u0151sen fokozhatj\u00e1k a SeNP-k tumorsejt-prolifer\u00e1ci\u00f3t g\u00e1tl\u00f3 k\u00e9pess\u00e9g\u00e9t \u00e9s j\u00f3 sejtszelektivit\u00e1ssal rendelkeznek, de a specifikus hat\u00e1smechanizmus\u00e1t tov\u00e1bb kell vizsg\u00e1lni.<\/p>","protected":false},"excerpt":{"rendered":"

Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation At present, besides cardiovascular disease, cancer has become the second leading cause of human death. Due to its difficult treatment, long treatment cycle, and high treatment cost, it brings a heavy burden to people’s lives. Chemotherapy is one of the main methods for […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nPreparation of fucoidan nano selenium and its inhibition of tumor cell proliferation - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/tumorsejt\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation At present, besides cardiovascular disease, cancer has become the second leading cause of human death. 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