{"id":5079,"date":"2024-08-04T17:15:11","date_gmt":"2024-08-04T17:15:11","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5079"},"modified":"2024-08-04T17:15:11","modified_gmt":"2024-08-04T17:15:11","slug":"chronic-fatigue-syndrome","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/chronic-fatigue-syndrome\/","title":{"rendered":"A Gynostemma pentaphyllum hat\u00e1smechanizmus\u00e1nak felt\u00e1r\u00e1sa a kr\u00f3nikus f\u00e1radts\u00e1g szindr\u00f3ma kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s az \u00e1llatmodell valid\u00e1l\u00e1sa alapj\u00e1n"},"content":{"rendered":"

A Gynostemma pentaphyllum hat\u00e1smechanizmus\u00e1nak felt\u00e1r\u00e1sa a kr\u00f3nikus f\u00e1radts\u00e1g szindr\u00f3ma kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s az \u00e1llatmodell valid\u00e1l\u00e1sa alapj\u00e1n
\nA kr\u00f3nikus f\u00e1radts\u00e1g szindr\u00f3ma (CFS), m\u00e1s n\u00e9ven myalgikus encephalomyelitis (ME), egy komplex, t\u00f6bb mint 6 h\u00f3napig tart\u00f3, t\u00f6bb rendszerre kiterjed\u0151 betegs\u00e9g. Klinikai megnyilv\u00e1nul\u00e1sai k\u00f6z\u00e9 tartozik a legyeng\u00edt\u0151 f\u00e1radts\u00e1g, neurokognit\u00edv zavarok, fejf\u00e1j\u00e1s, alv\u00e1szavarok \u00e9s egy sor vegetat\u00edv t\u00fcnet, amelyek s\u00falyosan befoly\u00e1solj\u00e1k a beteg munk\u00e1j\u00e1t \u00e9s \u00e9let\u00e9t. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban \u00fagy tartj\u00e1k, hogy a CFS az \u00f6t szervet \u00e9rinti, \u00e9s a S\u00e1rga Cs\u00e1sz\u00e1r Bels\u0151 K\u00e1nonj\u00e1ban \u00e1ltal\u00e1ban \"f\u00e1radts\u00e1g\", \"lazas\u00e1g\", \"gyenges\u00e9g\", \"neh\u00e9zked\u00e9s\", \"tests\u00faly\", \"nem emelhet\u0151 v\u00e9gtag\" n\u00e9ven eml\u00edtik. Az olyan betegs\u00e9gek kateg\u00f3ri\u00e1j\u00e1ba tartozik, mint a \"hi\u00e1nyf\u00e1radts\u00e1g\". Az emberek munkatemp\u00f3j\u00e1nak felgyorsul\u00e1s\u00e1val az \u00e9let nyom\u00e1sa fokozatosan n\u00f6vekszik, \u00e9s az el\u0151fordul\u00e1si ar\u00e1ny tov\u00e1bb emelkedik, \u00e9s a fiatalabb \u00e9letkor tendenci\u00e1j\u00e1t mutatja, ami a klinikai forr\u00f3 vita k\u00f6z\u00e9ppontj\u00e1ba ker\u00fclt. A betegs\u00e9g patogenezise m\u00e9g nem vil\u00e1gos, \u00e9s sz\u00e1mos patog\u00e9n t\u00e9nyez\u0151 l\u00e9tezik. A klinikai kezel\u00e9shez nincs specifikus gy\u00f3gyszer sem.
\nA hagyom\u00e1nyos k\u00ednai orvosl\u00e1snak t\u00f6bb \u00f6sszetev\u0151je, t\u00f6bb c\u00e9lpontja, valamint a modul\u00e1ci\u00f3 \u00e9s a kiegyenl\u00edt\u00e9s \u00e1ltal\u00e1nos hat\u00e1sa van. Alapvet\u0151 k\u00eds\u00e9rletek kimutatt\u00e1k, hogy a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s jelent\u0151s hat\u00e1sokkal \u00e9s el\u0151ny\u00f6kkel rendelkezik a kr\u00f3nikus f\u00e1radts\u00e1g szindr\u00f3ma megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben. A Gynostemma pentaphyllum (Thunb.) Maki no a t\u00f6kf\u00e9l\u00e9k csal\u00e1dj\u00e1ba tartoz\u00f3 teljes n\u00f6v\u00e9ny. A modern farmakol\u00f3giai kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a Gynostemma pentaphyllum k\u00fcl\u00f6nb\u00f6z\u0151 farmakol\u00f3giai tev\u00e9kenys\u00e9gekkel rendelkezik, p\u00e9ld\u00e1ul cs\u00f6kkenti a v\u00e9rzs\u00edrokat \u00e9s a v\u00e9rcukorszintet, tumorellenes, immunszab\u00e1lyoz\u00f3, antioxid\u00e1ns \u00e9s egy\u00e9b hat\u00e1sokkal, k\u00f6zismert nev\u00e9n \"d\u00e9li ginzeng\". Az irodalmi jelent\u00e9sek szerint a Gynostemma pentaphyllumb\u00f3l sz\u00e1rmaz\u00f3 poliszacharidok fokozhatj\u00e1k az edz\u00e9sid\u0151t \u00e9s el\u0151seg\u00edthetik a v\u00e1zizomzat differenci\u00e1l\u00f3d\u00e1s\u00e1t egerekben. Ugyanakkor a Gynostemma pentaphyllum sz\u00e1jon \u00e1t t\u00f6rt\u00e9n\u0151 bead\u00e1sa pozit\u00edv hat\u00e1ssal lehet a betegek ment\u00e1lis f\u00e1radts\u00e1g\u00e1ra \u00e9s kogn\u00edci\u00f3j\u00e1ra, valamint fokozhatja immunit\u00e1sukat. Hat\u00f3anyagai \u00e9s hat\u00e1smechanizmusa azonban m\u00e9g nem tiszt\u00e1zott, \u00e9s a CFS patogenezise \u00f6sszetett, ez\u00e9rt nagyon alkalmas a h\u00e1l\u00f3zati farmakol\u00f3giai m\u00f3dszerek alkalmaz\u00e1s\u00e1ra a kutat\u00e1sban. A h\u00e1l\u00f3zati farmakol\u00f3gia a sz\u00e1m\u00edt\u00f3g\u00e9pes technol\u00f3gi\u00e1n \u00e9s a h\u00e1l\u00f3zati adatb\u00e1zis-keres\u00e9sen alapul, a farmakol\u00f3gi\u00e1t a bioinformatik\u00e1val kombin\u00e1lja, hogy a gy\u00f3gyszerek \u00e9s a betegs\u00e9gek k\u00f6z\u00f6tti kapcsolatot szisztematikus szemsz\u00f6gb\u0151l tanulm\u00e1nyozza. Ez\u00e9rt ez a cikk a Gynostemma pentaphyllum relev\u00e1ns c\u00e9lpontjait, \u00fatvonalait \u00e9s hat\u00e1smechanizmusait k\u00edv\u00e1nja felt\u00e1rni a CFS kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1si technol\u00f3gia \u00e9s az \u00e1llatk\u00eds\u00e9rletek seg\u00edts\u00e9g\u00e9vel, \u00e9s n\u00e9mi hivatkoz\u00e1st ny\u00fajt a klinikai alkalmaz\u00e1shoz.<\/p>\n

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A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s kulcsszerepet j\u00e1tszik a CFS kezel\u00e9s\u00e9ben, els\u0151sorban a toniz\u00e1l\u00f3 gy\u00f3gyszerek alkalmaz\u00e1s\u00e1val. A Gynostemma pentaphyllum, mint egyfajta toniz\u00e1l\u00f3 gy\u00f3gyszer, a jelent\u00e9sek szerint olyan hat\u00f3anyagokat tartalmaz, amelyek gyullad\u00e1scs\u00f6kkent\u0151, f\u00e1radts\u00e1g elleni, oxidat\u00edv stresszt jav\u00edt\u00f3 \u00e9s immuner\u0151s\u00edt\u0151 hat\u00e1ssal rendelkeznek. Ez a cikk a Gynostemma pentaphyllum hat\u00f3anyagait elemzi a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1n kereszt\u00fcl. A \"Gynostemma pentaphyllum hat\u00f3anyagok c\u00e9lzott hat\u00e1sa\" h\u00e1l\u00f3zati diagramon kereszt\u00fcl meg\u00e1llap\u00edt\u00e1st nyert, hogy az olyan \u00f6sszetev\u0151k, mint a kvercetin, az izorhamnetin \u00e9s a panaxadiol magas fok\u00fa \u00e9rt\u00e9keket mutatnak. Modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy a kvercetin jelent\u0151sen n\u00f6velheti a katal\u00e1z (CAT) \u00e9s az \u00f6sszes szuperoxid-dizmut\u00e1z (T-SOD) aktivit\u00e1s\u00e1t s\u00falyt hordoz\u00f3, \u00fasz\u00f3 egerekben, mik\u00f6zben befoly\u00e1solja a gl\u00fckoneogenezist \u00e9s a gl\u00fck\u00f3z anyagcser\u00e9t, szerepet j\u00e1tszik a f\u00e1radts\u00e1g k\u00e9sleltet\u00e9s\u00e9ben vagy megsz\u00fcntet\u00e9s\u00e9ben. Gong \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izorhamnetin potenci\u00e1lis antioxid\u00e1nsk\u00e9nt szolg\u00e1lhat, \u00e9s hat\u00e1smechanizmusa a PI3K\/AKT \u00e9s Nrf2\/ARE jel\u00e1tviteli \u00fatvonalak szab\u00e1lyoz\u00e1s\u00e1val, az intracellul\u00e1ris glutation (GSH) expresszi\u00f3j\u00e1nak n\u00f6vel\u00e9s\u00e9vel, valamint kiv\u00e1l\u00f3 antioxid\u00e1ns \u00e9s f\u00e1radts\u00e1g elleni hat\u00e1s\u00e1val fejthet ki antioxid\u00e1ns hat\u00e1st. Wang \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a panaxadiol k\u00e9pes n\u00f6velni a glikog\u00e9n t\u00e1rol\u00e1s\u00e1t a f\u00e1radt egerek m\u00e1jizomzat\u00e1ban, cs\u00f6kkenti a sz\u00e9rum lakt\u00e1t (LD) tartalm\u00e1t, n\u00f6veli az LDH aktivit\u00e1st, \u00e9s jelent\u0151s f\u00e1radts\u00e1gellenes hat\u00e1ssal rendelkezik. El\u0151rejelzik, hogy ezek az \u00f6sszetev\u0151k kulcsfontoss\u00e1g\u00fa k\u00f6zponti \u00f6sszetev\u0151k lehetnek a CFS Gynostemma pentaphyllummal t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9ben.<\/p>\n

A kulcsfontoss\u00e1g\u00fa c\u00e9lpontokra vonatkoz\u00f3 PPI-h\u00e1l\u00f3zatok l\u00e9trehoz\u00e1s\u00e1val meg\u00e1llap\u00edtott\u00e1k, hogy az olyan feh\u00e9rj\u00e9k, mint a STAT3, a TP53, az SRC \u00e9s az AKT1 magasabb fok\u00fa \u00e9rt\u00e9kekkel rendelkeznek. A STAT3, mint jel\u00e1tviteli \u00e9s transzkripci\u00f3s aktiv\u00e1tor, szab\u00e1lyozhatja az ATP-szint\u00e1z aktivit\u00e1s\u00e1t \u00e9s az interleukinszintet, befoly\u00e1solva a szervezet energiaanyagcser\u00e9j\u00e9t \u00e9s gyullad\u00e1sos \u00e1llapot\u00e1t. Gilad \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az SRC immuner\u0151s\u00edt\u0151 hat\u00e1st fejthet ki, \u00e9s hat\u00e1smechanizmusa az NF - \u03ba B \u00fatvonal \u00e9s az immunsejtek szab\u00e1lyoz\u00e1sa, ez\u00e1ltal a gyullad\u00e1s \u00e9s az oxidat\u00edv stressz befoly\u00e1sol\u00e1sa. Fang \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a TP53 cs\u00f6kkentheti a sejtek apopt\u00f3zis\u00e1t \u00e9s szab\u00e1lyozhatja az izomf\u00e1radts\u00e1got az\u00e1ltal, hogy g\u00e1tolja a P53 feh\u00e9rje expresszi\u00f3j\u00e1t a f\u00e1radt patk\u00e1nyok v\u00e1zizomzat\u00e1ban. M\u00e1s vizsg\u00e1latok azt is kimutatt\u00e1k, hogy kiegyens\u00falyoz\u00f3 hat\u00e1ssal van az oxidat\u00edv stresszre. Az AKT1 el\u0151seg\u00edti a mitokondri\u00e1lis bioszint\u00e9zist \u00e9s befoly\u00e1solja a sz\u00f6veti energiaanyagcser\u00e9t a MAPK foszforil\u00e1ci\u00f3 szab\u00e1lyoz\u00e1s\u00e1val \u00e9s a PPAR \u03b1\/PGC-1 \u03b1 aktiv\u00e1l\u00e1s\u00e1val. A vizsg\u00e1latok kimutatt\u00e1k, hogy az energiaanyagcsere szab\u00e1lyoz\u00e1s\u00e1val befoly\u00e1solja a f\u00e1radts\u00e1gi \u00e1llapotot. Ez azt jelzi, hogy a STAT3, a TP53, az SRC \u00e9s az AKT1 az energiaanyagcsere, az oxidat\u00edv stressz \u00e9s a sejt apopt\u00f3zis szab\u00e1lyoz\u00e1s\u00e1val hathat a CFS-re, \u00e9s kulcsfontoss\u00e1g\u00fa c\u00e9lpontok lehetnek a CFS Gynostemma pentaphyllummal t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9ben. Ez a cikk tov\u00e1bb\u00e1 molekul\u00e1ris dokkol\u00e1st v\u00e9gez a kulcsfontoss\u00e1g\u00fa c\u00e9lpontok \u00e9s a magkomponensek k\u00f6z\u00f6tt, \u00e9s az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 magas k\u00f6t\u0151d\u00e9si aktivit\u00e1ssal rendelkezik, amelyek k\u00f6z\u00fcl a STAT3 feh\u00e9rje rendelkezik a legjobb k\u00f6t\u0151d\u00e9si k\u00e9pess\u00e9ggel a magkomponensekhez.<\/p>\n

A GO \u00e9s KEGG, a kulcsfontoss\u00e1g\u00fa c\u00e9lpontok gazdagod\u00e1si elemz\u00e9se azt mutatta, hogy a CFS kezel\u00e9se a Gynostemma pentaphyllummal mag\u00e1ban foglalja a P13K\/AKT, a folyad\u00e9k ny\u00edr\u00f3 stressz \u00e9s az ateroszkler\u00f3zis, a HIF-1 jel\u00e1tviteli \u00fatvonal, az AGE-RAGE \u00e9s m\u00e1s jel\u00e1tviteli \u00fatvonalakat, amelyek k\u00f6z\u00fcl a P13K\/AKT jel\u00fatvonal rendelkezik a legnagyobb sz\u00e1m\u00fa d\u00fas\u00edtott g\u00e9nnel. A CFS-t gyullad\u00e1s k\u00eds\u00e9ri az agyban, amely befoly\u00e1solja a neuron\u00e1lis prolifer\u00e1ci\u00f3t \u00e9s az apopt\u00f3zist. A P13K\/AKT jel\u00e1tviteli \u00fatvonal szorosan kapcsol\u00f3dik a k\u00fcl\u00f6nb\u00f6z\u0151 enzim biol\u00f3giai hat\u00e1sokhoz \u00e9s a gl\u00fck\u00f3z anyagcser\u00e9hez, \u00e9s befoly\u00e1solhatja az agy HPA tengely\u00e9t, hogy jav\u00edtsa a neuroinflamm\u00e1ci\u00f3t \u00e9s enyh\u00edtse a k\u00f6zponti f\u00e1radts\u00e1got. A P13K aktiv\u00e1lhatja az AKT feh\u00e9rje expresszi\u00f3s szintj\u00e9t, \u00e9s a P13K \u00e9s az AKT feh\u00e9rje foszforil\u00e1l\u00e1s\u00e1val r\u00e9szt vehet a sejtek anyagcser\u00e9j\u00e9ben, a prolifer\u00e1ci\u00f3ban \u00e9s a differenci\u00e1l\u00f3d\u00e1sban, az anti apopt\u00f3zisban \u00e9s m\u00e1s vonatkoz\u00e1sokban. Kor\u00e1bbi vizsg\u00e1latok kimutatt\u00e1k, hogy a Gynostemma pentaphyllum teljes szaponinjai aktiv\u00e1lhatj\u00e1k a P13K \/ AKT jel\u00e1tviteli \u00fatvonalat, g\u00e1tolhatj\u00e1k a downstream pro apoptotikus feh\u00e9rj\u00e9k felszabadul\u00e1s\u00e1t, cs\u00f6kkenthetik az oxidat\u00edv stresszt \u00e9s jav\u00edthatj\u00e1k az agyk\u00e1rosod\u00e1st, ami a P13K AKT jel\u00e1tviteli \u00fatvonal fontoss\u00e1g\u00e1t jelzi a CFS kezel\u00e9s\u00e9ben a Gynostemma pentaphyllummal. A P13K-AKT jel\u00e1tviteli \u00fatvonal \u00fajb\u00f3li felt\u00e9rk\u00e9pez\u00e9s\u00e9vel a KEGG Mapper seg\u00edts\u00e9g\u00e9vel meg\u00e1llap\u00edtott\u00e1k, hogy a legt\u00f6bb kulcsfontoss\u00e1g\u00fa c\u00e9lpontot erre a jel\u00e1tviteli \u00fatvonalra t\u00e9rk\u00e9pezt\u00e9k fel. A P13K\/AKT jel\u00e1tviteli \u00fatvonal potenci\u00e1lis \u00fatvonal a CFS Gynostemma pentaphyllummal t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9ben.<\/p>\n

A Gynostemma pentaphyllum CFS kezel\u00e9s\u00e9re vonatkoz\u00f3 mechanizmus\u00e1nak tov\u00e1bbi vizsg\u00e1lat\u00e1hoz CFS eg\u00e9rmodellt hoztak l\u00e9tre t\u00e1pl\u00e1l\u00e9kkorl\u00e1toz\u00e1ssal \u00e9s k\u00e9nyszer\u00edtett \u00fasz\u00e1ssal. A kimer\u00fclts\u00e9gi \u00fasz\u00e1s \u00e9s a botp\u00f6rget\u00e9s k\u00eds\u00e9rletein kereszt\u00fcl meg\u00e1llap\u00edtott\u00e1k, hogy a Gynostemma pentaphyllum jelent\u0151sen meg tudja hosszabb\u00edtani az egerek kimer\u00fclts\u00e9gi \u00fasz\u00e1si idej\u00e9t \u00e9s a botp\u00f6rget\u00e9si id\u0151t. Az edz\u00e9s\u00e1ll\u00f3k\u00e9pess\u00e9g javul\u00e1sa a legobjekt\u00edvebb mutat\u00f3 a gy\u00f3gyszeres f\u00e1radts\u00e1gellenes hat\u00e1s \u00e9rt\u00e9kel\u00e9s\u00e9re, ami azt jelzi, hogy a Gynostemma pentaphyllum szaponinok jelent\u0151s f\u00e1radts\u00e1gellenes hat\u00e1ssal rendelkeznek, cs\u00f6kkenthetik a f\u00e1radts\u00e1g metabolitok felhalmoz\u00f3d\u00e1s\u00e1t, \u00e9s fokozhatj\u00e1k az edz\u00e9sid\u0151t. Er\u0151teljes edz\u00e9s sor\u00e1n a szervezet viszonylag anaerob \u00e1llapotban van, az izomglikol\u00edzisre t\u00e1maszkodva az energiaell\u00e1t\u00e1s \u00e9rdek\u00e9ben, ami az LDH \u00e9s a BUN emelked\u00e9s\u00e9hez vezet, ami egy sor funkcion\u00e1lis rendelleness\u00e9get okoz, mint p\u00e9ld\u00e1ul az idegvezet\u00e9s \u00e9s az izom\u00f6sszeh\u00faz\u00f3d\u00e1s, ami befoly\u00e1solja az energia termel\u00e9s\u00e9t, felszabadul\u00e1s\u00e1t \u00e9s t\u00e1rol\u00e1s\u00e1t, \u00e9s tov\u00e1bb vezet a fizikai f\u00e1radts\u00e1ghoz. Ez a vizsg\u00e1lat meg\u00e1llap\u00edtotta, hogy a Gynostemma pentaphyllum jelent\u0151sen cs\u00f6kkentheti a BUN \u00e9s az LDH aktivit\u00e1s\u00e1nak szintj\u00e9t a CFS egerek sz\u00e9rum\u00e1ban, ami azt jelzi, hogy a Gynostemma pentaphyllum cs\u00f6kkentheti az anyagcsere-term\u00e9kek felhalmoz\u00f3d\u00e1s\u00e1t a szervezetben. A Western blot eredm\u00e9nyek azt mutatt\u00e1k, hogy a Gynostemma pentaphyllum n\u00f6velheti a PI3K \u00e9s Akt expresszi\u00f3s szintj\u00e9t, mik\u00f6zben cs\u00f6kkenti a P-PI3K, P-AKT \u00e9s STAT3 expresszi\u00f3s szintj\u00e9t, ez\u00e1ltal szab\u00e1lyozza a PI3K\/AKT jel\u00e1tviteli \u00fatvonalat. Ez arra utal, hogy a PI3K\/AKT jel\u00e1tviteli \u00fatvonal kulcsfontoss\u00e1g\u00fa \u00fatvonal lehet a Gynostemma pentaphyllum sz\u00e1m\u00e1ra a kr\u00f3nikus f\u00e1radts\u00e1g szindr\u00f3ma kezel\u00e9s\u00e9ben.<\/p>\n

\u00d6sszefoglalva, a Gynostemma pentaphyllum f\u0151 hat\u00f3anyagai, mint p\u00e9ld\u00e1ul a kvercetin \u00e9s az izorhamnetin, az oxidat\u00edv stressz \u00e9s az energiaanyagcsere szab\u00e1lyoz\u00e1s\u00e1val t\u00f6bb c\u00e9lpontra, p\u00e9ld\u00e1ul a STAT3, TP53, SRC, AKT1, HSP90AA1, hathatnak, \u00e9s t\u00f6bb \u00fatvonalat, p\u00e9ld\u00e1ul a PI3K\/AKT jel\u00e1tviteli \u00fatvonalat szab\u00e1lyozz\u00e1k. Lehet\u0151s\u00e9g\u00fck van a CFS kezel\u00e9s\u00e9re t\u00f6bb komponens, c\u00e9lpont \u00e9s \u00fatvonal seg\u00edts\u00e9g\u00e9vel. Ez a tanulm\u00e1ny referenci\u00e1t ny\u00fajthat a Gynostemma pentaphyllum m\u00e9lyrehat\u00f3 kutat\u00e1s\u00e1hoz \u00e9s klinikai alkalmaz\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism of action of Gynostemma pentaphyllum in treating chronic fatigue syndrome based on network pharmacology and animal model validation Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a complex multi system disease that lasts for more than 6 months. Its clinical manifestations include debilitating fatigue, neurocognitive disorders, headaches, sleep disturbances, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of action of Gynostemma pentaphyllum in treating chronic fatigue syndrome based on network pharmacology and animal model validation - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/chronic-fatigue-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of action of Gynostemma pentaphyllum in treating chronic fatigue syndrome based on network pharmacology and animal model validation - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of action of Gynostemma pentaphyllum in treating chronic fatigue syndrome based on network pharmacology and animal model validation Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a complex multi system disease that lasts for more than 6 months. 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