{"id":5055,"date":"2024-08-04T17:06:57","date_gmt":"2024-08-04T17:06:57","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5055"},"modified":"2024-08-04T17:06:57","modified_gmt":"2024-08-04T17:06:57","slug":"cisplatin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/ciszplatin\/","title":{"rendered":"Az \u00e9desgy\u00f6k\u00e9rben tal\u00e1lhat\u00f3 endofita bakt\u00e9riumok v\u00e9d\u0151 hat\u00e1sa \u00e9s mechanizmusa a ciszplatin \u00e1ltal kiv\u00e1ltott HEK293 sejtk\u00e1rosod\u00e1ssal szemben"},"content":{"rendered":"

Az \u00e9desgy\u00f6k\u00e9rben tal\u00e1lhat\u00f3 endofita bakt\u00e9riumok v\u00e9d\u0151 hat\u00e1sa \u00e9s mechanizmusa a ciszplatin \u00e1ltal kiv\u00e1ltott HEK293 sejtk\u00e1rosod\u00e1ssal szemben
\nA ciszplatin (CP), mint a klinikai gyakorlatban gyakran alkalmazott daganatellenes gy\u00f3gyszer, jelent\u0151s ter\u00e1pi\u00e1s hat\u00e1ssal, de er\u0151s toxikus mell\u00e9khat\u00e1sokkal rendelkezik. A f\u0151 megnyilv\u00e1nul\u00e1sok a nefrotoxicit\u00e1s, a hepatotoxicit\u00e1s, az ototoxicit\u00e1s \u00e9s a kardiotoxicit\u00e1s, a vesek\u00e1rosod\u00e1s pedig k\u00fcl\u00f6n\u00f6sen s\u00falyos. Id\u0151beli d\u00f3zisf\u00fcgg\u0151s\u00e9ggel rendelkezik. A CP \u00e1ltal okozott nefrotoxicit\u00e1sban t\u00f6bb patog\u00e9n mechanizmus is szerepet j\u00e1tszhat, bele\u00e9rtve a mitokondri\u00e1lis diszfunkci\u00f3t, a sejt apopt\u00f3zis indukci\u00f3j\u00e1t, oxidat\u00edv stresszt stb. Ez\u00e9rt a CP toxikus mell\u00e9khat\u00e1sainak hat\u00e9kony cs\u00f6kkent\u00e9se els\u0151dleges k\u00e9rd\u00e9ss\u00e9 v\u00e1lt a CP klinikai d\u00f3zis\u00e1nak kiterjeszt\u00e9se sor\u00e1n, \u00e9s a CP toxicit\u00e1s\u00e1t szinergikusan cs\u00f6kkent\u0151 \u00e9s a hat\u00e9konys\u00e1got n\u00f6vel\u0151 megfelel\u0151 kezel\u00e9si tervek vagy gy\u00f3gyszerek megtal\u00e1l\u00e1sa jelenleg a f\u0151 kutat\u00e1si ir\u00e1ny.
\nAz elm\u00falt \u00e9vekben a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s fejl\u0151d\u00e9s\u00e9vel a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s kombin\u00e1ci\u00f3ja a hat\u00e9konys\u00e1g fokoz\u00e1sa \u00e9s a toxicit\u00e1s cs\u00f6kkent\u00e9se \u00e9rdek\u00e9ben a kutat\u00e1s egyik f\u0151 forr\u00f3 pontj\u00e1v\u00e1 v\u00e1lt. Az \u00e9desgy\u00f6k\u00e9r, mint \"m\u00e9regtelen\u00edt\u0151 szent gy\u00f3gyn\u00f6v\u00e9ny\", \u00e9des \u00e9s enyhe \u00edz\u0171, a l\u00e9p \u00e9s a qi t\u00e1pl\u00e1l\u00e1s\u00e1ra, valamint a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00f3gyszerek harmoniz\u00e1l\u00e1s\u00e1ra szolg\u00e1l. Hat\u00f3anyagai enyh\u00edthetik a m\u00e9rgez\u00e9s t\u00fcneteit, cs\u00f6kkenthetik a hal\u00e1loz\u00e1st, \u00e9s jelent\u0151s m\u00e9regtelen\u00edt\u0151 hat\u00e1ssal vannak a gy\u00f3gyszerekre \u00e9s a toxinokra. Az endofita bakt\u00e9riumok a gy\u00f3gy\u00e1szati mikrobi\u00e1lis er\u0151forr\u00e1sok kateg\u00f3ri\u00e1j\u00e1ba tartoznak, amelyek az eg\u00e9szs\u00e9ges n\u00f6v\u00e9nyi sz\u00f6vetekben \u00e9s szervekben \u00e9l\u0151 gomb\u00e1kra vagy bakt\u00e9riumokra utalnak. A hossz\u00fa t\u00e1v\u00fa evol\u00faci\u00f3s folyamat sor\u00e1n genetikai rekombin\u00e1ci\u00f3n mennek kereszt\u00fcl a gazdan\u00f6v\u00e9nnyel, \u00e9s \u00e1tveszik a gazdan\u00f6v\u00e9ny g\u00e9njeit, \u00edgy olyan gy\u00f3gy\u00e1szati hat\u00f3anyagokat \u00e1ll\u00edtanak el\u0151, amelyek azonosak vagy hasonl\u00f3ak a gazdan\u00f6v\u00e9ny\u00e9ivel. Man \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az \u00e9desgy\u00f6k\u00e9r endofita t\u00f6rzsei ugyanolyan \u00e9lettani hat\u00e1sokkal rendelkeznek, mint a gazdan\u00f6v\u00e9ny, \u00e9s k\u00e9pesek az \u00e9desgy\u00f6k\u00e9rhez hasonl\u00f3 szaponin \u00e9s flavonoid hat\u00f3anyagokat metaboliz\u00e1lni, amelyek farmakol\u00f3giai hat\u00e1sa antibakteri\u00e1lis \u00e9s antioxid\u00e1ns. Yang \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az endofita bakt\u00e9riumok ferment\u00e1ci\u00f3s leve az \u00e9desgy\u00f6k\u00e9rben a gazdaszervezet f\u0151zet\u00e9hez hasonl\u00f3 k\u00f6h\u00f6g\u00e9scsillap\u00edt\u00f3 hat\u00e1s\u00fa, \u00f6sszes flavonoid \u00e9s \u00f6sszes szaponin. El\u0151zetes k\u00eds\u00e9rleti kutat\u00e1saink meger\u0151s\u00edtett\u00e9k, hogy az \u00e9desgy\u00f6k\u00e9rben l\u00e9v\u0151 endofita bakt\u00e9riumok k\u00fcl\u00f6nb\u00f6z\u0151 farmakol\u00f3giai hat\u00e1sokkal rendelkeznek, p\u00e9ld\u00e1ul antibakteri\u00e1lis, gyullad\u00e1scs\u00f6kkent\u0151, k\u00f6ptet\u0151 \u00e9s daganatellenes hat\u00e1ssal. K\u00e9pesek az amm\u00f3nium-glicirrizin\u00e1tot, a glicirrizint \u00e9s a glicirrizint metaboliz\u00e1lni, amelyek hasonl\u00f3ak a gazdaszervezet \u00e9desgy\u00f6k\u00e9rhez. Ez\u00e9rt az \u00e9desgy\u00f6k\u00e9rben l\u00e9v\u0151 endofita bakt\u00e9riumok az \u00e9desgy\u00f6k\u00e9rhez hasonl\u00f3 m\u00e9regtelen\u00edt\u0151 hat\u00e1ssal rendelkezhetnek. Kor\u00e1bbi m\u00e9regtelen\u00edt\u00e9si k\u00eds\u00e9rletek kimutatt\u00e1k, hogy az \u00e9desgy\u00f6k\u00e9r hat\u00e9konyan enyh\u00edti a CP \u00e1ltal okozott vesetoxicit\u00e1st. Nem volt azonban szisztematikus mechanizmus-vizsg\u00e1lat a CP \u00e1ltal okozott nefrotoxicit\u00e1sr\u00f3l az \u00e9desgy\u00f6k\u00e9rben tal\u00e1lhat\u00f3 endofita bakt\u00e9riumok \u00e1ltal okozott nefrotoxicit\u00e1sr\u00f3l.<\/p>\n

Ez\u00e9rt ez a cikk c\u00e9lja, hogy in vitro k\u00eds\u00e9rletekkel l\u00e9trehozzon egy CP induk\u00e1lt HEK293 sejtk\u00e1rosod\u00e1si modellt, \u00e9s felt\u00e1rja az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumok v\u00e9d\u0151 hat\u00e1s\u00e1t \u00e9s mechanizmus\u00e1t a CP induk\u00e1lt HEK293 sejtekre. Annak \u00e9rdek\u00e9ben, hogy alapot biztos\u00edtson az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumok \u00e9s a CP kombin\u00e1lt alkalmaz\u00e1s\u00e1hoz a hat\u00e9konys\u00e1g n\u00f6vel\u00e9se \u00e9s a toxicit\u00e1s cs\u00f6kkent\u00e9se \u00e9rdek\u00e9ben, valamint elm\u00e9leti referenci\u00e1t ny\u00fajtson az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumok m\u00e9regtelen\u00edt\u0151 hat\u00e1s\u00e1hoz, tov\u00e1bb b\u0151v\u00edtve az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumok farmakol\u00f3giai hat\u00e1sait.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nMivel a CP a szervezet f\u0151 kiv\u00e1laszt\u00f3 szerve, els\u0151sorban a ves\u00e9n kereszt\u00fcl \u00fcr\u00fcl ki, \u00e9s felhalmoz\u00f3dik a proxim\u00e1lis tubulusokban, magas koncentr\u00e1ci\u00f3t \u00e9s hossz\u00fa t\u00e1v\u00fa felhalmoz\u00f3d\u00e1si \u00e1llapotot k\u00e9pezve, el\u0151seg\u00edtve a ROS keletkez\u00e9s\u00e9t \u00e9s g\u00e1tolva a metabolikus enzimek lebont\u00e1s\u00e1t, ami a szervezetben a ROS nagym\u00e9rt\u00e9k\u0171 felhalmoz\u00f3d\u00e1s\u00e1t eredm\u00e9nyezi, ami viszont sejt apopt\u00f3zist induk\u00e1l \u00e9s vesek\u00e1rosod\u00e1st okoz. Az \u00e9desgy\u00f6k\u00e9r farmakol\u00f3giai hat\u00e1sai a daganatellenes, gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns \u00e9s szabadgy\u00f6kfog\u00f3, amely cs\u00f6kkentheti a ROS gener\u00e1ci\u00f3t \u00e9s jav\u00edthatja a sejtek apopt\u00f3zis \u00e1llapot\u00e1t. Az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumai az \u00e9desgy\u00f6k\u00e9rrel egy\u00fctt \u00e9lnek, \u00e9s a gy\u00f3gy\u00e1szati mikrobi\u00e1lis er\u0151forr\u00e1sok k\u00f6z\u00e9 tartoznak. A gazdaszervezet \u00e9desgy\u00f6k\u00e9rhez hasonl\u00f3 farmakol\u00f3giai aktivit\u00e1ssal rendelkeznek, \u00e9s cs\u00f6kkenthetik a l\u00f3sz\u0151r \u00e1ltal okozott vesek\u00e1rosod\u00e1st. Lehet\u0151s\u00e9g\u00fck van a ciszplatin nefrotoxicit\u00e1s jav\u00edt\u00e1s\u00e1ra is. Ebben a tanulm\u00e1nyban MTT-tesztet haszn\u00e1ltak a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00f3gyszeres beavatkoz\u00e1si csoportok abszorbanci\u00e1j\u00e1nak m\u00e9r\u00e9s\u00e9re. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a CP \u00e1ltal kiv\u00e1ltott HEK293 sejtk\u00e1rosod\u00e1s id\u0151- \u00e9s d\u00f3zisf\u00fcgg\u0151 volt. A CP csoporttal \u00f6sszehasonl\u00edtva az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9rium kezel\u00e9si csoport jelent\u0151sen jav\u00edtotta a sejtk\u00e1rosod\u00e1st, \u00e9s a k\u00fcl\u00f6nbs\u00e9g statisztikailag szignifik\u00e1ns volt (P<0,01). Invert\u00e1lt mikroszk\u00f3p alatt megfigyelhet\u0151 volt, hogy a kombin\u00e1lt ter\u00e1pi\u00e1s csoportban a sejtek zsugorod\u00e1si morfol\u00f3gi\u00e1ja jelent\u0151sen cs\u00f6kkent, \u00e9s az adh\u00e9zi\u00f3s k\u00e9pess\u00e9g helyre\u00e1llt, \u00f6sszhangban az irodalmi jelent\u00e9sekkel. Az \u00e1raml\u00e1si citometri\u00e1s elemz\u00e9s kimutatta, hogy a Con csoporthoz k\u00e9pest a CP csoport apopt\u00f3zis ar\u00e1nya szignifik\u00e1nsan megn\u00f6vekedett (P<0,01). A CP csoporttal \u00f6sszehasonl\u00edtva a kombin\u00e1lt ter\u00e1pi\u00e1s csoport apopt\u00f3zisr\u00e1t\u00e1ja cs\u00f6kkent, \u00e9s a CPJT-H csoportnak volt a legjelent\u0151sebb hat\u00e1sa (P<0,01). \u00d6sszhangban az MTT-vizsg\u00e1lat eredm\u00e9nyeivel, ez tov\u00e1bb sugallja, hogy az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumok v\u00e9d\u0151hat\u00e1ssal rendelkeznek a CP \u00e1ltal kiv\u00e1ltott HEK293 sejtk\u00e1rosod\u00e1ssal szemben.
\nA sejtek apopt\u00f3zis\u00e1nak folyamata nagyon \u00f6sszetett, \u00e9s endog\u00e9n, exog\u00e9n \u00e9s endoplazmatikus retikulum stressz \u00fatvonalakra oszthat\u00f3. A Bcl-2 csal\u00e1d kulcsszerepet j\u00e1tszik a sejtek apopt\u00f3zis\u00e1ban, bele\u00e9rtve az antiapoptotikus feh\u00e9rj\u00e9ket, mint a Bcl-2, \u00e9s a proapoptotikus feh\u00e9rj\u00e9ket, mint a Bax. A Bcl-2 fontos szab\u00e1lyoz\u00f3 szerepet j\u00e1tszik a mitokondri\u00e1lis apopt\u00f3zis \u00fatvonal\u00e1ban, \u00e9s a downstream g\u00e9nek aktiv\u00e1l\u00e1s\u00e1val okozhat sejt apopt\u00f3zist. A kaszp\u00e1z-3, a kaszp\u00e1z-8 \u00e9s a kaszp\u00e1z-9 a kaszp\u00e1z-csal\u00e1d f\u0151 komponensei, \u00e9s gyakran haszn\u00e1lj\u00e1k \u0151ket fontos indik\u00e1tork\u00e9nt a sejt apopt\u00f3zis m\u00e9rt\u00e9k\u00e9nek kimutat\u00e1s\u00e1ra. A GRP78 \u00e9s a CHOP az endoplazmatikus retikulum stressz markerfeh\u00e9rj\u00e9i \u00e9s az endoplazmatikus retikulum stressz \u00e1ltal kiv\u00e1ltott sejt apopt\u00f3zis fontos \u00f6sszetev\u0151i. A Bcl-2 csal\u00e1d, a kaszp\u00e1z csal\u00e1d \u00e9s az endoplazmatikus retikulum stressz \u00e1ltal induk\u00e1lt apopt\u00f3zis feh\u00e9rj\u00e9k vizsg\u00e1lat\u00e1val az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumok v\u00e9d\u0151mechanizmus\u00e1t vizsg\u00e1ltuk a CP \u00e1ltal induk\u00e1lt apopt\u00f3zissal szemben HEK293 sejtekben. A k\u00eds\u00e9rleti eredm\u00e9nyek azt mutatt\u00e1k, hogy a Con csoporthoz k\u00e9pest a CP beavatkoz\u00e1s felszab\u00e1lyozta a Bax, Caspase-3, Caspase-8, Caspase-9, GRP78 \u00e9s CHOP mRNS \u00e9s feh\u00e9rje relat\u00edv expresszi\u00f3s szintj\u00e9t (P<0,05, P<0,01), mik\u00f6zben cs\u00f6kkentette a Bcl-2 mRNS \u00e9s feh\u00e9rje relat\u00edv expresszi\u00f3s szintj\u00e9t (P<0,01). A CP csoporttal \u00f6sszehasonl\u00edtva, az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumok k\u00fcl\u00f6nb\u00f6z\u0151 ter\u00e1pi\u00e1s gy\u00f3gyszereinek beavatkoz\u00e1sa bizonyos fok\u00fa javul\u00e1st mutatott a CP \u00e1ltal kiv\u00e1ltott HEK293 sejtk\u00e1rosod\u00e1sban. A CPJT-H csoportban a Bax, Caspase-3, Caspase-8, Caspase-8, Caspase-9, GRP78 \u00e9s CHOP mRNS \u00e9s feh\u00e9rje relat\u00edv expresszi\u00f3s szintje jelent\u0151sen cs\u00f6kkent (P<0,05, P<0,01), m\u00edg a Bcl-2 mRNS \u00e9s feh\u00e9rje relat\u00edv expresszi\u00f3s szintje n\u0151tt (P<0,01).
\n\u00d6sszefoglalva, az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumai cs\u00f6kkenthetik a CP \u00e1ltal kiv\u00e1ltott apopt\u00f3zist a HEK293 sejtekben, \u00e9s enyh\u00edtik a CP \u00e1ltal kiv\u00e1ltott nefrotoxicit\u00e1st az\u00e1ltal, hogy g\u00e1tolj\u00e1k a Bax, Caspase-3, Caspase-8, Caspase-9, GRP78, CHOP pro-apoptotikus feh\u00e9rj\u00e9k expresszi\u00f3j\u00e1t, \u00e9s el\u0151seg\u00edtik a Bcl-2 antiapoptotikus feh\u00e9rje expresszi\u00f3j\u00e1t. Ez megalapozza az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumainak \u00e9s a CP-nek a m\u00e9regtelen\u00edt\u00e9sre t\u00f6rt\u00e9n\u0151 egy\u00fcttes alkalmaz\u00e1s\u00e1t, \u00e9s kiterjeszti az \u00e9desgy\u00f6k\u00e9r endofita bakt\u00e9riumainak farmakol\u00f3giai hat\u00e1sait.<\/p>","protected":false},"excerpt":{"rendered":"

Protective effect and mechanism of endophytic bacteria in licorice against cisplatin induced HEK293 cell damage Cisplatin (CP), as a commonly used anti-tumor drug in clinical practice, has significant therapeutic effects but strong toxic side effects. The main manifestations are nephrotoxicity, hepatotoxicity, ototoxicity, and cardiotoxicity, with renal injury being particularly severe. It has a time dose […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nProtective effect and mechanism of endophytic bacteria in licorice against cisplatin induced HEK293 cell damage - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/ciszplatin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protective effect and mechanism of endophytic bacteria in licorice against cisplatin induced HEK293 cell damage - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Protective effect and mechanism of endophytic bacteria in licorice against cisplatin induced HEK293 cell damage Cisplatin (CP), as a commonly used anti-tumor drug in clinical practice, has significant therapeutic effects but strong toxic side effects. The main manifestations are nephrotoxicity, hepatotoxicity, ototoxicity, and cardiotoxicity, with renal injury being particularly severe. 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