{"id":5043,"date":"2024-08-04T16:58:49","date_gmt":"2024-08-04T16:58:49","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5043"},"modified":"2024-08-04T16:58:49","modified_gmt":"2024-08-04T16:58:49","slug":"yam","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/yam\/","title":{"rendered":"Az allantoin v\u00e9d\u0151hat\u00e1sa a jamgy\u00f6k\u00e9rben a ciklofoszfamid \u00e1ltal kiv\u00e1ltott korai petef\u00e9szek-el\u00e9gtelens\u00e9ggel szemben"},"content":{"rendered":"

Az allantoin v\u00e9d\u0151hat\u00e1sa a jamgy\u00f6k\u00e9rben a ciklofoszfamid \u00e1ltal kiv\u00e1ltott korai petef\u00e9szek-el\u00e9gtelens\u00e9ggel szemben
\nA korai petef\u00e9szek-el\u00e9gtelens\u00e9g (POF) a n\u0151gy\u00f3gy\u00e1szati endokrin rendszer gyakori betegs\u00e9ge. Az ut\u00f3bbi \u00e9vekben a POF el\u0151fordul\u00e1si ar\u00e1nya a sz\u00fcl\u0151k\u00e9pes kor\u00fa n\u0151k k\u00f6r\u00e9ben megn\u0151tt, \u00e9s a petef\u00e9szek funkci\u00f3j\u00e1nak cs\u00f6kken\u00e9se s\u00falyosan befoly\u00e1solta a betegek \u00e9letmin\u0151s\u00e9g\u00e9t, \u00e9s jelent\u0151sen megn\u00f6velte a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek, a csontritkul\u00e1s, az anyagcserezavarok \u00e9s m\u00e1s kapcsol\u00f3d\u00f3 betegs\u00e9gek kock\u00e1zat\u00e1t. R\u00e1kos \u00e9s sziszt\u00e9m\u00e1s lupus erythematosusos betegekn\u00e9l a POF \u00e9s a ciklofoszfamid (CP) klinikai alkalmaz\u00e1sa szorosan \u00f6sszef\u00fcgg. A CP oxidat\u00edv stressz, hormonszekr\u00e9ci\u00f3 \u00e9s gyullad\u00e1s r\u00e9v\u00e9n befoly\u00e1solhatja a petef\u00e9szek m\u0171k\u00f6d\u00e9s\u00e9t. A biztons\u00e1gos \u00e9s hat\u00e9kony petef\u00e9szekfunkci\u00f3-v\u00e9d\u0151szer megtal\u00e1l\u00e1sa a k\u00e9s\u0151bbi klinikai gy\u00f3gyszerfejleszt\u00e9s kulcsa.
\nA jamgy\u00f6k\u00e9r, mint az egyik hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szati \u00e9s \u00e9lelmiszer eredet\u0171 gy\u00f3gy\u00e1szati anyag, gazdag hat\u00f3anyagokat, p\u00e9ld\u00e1ul szteroid szaponinokat, poliszacharidokat, allantoint, flavonoidokat \u00e9s fenolos glikozidokat tartalmaz. K\u00e9miai \u00f6sszet\u00e9tel\u00e9nek sokf\u00e9les\u00e9ge k\u00fcl\u00f6nb\u00f6z\u0151 farmakol\u00f3giai hat\u00e1sokat biztos\u00edt, mint p\u00e9ld\u00e1ul antioxid\u00e1ns, gyullad\u00e1scs\u00f6kkent\u0151, immunszab\u00e1lyoz\u00f3, h\u00fagysavcs\u00f6kkent\u0151, daganatellenes \u00e9s vesebetegs\u00e9gekre gyakorolt ter\u00e1pi\u00e1s hat\u00e1s. A kutat\u00e1sok kimutatt\u00e1k, hogy a k\u00ednai gy\u00f3gy\u00e1szati anyagok \u00e9s az \u00e9lelmiszerekkel \u00e9s gy\u00f3gyszerekkel azonos eredet\u0171 term\u00e9szetes term\u00e9kek fejleszt\u00e9se \u00e9s felhaszn\u00e1l\u00e1sa nagy jelent\u0151s\u00e9ggel b\u00edr a petef\u00e9szek v\u00e9delm\u00e9ben. Az allantoin (ALL) a jamgy\u00f6k\u00e9r f\u0151 hat\u00f3anyaga, amelynek olyan funkci\u00f3i vannak, mint a stressz elleni, gyullad\u00e1scs\u00f6kkent\u0151, a b\u00e9l mikrobi\u00f3ta szab\u00e1lyoz\u00e1sa \u00e9s a sejtn\u00f6veked\u00e9s el\u0151seg\u00edt\u00e9se. Kor\u00e1bbi tanulm\u00e1nyokban a kutat\u00f3csoport meg\u00e1llap\u00edtotta, hogy a jamgy\u00f6k\u00e9r \u00e9s az ALL \u00f6sztrog\u00e9nszer\u0171 hat\u00e1ssal rendelkezik az \u00f6sztrog\u00e9n receptor alfa \u00e9s a G feh\u00e9rj\u00e9hez kapcsolt \u00f6sztrog\u00e9n receptorok m\u00e9hsz\u00f6vetben t\u00f6rt\u00e9n\u0151 expresszi\u00f3j\u00e1n kereszt\u00fcl. A term\u00e9szetes n\u00f6v\u00e9nyi \u00f6sztrog\u00e9nek pozit\u00edv hat\u00e1ssal vannak a petef\u00e9szek t\u00fcsz\u0151k fejl\u0151d\u00e9s\u00e9re patk\u00e1nyokban. Ez\u00e9rt ez a tanulm\u00e1ny egy CP \u00e1ltal induk\u00e1lt korai petef\u00e9szek-el\u00e9gtelens\u00e9g patk\u00e1nymodellt haszn\u00e1lt annak felt\u00e1r\u00e1s\u00e1ra, hogy az ALL hogyan jav\u00edtja a hormonszinteket, a t\u00fcsz\u0151fejl\u0151d\u00e9st \u00e9s az \u00e9r\u00e9si szinteket POF patk\u00e1nyokban, \u00e9s felt\u00e1rta a POF jav\u00edt\u00e1s\u00e1nak mechanizmus\u00e1t az oxidat\u00edv stressz szempontj\u00e1b\u00f3l, referenci\u00e1t ny\u00fajtva a jamgy\u00f6k\u00e9r \u00e9s ALL hat\u00f3anyag\u00e1nak fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz a n\u0151i reprodukci\u00f3s v\u00e9delemben.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"A ciklofoszfamid (CP) egy kemoter\u00e1pi\u00e1s gy\u00f3gyszer, amelyet sz\u00e9les k\u00f6rben alkalmaznak rosszindulat\u00fa daganatok \u00e9s autoimmun betegs\u00e9gek kezel\u00e9s\u00e9re, de toxikus mell\u00e9khat\u00e1sai er\u0151sek, \u00e9s maradand\u00f3 k\u00e1rosod\u00e1st okozhatnak a petef\u00e9szkekben. Az elm\u00falt \u00e9vtizedekben a reprodukci\u00f3s k\u00e9pess\u00e9g v\u00e9delme \u00e9s a petef\u00e9szekfunkci\u00f3 helyre\u00e1ll\u00edt\u00e1sa nagyon fontoss\u00e1 v\u00e1lt a r\u00e1kkezel\u00e9sben, mivel ez a kezel\u00e9si s\u00e9ma jav\u00edthatja a n\u0151i r\u00e1kos betegek \u00e9letmin\u0151s\u00e9g\u00e9t. Ezenk\u00edv\u00fcl a CP az oxidat\u00edv stresszmarkerek aktiv\u00e1l\u00e1s\u00e1val \u00e9s az antioxid\u00e1ns v\u00e9dekez\u0151 mechanizmusok t\u00falfogyaszt\u00e1s\u00e1val olyan fontos szervekre is hat\u00e1ssal lehet, mint a sz\u00edv \u00e9s a vese. Ez\u00e9rt a CP szerveket \u00e9rint\u0151 k\u00e1rosod\u00e1s\u00e1nak jav\u00edt\u00e1sa az oxidat\u00edv stressz szab\u00e1lyoz\u00e1s\u00e1val a tanulm\u00e1ny egyik f\u00f3kusza.<\/p>\n

A CP toxicit\u00e1sa az egyik metabolitj\u00e1nak, az akroleinnek a keletkez\u00e9s\u00e9vel f\u00fcgg \u00f6ssze. A CP-kezel\u00e9st k\u00f6vet\u0151en a r\u00e1kos betegekn\u00e9l a glutation (GSH) szintje jelent\u0151sen cs\u00f6kken, ami az akrolein megk\u00f6t\u00e9s\u00e9nek eredm\u00e9nye lehet. A GSH egy tripeptid \u00e9s fontos antioxid\u00e1ns \u00e9s szabadgy\u00f6kfog\u00f3 a szervezetben. Ugyanakkor a CP az eg\u00e9szs\u00e9ges petef\u00e9szeksz\u00f6vetben m\u00e1s endog\u00e9n antioxid\u00e1nsok, p\u00e9ld\u00e1ul a SOD aktivit\u00e1s\u00e1t is megv\u00e1ltoztatja, el\u0151seg\u00edtve a petef\u00e9szeksejtek intracellul\u00e1ris szabadgy\u00f6k-k\u00e1rosod\u00e1s\u00e1t. Ebben a vizsg\u00e1latban az ALL jelent\u0151sen megv\u00e9dte a patk\u00e1ny petef\u00e9szkeket a CP \u00e1ltal okozott oxidat\u00edv stresszt\u0151l. Az ALL egy purinlebont\u00e1s sor\u00e1n keletkez\u0151 metabolit, amely az \u00e1llatok \u00e9s n\u00f6v\u00e9nyek szervezet\u00e9ben is megtal\u00e1lhat\u00f3. El\u0151seg\u00edtheti a b\u0151rsejtek n\u00f6veked\u00e9s\u00e9t \u00e9s a sebgy\u00f3gyul\u00e1st, serkenti a fibroblasztok n\u00f6veked\u00e9s\u00e9t, \u00e9s \u00f6sztrog\u00e9nszer\u0171 hat\u00e1sa van. Ez\u00e9rt a szervk\u00e1rosod\u00e1ssal szembeni v\u00e9d\u0151hat\u00e1s\u00e1nak felt\u00e1r\u00e1sa mellett ez a tanulm\u00e1ny antioxid\u00e1ns hat\u00e1saira \u00e9s hat\u00e1smechanizmusaira is \u00f6sszpontos\u00edt. Ebben a vizsg\u00e1latban 70mg\/kg \u00e9s 140mg\/kg allantoin fenntartotta a petef\u00e9szek GSH Px \u00e9s SOD aktivit\u00e1s\u00e1t, \u00e9s jelent\u0151sen g\u00e1tolta az MDA-t, megv\u00e9dve a patk\u00e1ny petef\u00e9szkeket a CP \u00e1ltal kiv\u00e1ltott oxidat\u00edv stressz okozta petef\u00e9szek-k\u00e1rosod\u00e1st\u00f3l.<\/p>\n

Az Nrf2 nukle\u00e1ris transzkripci\u00f3s faktor a CNC leucin cipz\u00e1r transzkripci\u00f3s aktiv\u00e1tor csal\u00e1dba tartozik, amely antioxid\u00e1ns aktivit\u00e1s induk\u00e1l\u00e1s\u00e1val v\u00e9di a feh\u00e9rjek\u00f3dol\u00f3 g\u00e9neket, \u00e9s szab\u00e1lyozza az oxidat\u00edv dezoxig\u00e9nez\u00e9si reakci\u00f3kat az intracellul\u00e1ris k\u00f6rnyezetben. Az Nrf2 az antioxid\u00e1ns v\u00e1laszelemekhez (ARE) k\u00f6t\u0151dve aktiv\u00e1lja a downstream antioxid\u00e1ns feh\u00e9rj\u00e9ket \u00e9s enzimeket, \u00e9s v\u00e9d az oxidat\u00edv stresszel szemben. Ebben a vizsg\u00e1latban az Nrf2 expresszi\u00f3j\u00e1nak cs\u00f6kken\u00e9s\u00e9t \u00e9s az oxidat\u00edv stressz n\u00f6veked\u00e9s\u00e9t tal\u00e1ltuk POF patk\u00e1nyok petef\u00e9szkeiben; az ALL egy bizonyos d\u00f3zisban szab\u00e1lyozza az Nrf2 szintj\u00e9t. A kutat\u00e1sok kimutatt\u00e1k, hogy a downstream c\u00e9lg\u00e9nek (HO-1, NQO1 stb.) expresszi\u00f3ja \u00f6sszhangban van az Nrf2 nukle\u00e1ris transzlok\u00e1ci\u00f3j\u00e1val, ami nemcsak meger\u0151s\u00edti a Kelch like as social protein 1 (Keap1) - Nrf2 ARE \u00fatvonal r\u00e9szv\u00e9tel\u00e9t, hanem arra is utal, hogy a HO-1 \u00e9s az NQO1 kritikus szerepet j\u00e1tszik a redox homeoszt\u00e1zis fenntart\u00e1s\u00e1ban. A HO-1 a heme-oxigen\u00e1z egyik alt\u00edpusa, amely k\u00f6nnyen stimul\u00e1lhat\u00f3 \u00e9s induk\u00e1lhat\u00f3, \u00e9s k\u00f6zvetett antioxid\u00e1ns szerepet j\u00e1tszik. Az NQO1 k\u00e9pes a szuperoxid-anion gy\u00f6k\u00f6k elt\u00e1vol\u00edt\u00e1s\u00e1ra \u00e9s az oxidat\u00edv stressz \u00e1ltal felszab\u00e1lyozott reakt\u00edv oxig\u00e9nfajok (ROS) t\u00falzott felhalmoz\u00f3d\u00e1s\u00e1nak enyh\u00edt\u00e9s\u00e9re. Vizsg\u00e1latunkban a POF patk\u00e1nymodell petef\u00e9szkeiben nem mutatkozott jelent\u0151s NQO1-expresszi\u00f3. Azonban 14 napos folyamatos adagol\u00e1st k\u00f6vet\u0151en a pozit\u00edv hat\u00e1s\u00fa EV \u00e9s ALL 70mg\/kg d\u00f3zisban szignifik\u00e1nsan megn\u00f6velte az NQO1 expresszi\u00f3s szintj\u00e9t, ami arra utal, hogy a petef\u00e9szek s\u00e9r\u00fcl\u00e9si stresszben is pozit\u00edv szerepet j\u00e1tszhatnak. Ez az eredm\u00e9ny \u00f6sszef\u00fcgghet az NQO1 stabilit\u00e1s\u00e1val, kett\u0151s akt\u00edv hely\u00e9vel \u00e9s nem enzimatikus aktivit\u00e1s\u00e1val. Lehets\u00e9ges, hogy a CP stimul\u00e1ci\u00f3 nem aktiv\u00e1lta az NQO1-et, m\u00edg az ALL bizonyos d\u00f3zisban k\u00e9pes k\u00f6t\u0151dni az akt\u00edv helyhez. Ez\u00e9rt tov\u00e1bbi kutat\u00e1sokra \u00e9s felt\u00e1r\u00e1sra van sz\u00fcks\u00e9g. A POF patk\u00e1nymodell jelent\u0151sen cs\u00f6kkentette a HO-1 expresszi\u00f3j\u00e1t a petef\u00e9szekben, m\u00edg a pozit\u00edv gy\u00f3gyszer EV \u00e9s ALL 140mg\/kg d\u00f3zisban jelent\u0151s javul\u00e1st mutatott a HO-1 expresszi\u00f3j\u00e1ban. A HO-1 egy stresszre reag\u00e1l\u00f3 feh\u00e9rje, amely kataliz\u00e1lja a hemefeh\u00e9rj\u00e9k lebont\u00e1s\u00e1t \u00e9s bilirubinn\u00e1 t\u00f6rt\u00e9n\u0151 \u00e1talak\u00edt\u00e1s\u00e1t. A lebont\u00e1si anyagcser\u00e9j\u00e9nek term\u00e9kei antioxid\u00e1ns, antiapoptotikus \u00e9s immunmodul\u00e1l\u00f3 hat\u00e1s\u00faak. Ez\u00e9rt a HO-1 stressz alatt v\u00e9d\u0151 szerepet j\u00e1tszhat, ami arra utal, hogy az ALL jav\u00edthatja a POF patk\u00e1nyok petef\u00e9szek-k\u00e1rosod\u00e1s\u00e1t a HO-1 szab\u00e1lyoz\u00e1s\u00e1val, hogy antioxid\u00e1ns stresszhat\u00e1st fejtsen ki. Tov\u00e1bbi kutat\u00e1sokra van sz\u00fcks\u00e9g az oxidat\u00edv stressz NQO1 \u00fatvonalra gyakorolt hat\u00e1s\u00e1nak vizsg\u00e1lat\u00e1hoz ebben a tanulm\u00e1nyban.<\/p>\n

Az ALL n\u00f6velte a HO-1 \u00e9s az Nrf2 expresszi\u00f3j\u00e1t a POF patk\u00e1nyok petef\u00e9szeksz\u00f6vet\u00e9ben, enyh\u00edtette az oxidat\u00edv stresszt, szab\u00e1lyozta a hormonszinteket \u00e9s jav\u00edtotta a petef\u00e9szek diszfunkci\u00f3j\u00e1t a POF patk\u00e1nyokban. Ez a tanulm\u00e1ny referenci\u00e1t ny\u00fajt a jamgy\u00f6k\u00e9r \u00e9s ALL hat\u00f3anyag\u00e1nak fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"

The protective effect of allantoin in yam on cyclophosphamide induced premature ovarian failure Premature ovarian failure (POF) is a common disease of the gynecological endocrine system. In recent years, the incidence rate of POF in women of childbearing age has increased, and the decline of ovarian function has seriously affected the quality of life of […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nThe protective effect of allantoin in yam on cyclophosphamide induced premature ovarian failure - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/yam\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The protective effect of allantoin in yam on cyclophosphamide induced premature ovarian failure - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The protective effect of allantoin in yam on cyclophosphamide induced premature ovarian failure Premature ovarian failure (POF) is a common disease of the gynecological endocrine system. 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