{"id":4983,"date":"2024-08-04T16:44:55","date_gmt":"2024-08-04T16:44:55","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4983"},"modified":"2024-08-04T16:44:55","modified_gmt":"2024-08-04T16:44:55","slug":"turtle-shell-glue","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/turtle-shell-glue\/","title":{"rendered":"A k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3k tekn\u0151sp\u00e1nc\u00e9l-ragaszt\u00f3j\u00e1nak aminosavtartalm\u00e1ban \u00e9s az antiosteopor\u00f3zis potenci\u00e1lis mechanizmusaiban rejl\u0151 k\u00fcl\u00f6nbs\u00e9gek felt\u00e1r\u00e1sa UHPLC-QTRAP-MS\/MS \u00e9s h\u00e1l\u00f3zati farmakol\u00f3gia kombin\u00e1ci\u00f3j\u00e1n alapul\u00f3 UHPLC-QTRAP-MS\/MS alapj\u00e1n"},"content":{"rendered":"<p>A k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3k tekn\u0151sp\u00e1nc\u00e9l-ragaszt\u00f3j\u00e1nak aminosavtartalm\u00e1ban \u00e9s az antiosteopor\u00f3zis potenci\u00e1lis mechanizmusaiban rejl\u0151 k\u00fcl\u00f6nbs\u00e9gek felt\u00e1r\u00e1sa UHPLC-QTRAP-MS\/MS \u00e9s h\u00e1l\u00f3zati farmakol\u00f3gia kombin\u00e1ci\u00f3j\u00e1n alapul\u00f3 UHPLC-QTRAP-MS\/MS alapj\u00e1n<br \/>\nA Testudinis Carapacis et Plasti Colla (TCPC) egy hagyom\u00e1nyos k\u00ednai t\u00e1pl\u00e1l\u00f3 gy\u00f3gyszer, amely a Chinemys reevesii (Gray) tekn\u0151sb\u00e9ka csal\u00e1dba tartoz\u00f3 tekn\u0151sb\u00e9ka p\u00e1nc\u00e9lj\u00e1nak v\u00edzben val\u00f3 forral\u00e1s\u00e1val \u00e9s koncentr\u00e1l\u00e1s\u00e1val k\u00e9sz\u00fclt szil\u00e1rd g\u00e9l. El\u0151sz\u00f6r a \"Compendium of Materia Medica\" c\u00edm\u0171 k\u00f6nyvben jegyezt\u00e9k fel. H\u0171v\u00f6s jelleg\u0171, s\u00f3s \u00e9s \u00e9des \u00edz\u0171, \u00e9s alkalmas a m\u00e1j, a vese \u00e9s a sz\u00edv meridi\u00e1nok kezel\u00e9s\u00e9re. A klinikai gyakorlatban gyakran haszn\u00e1lj\u00e1k a csontritkul\u00e1s kezel\u00e9s\u00e9ben. A f\u0151k\u00e9nt tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3b\u00f3l \u00e1ll\u00f3 klasszikus formul\u00e1k, mint p\u00e9ld\u00e1ul a Guilu Erxian sorozat\u00fa formula, a Zuogui Wan, Huqian Wan stb. jelent\u0151s hat\u00e1ssal vannak a l\u00e9nyeg t\u00e1pl\u00e1l\u00e1s\u00e1ra, a csontvel\u0151 felt\u00f6lt\u00e9s\u00e9re, az inak \u00e9s csontok er\u0151s\u00edt\u00e9s\u00e9re. A tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3 gazdag kollag\u00e9nben, keratinban \u00e9s szabad aminosavakban. A feh\u00e9rje hidrol\u00edzis\u00e9b\u0151l nyert aminosavak a tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3 f\u0151 hat\u00f3anyagai, amelyek v\u00e9g\u00fcl felsz\u00edv\u00f3dnak \u00e9s hasznosulnak az emberi szervezetben. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s diagn\u00f3zis\u00e1ban \u00e9s kezel\u00e9s\u00e9ben a csontritkul\u00e1st t\u00f6bbnyire a \"csontelz\u00e1r\u00f3d\u00e1s\", a \"csontnekr\u00f3zis\" \u00e9s a \"csontsipoly\" kateg\u00f3ri\u00e1kba sorolj\u00e1k. A \"S\u00fcrg\u0151ss\u00e9gi ell\u00e1t\u00e1s alapvet\u0151 receptjei\" szerint: \"Az extr\u00e9m csontbetegs\u00e9gben szenved\u0151kn\u00e9l... f\u00e1jdalmat tapasztalhatnak a kez\u00fckben \u00e9s a l\u00e1bukban, k\u00e9ptelenek hossz\u00fa ideig \u00e1llni, \u00e9s neh\u00e9zs\u00e9get tapasztalhatnak a hajl\u00edt\u00e1sban \u00e9s ny\u00fajt\u00e1sban, ami a test elz\u00e1r\u00f3d\u00e1s\u00e1hoz, agyi \u00e9s gerincvel\u0151i diszfunkci\u00f3hoz vezethet. A vese t\u00e1rolja az esszenci\u00e1t \u00e9s szab\u00e1lyozza a csontvel\u0151 termel\u00e9s\u00e9t. Ha nem elegend\u0151, a csontvel\u0151 cs\u00f6kken, \u00e9s a csont elsorvad. A csontvel\u0151 elveszt\u00e9se fokozott csontt\u00f6r\u00e9kenys\u00e9ghez \u00e9s csontritkul\u00e1shoz vezet. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3 \u00e9s klasszikus formul\u00e1i j\u00f3 hat\u00e1ssal vannak a csontok eg\u00e9szs\u00e9g\u00e9re, az immunrendszer er\u0151s\u00edt\u00e9s\u00e9re, a daganatellenes \u00e9s egy\u00e9b szempontok szerint. A tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3ban tal\u00e1lhat\u00f3 glicin \u00e9s prolin potenci\u00e1lis biomarkerekk\u00e9nt szolg\u00e1lhatnak a posztmenopauz\u00e1lis csontritkul\u00e1s diagnosztiz\u00e1l\u00e1s\u00e1ban. Az aminosavak maguk is jelz\u0151molekul\u00e1k, \u00e9s szinergikusan aktiv\u00e1lhatj\u00e1k a kalcium-\u00e9rz\u00e9keny receptorokat a kalciumionokkal, n\u00f6velhetik a csonts\u0171r\u0171s\u00e9get, el\u0151seg\u00edthetik az oszteoblasztok differenci\u00e1l\u00f3d\u00e1s\u00e1t \u00e9s fokozhatj\u00e1k a csontok meszesed\u00e9s\u00e9t. A k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3kt\u00f3l sz\u00e1rmaz\u00f3 tekn\u0151sp\u00e1nc\u00e9lragaszt\u00f3 aminosavtartalm\u00e1nak k\u00fcl\u00f6nbs\u00e9geinek felt\u00e1r\u00e1sa \u00e9rdek\u00e9ben ez a tanulm\u00e1ny 4 k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3t\u00f3l sz\u00e1rmaz\u00f3 15 t\u00e9tel tekn\u0151sp\u00e1nc\u00e9lragaszt\u00f3-mint\u00e1t v\u00e1lasztott ki. Folyad\u00e9kkromatogr\u00e1fia-t\u00f6megspektrometri\u00e1t haszn\u00e1ltak 17 aminosav meghat\u00e1roz\u00e1s\u00e1ra a tekn\u0151sp\u00e1nc\u00e9lragaszt\u00f3 savas hidrol\u00edzise ut\u00e1n. T\u00f6bbv\u00e1ltoz\u00f3s statisztik\u00e1t alkalmaztunk a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3k tekn\u0151sp\u00e1nc\u00e9l-ragaszt\u00f3j\u00e1ban l\u00e9v\u0151 hidroliz\u00e1lt aminosavkomponensek \u00f6sszet\u00e9tel\u00e9nek k\u00fcl\u00f6nbs\u00e9geinek \u00f6sszehasonl\u00edt\u00e1s\u00e1ra, ami referenci\u00e1t szolg\u00e1ltat a tekn\u0151sp\u00e1nc\u00e9l-ragaszt\u00f3 min\u0151s\u00e9gellen\u0151rz\u00e9s\u00e9hez. \u00c9s a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1val kombin\u00e1lva elemezt\u00e9k a tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3ban l\u00e9v\u0151 aminosavkomponenseket, ami alapot szolg\u00e1ltatott a tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3 f\u0151 hat\u00f3anyagainak \u00e9s c\u00e9lpontjainak tov\u00e1bbi el\u0151rejelz\u00e9s\u00e9hez a csontritkul\u00e1s elleni k\u00fczdelemben.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4984\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png\" alt=\"\" width=\"782\" height=\"418\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108-768x411.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4985\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-94.png\" alt=\"\" width=\"778\" height=\"320\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-94.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-94-768x316.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4986\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-90.png\" alt=\"\" width=\"781\" height=\"482\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-90.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-90-768x474.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4987\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-79.png\" alt=\"\" width=\"776\" height=\"249\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-79.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-79-768x246.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4988\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-73.png\" alt=\"\" width=\"778\" height=\"498\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-73.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-73-768x492.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4989\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-65.png\" alt=\"\" width=\"776\" height=\"275\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-65.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-65-768x272.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4990\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-61.png\" alt=\"\" width=\"779\" height=\"285\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-61.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-61-768x281.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4991\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-55.png\" alt=\"\" width=\"780\" height=\"425\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-55.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-55-768x418.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4992\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-49.png\" alt=\"\" width=\"766\" height=\"241\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4993\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-42.png\" alt=\"\" width=\"779\" height=\"453\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-42.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-42-768x447.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4994\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-36.png\" alt=\"\" width=\"776\" height=\"748\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-36.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-36-768x740.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-36-747x720.png 747w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4995\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-32.png\" alt=\"\" width=\"779\" height=\"838\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-32.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-32-768x826.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-32-669x720.png 669w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4996\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-27.png\" alt=\"\" width=\"780\" height=\"311\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-27.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-27-768x306.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4997\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-23.png\" alt=\"\" width=\"780\" height=\"146\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-23.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-23-768x144.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4998\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-17.png\" alt=\"\" width=\"777\" height=\"330\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-17.png 777w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-17-768x326.png 768w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4999\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-14.png\" alt=\"\" width=\"779\" height=\"308\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-14.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-14-768x304.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5000\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-12.png\" alt=\"\" width=\"778\" height=\"300\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-12.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-12-768x296.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5001\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-10.png\" alt=\"\" width=\"782\" height=\"303\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-10.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-10-768x298.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/>A k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3kb\u00f3l \u00e9s t\u00e9telekb\u0151l sz\u00e1rmaz\u00f3 hidroliz\u00e1lt tekn\u0151sp\u00e1nc\u00e9l-ragaszt\u00f3 teljes aminosavtartalma ebben a cikkben alacsonyabb, mint a gy\u00f3gyszerk\u00f6nyvi szint. Ennek oka nemcsak mag\u00e1val a minta min\u0151s\u00e9g\u00e9vel, hanem a vizsg\u00e1lati m\u00f3dszerrel is \u00f6sszef\u00fcgghet. A hidroliz\u00e1lt aminosavak jellegzetes ionp\u00e1rjainak kimutat\u00e1s\u00e1ra folyad\u00e9kkromatogr\u00e1fia-t\u00f6megspektrometri\u00e1t haszn\u00e1lunk, amely nagy \u00e9rz\u00e9kenys\u00e9ggel \u00e9s specifikuss\u00e1ggal rendelkezik; A gy\u00f3gyszerk\u00f6nyvben haszn\u00e1lt HPLC-m\u00f3dszer a vegy\u00fcletek jellegzetes funkcion\u00e1lis csoportjainak abszorbanciajeleit \u00e9rz\u00e9keli, ami megnehez\u00edti a hasonl\u00f3 szerkezet\u0171 vegy\u00fcletek megk\u00fcl\u00f6nb\u00f6ztet\u00e9s\u00e9t. A folyad\u00e9kkromatogr\u00e1fia-t\u00f6megspektrometria (LC-MS) m\u00f3dszer pontosabb \u00e9s k\u00e9pes kik\u00fcsz\u00f6b\u00f6lni a nem specifikus komponensek interferenci\u00e1j\u00e1t, \u00edgy a hidroliz\u00e1lt aminosavak tartalma alacsonyabb lehet, mint a gy\u00f3gyszerk\u00f6nyvben szerepl\u0151. A h\u00e1l\u00f3zati farmakol\u00f3gia eredm\u00e9nyei azt mutatj\u00e1k, hogy a tekn\u0151sp\u00e1nc\u00e9l-ragaszt\u00f3 kulcsfontoss\u00e1g\u00fa \u00f6sszetev\u0151i a csontritkul\u00e1s kezel\u00e9s\u00e9ben az Ala \u00e9s a Gly. Az Ala seg\u00edtheti a cukrok \u00e9s szerves savak anyagcser\u00e9j\u00e9t, \u00e9s jav\u00edthatja a posztmenopauz\u00e1lis csontritkul\u00e1st. A Gly k\u00f6zvetlen\u00fcl \u00f6sszef\u00fcgg a f\u00e9rfiakn\u00e1l a t\u00f6r\u00e9sek kock\u00e1zat\u00e1val, a kollag\u00e9n mut\u00e1ci\u00f3i pedig osteogenesis imperfect\u00e1t okozhatnak. A csontritkul\u00e1s tekn\u0151sp\u00e1nc\u00e9lragaszt\u00f3val t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9nek kulcsfontoss\u00e1g\u00fa c\u00e9lpontjai k\u00f6z\u00e9 tartozik a CAT, a NOS1, NOS3, F2 stb. A katal\u00e1z (CAT) az oxidat\u00edv stressz g\u00e1tl\u00e1s\u00e1val n\u00f6velheti a csonts\u0171r\u0171s\u00e9get \u00e9s a csont \u00e1sv\u00e1nyianyag-tartalm\u00e1t egerekben; a neuron\u00e1lis nitrog\u00e9n-oxid-szint\u00e1z (NOS1) a csontgy\u00f3gyul\u00e1shoz kapcsol\u00f3dik, \u00e9s f\u0151k\u00e9nt a rostos sz\u00f6vet \u00e9s a kallusz k\u00f6z\u00f6tti fibrocsont r\u00e9gi\u00f3ban fejez\u0151dik ki; az endothelialis nitrog\u00e9n-oxid-szint\u00e1z (NOS3) szint\u00e9n a csontgy\u00f3gyul\u00e1shoz kapcsol\u00f3dik, \u00e9s f\u0151k\u00e9nt a kondrocit\u00e1kban \u00e9s a perivascularis sejtekben fejez\u0151dik ki; a protrombin specifikus agonista az oszteoblasztokban, amely szervkult\u00far\u00e1ban stimul\u00e1lhatja a csontfelsz\u00edv\u00f3d\u00e1st. A KEGG \u00e9s GO d\u00fas\u00edt\u00e1si elemz\u00e9s eredm\u00e9nyei azt sugallj\u00e1k, hogy a tekn\u0151sp\u00e1nc\u00e9l gumi egy sor biol\u00f3giai funkci\u00f3ban vehet r\u00e9szt, mint p\u00e9ld\u00e1ul a vitamink\u00f6t\u00e9s, a piridox\u00e1l-foszf\u00e1t k\u00f6t\u00e9s, a szerves savak k\u00f6t\u00e9se \u00e9s az aminosavszint\u00e9zis anyagcser\u00e9je a csontsejtekben; \u00dagy m\u0171k\u00f6dik, hogy befoly\u00e1solja az olyan jel\u00e1tviteli \u00fatvonalakat, mint az inzulin jel\u00e1tvitel, a kalcium jel\u00e1tvitel, a ciklikus guanozin-monofoszf\u00e1t protein kin\u00e1z G (cGMP PKG) jel\u00e1tvitel, a sz\u00e9n anyagcsere \u00e9s az aminosavszint\u00e9zis. Az inzulin jel\u00e1tviteli \u00fatvonal serkentheti a v\u00e1zizmokat, hogy felvegy\u00e9k a szervezet 80% gl\u00fck\u00f3z\u00e1t; A cGMP PKG jel\u00e1tviteli \u00fatvonal szab\u00e1lyozhatja a csontk\u00e9pz\u0151d\u00e9st \u00e9s el\u0151seg\u00edtheti az oszteoblasztok mineraliz\u00e1ci\u00f3j\u00e1t \u00e9s \u00e9r\u00e9s\u00e9t, k\u00e9tir\u00e1ny\u00fa \u00e9s komplex szab\u00e1lyoz\u00e1st mutatva az oszteogenezisben.<br \/>\n\u00d6sszefoglalva, ez a cikk az UHPLC-QTRAP-MS \/ MS-t haszn\u00e1lja t\u00f6bbv\u00e1ltoz\u00f3s statisztikai elemz\u00e9ssel kombin\u00e1lva, hogy meg\u00e1llap\u00edtsa, hogy a n\u00e9gy gy\u00e1rt\u00f3 k\u00f6z\u00fcl az A gy\u00e1rt\u00f3 stabil min\u0151s\u00e9g\u0171 tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3val \u00e9s magas hidroliz\u00e1lt aminosavtartalommal rendelkezik; A tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3 szab\u00e1lyozhatja a csontritkul\u00e1s 68 alapvet\u0151 c\u00e9lpontj\u00e1t, bele\u00e9rtve a CAT, NOS1, NOS3 stb., stb, olyan \u00f6sszetev\u0151k\u00f6n kereszt\u00fcl, mint az alanin \u00e9s a glicin, ez\u00e1ltal 212 jel\u00e1tviteli \u00fatvonalat befoly\u00e1solva, mint az aminosavszint\u00e9zis, az arginin \u00e9s prolin anyagcsere \u00e9s a sz\u00e9nanyagcsere, hogy ter\u00e1pi\u00e1s hat\u00e1st gyakoroljon a csontritkul\u00e1son.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology Testudinis Carapacis et Plasti Colla (TCPC) is a traditional Chinese nourishing medicine, which is a solid gel made by boiling and concentrating the turtle shell of the turtle [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/turtle-shell-glue\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology Testudinis Carapacis et Plasti Colla (TCPC) is a traditional Chinese nourishing medicine, which is a solid gel made by boiling and concentrating the turtle shell of the turtle [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/hu\/turtle-shell-glue\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T16:44:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Szerz\u0151:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Becs\u00fclt olvas\u00e1si id\u0151\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 perc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/turtle-shell-glue\/\",\"url\":\"https:\/\/longchangextracts.com\/turtle-shell-glue\/\",\"name\":\"Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/turtle-shell-glue\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/turtle-shell-glue\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png\",\"datePublished\":\"2024-08-04T16:44:55+00:00\",\"dateModified\":\"2024-08-04T16:44:55+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/turtle-shell-glue\/#breadcrumb\"},\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/turtle-shell-glue\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/turtle-shell-glue\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/turtle-shell-glue\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"hu\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Az UHPLC-QTRAP-MS\/MS alapj\u00e1n a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3k tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3j\u00e1nak az anti osteoporosis aminosavtartalm\u00e1nak \u00e9s potenci\u00e1lis mechanizmusainak a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3k UHPLC-QTRAP-MS\/MS kombin\u00e1lt h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1j\u00e1val kombin\u00e1lt k\u00fcl\u00f6nbs\u00e9geit felt\u00e1r\u00f3 - K\u00edna Vegyi Gy\u00e1rt\u00f3","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/hu\/turtle-shell-glue\/","og_locale":"hu_HU","og_type":"article","og_title":"Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology - China Chemical Manufacturer","og_description":"Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology Testudinis Carapacis et Plasti Colla (TCPC) is a traditional Chinese nourishing medicine, which is a solid gel made by boiling and concentrating the turtle shell of the turtle [&hellip;]","og_url":"https:\/\/longchangextracts.com\/hu\/turtle-shell-glue\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T16:44:55+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Szerz\u0151:":"longcha9","Becs\u00fclt olvas\u00e1si id\u0151":"8 perc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/turtle-shell-glue\/","url":"https:\/\/longchangextracts.com\/turtle-shell-glue\/","name":"Az UHPLC-QTRAP-MS\/MS alapj\u00e1n a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3k tekn\u0151sp\u00e1nc\u00e9l ragaszt\u00f3j\u00e1nak az anti osteoporosis aminosavtartalm\u00e1nak \u00e9s potenci\u00e1lis mechanizmusainak a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00e1rt\u00f3k UHPLC-QTRAP-MS\/MS kombin\u00e1lt h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1j\u00e1val kombin\u00e1lt k\u00fcl\u00f6nbs\u00e9geit felt\u00e1r\u00f3 - K\u00edna Vegyi Gy\u00e1rt\u00f3","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/turtle-shell-glue\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/turtle-shell-glue\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png","datePublished":"2024-08-04T16:44:55+00:00","dateModified":"2024-08-04T16:44:55+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/turtle-shell-glue\/#breadcrumb"},"inLanguage":"hu","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/turtle-shell-glue\/"]}]},{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/turtle-shell-glue\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/turtle-shell-glue\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"K\u00edna Vegyi Gy\u00e1rt\u00f3","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4983"}],"collection":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/comments?post=4983"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4983\/revisions"}],"predecessor-version":[{"id":5002,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4983\/revisions\/5002"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/media?parent=4983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/categories?post=4983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/tags?post=4983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}