{"id":4840,"date":"2024-08-04T16:03:22","date_gmt":"2024-08-04T16:03:22","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4840"},"modified":"2024-08-04T16:03:22","modified_gmt":"2024-08-04T16:03:22","slug":"allergic-rhinitis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/allergias-natha\/","title":{"rendered":"A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s gy\u00f3gyszerel\u00e9si szab\u00e1lyainak \u00e9s a kapcsol\u00f3d\u00f3 farmakol\u00f3giai elemz\u00e9s\u00e9nek felt\u00e1r\u00e1sa az allergi\u00e1s rhinitis kezel\u00e9s\u00e9ben az adatb\u00e1ny\u00e1szat, a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n"},"content":{"rendered":"

A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s gy\u00f3gyszerel\u00e9si szab\u00e1lyainak \u00e9s a kapcsol\u00f3d\u00f3 farmakol\u00f3giai elemz\u00e9s\u00e9nek felt\u00e1r\u00e1sa az allergi\u00e1s rhinitis kezel\u00e9s\u00e9ben az adatb\u00e1ny\u00e1szat, a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n
\nAz allergi\u00e1s rhinitis (AR), m\u00e1s n\u00e9ven allergi\u00e1s rhinitis, az orrny\u00e1lkah\u00e1rtya kr\u00f3nikus, nem fert\u0151z\u0151 gyullad\u00e1sa, amelyet az allerg\u00e9neknek val\u00f3 kitetts\u00e9get k\u00f6vet\u0151en az at\u00f3pi\u00e1s egy\u00e9nekn\u00e9l az immunglobulin E (IgE) \u00e1ltal k\u00f6zvet\u00edtett gyullad\u00e1sos faktorok (hisztamin, leukotri\u00e9nek, prosztaglandinok, trombocita aktiv\u00e1l\u00f3 faktorok stb.) felszabadul\u00e1sa okoz, \u00e9s amelyben t\u00f6bb immunakt\u00edv sejt \u00e9s immunfaktor vesz r\u00e9szt. A gyullad\u00e1sos faktorok a helyi orrny\u00e1lkah\u00e1rtya \u00f6d\u00e9m\u00e1j\u00e1t \u00e9s exsud\u00e1ci\u00f3j\u00e1t okozz\u00e1k, stimul\u00e1lj\u00e1k az orr \u00e9rz\u0151idegeit, ami olyan tipikus t\u00fcneteket eredm\u00e9nyez, mint a paroxysmalis \u00e9s visszat\u00e9r\u0151 orrviszket\u00e9s, t\u00fcssz\u00f6g\u00e9s \u00e9s vizes orrfoly\u00e1s. Emellett orrdugul\u00e1s, cs\u00f6kkent szagl\u00e1s, asztma \u00e9s egy\u00e9b t\u00fcnetek is k\u00eds\u00e9rhetik. Az AR az allerg\u00e9neken k\u00edv\u00fcl szorosan \u00f6sszef\u00fcgg a genetikai t\u00e9nyez\u0151kkel, a region\u00e1lis \u00e9ghajlattal, a l\u00e9gszennyezetts\u00e9ggel, a neurol\u00f3giai \u00e9s pszichol\u00f3giai t\u00e9nyez\u0151kkel, valamint a t\u00e1rsadalmi-gazdas\u00e1gi t\u00e9nyez\u0151kkel. Az AR a hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban az \"orrdugul\u00e1s\" kateg\u00f3ri\u00e1j\u00e1ba tartozik. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u00fagy v\u00e9li, hogy ez a betegs\u00e9g a bels\u0151 \u00e9s k\u00fcls\u0151 t\u00e9nyez\u0151k egy\u00fcttes hat\u00e1s\u00e1nak eredm\u00e9nye. A bels\u0151 t\u00e9nyez\u0151k t\u00f6bbnyire szervhi\u00e1ny \u00e9s el\u00e9gtelen pozit\u00edv qi, m\u00edg a k\u00fcls\u0151 t\u00e9nyez\u0151k t\u00f6bbnyire sz\u00e9l, hideg vagy idegen qi inv\u00e1zi\u00f3, a rossz \u00e9s pozit\u00edv qi \u00f6ssze\u00fctk\u00f6z\u00e9se, valamint a t\u00fcd\u0151 qi felszabad\u00edt\u00e1s\u00e1nak k\u00e9ptelens\u00e9ge, ami orrdugul\u00e1shoz vezet. A klinikai gyakorlatban az AR kezel\u00e9s\u00e9re els\u0151sorban antihisztaminokat \u00e9s orrcortikoszteroidokat haszn\u00e1lnak, de a hossz\u00fa t\u00e1v\u00fa haszn\u00e1lat gyenge hat\u00e9konys\u00e1g\u00fa \u00e9s hajlamos a ki\u00fajul\u00e1sra. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s az AR-t sz\u00e1jon \u00e1t t\u00f6rt\u00e9n\u0151 adagol\u00e1ssal, k\u00ednai gy\u00f3gyn\u00f6v\u00e9nykivonatok orrmos\u00e1s\u00e1val vagy akupunkt\u00far\u00e1s alkalmaz\u00e1s\u00e1val, k\u00ednai gy\u00f3gyn\u00f6v\u00e9nyes f\u00fcst\u00f6l\u00e9ssel, porlaszt\u00e1ssal \u00e9s m\u00e1s m\u00f3dszerekkel kezeli. Ez a cikk adatb\u00e1ny\u00e1szati m\u00f3dszereket haszn\u00e1l a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s gy\u00f3gyszermint\u00e1inak elemz\u00e9s\u00e9re az AR kezel\u00e9s\u00e9ben, \u00e9s h\u00e1l\u00f3zati farmakol\u00f3giai \u00e9s in vivo farmakol\u00f3giai ellen\u0151rz\u00e9si m\u00f3dszereket haszn\u00e1l a nagyfrekvenci\u00e1s hagyom\u00e1nyos k\u00ednai orvosl\u00e1s lehets\u00e9ges hat\u00e1smechanizmus\u00e1nak el\u0151rejelz\u00e9s\u00e9re \u00e9s ellen\u0151rz\u00e9s\u00e9re az AR kezel\u00e9s\u00e9ben, racion\u00e1lis hivatkoz\u00e1si \u00e9s tudom\u00e1nyos elm\u00e9leti alapot biztos\u00edtva az AR klinikai kezel\u00e9s\u00e9hez.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Az AR kezel\u00e9s\u00e9re haszn\u00e1lt hagyom\u00e1nyos k\u00ednai orvosl\u00e1s gyakoris\u00e1gi elemz\u00e9s\u00e9ben az els\u0151 \u00f6t leggyakrabban haszn\u00e1lt gy\u00f3gyn\u00f6v\u00e9ny a Xinyi, a Huangqi, a Fangfeng, az \u00e9desgy\u00f6k\u00e9r \u00e9s a Cang'er Zi. A Xinyi, mint a leggyakrabban haszn\u00e1lt hagyom\u00e1nyos k\u00ednai gy\u00f3gyn\u00f6v\u00e9ny, meleg term\u00e9szet\u0171, k\u00e9pes el\u0171zni a szelet \u00e9s a hideget, \u00e9s el\u0151seg\u00edti az orrny\u00edl\u00e1st. F\u0151 \u00f6sszetev\u0151i az ill\u00f3olajok, lign\u00e1nok \u00e9s alkaloidok, amelyeknek sz\u00e1mos farmakol\u00f3giai hat\u00e1sa van, mint p\u00e9ld\u00e1ul a ny\u00e1lkah\u00e1rtya v\u00e9delme, a helyi v\u00e9rkering\u00e9s jav\u00edt\u00e1sa, gyullad\u00e1scs\u00f6kkent\u0151, antibakteri\u00e1lis, antiallergi\u00e1s, antioxid\u00e1ns \u00e9s a simaizmok ellaz\u00edt\u00e1sa. A Xinyi-t gyakran haszn\u00e1lj\u00e1k kir\u00e1lyi gy\u00f3gyszerk\u00e9nt a k\u00fcl\u00f6nb\u00f6z\u0151 n\u00e1tha \u00e9s orrbetegs\u00e9gek kezel\u00e9s\u00e9ben, mint p\u00e9ld\u00e1ul a Xinyi n\u00e1tha tablett\u00e1k, Biyan Kang tablett\u00e1k, Biyuan tablett\u00e1k, Tongqiao n\u00e1tha granul\u00e1tum, Xinfang n\u00e1tha kapszula, Xinyi por, Xinyi tablett\u00e1k, Xinyi ken\u0151cs, Sinus inf\u00fazi\u00f3s folyad\u00e9k, stb. Li Shizhen is feljegyezte a Compendium of Materia Medica-ban, hogy \"a Xinyi k\u00e9pes felmeleg\u00edteni a k\u00f6z\u00e9ps\u0151t \u00e9s kezelni a fej, az arc, az orr \u00e9s a kilenc testny\u00edl\u00e1s betegs\u00e9geit\".
\nA kutat\u00e1s sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy a 252 hagyom\u00e1nyos k\u00ednai orvosl\u00e1s receptjei k\u00f6z\u00f6tt a gy\u00f3gyszeroszt\u00e1lyoz\u00e1s els\u0151sorban a felsz\u00edni tiszt\u00edt\u00f3 gy\u00f3gyszerek (mint p\u00e9ld\u00e1ul a Xinyi, Fangfeng, Xixin, Baizhi, Guizhi stb.) \u00e9s a hi\u00e1nyt toniz\u00e1l\u00f3 gy\u00f3gyszerek (mint p\u00e9ld\u00e1ul a Huangqi, az \u00e9desgy\u00f6k\u00e9r, az Atractylodes macrocephala stb.) alapj\u00e1n t\u00f6rt\u00e9nik. A gy\u00f3gyhat\u00e1s\u00fa tulajdons\u00e1gok t\u00f6bbnyire a meleg\u00edt\u00e9sre \u00f6sszpontos\u00edtanak, a gy\u00f3gyhat\u00e1s\u00fa \u00edzek pedig f\u0151k\u00e9nt f\u0171szeresek \u00e9s \u00e9desek. A meleg gy\u00f3gyn\u00f6v\u00e9nyek a k\u00f6z\u00e9ps\u0151t felmeleg\u00edt\u0151 \u00e9s a hideget el\u0171z\u0151, a t\u00fczet toniz\u00e1l\u00f3 \u00e9s a jangot seg\u00edt\u0151 hat\u00e1s\u00faak. A f\u0171szeres gy\u00f3gyn\u00f6v\u00e9nyek el\u0171zik a szelet \u00e9s a hideget, el\u0151seg\u00edtik a qi \u00e9s a v\u00e9r kering\u00e9s\u00e9t. Az \u00e9des gy\u00f3gyn\u00f6v\u00e9nyek gy\u00f3gyhat\u00e1sa harmoniz\u00e1l\u00f3, a k\u00f6z\u00e9ps\u0151t t\u00e1pl\u00e1l\u00f3, valamint a t\u00fcd\u0151, a l\u00e9p \u00e9s a m\u00e1j meridi\u00e1njait szab\u00e1lyoz\u00f3 hat\u00e1s\u00faak. \u00c1tfog\u00f3 elemz\u00e9s alapj\u00e1n az AR kezel\u00e9s\u00e9re haszn\u00e1lt egyetlen hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat t\u00f6bbnyire a Xinyi, Fangfeng, Cang'er Zi, Xixin, Baizhi, Guizhi stb., amelyeket f\u0151k\u00e9nt a sz\u00e9l \u00e9s a hideg megnyilv\u00e1nul\u00e1saira haszn\u00e1lnak, mint a hidegr\u00e1z\u00e1s, l\u00e1z, fejf\u00e1j\u00e1s, izzad\u00e1s, v\u00e9gtagf\u00e1jdalom, orrfoly\u00e1s, orrdugul\u00e1s, v\u00e9kony \u00e9s feh\u00e9r sz\u0151rzet, torokviszket\u00e9s \u00e9s k\u00f6h\u00f6g\u00e9s, valamint lebeg\u0151 pulzus.
\nAz asszoci\u00e1ci\u00f3s szab\u00e1lyok elemz\u00e9se sor\u00e1n, a magas t\u00e1mogatotts\u00e1g\u00fa alapvet\u0151 gy\u00f3gyszerkombin\u00e1ci\u00f3k a k\u00f6vetkez\u0151k: Huangqi Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylo. A Schisandra chinensis, a Cicada molt \u00e9s a borsmenta kiv\u00e9tel\u00e9vel a t\u00f6bbi nagyfrekvenci\u00e1s gy\u00f3gyszer \u00e1ltal\u00e1nosan haszn\u00e1lt d\u00f3zisai a K\u00ednai Gy\u00f3gyszerk\u00f6nyvben meghat\u00e1rozott adagol\u00e1si tartom\u00e1nyon bel\u00fcl vannak.
\nA klaszterelemz\u00e9sben a hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerek egy csoportja els\u0151sorban a hi\u00e1nyoss\u00e1g toniz\u00e1l\u00e1s\u00e1ra \u00e9s a k\u00fcls\u0151 t\u00fcnetek enyh\u00edt\u00e9s\u00e9re \u00f6sszpontos\u00edt. K\u00f6z\u00fcl\u00fck az Astragalus membranaceus f\u0151 hat\u00f3anyaga, az Astragalus poliszacharidok olyan t\u00fcneteket k\u00e9pesek enyh\u00edteni, mint a t\u00fcssz\u00f6g\u00e9s, az orrvakar\u00e1s \u00e9s az orrfoly\u00e1s AR patk\u00e1nyokn\u00e1l. Cs\u00f6kkentheti az AR patk\u00e1nyok orrny\u00e1lkah\u00e1rtya-sz\u00f6vet\u00e9nek gyullad\u00e1s\u00e1t a T-bet \u00e9s az IFN - \u03b3 mRNS expresszi\u00f3j\u00e1nak felszab\u00e1lyoz\u00e1s\u00e1val, a GATA-3 \u00e9s az IL-4 mRNS expresszi\u00f3j\u00e1nak leszab\u00e1lyoz\u00e1s\u00e1val, \u00e9s el\u0151seg\u00edtheti az AR gy\u00f3gyul\u00e1s\u00e1t a gyullad\u00e1sos faktorok, p\u00e9ld\u00e1ul a sz\u00e9rum IL-4, IL-6, IL1 \u03b2, IgE, TNF - \u03b1, stb. szintj\u00e9nek cs\u00f6kkent\u00e9s\u00e9vel. A sz\u00e9l\u00e1ll\u00f3 hat\u00e1sai eloszlatj\u00e1k a szelet, enyh\u00edtik a fel\u00fcleti nedvess\u00e9get \u00e9s enyh\u00edtik a viszket\u00e9st. A Windproof poliszacharidok in vitro k\u00eds\u00e9rletekkel bizony\u00edtott\u00e1k, hogy j\u00f3 antiallergi\u00e1s hat\u00e1ssal rendelkeznek. A Windproof alkoholos kivonatok a PAR-2 in vitro sejtek PAR-2 expresszi\u00f3j\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel in vitro sejtekben antiallergi\u00e1s hat\u00e1st fejthetnek ki. A Guizhi izzaszt\u00f3 \u00e9s izomlaz\u00edt\u00f3, meleg\u00edt\u0151 \u00e9s el\u0151seg\u00edt\u0151 hat\u00e1s\u00fa a meridi\u00e1nokn\u00e1l, seg\u00edti a yang qi \u00e1talakul\u00e1s\u00e1t, \u00e9s eloszlatja a k\u00fcls\u0151 sz\u00e9l k\u00f3rokoz\u00f3kat. A Ju Er Cang Er Zi a sz\u00e9l \u00e9s a hideg eloszlat\u00e1s\u00e1ra, az orrny\u00edl\u00e1s el\u0151seg\u00edt\u00e9s\u00e9re, valamint a sz\u00e9l \u00e9s a nedvess\u00e9g eloszlat\u00e1s\u00e1ra hat. Sz\u00e9l \u00e9s hideg fejf\u00e1j\u00e1s, orrdugul\u00e1s \u00e9s orrfoly\u00e1s, orrdugul\u00e1s, orrmell\u00e9k\u00fcregek, reuma \u00e9s viszket\u00e9s, valamint nedvess\u00e9g pang\u00e1s \u00e9s g\u00f6rcs\u00f6k kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k; A Fructus Xanthii n-butanol kivonata AR tengerimalacokban enyh\u00edti az orrny\u00e1lkah\u00e1rtya gyullad\u00e1st, cs\u00f6kkenti a feh\u00e9rv\u00e9rsejtek sz\u00e1m\u00e1t, az eozinofilok ar\u00e1ny\u00e1t \u00e9s a sz\u00e9rum SIgE szintj\u00e9t; Az Atractylodes macrocephala vizes kivonata enyh\u00edtheti az olyan t\u00fcneteket, mint az orrny\u00e1lkah\u00e1rtya lev\u00e1l\u00e1sa, a sz\u00f6veti \u00f6d\u00e9ma \u00e9s a gyullad\u00e1sos sejtek besziv\u00e1rg\u00e1sa AR tengerimalacokban, \u00e9s cs\u00f6kkentheti a gyullad\u00e1sos citokinek IgE, IL-4 \u00e9s IFN - \u03b3 expresszi\u00f3s szintj\u00e9t a sz\u00e9rumban.
\nEz a cikk a TCMSP adatb\u00e1zis\u00e1ban keresett \u00e9s kieg\u00e9sz\u00edtette a szakirodalmat, \u00e9s \u00f6sszesen 48 hat\u00f3anyagot tal\u00e1lt a Huangqi Xinyi gy\u00f3gyszerp\u00e1rban, amelyek 306 c\u00e9lpontnak felelnek meg. Minden egyes hat\u00f3anyagot t\u00f6bb c\u00e9lpontra is alkalmaznak. A c\u00e9lpontok \u00e9s \u00f6sszetev\u0151k k\u00f6z\u00f6tti kapcsolat tov\u00e1bbi illusztr\u00e1l\u00e1sa \u00e9rdek\u00e9ben egy \"\u00f6sszetev\u0151-c\u00e9lbetegs\u00e9g\" h\u00e1l\u00f3zatot \u00e9p\u00edtett\u00fcnk ki az \u00f6sszetev\u0151-c\u00e9lpontok \u00e9s a betegs\u00e9g-c\u00e9lpontok metsz\u00e9spontj\u00e1nak figyelembev\u00e9tel\u00e9vel. A f\u0151 \u00f6sszetev\u0151k, a kaempferol \u00e9s a kvercetin, a legmagasabb korrel\u00e1ci\u00f3t mutatt\u00e1k a c\u00e9lpontokkal, \u00e9s a Huangqi Xinyi kulcsfontoss\u00e1g\u00fa \u00f6sszetev\u0151i lehetnek az AR kezel\u00e9s\u00e9ben, fontos farmakol\u00f3giai szerepet j\u00e1tszva. Vizsg\u00e1latok kimutatt\u00e1k, hogy a kaempferol a b\u00e9lg\u00e1t integrit\u00e1s\u00e1nak jav\u00edt\u00e1s\u00e1val cs\u00f6kkentheti a b\u00e9lgyullad\u00e1s el\u0151fordul\u00e1s\u00e1t, \u00e9s jelent\u0151s antihiperglik\u00e9mi\u00e1s \u00e9s antioxid\u00e1ns hat\u00e1ssal rendelkezik; a kvercetin a galektin-3 \u00e9s az NLRP3 k\u00f6t\u0151d\u00e9s\u00e9nek g\u00e1tl\u00e1s\u00e1val jelent\u0151sen cs\u00f6kkentheti az ateroszklerotikus gyullad\u00e1st. A KEGG \u00fatvonal tov\u00e1bbi elemz\u00e9se felt\u00e1rta, hogy a neuroakt\u00edv ligand receptor k\u00f6lcs\u00f6nhat\u00e1si \u00fatvonal, a kalciumion jel\u00e1tviteli \u00fatvonal, a szteroid hormon bioszint\u00e9zis \u00fatvonal \u00e9s a r\u00e1kos \u00fatvonal a f\u0151 \u00fatvonalak, amelyeken kereszt\u00fcl a Huangqi Xinyi kifejti AR-ellenes hat\u00e1s\u00e1t, 34 hat\u00f3anyagot \u00e9s 39 f\u0151 c\u00e9lpontot \u00e9rintve. Az \"\u00f6sszetev\u0151 c\u00e9l\u00fatvonal betegs\u00e9g\" kapcsolat\u00e1nak elemz\u00e9s\u00e9vel meg\u00e1llap\u00edtottuk, hogy a PTGS2, HSP90, NOS2, CALM1, CHRM1, CYP1B1 \u00e9s m\u00e1s c\u00e9lfeh\u00e9rj\u00e9k fontos szerepet j\u00e1tszanak az \u00fatvonalban. A PTGS2 r\u00e9szt vesz az olyan patol\u00f3giai reakci\u00f3kban, mint a gyullad\u00e1s vagy a daganatok, \u00e9s a nem szteroid gyullad\u00e1scs\u00f6kkent\u0151k c\u00e9lpontja. A pro-inflammatorikus citokinek \u00e9s n\u00f6veked\u00e9si faktorok nagym\u00e9rt\u00e9kben induk\u00e1lhatj\u00e1k a gyullad\u00e1sos faktorok szekr\u00e9ci\u00f3j\u00e1ra, gyullad\u00e1sos v\u00e1laszt kiv\u00e1ltva. A HSP90 egy ATP-f\u00fcgg\u0151 molekul\u00e1ris chaperon, amely seg\u00edtheti az \u00fcgyf\u00e9lfeh\u00e9rj\u00e9ket a helyes t\u00e9rbeli hajtogat\u00e1s befejez\u00e9s\u00e9ben \u00e9s r\u00e9szt vesz a sejtciklus szab\u00e1lyoz\u00e1s\u00e1ban. Tanulm\u00e1nyok kimutatt\u00e1k, hogy a HSP90 szab\u00e1lyozhatja a limfocit\u00e1k aktiv\u00e1l\u00f3d\u00e1s\u00e1t, el\u0151seg\u00edtheti a limfocit\u00e1k migr\u00e1ci\u00f3j\u00e1t a fert\u0151z\u00e9s hely\u00e9re, \u00e9s megk\u00f6nny\u00edtheti a helyi gyullad\u00e1sos v\u00e1laszokat a szervezetben fiziol\u00f3gi\u00e1s stressz eset\u00e9n. A NOS2 egy induk\u00e1lhat\u00f3 nitrog\u00e9n-oxid-szint\u00e1z, amely a szervezetben s\u00e9r\u00fcl\u00e9sek ut\u00e1n expressz\u00e1l\u00f3dik, \u00e9s amely a nitrog\u00e9n-oxid oxidat\u00edv stressz\u00e9t felhaszn\u00e1lva r\u00e9szt vehet az immunszab\u00e1lyoz\u00e1sban \u00e9s a szervezet gyullad\u00e1sos v\u00e1lasz\u00e1ban. A CALM1 egy kalmodulin feh\u00e9rje, \u00e9s a CALM1 t\u00falterjed\u00e9se abnorm\u00e1lisan aktiv\u00e1lhatja a sejtek kalciumion jel\u00e1tviteli csatorn\u00e1it, ami v\u00e9g\u00fcl gyullad\u00e1sos reakci\u00f3khoz \u00e9s bizonyos fok\u00fa m\u00e1jk\u00e1rosod\u00e1shoz vezet a szervezetben. A CHRM1 egy paraszimpatikus receptor, \u00e9s vizsg\u00e1latok kimutatt\u00e1k, hogy a CHRM1 agonist\u00e1k a sejtek kalciumion-aktivit\u00e1s\u00e1nak fokoz\u00e1s\u00e1val szab\u00e1lyozhatj\u00e1k a neuron\u00e1lis differenci\u00e1l\u00f3d\u00e1st. A molekul\u00e1ris dokkol\u00e1si valid\u00e1ci\u00f3 sor\u00e1n alacsony k\u00f6t\u00e9si energi\u00e1val rendelkeznek a kaempferolhoz, \u00e9s a kalciumion-csatorn\u00e1k aktiv\u00e1l\u00e1s\u00e1nak szab\u00e1lyoz\u00e1s\u00e1val kiv\u00e1lthatj\u00e1k a gyullad\u00e1sos citokinek felszabadul\u00e1s\u00e1t. A CYP1B1 a szteroidhormon-szint\u00e9zis \u00fatvonal\u00e1ban r\u00e9szt vev\u0151 egyik f\u0151 feh\u00e9rje. A szteroidok jelent\u0151s gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s antiallergi\u00e1s immunszab\u00e1lyoz\u00f3 hat\u00e1ssal rendelkeznek, \u00e9s a molekul\u00e1ris dokkol\u00e1s valid\u00e1l\u00e1sa sor\u00e1n j\u00f3 \u00e9s stabil k\u00f6t\u0151d\u00e9si k\u00e9pess\u00e9get mutattak a kvercetinhez \u00e9s a kaempferolhoz. A fenti elemz\u00e9sb\u0151l l\u00e1that\u00f3, hogy a Huangqi Xinyi f\u0151 \u00f6sszetev\u0151i a neuroakt\u00edv ligand receptor k\u00f6lcs\u00f6nhat\u00e1si \u00fatvonalra, a kalciumion jel\u00e1tviteli \u00fatvonalra, a szteroid hormon bioszint\u00e9zis \u00fatvonalra \u00e9s a r\u00e1kos \u00fatvonalra hathatnak olyan c\u00e9lpontokon kereszt\u00fcl, mint a PTGS2, HSP90, NOS2, CALM1, CHRM1, CYP1B1, hogy ter\u00e1pi\u00e1s hat\u00e1st gyakoroljanak az AR-ra. A fenti el\u0151rejelz\u00e9si eredm\u00e9nyek megb\u00edzhat\u00f3s\u00e1g\u00e1nak tov\u00e1bbi ellen\u0151rz\u00e9se \u00e9rdek\u00e9ben egy parlagf\u0171pollen \u00e1ltal induk\u00e1lt AR eg\u00e9rmodellt hoztak l\u00e9tre in vivo k\u00eds\u00e9rleti ellen\u0151rz\u00e9s c\u00e9lj\u00e1b\u00f3l. A kutat\u00e1si eredm\u00e9nyek azt mutatt\u00e1k, hogy a Huangqi Xinyi gy\u00f3gyszer cs\u00f6kkentheti a PTGS2, HSP90 \u00e9s NOS2 feh\u00e9rje expresszi\u00f3j\u00e1t AR egerekben, g\u00e1tolja a gyullad\u00e1sos faktorok hisztamin, IgE, TNF - \u03b1 \u00e9s IL-6 expresszi\u00f3s szintj\u00e9t AR eg\u00e9r sz\u00e9rumban, orrmos\u00f3 folyad\u00e9kban \u00e9s bronchoalveol\u00e1ris mos\u00f3folyad\u00e9kban, n\u00f6veli az IL-10 gyullad\u00e1scs\u00f6kkent\u0151 faktor expresszi\u00f3j\u00e1t, jelent\u0151sen enyh\u00edti az AR eg\u00e9r vakar\u00f3z\u00e1si \u00e9s t\u00fcssz\u00f6g\u00e9si t\u00fcneteit, \u00e9s felt\u00e1rja, hogy a Huangqi Xinyi gy\u00f3gyszer a HSP90\/PTGS2\/NOS2 \u00fatvonal g\u00e1tl\u00e1s\u00e1val g\u00e1tolhatja a gyullad\u00e1sos reakci\u00f3k el\u0151fordul\u00e1s\u00e1t \u00e9s kialakul\u00e1s\u00e1t, ez\u00e1ltal el\u00e9rve az AR-ben val\u00f3 beavatkoz\u00e1s hat\u00e1s\u00e1t.
\n\u00d6sszefoglalva, az AR klinikai kezel\u00e9s\u00e9re vonatkoz\u00f3 gy\u00f3gyszerel\u00e9si szab\u00e1lyokat az adatb\u00e1ny\u00e1szati statisztikai elemz\u00e9s \u00e9s a h\u00e1l\u00f3zati farmakol\u00f3giai technik\u00e1k seg\u00edts\u00e9g\u00e9vel \u00f6sszegezt\u00e9k, \u00e9s m\u00e9lyen tanulm\u00e1nyozt\u00e1k a Huangqi Xinyi nagyfrekvenci\u00e1s gy\u00f3gyszerkombin\u00e1ci\u00f3 molekul\u00e1ris mechanizmus\u00e1t az AR kezel\u00e9s\u00e9ben. A molekul\u00e1ris dokkol\u00e1si szimul\u00e1ci\u00f3 igazolta a Huangqi Xinyi t\u00f6bbkomponens\u0171, t\u00f6bb c\u00e9lpont\u00fa \u00e9s t\u00f6bb \u00fatvonalra vonatkoz\u00f3 jellemz\u0151it, \u00e9s az in vivo k\u00eds\u00e9rletek meger\u0151s\u00edtett\u00e9k, hogy a Huangqi Xinyi gy\u00f3gyszerek g\u00e1tolhatj\u00e1k a gyullad\u00e1sos reakci\u00f3k el\u0151fordul\u00e1s\u00e1t, enyh\u00edthetik az AR t\u00fcneteit egerekben, \u00e9s v\u00e9g\u00fcl el\u00e9rhetik az AR kezel\u00e9s\u00e9nek hat\u00e1s\u00e1t a HSP90\/PTGS2\/NOS2 \u00fatvonal g\u00e1tl\u00e1s\u00e1val. E tanulm\u00e1ny eredm\u00e9nyei tudom\u00e1nyos elm\u00e9leti alapot ny\u00fajthatnak a Xinyi Huangqi gy\u00f3gyszer \u00e9sszer\u0171 haszn\u00e1lat\u00e1hoz a klinikai gyakorlatban, \u00e9s tov\u00e1bb seg\u00edthetik a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s alkalmaz\u00e1s\u00e1t az allergi\u00e1s rhinitis kezel\u00e9s\u00e9ben.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the medication rules and related pharmacological analysis of traditional Chinese medicine in the treatment of allergic rhinitis based on data mining, network pharmacology, and experimental verification Allergic rhinitis (AR), also known as allergic rhinitis, is a chronic non infectious inflammation of the nasal mucosa caused by the release of inflammatory factors (histamine, leukotrienes, prostaglandins, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the medication rules and related pharmacological analysis of traditional Chinese medicine in the treatment of allergic rhinitis based on data mining, network pharmacology, and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/allergias-natha\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the medication rules and related pharmacological analysis of traditional Chinese medicine in the treatment of allergic rhinitis based on data mining, network pharmacology, and experimental verification - 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