{"id":4806,"date":"2024-08-04T15:51:27","date_gmt":"2024-08-04T15:51:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4806"},"modified":"2024-08-04T15:51:27","modified_gmt":"2024-08-04T15:51:27","slug":"wild-silkworm-bean-root","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/vad-selyemhernyobab-gyoker\/","title":{"rendered":"A vadon \u00e9l\u0151 selyemherny\u00f3 sz\u00f3jabab gy\u00f6ker\u00e9nek antioxid\u00e1ns aktivit\u00e1s\u00e1nak \u00e9s mechanizmus\u00e1nak felt\u00e1r\u00e1sa h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s in vitro k\u00eds\u00e9rletek alapj\u00e1n"},"content":{"rendered":"

A vadon \u00e9l\u0151 selyemherny\u00f3 sz\u00f3jabab gy\u00f6ker\u00e9nek antioxid\u00e1ns aktivit\u00e1s\u00e1nak \u00e9s mechanizmus\u00e1nak felt\u00e1r\u00e1sa h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s in vitro k\u00eds\u00e9rletek alapj\u00e1n
\nA vad selyembab gy\u00f6kere a Centrantheragrandiflora Benth, a Scrophulariaceae csal\u00e1dba tartoz\u00f3, f\u0151k\u00e9nt Yunnanban, Guizhouban, Guangxiban \u00e9s m\u00e1s helyeken elterjedt n\u00f6v\u00e9ny gy\u00f6kere. A vad selyemherny\u00f3bab gy\u00f6kere gy\u00f3gy- \u00e9s ehet\u0151 n\u00f6v\u00e9ny, amely k\u00fcl\u00f6nb\u00f6z\u0151 hat\u00f3anyagokban, p\u00e9ld\u00e1ul ciklohex\u00e9n\u00e9terterp\u00e9nekben, feniletanolos glikozidokban, iononokban, karotinoidokban, monoterp\u00e9nekben \u00e9s m\u00e1s vegy\u00fcletekben gazdag. Olyan \u00e9lettani tev\u00e9kenys\u00e9gekkel rendelkeznek, mint az antioxid\u00e1ns, gyullad\u00e1scs\u00f6kkent\u0151, v\u00e9ralvad\u00e1sg\u00e1tl\u00f3 \u00e9s a sz\u00edvizom iszk\u00e9mi\u00e1t, valamint a sebgy\u00f3gyul\u00e1s el\u0151seg\u00edt\u00e9se. Az \u0151si k\u00f6nyvek feljegyezt\u00e9k, hogy a bor k\u00e9sz\u00edt\u00e9s\u00e9hez olyan betegs\u00e9gek megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k, mint az agyi tromb\u00f3zis \u00e9s a stroke. Yunnanban Yi etnikai gy\u00f3gyn\u00f6v\u00e9nyk\u00e9nt \u00fcltetik, \u00e9s sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k az etnikai gy\u00f3gy\u00e1szatban. Jelenleg a kutat\u00e1s els\u0151sorban a vadon \u00e9l\u0151 selyembab gy\u00f6kereinek kivon\u00e1s\u00e1ra \u00e9s elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re, valamint az aktivit\u00e1si vizsg\u00e1latokra \u00f6sszpontos\u00edt. A vadon \u00e9l\u0151 selyemherny\u00f3bab gy\u00f6kerei gazdagok iridoid glikozidokban, amelyek antioxid\u00e1ns, lipidcs\u00f6kkent\u0151, m\u00e1jv\u00e9d\u0151 \u00e9s megel\u0151z\u0151 hat\u00e1ssal rendelkeznek a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s cerebrovaszkul\u00e1ris betegs\u00e9gek ellen, \u00e9s nagy fejleszt\u00e9si potenci\u00e1llal rendelkeznek.<\/p>\n

Az oxidat\u00edv stressz olyan stressz\u00e1llapotot jelent, amelyben a szervezetet t\u00falzott m\u00e9rt\u00e9k\u0171 reakt\u00edv oxig\u00e9nfajok (ROS) termel\u00e9s\u00e9re serkentik, ami az antioxid\u00e1nsok egyens\u00faly\u00e1nak felborul\u00e1s\u00e1hoz vezet, \u00e9s sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9geket, neurol\u00f3giai rendelleness\u00e9geket \u00e9s r\u00e1kot okoz. A feldolgozott \u00e9s szintetiz\u00e1lt antioxid\u00e1nsok eg\u00e9szs\u00e9gre gyakorolt potenci\u00e1lis k\u00e1ros hat\u00e1sa miatt az emberek egyre elk\u00f6telezettebben keresik a term\u00e9szetes antioxid\u00e1nsokat. A term\u00e9szetes antioxid\u00e1nsok jelent\u0151s ter\u00e1pi\u00e1s hat\u00e1suk, valamint alacsony toxicit\u00e1suk \u00e9s mell\u00e9khat\u00e1saik miatt egyre nagyobb figyelmet kapnak. A vadon \u00e9l\u0151 selyembabgy\u00f6k\u00e9r, mint term\u00e9szetes gy\u00f3gyszer, j\u00f3 antioxid\u00e1ns aktivit\u00e1ssal rendelkezik, de a konkr\u00e9t hat\u00f3anyagaival \u00e9s hat\u00e1smechanizmus\u00e1val kapcsolatban korl\u00e1tozottak a kutat\u00e1sok.<\/p>\n

A h\u00e1l\u00f3zati farmakol\u00f3gia egy \u00fajonnan kialakul\u00f3ban l\u00e9v\u0151 tudom\u00e1ny\u00e1g, amely felt\u00e1rja a gy\u00f3gyszerek szab\u00e1lyoz\u00f3 h\u00e1l\u00f3zat\u00e1t a szervezetben sziszt\u00e9m\u00e1s szinten. A gy\u00f3gyszerek, hat\u00f3anyagok, c\u00e9lpontok \u00e9s betegs\u00e9gek k\u00f6z\u00f6tti komplex h\u00e1l\u00f3zati kapcsolat megkonstru\u00e1l\u00e1s\u00e1val a gy\u00f3gyszerek hat\u00e1smechanizmusa megj\u00f3solhat\u00f3, k\u00fcl\u00f6n\u00f6sen a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat fejleszt\u00e9s\u00e9ben a t\u00f6bb c\u00e9lpontot \u00e9rint\u0151 gy\u00f3gyszerek hat\u00e1smechanizmus\u00e1nak el\u0151rejelz\u00e9s\u00e9re. Ez a cikk a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t haszn\u00e1lja a vadon \u00e9l\u0151 selyemk\u00f3r\u00f3 sz\u00f3jabab gy\u00f6ker\u00e9nek f\u0151 hat\u00f3anyagainak \u00e9s c\u00e9lkomponenseinek elemz\u00e9s\u00e9re, \u00e9s m\u00e9lyen felt\u00e1rja antioxid\u00e1ns hat\u00e1s\u00e1nak molekul\u00e1ris mechanizmus\u00e1t. Ezt in vitro antioxid\u00e1ns k\u00eds\u00e9rletekkel \u00e9s biol\u00f3giai m\u00f3dszerekkel igazolja, elm\u00e9leti alapot ny\u00fajtva a vadon \u00e9l\u0151 selyemherny\u00f3 sz\u00f3jabab gy\u00f6ker\u00e9nek tov\u00e1bbi k\u00eds\u00e9rleti alapkutat\u00e1saihoz.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Vad selyemherny\u00f3bab gy\u00f6k\u00e9r\"\"\"\"
\nA vad selyembab gy\u00f6kere K\u00edn\u00e1ban hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer, amely k\u00fcl\u00f6nb\u00f6z\u0151 hat\u00f3anyagokat, p\u00e9ld\u00e1ul ciklohex\u00e9n\u00e9terterp\u00e9neket, feniletanolokat, karotinoidokat stb. tartalmaz. K\u00fcl\u00f6nb\u00f6z\u0151 farmakol\u00f3giai aktivit\u00e1sokkal rendelkezik, mint p\u00e9ld\u00e1ul antioxid\u00e1ns, hipoglik\u00e9mi\u00e1s, v\u00e9ralvad\u00e1sg\u00e1tl\u00f3 \u00e9s sz\u00edvizom iszk\u00e9mi\u00e1s. Jelenleg a vadon \u00e9l\u0151 selyemherny\u00f3bab gy\u00f6kereinek antioxid\u00e1ns hat\u00e1s\u00e1val kapcsolatos kutat\u00e1sok fokozatosan elm\u00e9ly\u00fclnek, de a specifikus hat\u00f3anyagokat \u00e9s mechanizmusokat m\u00e9g nem fedezt\u00e9k fel. A vad selyemherny\u00f3 sz\u00f3jabab gy\u00f6ker\u00e9nek antioxid\u00e1ns stressz mechanizmus\u00e1nak tov\u00e1bbi felt\u00e1r\u00e1sa \u00e9rdek\u00e9ben ez a tanulm\u00e1ny in vitro antioxid\u00e1ns k\u00eds\u00e9rleteket, h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t, molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1t \u00e9s Western blot kimutat\u00e1s\u00e1t v\u00e9gezte a tov\u00e1bbi vizsg\u00e1lathoz.
\nAz in vitro antioxid\u00e1ns k\u00eds\u00e9rletek sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy a vadon \u00e9l\u0151 selyemherny\u00f3bab gy\u00f6k\u00e9rkivonat k\u00e9pes a DPPH szabad gy\u00f6k\u00f6k, az ABTS szabad gy\u00f6k\u00f6k \u00e9s a hidroxil szabad gy\u00f6k\u00f6k elt\u00e1vol\u00edt\u00e1s\u00e1ra, \u00e9s egy bizonyos koncentr\u00e1ci\u00f3tartom\u00e1nyon bel\u00fcl a vadon \u00e9l\u0151 selyemherny\u00f3bab gy\u00f6k\u00e9rkivonat h\u00e1rom szabad gy\u00f6kfog\u00f3 ar\u00e1nya bizonyos line\u00e1ris \u00f6sszef\u00fcgg\u00e9st mutat. 320 \u03bc g\/ml koncentr\u00e1ci\u00f3ban a h\u00e1rom szabadgy\u00f6k elt\u00e1vol\u00edt\u00e1si ar\u00e1nya 3,86%, 83,89% \u00e9s 59,15% volt. Az IC50 \u00e9rt\u00e9kek 0,166 mg\/ml, 0,054 mg\/ml, illetve 0,180 mg\/ml voltak, ami j\u00f3 antioxid\u00e1ns kapacit\u00e1st jelez.
\nAz irodalmi \u00e1ttekint\u00e9s \u00e9s a vonatkoz\u00f3 adatb\u00e1zisok \u00e1tvizsg\u00e1l\u00e1sa r\u00e9v\u00e9n 22 hat\u00f3anyagot nyertek a vadon \u00e9l\u0151 selyemherny\u00f3 sz\u00f3jabab gy\u00f6ker\u00e9b\u0151l, k\u00f6zt\u00fck aucubint, rodopszint, \u03b2-szitoszterint, genipozid-metil\u00e9sztert, katalpolt stb. K\u00f6z\u00fcl\u00fck az \u0151szibaracklev\u00e9lben l\u00e9v\u0151 aucubin a legmagasabb a vad selyemk\u00f3r\u00f3 gy\u00f6kerekben, \u00e9s sz\u00e9les k\u00f6r\u0171 aktivit\u00e1ssal rendelkezik, p\u00e9ld\u00e1ul antioxid\u00e1ns, antibakteri\u00e1lis \u00e9s r\u00e1kellenes hat\u00e1s\u00fa. Az Nrf2 az antioxid\u00e1ns stressz egyik k\u00f6zponti transzkripci\u00f3s faktor, amely szab\u00e1lyozza a downstream antioxid\u00e1ns faktorok aktiv\u00e1l\u00f3d\u00e1s\u00e1t \u00e9s expresszi\u00f3j\u00e1t, valamint fenntartja a sejtek homeoszt\u00e1zis\u00e1t. Vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy az aucubin az Nrf2 \u00e1ltal k\u00f6zvet\u00edtett antioxid\u00e1ns \u00fatvonalakon kereszt\u00fcl g\u00e1tolhatja az eg\u00e9r-osteoklasztok differenci\u00e1l\u00f3d\u00e1s\u00e1t, ez\u00e1ltal lass\u00edtja a csontritkul\u00e1s kialakul\u00e1s\u00e1t. A rododendron v\u00f6r\u00f6s pigment egy term\u00e9szetes karotinoid \u00e9s a vadon \u00e9l\u0151 selyemk\u00f3r\u00f3 gy\u00f6ker\u00e9nek fontos hat\u00f3anyaga. A kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a vadon \u00e9l\u0151 selyembab gy\u00f6kereiben l\u00e9v\u0151 rodopszin v\u00e9d\u0151hat\u00e1st fejthet ki a sejtek oxidat\u00edv stressz okozta k\u00e1rosod\u00e1s\u00e1val szemben a szuperoxid-dizmut\u00e1z (SOD) aktivit\u00e1s\u00e1nak n\u00f6vel\u00e9s\u00e9vel. Ek\u00f6zben az Nrf2 ARE \u00fatvonal serkent\u00e9s\u00e9vel a sz\u00edvizomk\u00e1rosod\u00e1ssal szemben is v\u00e9d\u0151hat\u00e1st fejthet ki. A zichun egyfajta iridoid glikozid vegy\u00fclet is, amely sz\u00e1mos farmakol\u00f3giai tev\u00e9kenys\u00e9ggel, p\u00e9ld\u00e1ul gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s antioxid\u00e1ns tulajdons\u00e1gokkal rendelkezik. A kutat\u00e1sok azt tal\u00e1lt\u00e1k, hogy a Zichun k\u00e9pes az Nrf2 \u00e9s a HO-1 expresszi\u00f3j\u00e1nak felszab\u00e1lyoz\u00e1s\u00e1ra, a SOD aktivit\u00e1s n\u00f6vel\u00e9s\u00e9re, az MDA aktivit\u00e1s cs\u00f6kkent\u00e9s\u00e9re, az agysejtek apopt\u00f3zis\u00e1nak cs\u00f6kkent\u00e9s\u00e9re, a Bcl-2 feh\u00e9rje expresszi\u00f3j\u00e1nak el\u0151seg\u00edt\u00e9s\u00e9re, a Bax feh\u00e9rje expresszi\u00f3j\u00e1nak g\u00e1tl\u00e1s\u00e1ra \u00e9s az oxidat\u00edv stressz okozta k\u00e1rok enyh\u00edt\u00e9s\u00e9re.
\nA feh\u00e9rje k\u00f6lcs\u00f6nhat\u00e1si h\u00e1l\u00f3zatelemz\u00e9s sor\u00e1n 82 c\u00e9lpontot azonos\u00edtottak a vadon \u00e9l\u0151 selyemherny\u00f3 sz\u00f3jabab gy\u00f6ker\u00e9b\u0151l sz\u00e1rmaz\u00f3 hat\u00f3anyagok antioxid\u00e1ns stresszre hat\u00f3 c\u00e9lpontjait. Ez f\u0151k\u00e9nt 23 alapvet\u0151 c\u00e9lpontot tartalmaz, mint p\u00e9ld\u00e1ul a STAT3, HSP90AA1, HDAC1, PPARG, HSPAB1 stb. A h\u0151sokkfeh\u00e9rj\u00e9k (HSP-k) molekul\u00e1ris gardonfeh\u00e9rj\u00e9k, amelyek k\u00e9pesek megv\u00e1ltoztatni m\u00e1s feh\u00e9rj\u00e9k szerkezet\u00e9t \u00e9s k\u00f6lcs\u00f6nhat\u00e1sait, \u00e9s amelyeket h\u0151sokk \u00e9s m\u00e1s k\u00e9miai \u00e9s fizikai stresszek induk\u00e1lnak. A HSP90AA1 \u00e9s a HSP90AB1 a HSP90 HSP-k csal\u00e1dj\u00e1ba tartozik. Amikor oxidat\u00edv stressz l\u00e9p fel, az aktiv\u00e1lja az intracellul\u00e1ris h\u0151sokkfeh\u00e9rj\u00e9k expresszi\u00f3j\u00e1t. A kutat\u00e1sok szerint a HSP90 a Keap1 (INrf2) - Nrf2 jel\u00e1tviteli \u00fatvonal modul\u00e1l\u00e1s\u00e1val szab\u00e1lyozhatja az oxidat\u00edv k\u00e1rosod\u00e1st a szervezetben. Oxidat\u00edv stressz hat\u00e1s\u00e1ra a HSP90 reag\u00e1l a Keap1-gyel, el\u0151seg\u00edtve a Keap1 Nrf2 komplex disszoci\u00e1ci\u00f3j\u00e1t \u00e9s az Nrf2 felszabadul\u00e1s\u00e1t. V\u00e9di a sejteket az oxidat\u00edv stresszel szemben az Nrf2 \u00e9s a downstream feh\u00e9rj\u00e9k transzkripci\u00f3s aktiv\u00e1l\u00e1s\u00e1n kereszt\u00fcl. A STAT3 fontos k\u00f6zvet\u00edt\u0151je a sejtek oxidat\u00edv stressz ut\u00e1ni t\u00fal\u00e9l\u00e9s\u00e9nek, er\u0151s proliferat\u00edv \u00e9s apoptotikus rezisztenciahat\u00e1ssal. Kutat\u00e1sok kimutatt\u00e1k, hogy a STATA3 a Bcl XL antiapoptotikus feh\u00e9rje Bcl XL expresszi\u00f3j\u00e1nak felszab\u00e1lyoz\u00e1s\u00e1val \u00e9s a kaszp\u00e1zok inaktiv\u00e1l\u00e1s\u00e1nak el\u0151seg\u00edt\u00e9s\u00e9vel fejtheti ki sejtv\u00e9d\u0151 hat\u00e1s\u00e1t. A HDAC1 egy olyan enzimt\u00edpus, amely kataliz\u00e1lja a hisztonok \u00e9s nem hisztonok deacetil\u00e1ci\u00f3j\u00e1t, \u00e9s a hisztonok \u00e9s transzkripci\u00f3s faktorok deacetil\u00e1ci\u00f3j\u00e1n kereszt\u00fcl cs\u00f6kkentheti az antioxid\u00e1ns enzimek expresszi\u00f3j\u00e1t. Ek\u00f6zben a vizsg\u00e1latok azt tal\u00e1lt\u00e1k, hogy a HDAC1 expresszi\u00f3j\u00e1nak g\u00e1tl\u00e1sa megakad\u00e1lyozhatja a k\u00e9miai hipoxia \u00e1ltal kiv\u00e1ltott oxidat\u00edv stressz egyens\u00falyhi\u00e1nyt a H9c2 sejtekben a sejtek \u00e9letk\u00e9pess\u00e9g\u00e9nek jav\u00edt\u00e1s\u00e1val \u00e9s a SOD-aktivit\u00e1s n\u00f6vel\u00e9s\u00e9vel.
\nA KEGG d\u00fas\u00edt\u00e1si elemz\u00e9s kimutatta, hogy a vadon \u00e9l\u0151 selyemherny\u00f3 sz\u00f3jabab gy\u00f6kereinek antioxid\u00e1ns kapacit\u00e1sa els\u0151sorban a PI3K\/Akt jel\u00e1tviteli \u00fatvonalhoz, a nukleotid anyagcsere \u00fatvonalhoz, az \u00f6sztrog\u00e9n jel\u00e1tviteli \u00fatvonalhoz stb. kapcsol\u00f3dik. A PI3K\/Akt jel\u00e1tviteli \u00fatvonal fontos szerepet j\u00e1tszik az antioxid\u00e1ns stresszben, \u00e9s sz\u00e9les k\u00f6rben jelen van az eml\u0151s sejtekben, j\u00f3 neuroprotekt\u00edv tulajdons\u00e1gokkal. A PI3K\/Akt jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1sa el\u0151seg\u00edti az Akt kaszk\u00e1d foszforil\u00e1ci\u00f3j\u00e1t \u00e9s megakad\u00e1lyozza az oxidat\u00edv k\u00e1rosod\u00e1st. Kutat\u00e1sok kimutatt\u00e1k, hogy a PI3K\/Akt jel\u00e1tviteli \u00fatvonal szab\u00e1lyoz\u00e1sa jav\u00edthatja az apopt\u00f3zist \u00e9s az oxidat\u00edv stresszt a chondrocit\u00e1kban \u00e9s a H9c2 kardiomiocit\u00e1kban.
\nA molekul\u00e1ris dokkol\u00e1si eredm\u00e9nyek azt mutatt\u00e1k, hogy a vadon \u00e9l\u0151 selyemherny\u00f3bab gy\u00f6ker\u00e9nek hat\u00f3anyagai \u00e9s az alapvet\u0151 c\u00e9lpont k\u00f6z\u00f6tt j\u00f3 k\u00f6t\u0151d\u00e9si hat\u00e1s volt, er\u0151s k\u00f6lcs\u00f6n\u00f6s k\u00f6t\u0151d\u00e9si k\u00e9pess\u00e9ggel \u00e9s szoros k\u00f6lcs\u00f6nhat\u00e1ssal.
\nA PI3K a citoplazmatikus lipidkin\u00e1zok k\u00f6z\u00e9 tartozik. Amikor a PI3K foszforil\u00e1l\u00f3dik, rekrut\u00e1lja \u00e9s induk\u00e1lja az Akt foszforil\u00e1ci\u00f3j\u00e1t, ez\u00e1ltal szab\u00e1lyozza az olyan fiziol\u00f3giai tev\u00e9kenys\u00e9geket, mint az oxidat\u00edv stressz \u00e9s az apopt\u00f3zis. A Western blot elemz\u00e9s kimutatta, hogy a vadon \u00e9l\u0151 selyemk\u00f3r\u00f3 sz\u00f3jabab gy\u00f6ker\u00e9nek n-butanolos kivonata el\u0151seg\u00edtheti a PI3K \u00e9s az Akt feh\u00e9rje foszforil\u00e1ci\u00f3j\u00e1t, ez\u00e1ltal aktiv\u00e1lva a PI3K\/Akt jel\u00e1tviteli \u00fatvonalat \u00e9s jav\u00edtva az oxidat\u00edv stresszt.
\n\u00d6sszefoglalva, ez a cikk a vadon \u00e9l\u0151 selyemk\u00f3r\u00f3 sz\u00f3jabab gy\u00f6kereinek antioxid\u00e1ns aktivit\u00e1s\u00e1t \u00e9rt\u00e9kelte in vitro antioxid\u00e1ns k\u00eds\u00e9rletek seg\u00edts\u00e9g\u00e9vel. A vad selyemherny\u00f3 sz\u00f3jabab gy\u00f6kerekben l\u00e9v\u0151 antioxid\u00e1ns stressz hat\u00f3anyagait, c\u00e9lpontjait \u00e9s jel\u00e1tviteli \u00fatvonalait h\u00e1l\u00f3zati farmakol\u00f3giai \u00e9s molekul\u00e1ris dokkol\u00e1si technik\u00e1k seg\u00edts\u00e9g\u00e9vel j\u00f3soltuk meg. V\u00e9g\u00fcl Western blot anal\u00edzissel igazolt\u00e1k a hat\u00e1smechanizmus\u00e1t. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a vad selyemherny\u00f3 gy\u00f6k\u00e9rkivonat IC50 \u00e9rt\u00e9kei a DPPH szabad gy\u00f6k\u00f6k, az ABTS szabad gy\u00f6k\u00f6k \u00e9s a hidroxil szabad gy\u00f6k\u00f6k elsz\u00edv\u00e1s\u00e1ra 0,166, 0,054, illetve 0,180 mg\/ml volt, ami meger\u0151s\u00edti j\u00f3 antioxid\u00e1ns aktivit\u00e1s\u00e1t. A h\u00e1l\u00f3zati farmakol\u00f3gia eredm\u00e9nyei azt mutatj\u00e1k, hogy a vad selyembab gy\u00f6kerei t\u00f6bb komponens, c\u00e9lpont \u00e9s \u00fatvonal r\u00e9v\u00e9n jav\u00edthatj\u00e1k az oxidat\u00edv stresszt, amelyek k\u00f6z\u00fcl a PI3K\/Akt jel\u00e1tviteli \u00fatvonal lehet az antioxid\u00e1ns hat\u00e1s kulcsfontoss\u00e1g\u00fa \u00fatvonala. A Western blot elemz\u00e9s tov\u00e1bb\u00e1 kimutatta, hogy a vadszilva gy\u00f6k\u00e9r kivonata aktiv\u00e1lhatja a PI3K\/Akt jel\u00e1tviteli \u00fatvonalat a kapcsol\u00f3d\u00f3 feh\u00e9rj\u00e9k foszforil\u00e1ci\u00f3j\u00e1nak el\u0151seg\u00edt\u00e9s\u00e9vel, ez\u00e1ltal antioxid\u00e1ns hat\u00e1st fejt ki. Ez igazolja a vad sz\u00f3jabab gy\u00f6k\u00e9r oxidat\u00edv stressz elleni hat\u00e1smechanizmus\u00e1t, ir\u00e1nyt mutat \u00e9s megalapozza a vad sz\u00f3jabab gy\u00f6k\u00e9r antioxid\u00e1ns stresszhat\u00e1s\u00e1nak tov\u00e1bbi kutat\u00e1s\u00e1t.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the antioxidant activity and mechanism of wild silkworm soybean root based on network pharmacology and in vitro experiments Wild silkworm bean root is the root of Centrantheragrandiflora Benth, a plant in the Scrophulariaceae family, mainly distributed in Yunnan, Guizhou, Guangxi and other places. Wild silkworm bean roots are medicinal and edible plants, rich in […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the antioxidant activity and mechanism of wild silkworm soybean root based on network pharmacology and in vitro experiments - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/vad-selyemhernyobab-gyoker\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the antioxidant activity and mechanism of wild silkworm soybean root based on network pharmacology and in vitro experiments - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the antioxidant activity and mechanism of wild silkworm soybean root based on network pharmacology and in vitro experiments Wild silkworm bean root is the root of Centrantheragrandiflora Benth, a plant in the Scrophulariaceae family, mainly distributed in Yunnan, Guizhou, Guangxi and other places. 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