{"id":4800,"date":"2024-08-04T15:48:24","date_gmt":"2024-08-04T15:48:24","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4800"},"modified":"2024-08-04T15:48:24","modified_gmt":"2024-08-04T15:48:24","slug":"nafld","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/nafld\/","title":{"rendered":"A nem-alkoholista zs\u00edrm\u00e1jbetegs\u00e9g hagyom\u00e1nyos k\u00ednai orvosl\u00e1ssal t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9vel kapcsolatos jel\u00e1tviteli \u00fatvonalakkal kapcsolatos kutat\u00e1si el\u0151rehalad\u00e1s"},"content":{"rendered":"<p>A nem-alkoholista zs\u00edrm\u00e1jbetegs\u00e9g hagyom\u00e1nyos k\u00ednai orvosl\u00e1ssal t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9vel kapcsolatos jel\u00e1tviteli \u00fatvonalakkal kapcsolatos kutat\u00e1si el\u0151rehalad\u00e1s<br \/>\nA nem alkoholos zs\u00edrm\u00e1jbetegs\u00e9g (NAFLD) a m\u00e1jsejtek steatosis\u00e1nak els\u0151sorban nagy bubor\u00e9kokkal jellemezhet\u0151 betegs\u00e9ge, amely t\u00falzott alkoholfogyaszt\u00e1s vagy m\u00e1jk\u00e1rosod\u00e1s n\u00e9lk\u00fcl jelentkezik. El\u0151fordul\u00e1sa folyamatosan n\u00f6vekszik, \u00e9s tendencia szerint egyre fiatalabb korban kezd\u0151dik. A k\u00f3ros fejl\u0151d\u00e9s s\u00falyoss\u00e1ga szerint a NAFLD n\u00e9gy st\u00e1diumra oszthat\u00f3: egyszer\u0171 zs\u00edrm\u00e1j, zs\u00edrhepatitis, zs\u00edrm\u00e1jfibr\u00f3zis \u00e9s zs\u00edrm\u00e1jcirr\u00f3zis. A magas energiatartalm\u00fa \u00e9trend, az elh\u00edz\u00e1s, a genetikai fog\u00e9konys\u00e1g, a genetikai polimorfizmus, a citokinek \u00e9s a b\u00e9lmikrobi\u00f3ta diszbi\u00f3zisa a NAFLD f\u0151 okai. A \"m\u00e1sodik csap\u00e1s\" elm\u00e9lete r\u00e9szben felt\u00e1rhatja a NAFLD mechanizmus\u00e1t. Az inzulinrezisztencia (IR) a zs\u00edrsejtek nagym\u00e9rt\u00e9k\u0171 felhalmoz\u00f3d\u00e1s\u00e1hoz vezet a m\u00e1jsz\u00f6vetben, ami az els\u0151 csap\u00e1s a NAFLD patogenezis\u00e9ben. Az ennek alapj\u00e1n fell\u00e9p\u0151 citotoxikus reakci\u00f3k, bele\u00e9rtve az oxidat\u00edv stresszt \u00e9s a gyullad\u00e1sos reakci\u00f3kat, a NAFLD patogenezis\u00e9nek m\u00e1sodik csap\u00e1s\u00e1v\u00e1 v\u00e1lnak, ami v\u00e9g\u00fcl m\u00e1jfibr\u00f3zishoz vezet. A modern kutat\u00e1sok folyamatos elm\u00e9ly\u00fcl\u00e9s\u00e9vel a \"t\u00f6bb csap\u00e1s\" elm\u00e9let pontosabb magyar\u00e1zatot ad a NAFLD patogenezis\u00e9re. Ez az elm\u00e9let \u00fagy v\u00e9li, hogy a citokin \u00e9s az endoplazmatikus retikulum \u00e1ltal induk\u00e1lt steatosis \u00e9s gyullad\u00e1sos v\u00e1lasz a NAFLD patogenezis\u00e9nek alapja, \u00e9s az IR, a lipidfelhalmoz\u00f3d\u00e1s, az epesavak, a genetikai polimorfizmus stb. a NAFLD-t kiv\u00e1lt\u00f3 f\u0151 t\u00e9nyez\u0151k. Mindk\u00e9t fenti elm\u00e9let \u00fagy v\u00e9li, hogy a NAFLD kialakul\u00e1s\u00e1nak \u00e9s fejl\u0151d\u00e9s\u00e9nek kulcsa a rendellenes lipidanyagcser\u00e9ben \u00e9s a gyullad\u00e1sos v\u00e1laszban rejlik. Ez\u00e9rt a NAFLD kezel\u00e9s\u00e9nek k\u00f6z\u00e9ppontj\u00e1ban a m\u00e1j rendellenes lipidanyagcser\u00e9j\u00e9nek \u00e9s a gyullad\u00e1s kialakul\u00e1s\u00e1nak alapvet\u0151 mechanizmus\u00e1nak tanulm\u00e1nyoz\u00e1sa \u00e1ll.<br \/>\nJelenleg nincs specifikus kezel\u00e9s a NAFLD-re. A modern orvostudom\u00e1ny els\u0151sorban az inzulinrezisztencia jav\u00edt\u00e1s\u00e1ra, a m\u00e1jzs\u00edrsavszint cs\u00f6kkent\u00e9s\u00e9re, az oxidat\u00edv stressz \u00e9s az endoplazmatikus retikulum stressz jav\u00edt\u00e1s\u00e1ra t\u00f6rekszik. A gy\u00f3gyszerfajt\u00e1k k\u00f6z\u00e9 els\u0151sorban inzulin\u00e9rz\u00e9keny\u00edt\u0151k, antioxid\u00e1nsok, sejtv\u00e9d\u0151 szerek, tumor nekr\u00f3zis faktor alfa (TNF - \u03b1) g\u00e1tl\u00f3k stb. tartoznak. De a NAFLD eset\u00e9ben, k\u00fcl\u00f6n\u00f6sen a m\u00e1jfibr\u00f3zist kialak\u00edt\u00f3 betegek eset\u00e9ben, ezeknek a gy\u00f3gyszereknek a hat\u00e9konys\u00e1ga m\u00e9g tov\u00e1bbi kutat\u00e1sokat ig\u00e9nyel. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s a \"k\u00f6v\u00e9r embereknek t\u00f6bb a v\u00e1lad\u00e9k \u00e9s a nedvess\u00e9g\" \u00e9s a \"k\u00f6v\u00e9r embereknek t\u00f6bb a qi-hi\u00e1nya\" szemsz\u00f6g\u00e9b\u0151l r\u00e1mutat arra, hogy a NAFLD l\u00e9nyege legink\u00e1bb a gy\u00f6k\u00e9r hi\u00e1ny\u00e1n, valamint a l\u00e9p \u00e9s a m\u00e1j hi\u00e1ny\u00e1n, tov\u00e1bb\u00e1 a nedvess\u00e9g, a v\u00e1lad\u00e9k \u00e9s a v\u00e9r pang\u00e1s\u00e1n alapul. A gyakori szindr\u00f3mat\u00edpusok nedvess\u00e9g- \u00e9s zavaross\u00e1gi ellen\u00e1ll\u00e1s, nedves h\u0151felhalmoz\u00f3d\u00e1s, m\u00e1jdepresszi\u00f3 \u00e9s l\u00e9phi\u00e1ny, valamint ny\u00e1lka-v\u00e9r pang\u00e1s szerint oszthat\u00f3k meg. A kezel\u00e9si m\u00f3dszerek els\u0151sorban a m\u00e1j \u00e9s a l\u00e9p megnyugtat\u00e1s\u00e1ra, a v\u00e1lad\u00e9k \u00e9s a nedvess\u00e9g felold\u00e1s\u00e1ra, a h\u0151 \u00e9s a nedvess\u00e9g tiszt\u00edt\u00e1s\u00e1ra, valamint a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9re \u00f6sszpontos\u00edtanak. A NAFLD hossz\u00fa \u00e9s tart\u00f3s lefoly\u00e1s\u00fa kr\u00f3nikus betegs\u00e9g. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s (TCM) saj\u00e1t rendszert dolgozott ki a NAFLD megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re, amely a \"betegs\u00e9gek gy\u00f6keres okkal val\u00f3 kezel\u00e9se\", az \"ember el\u0151t\u00e9rbe helyez\u00e9se\" \u00e9s a \"szindr\u00f3m\u00e1k differenci\u00e1l\u00e1s\u00e1n alapul\u00f3 kezel\u00e9s\" elvein alapul. Sz\u00e1mos k\u00eds\u00e9rlet kimutatta, hogy a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s eredeti el\u0151nye a NAFLD kezel\u00e9s\u00e9ben a t\u00f6bb c\u00e9lpontot \u00e9s t\u00f6bb \u00fatvonalat \u00e9rint\u0151 ter\u00e1pia r\u00e9v\u00e9n a kiv\u00e1l\u00f3 hat\u00e9konys\u00e1g \u00e9s az egyetemes alkalmazhat\u00f3s\u00e1g. Ez a cikk \u00f6sszefoglalja a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s k\u00f6z\u00f6s jel\u00e1tviteli \u00fatvonalait a NAFLD kezel\u00e9s\u00e9ben a lipidanyagcsere \u00e9s a gyullad\u00e1sos v\u00e1lasz szempontj\u00e1b\u00f3l, elm\u00e9leti alapot ny\u00fajtva a klinikai kezel\u00e9shez \u00e9s a k\u00eds\u00e9rleti kutat\u00e1shoz.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4801\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-95.png\" alt=\"\" width=\"661\" height=\"401\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4802\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-83.png\" alt=\"\" width=\"655\" height=\"400\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4803\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-78.png\" alt=\"\" width=\"660\" height=\"681\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4804\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-66.png\" alt=\"\" width=\"664\" height=\"719\" \/>\u00d6sszefoglalva, a lipidanyagcsere \u00e9s a gyullad\u00e1sos v\u00e1lasz k\u00e9t fontos c\u00e9lpontja a NAFLD hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szati kezel\u00e9s\u00e9nek. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s cs\u00f6kkenti a lipidlerak\u00f3d\u00e1st olyan jel\u00e1tviteli utak k\u00f6zvet\u00edt\u00e9s\u00e9vel, mint az FXR, a PPAR \u03b1, a G-protein, \u00e9s az epesav-anyagcsere szab\u00e1lyoz\u00e1s\u00e1val. Emellett cs\u00f6kkenti a gyullad\u00e1sos v\u00e1laszt \u00e9s az oxidat\u00edv stresszt olyan jel\u00e1tviteli utak k\u00f6zvet\u00edt\u00e9s\u00e9vel, mint az NF - \u03ba B, Nrf2, Th17\/Treg, JNK, v\u00e9gs\u0151 soron megel\u0151zve \u00e9s kezelve a NAFLD progresszi\u00f3j\u00e1t (a r\u00e9szleteket l\u00e1sd az 1. t\u00e1bl\u00e1zatban). Ezen t\u00falmen\u0151en a legt\u00f6bb hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u00e9s \u00f6sszetett formula hat\u00e1sa a h\u0151tiszt\u00edt\u00e1s, a m\u00e1j megnyugtat\u00e1sa, a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9se, a nedvess\u00e9g eloszlat\u00e1sa \u00e9s a test t\u00e1pl\u00e1l\u00e1sa, ami \u00f6sszhangban van a NAFLD etiol\u00f3gi\u00e1j\u00e1val \u00e9s patogenezis\u00e9vel a hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s holisztikus, t\u00f6bbdimenzi\u00f3s \u00e9s t\u00f6bbc\u00e9l\u00fa szemsz\u00f6gb\u0151l \u00e1tfog\u00f3 kezel\u00e9st ny\u00fajt a NAFLD kezel\u00e9s\u00e9re, \u00e9s hat\u00e9konys\u00e1g\u00e1t \u00e9s biztons\u00e1goss\u00e1g\u00e1t is sz\u00e9les k\u00f6rben elismert\u00e9k.<br \/>\nA szerz\u0151 azonban az irodalomkutat\u00e1s sor\u00e1n meg\u00e1llap\u00edtotta, hogy a NAFLD hagyom\u00e1nyos k\u00ednai orvosl\u00e1s\u00e1nak sz\u00e1mos hi\u00e1nyoss\u00e1ga is van. El\u0151sz\u00f6r is, a NAFLD k\u00e9pletter\u00e1pi\u00e1j\u00e1nak tanulm\u00e1nyoz\u00e1s\u00e1ban gyakran t\u00fckr\u00f6zi a k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00f3gyszerek \u00e1tfog\u00f3 hat\u00e1sait, \u00f6sszetett befoly\u00e1sol\u00f3 t\u00e9nyez\u0151kkel, tiszt\u00e1zatlan specifikus hat\u00f3anyagokkal \u00e9s hat\u00e1smechanizmusokkal, valamint a m\u00e9lyrehat\u00f3 mechanizmus-kutat\u00e1s hi\u00e1ny\u00e1val. M\u00e1sodszor, a NAFLD hagyom\u00e1nyos k\u00ednai orvosl\u00e1ssal t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9ben r\u00e9szt vev\u0151 egyes jel\u00e1tviteli \u00fatvonalaknak nincs felt\u00e1r\u00f3 kutat\u00e1sa \u00e9s hiteles elm\u00e9leti t\u00e1mogat\u00e1sa, \u00e9s az alapvet\u0151 k\u00eds\u00e9rleti kutat\u00e1s \u00e9s az azt k\u00f6vet\u0151 klinikai alkalmaz\u00e1si kutat\u00e1s viszonylag el\u00e9gtelen. Ism\u00e9tlem, a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s t\u00f6bb jel\u00e1tviteli \u00fatvonalat \u00e9rint a NAFLD kezel\u00e9s\u00e9ben, \u00e9s az egyes \u00fatvonalak nem m\u0171k\u00f6dnek f\u00fcggetlen\u00fcl. A jel\u00e1tviteli \u00fatvonalak sokas\u00e1ga \u00e9s az, hogy vannak-e k\u00f6zt\u00fck antagonisztikus \u00e9s szinergikus kapcsolatok, valamint hogy vannak-e m\u00e1s befoly\u00e1sol\u00f3 t\u00e9nyez\u0151k \u00e9s kapcsol\u00f3d\u00f3 \u00fatvonalak, m\u00e9g mindig olyan k\u00e9rd\u00e9sek, amelyeket fel kell t\u00e1rnunk. Ez\u00e9rt t\u00f6bb tud\u00f3snak m\u00e9lyrehat\u00f3 kutat\u00e1st kell v\u00e9geznie a c\u00e9lpontjaik \u00e9s mechanizmusaik tekintet\u00e9ben, hogy technikai \u00e9s elm\u00e9leti t\u00e1mogat\u00e1st ny\u00fajtson a j\u00f6v\u0151beli klinikai gy\u00f3gyszerekhez.<\/p>","protected":false},"excerpt":{"rendered":"<p>Research progress on signaling pathways related to the treatment of non-alcoholic fatty liver disease with traditional Chinese medicine Non alcoholic fatty liver disease (NAFLD) is a liver cell steatosis disease mainly characterized by large bubbles, which occurs without excessive alcohol consumption or liver damage. Its incidence continues to increase and shows a trend of younger [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research progress on signaling pathways related to the treatment of non-alcoholic fatty liver disease with traditional Chinese medicine - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/nafld\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research progress on signaling pathways related to the treatment of non-alcoholic fatty liver disease with traditional Chinese medicine - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research progress on signaling pathways related to the treatment of non-alcoholic fatty liver disease with traditional Chinese medicine Non alcoholic fatty liver disease (NAFLD) is a liver cell steatosis disease mainly characterized by large bubbles, which occurs without excessive alcohol consumption or liver damage. 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