{"id":4790,"date":"2024-08-04T15:31:10","date_gmt":"2024-08-04T15:31:10","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4790"},"modified":"2024-08-04T15:31:10","modified_gmt":"2024-08-04T15:31:10","slug":"alocasia-cucullata","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/alocasia-cucullata\/","title":{"rendered":"Tanulm\u00e1nyok a Taro acuminata petr\u00f3leum\u00e9ter frakci\u00f3j\u00e1nak k\u00e9miai \u00f6sszetev\u0151ir\u0151l \u00e9s citotoxikus aktivit\u00e1s\u00e1r\u00f3l eml\u0151r\u00e1kban"},"content":{"rendered":"

Tanulm\u00e1nyok a Taro acuminata petr\u00f3leum\u00e9ter frakci\u00f3j\u00e1nak k\u00e9miai \u00f6sszetev\u0151ir\u0151l \u00e9s citotoxikus aktivit\u00e1s\u00e1r\u00f3l eml\u0151r\u00e1kban
\nAz Alocasia cuculata (Lour.) Schott, az Araceae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9ny, sz\u00e1r\u00edtott gy\u00f6kereit \u00e9s sz\u00e1r\u00e1t gy\u00f3gyszerk\u00e9nt haszn\u00e1lj\u00e1k. El\u0151sz\u00f6r a \"New Selection of Practical Chinese Herbal Medicines in Guangxi\" c\u00edm\u0171 k\u00f6nyvben jegyezt\u00e9k fel. Cs\u00edp\u0151s \u00e9s enyh\u00e9n keserny\u00e9s \u00edz\u0171, hideg term\u00e9szet\u0171 \u00e9s m\u00e9rgez\u0151. A t\u00fcd\u0151 meridi\u00e1nhoz tartozik, \u00e9s h\u0151elvezet\u0151, m\u00e9regtelen\u00edt\u0151, duzzanatcs\u00f6kkent\u0151 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1s\u00fa. A tar\u00f3 gy\u00f6ker\u00e9t \u00e9s sz\u00e1r\u00e1t a n\u00e9pi gy\u00f3gy\u00e1szatban gyakran haszn\u00e1lj\u00e1k magas l\u00e1z, influenza, leptospir\u00f3zis, t\u00edfusz, skroful\u00f3zis \u00e9s tuberkul\u00f3zis kezel\u00e9s\u00e9re; helyi kezel\u00e9s sebekre, \u00e9g\u00e9si s\u00e9r\u00fcl\u00e9sekre, m\u00e9rges k\u00edgy\u00f3mar\u00e1sra \u00e9s dar\u00e1zscs\u00edp\u00e9sre. A Jianwei taro m\u00e9rgez\u0151, \u00e9s sz\u00e1jon \u00e1t t\u00f6rt\u00e9n\u0151 bevitel el\u0151tt legal\u00e1bb 6 \u00f3r\u00e1n \u00e1t kell f\u0151zni. Ha v\u00e9letlen\u00fcl fogyasztj\u00e1k, \u00e1ltal\u00e1ban ecettel \u00e9s kis mennyis\u00e9g\u0171 gy\u00f6mb\u00e9rl\u00e9vel f\u0151zik, sz\u00e1jon \u00e1t vagy \u00f6bl\u00edt\u00e9ssel fogyasztj\u00e1k m\u00e9regtelen\u00edt\u00e9s c\u00e9lj\u00e1b\u00f3l. A klinikai gyakorlatban difenhidramin intramuszkul\u00e1ris injekci\u00f3j\u00e1val \u00e9s gl\u00fck\u00f3z s\u00f3oldat intrav\u00e9n\u00e1s injekci\u00f3j\u00e1val m\u00e9regtelen\u00edtik. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a tar\u00f3 v\u00edz- \u00e9s alkoholkivonata jelent\u0151s farmakol\u00f3giai tev\u00e9kenys\u00e9ggel rendelkezik, p\u00e9ld\u00e1ul gyullad\u00e1scs\u00f6kkent\u0151, daganatellenes \u00e9s l\u00e9pv\u00e9d\u0151 hat\u00e1ssal. A taro farmakol\u00f3giai anyagb\u00e1zis\u00e1nak kutat\u00e1sa azonban viszonylag gyenge, k\u00fcl\u00f6n\u00f6sen a petr\u00f3leum\u00e9ter frakci\u00f3j\u00e1nak k\u00e9miai \u00f6sszet\u00e9tele, amely a GC-MS anal\u00edzisre korl\u00e1toz\u00f3dik. Ez\u00e9rt ebben a tanulm\u00e1nyban a Tara acuminata petr\u00f3leum\u00e9ter r\u00e9sz\u00e9t vett\u00e9k kutat\u00e1si t\u00e1rgynak, \u00e9s szilikag\u00e9lt, Sephadex LH-20 \u00e9s m\u00e1s kromatogr\u00e1fi\u00e1s m\u00f3dszereket haszn\u00e1ltak a Tara acuminata petr\u00f3leum\u00e9ter r\u00e9sz\u00e9nek elv\u00e1laszt\u00e1s\u00e1ra \u00e9s tiszt\u00edt\u00e1s\u00e1ra, \u00e9s a Tara acuminata petr\u00f3leum\u00e9ter r\u00e9sz\u00e9nek k\u00e9miai \u00f6sszetev\u0151it UV spektrummal, egydimenzi\u00f3s nukle\u00e1ris m\u00e1gneses rezonancia spektrummal \u00e9s m\u00e1s spektr\u00e1lis technik\u00e1kkal azonos\u00edtott\u00e1k, hogy felt\u00e1rj\u00e1k a petr\u00f3leum\u00e9ter r\u00e9sz hat\u00e9konys\u00e1g\u00e1nak anyagi alapj\u00e1t. Ugyanakkor az emberi eml\u0151r\u00e1k MDA-MB-231, MCF-7 sejtekkel \u00e9s eg\u00e9r eml\u0151r\u00e1k 4T1 sejtekkel mint sz\u0171r\u00e9si modellekkel vizsg\u00e1lt\u00e1k az izol\u00e1lt monomer vegy\u00fcletek citotoxicit\u00e1s\u00e1t eml\u0151r\u00e1kban. Annak \u00e9rdek\u00e9ben, hogy alapot biztos\u00edtsunk a hegyes farok taro m\u00e9lyrehat\u00f3 kutat\u00e1s\u00e1hoz \u00e9s fejleszt\u00e9s\u00e9hez.<\/p>\n

Kor\u00e1bbi tanulm\u00e1nyokban kutat\u00f3csoportunk meg\u00e1llap\u00edtotta, hogy a Taro acuminata alkoholos kivonat\u00e1nak petr\u00f3leum\u00e9teres r\u00e9sze j\u00f3 mellr\u00e1kellenes hat\u00e1ssal rendelkezik, \u00e9s mechanizmusa a MAPK-\u00fatvonal p-ERK\/ERK expresszi\u00f3j\u00e1nak g\u00e1tl\u00e1s\u00e1hoz kapcsol\u00f3dik. Azonban a Taro acuminata alkoholos kivonat\u00e1nak petr\u00f3leum\u00e9teres r\u00e9sz\u00e9nek anyagi alapja az eml\u0151r\u00e1kellenes hat\u00e1s\u00e9rt m\u00e9g mindig nem vil\u00e1gos. Ez\u00e9rt ebben a tanulm\u00e1nyban 16 vegy\u00fcletet izol\u00e1ltunk a taro riz\u00f3m\u00e1j\u00e1nak petr\u00f3leum\u00e9teres frakci\u00f3j\u00e1b\u00f3l, k\u00f6zt\u00fck \u00e9sztereket (metilmiriszt\u00e1t, etil-vanillinsav), terp\u00e9neket (szkval\u00e9n, oleanolsav, ursolsav, perillaalkohol, perillalakton), fenilpropanoidok (p-hidroxibenzaldehid, 7-hidroxikumarin), polifenolok (etilgall\u00e1t, protokatechualdehid, protokatechuinsav), arom\u00e1s savak (benzoesav), zs\u00edralkoholok (oktacosanol) \u00e9s fenolsavak (galluszsav). A 2-15 vegy\u00fcleteket el\u0151sz\u00f6r izol\u00e1lt\u00e1k a taro nemzets\u00e9gben, \u00e9s valamennyi vegy\u00fcletet el\u0151sz\u00f6r izol\u00e1lt\u00e1k a tar\u00f3ban. Az eml\u0151r\u00e1ksejtek prolifer\u00e1ci\u00f3j\u00e1nak in vitro g\u00e1tl\u00e1s\u00e1nak eredm\u00e9nyei azt mutatt\u00e1k, hogy a 4., 8. \u00e9s 9. vegy\u00fclet bizonyos g\u00e1tl\u00f3 hat\u00e1ssal volt az emberi eml\u0151r\u00e1k MDA-MB-231, MCF-7 sejtek \u00e9s az eg\u00e9r eml\u0151r\u00e1k 4T1 sejtek prolifer\u00e1ci\u00f3j\u00e1ra. Meg\u00e1llap\u00edtott\u00e1k, hogy az oleanolsav, az ursolsav \u00e9s az etil-gall\u00e1t g\u00e1tolni tudta a k\u00fcl\u00f6nb\u00f6z\u0151 tumorsejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s szaporod\u00e1s\u00e1t, \u00e9s a tumorsejtek apopt\u00f3zis\u00e1t induk\u00e1lta. Tumorellenes hat\u00e1suk a PI3K\/Akt, MAPK, Wnt\/\u03b2 - catenin \u00e9s m\u00e1s jel\u00e1tviteli utak szab\u00e1lyoz\u00e1s\u00e1val f\u00fcgghet \u00f6ssze, ami \u00f6sszhangban van a taro petr\u00f3leum\u00e9ter frakci\u00f3j\u00e1nak a kor\u00e1bbi eml\u0151r\u00e1kkal kapcsolatos kutat\u00e1sainkban bemutatott mechanizmus\u00e1val. \u00d6sszefoglalva, ez a tanulm\u00e1ny tov\u00e1bb gazdag\u00edtotta a Tara acuminata petr\u00f3leum\u00e9ter r\u00e9sz\u00e9nek k\u00e9miai \u00f6sszet\u00e9tel\u00e9t, \u00e9s kisz\u0171rte az eml\u0151r\u00e1ksejtek prolifer\u00e1ci\u00f3j\u00e1t in vitro g\u00e1tl\u00f3 hat\u00f3anyagait, bizonyos k\u00eds\u00e9rleti alapot biztos\u00edtva a Tara acuminata petr\u00f3leum\u00e9ter r\u00e9sz\u00e9nek anyagi alapjainak tanulm\u00e1nyoz\u00e1s\u00e1hoz az eml\u0151r\u00e1k ellen.<\/p>","protected":false},"excerpt":{"rendered":"

Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer Alocasia cuculata (Lour.) Schott, a plant belonging to the Araceae family, is used as medicine with its dried roots and stems. It was first recorded in the “New Selection of Practical Chinese Herbal Medicines in Guangxi”. […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/alocasia-cucullata\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer Alocasia cuculata (Lour.) Schott, a plant belonging to the Araceae family, is used as medicine with its dried roots and stems. It was first recorded in the “New Selection of Practical Chinese Herbal Medicines in Guangxi”. […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/hu\/alocasia-cucullata\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T15:31:10+00:00\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Szerz\u0151:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Becs\u00fclt olvas\u00e1si id\u0151\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 perc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/alocasia-cucullata\/\",\"url\":\"https:\/\/longchangextracts.com\/alocasia-cucullata\/\",\"name\":\"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"datePublished\":\"2024-08-04T15:31:10+00:00\",\"dateModified\":\"2024-08-04T15:31:10+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/alocasia-cucullata\/#breadcrumb\"},\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/alocasia-cucullata\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/alocasia-cucullata\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"hu\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tanulm\u00e1nyok a Taro acuminata petr\u00f3leum\u00e9ter frakci\u00f3j\u00e1nak k\u00e9miai \u00f6sszetev\u0151ir\u0151l \u00e9s citotoxikus aktivit\u00e1s\u00e1r\u00f3l mellr\u00e1kban - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/hu\/alocasia-cucullata\/","og_locale":"hu_HU","og_type":"article","og_title":"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer - China Chemical Manufacturer","og_description":"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer Alocasia cuculata (Lour.) Schott, a plant belonging to the Araceae family, is used as medicine with its dried roots and stems. It was first recorded in the “New Selection of Practical Chinese Herbal Medicines in Guangxi”. […]","og_url":"https:\/\/longchangextracts.com\/hu\/alocasia-cucullata\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T15:31:10+00:00","author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Szerz\u0151:":"longcha9","Becs\u00fclt olvas\u00e1si id\u0151":"3 perc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/alocasia-cucullata\/","url":"https:\/\/longchangextracts.com\/alocasia-cucullata\/","name":"Tanulm\u00e1nyok a Taro acuminata petr\u00f3leum\u00e9ter frakci\u00f3j\u00e1nak k\u00e9miai \u00f6sszetev\u0151ir\u0151l \u00e9s citotoxikus aktivit\u00e1s\u00e1r\u00f3l mellr\u00e1kban - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"datePublished":"2024-08-04T15:31:10+00:00","dateModified":"2024-08-04T15:31:10+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/alocasia-cucullata\/#breadcrumb"},"inLanguage":"hu","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/alocasia-cucullata\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/alocasia-cucullata\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"K\u00edna Vegyi Gy\u00e1rt\u00f3","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4790"}],"collection":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/comments?post=4790"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4790\/revisions"}],"predecessor-version":[{"id":4792,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4790\/revisions\/4792"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/media?parent=4790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/categories?post=4790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/tags?post=4790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}