{"id":4780,"date":"2024-08-04T15:26:43","date_gmt":"2024-08-04T15:26:43","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4780"},"modified":"2024-08-04T15:26:43","modified_gmt":"2024-08-04T15:26:43","slug":"cyclopamine","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/cyclopamine\/","title":{"rendered":"Az \u00e9desgy\u00f6k\u00e9r-ciklopamin \u00e9s az illatos orchidea \u00f6sszes flavonoidjainak kombin\u00e1lt ter\u00e1pi\u00e1j\u00e1nak hat\u00e1sa t\u00fcd\u0151fibr\u00f3zisos egerekre"},"content":{"rendered":"

Az \u00e9desgy\u00f6k\u00e9r-ciklopamin \u00e9s az illatos orchidea \u00f6sszes flavonoidjainak kombin\u00e1lt ter\u00e1pi\u00e1j\u00e1nak hat\u00e1sa t\u00fcd\u0151fibr\u00f3zisos egerekre
\nA t\u00fcd\u0151fibr\u00f3zis (PF) kr\u00f3nikus progressz\u00edv t\u00fcd\u0151betegs\u00e9g, amely nyilv\u00e1nval\u00f3 sz\u00f6vettani mint\u00e1zattal rendelkezik, bele\u00e9rtve sz\u00e1mos kr\u00f3nikus l\u00e9g\u00fati elv\u00e1ltoz\u00e1st, amelyet a k\u00f6t\u0151sz\u00f6vet n\u00f6veked\u00e9se k\u00eds\u00e9r a k\u00fcl\u00f6nb\u00f6z\u0151 t\u00fcd\u0151r\u00e9szekben. K\u00f6z\u00fcl\u00fck az interstiti\u00e1lis t\u00fcd\u0151betegs\u00e9g \u00e9s az idiop\u00e1ti\u00e1s t\u00fcd\u0151fibr\u00f3zis (IPF) a t\u00fcd\u0151parenchima progressz\u00edv fibr\u00f3zis\u00e1nak legs\u00falyosabb \u00e9s legvisszaford\u00edthatatlanabb betegs\u00e9gei. A PF-t k\u00f3ros sz\u00f6veti javul\u00e1s okozza, \u00e9s tart\u00f3san fenn\u00e1ll\u00f3 s\u00falyos sz\u00f6vetk\u00e1rosod\u00e1ssal \u00e9s sejtstresszel j\u00e1r. Ez az abnorm\u00e1lis tulajdons\u00e1g a h\u00e1msejtek g\u00e1tj\u00e1nak el\u00e9gtelen jav\u00edt\u00e1s\u00e1val j\u00e1r, amelyet a fibroblasztok k\u00e1rosodott szab\u00e1lyoz\u00e1sa k\u00eds\u00e9r, ami az alveol\u00e1ris h\u00e1msejtek \u00e9s a fibroblasztok m\u00e9lyrehat\u00f3 v\u00e1ltoz\u00e1saihoz vezet, ami kontroll\u00e1latlan fibr\u00f3zist eredm\u00e9nyez, amelyet a fibrotikus alveol\u00e1ris falak megvastagod\u00e1sa, k\u00e1rosodott g\u00e1ztranszport, korl\u00e1tozott szell\u0151z\u00e9si mint\u00e1k \u00e9s v\u00e9g\u00fcl l\u00e9gz\u00e9si el\u00e9gtelens\u00e9g jellemez. Az elm\u00falt \u00e9vekben a PF betegs\u00e9g komolyan vesz\u00e9lyeztette az emberi eg\u00e9szs\u00e9get a modern orvostudom\u00e1ny ter\u00fclet\u00e9n. A diagnosztikai m\u00f3dszerek folyamatos fejl\u0151d\u00e9se \u00e9s a n\u00e9pess\u00e9g el\u00f6reged\u00e9se miatt a PF hal\u00e1loz\u00e1si \u00e9s el\u0151fordul\u00e1si ar\u00e1nya folyamatosan emelkedik. A betegs\u00e9g patogenezise \u00f6sszetett, \u00e9s a patol\u00f3giai mechanizmus m\u00e9g mindig tiszt\u00e1zatlan. A betegek klinikai megnyilv\u00e1nul\u00e1sai a t\u00fcd\u0151sz\u00f6veti compliance progressz\u00edv cs\u00f6kken\u00e9se, a cs\u00f6kkent diff\u00fazi\u00f3s funkci\u00f3 \u00e9s a ventil\u00e1ci\u00f3\/v\u00e9r\u00e1raml\u00e1s egyens\u00faly\u00e1nak felborul\u00e1sa, ami a betegekn\u00e9l refrakter dyspno\u00e9hoz, v\u00e9g\u00fcl pedig l\u00e9gz\u00e9si el\u00e9gtelens\u00e9ghez \u00e9s hal\u00e1lhoz vezet.
\nA Hedgehog (Hh) \u00fatvonal fontos szerepet j\u00e1tszik az embrion\u00e1lis fejl\u0151d\u00e9sben \u00e9s a sz\u00f6vetek \u00e1talak\u00edt\u00e1s\u00e1ban. A Hh jel\u00e1tviteli \u00fatvonal els\u0151sorban jelz\u0151molekul\u00e1kb\u00f3l (SHH, IHH, DHH), transzmembr\u00e1n receptorokb\u00f3l (Ptch, SMO) \u00e9s downstream transzkripci\u00f3s faktorokb\u00f3l (Gli1 feh\u00e9rjecsal\u00e1d) \u00e1ll. Aktiv\u00e1l\u00f3d\u00e1s ut\u00e1n a Hh \u00fatvonal els\u0151sorban a Gli1 feh\u00e9rjecsal\u00e1don kereszt\u00fcl fejti ki hat\u00e1s\u00e1t. IPF-ben igazolt\u00e1k, hogy a Hh-\u00fatvonal aktivit\u00e1sa megn\u0151, \u00e9s az SHH \u00e9s jel\u00e1tviteli effektorainak jelent\u0151s expresszi\u00f3j\u00e1t mutatt\u00e1k ki az alveol\u00e1ris epitheliumban \u00e9s a szubmucos\u00e1lis fibroblasztokban a fibr\u00f3zis remodellingben l\u00e9v\u0151 ter\u00fcleten. A t\u00fcd\u0151ben az SHH-kezel\u00e9s n\u00f6velte a fibroblasztok prolifer\u00e1ci\u00f3j\u00e1t, t\u00fal\u00e9l\u00e9s\u00e9t, migr\u00e1ci\u00f3j\u00e1t \u00e9s extracellul\u00e1ris m\u00e1trix (ECM) termel\u00e9s\u00e9t, de nem n\u00f6velte az \u03b1 - simaizomaktin (\u03b1 - SMA) expresszi\u00f3j\u00e1t. A bleomicinnel induk\u00e1lt PF modellben az SHH expresszi\u00f3ja emelkedett a l\u00e9g\u00fati \u00e9s alveol\u00e1ris epithelsejtekben. A bleomicin modellben a Hh jel\u00e1tvitel g\u00e1tl\u00e1sa nem akad\u00e1lyozza meg a fibr\u00f3zist, de az SHH t\u00falterjed\u00e9se a fibr\u00f3zis sor\u00e1n s\u00falyosb\u00edtja a PF-et. Ez\u00e9rt, b\u00e1r az SHH jel\u00e1tvitel kulcsfontoss\u00e1g\u00fa a norm\u00e1l t\u00fcd\u0151fejl\u0151d\u00e9shez \u00e9s az interstici\u00e1lis homeoszt\u00e1zis fenntart\u00e1s\u00e1hoz, a PF-ben kr\u00f3nikusan is aktiv\u00e1l\u00f3dik.
\nA ciklopamin (Cyc) egy szteroid alkaloid \u00e9s a Hh jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00f3ja. Az SMO t\u00e9rbeli konform\u00e1ci\u00f3j\u00e1nak megv\u00e1ltoztat\u00e1s\u00e1val g\u00e1tolja az SMO aktivit\u00e1s\u00e1t, hogy elnyomja a Hh jel\u00e1tviteli \u00fatvonal downstream jel\u00e1tvitel\u00e9t, ez\u00e1ltal a Hh \u00fatvonalat g\u00e1tolt \u00e1llapotba hozza. A Cyc g\u00e1tolhatja a tumorg\u00e9nek transzkripci\u00f3j\u00e1t \u00e9s expresszi\u00f3j\u00e1t, beavatkozhat az SHH \u00e1ltal k\u00f6zvet\u00edtett Hh jel\u00e1tviteli \u00fatvonalba, tumorellenes \u00e9s PF-ellenes hat\u00e1st fejthet ki, \u00e9s ez\u00e1ltal g\u00e1tolhatja a kapcsol\u00f3d\u00f3 betegs\u00e9gek progresszi\u00f3j\u00e1t. Kapcsol\u00f3d\u00f3 vizsg\u00e1latok kimutatt\u00e1k, hogy a Hh jel\u00e1tviteli \u00fatvonalban az SMO feh\u00e9rj\u00e9khez k\u00f6t\u0151dve \u00e9s az SMO feh\u00e9rj\u00e9k downstream jel\u00e1tvitel\u00e9t befoly\u00e1solva cs\u00f6kkenthet\u0151 az \u03b1 - SMA \u00e9s az 1-es t\u00edpus\u00fa kollag\u00e9n (Col-1) feh\u00e9rj\u00e9k expresszi\u00f3ja, ez\u00e1ltal gyeng\u00edtve vagy ak\u00e1r megakad\u00e1lyozva a nagy \u00e9rz\u00e9kenys\u00e9g\u0171 C-reakt\u00edv feh\u00e9rje ezen v\u00e1ltoz\u00e1s\u00e1t \u00e9s jav\u00edtva a port\u00e1lis hipert\u00f3ni\u00e1t. Ezenk\u00edv\u00fcl a Hh jel\u00e1tvitelt zavar\u00f3 gy\u00f3gyszerek, mint p\u00e9ld\u00e1ul a Cyc, seg\u00edthetnek megel\u0151zni az androg\u00e9nrezisztenci\u00e1t \u00e9s a betegs\u00e9g progresszi\u00f3j\u00e1t a prosztatar\u00e1kos sejtekben. A Hh jel\u00e1tviteli \u00fatvonal befoly\u00e1solja a betegs\u00e9gek el\u0151fordul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, azonban a Cyc szerepe a PF-hez kapcsol\u00f3d\u00f3 betegs\u00e9gekben m\u00e9g mindig nem vil\u00e1gos.
\nA Dracocephalum moldevica L. a Labiatae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9ny, amelyet gy\u00f3gyszerk\u00e9nt haszn\u00e1lnak az eg\u00e9sz f\u00fcves ter\u00fcleten. F\u0151 k\u00e9miai \u00f6sszetev\u0151i az ill\u00f3olaj, poliszacharid, terpenoidok, flavonoidok, aminosavak \u00e9s nyomelemek. Sz\u00e1mos farmakol\u00f3giai hat\u00e1sa van, mint p\u00e9ld\u00e1ul a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi erek v\u00e9delme, \u00e9relmeszesed\u00e9s elleni, asztmaellenes, h\u0151tiszt\u00edt\u00f3 \u00e9s m\u00e9regtelen\u00edt\u0151, a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9se \u00e9s a kollater\u00e1lisok felold\u00e1sa, antioxid\u00e1ns, a diszlipid\u00e9mia szab\u00e1lyoz\u00e1sa, valamint a sz\u00e9l- \u00e9s h\u0151tiszt\u00edt\u00e1s, a megf\u00e1z\u00e1s \u00e9s l\u00e1z, a k\u00f6h\u00f6g\u00e9s \u00e9s az asztma. A kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a Xiangqinglan \u00f6sszesen 41 flavonoidot tartalmaz, \u00e9s a Xiangqinglan gy\u00f3gyhat\u00e1sai f\u0151k\u00e9nt a flavonoidokb\u00f3l sz\u00e1rmaznak. Kor\u00e1bbi tanulm\u00e1nyok kimutatt\u00e1k, hogy a TFDM, mint a Xiangqinglan egyik f\u0151 hat\u00f3anyaga, nagyon hat\u00e9kony hat\u00e1ssal van a k\u00f6h\u00f6g\u00e9s \u00e9s az asztma enyh\u00edt\u00e9s\u00e9re. Jelent\u0151sen k\u00e9pes lelass\u00edtani a magas reaktivit\u00e1st az egerek l\u00e9g\u00fatjain bel\u00fcl, ez\u00e1ltal helyre\u00e1ll\u00edtva a t\u00fcd\u0151funkci\u00f3 k\u00e1rosod\u00e1s\u00e1t. Az interleukin-6 (IL-6), interleukin-17 (IL-17) \u00e9s tumor nekr\u00f3zis faktor - \u03b1 (TNF - \u03b1) felszabadul\u00e1sa egerekben jelent\u0151sen cs\u00f6kkentette az interleukin-4 (IL-4) \u00e9s az interferon - \u03b3 (IFN - \u03b3) ar\u00e1ny\u00e1t, ez\u00e1ltal be\u00e1ll\u00edtva a Th1\/Th2 immunrendszer egyens\u00falytalans\u00e1g\u00e1t. K\u00f6z\u00fcl\u00fck a TFDM k\u00e9pes szab\u00e1lyozni a NOD-szer\u0171 receptor termikus feh\u00e9rje dom\u00e9nhez kapcsol\u00f3d\u00f3 3. feh\u00e9rje (NL-RP3) expresszi\u00f3j\u00e1t az\u00e1ltal, hogy cs\u00f6kkenti a Col-1 tartalm\u00e1t a t\u00fcd\u0151sz\u00f6vetben, v\u00e9gs\u0151 soron el\u00e9rve a t\u00fcd\u0151fibr\u00f3zis enyh\u00edt\u00e9s\u00e9nek c\u00e9lj\u00e1t. Kor\u00e1bbi tanulm\u00e1nyok pedig kimutatt\u00e1k, hogy a Dracocephalum moldavica L. (TFDM) teljes flavonoidjai hat\u00e9konyan enyh\u00edtik a bleomicin \u00e1ltal okozott PF-t az\u00e1ltal, hogy a Hh jel\u00e1tviteli \u00fatvonalban l\u00e9v\u0151 fontos szab\u00e1lyoz\u00f3 feh\u00e9rj\u00e9ket, mint p\u00e9ld\u00e1ul az SHH, Ptch1, SMO, SUFU, Gli1, le- vagy felszab\u00e1lyozz\u00e1k. Ez\u00e9rt ez a cikk a Cyc \u00e9s a TFDM PF-re gyakorolt hat\u00e1smechanizmus\u00e1t vizsg\u00e1lja a Hh jel\u00e1tviteli \u00fatvonal alapj\u00e1n.<\/p>\n

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\nA Xiangqinglan korai szakasz\u00e1ban nagy mennyis\u00e9g\u0171 kutat\u00e1st v\u00e9geztek, \u00e9s meghat\u00e1rozt\u00e1k az optim\u00e1lis kivon\u00e1si elj\u00e1r\u00e1st. A Xiangqinglan kivonatot makropor\u00f3zus adszorpci\u00f3s gyant\u00e1val tiszt\u00edtott\u00e1k, hogy a Xiangqinglan hat\u00e9kony r\u00e9szeit megkapj\u00e1k. A Xiangqinglan hat\u00e9kony r\u00e9szeit elk\u00fcl\u00f6n\u00edtett\u00e9k \u00e9s szerkezetileg elemezt\u00e9k az azonos\u00edt\u00e1s \u00e9rdek\u00e9ben. Ezt megel\u0151z\u0151en meghat\u00e1rozt\u00e1k a Xiangqinglan hat\u00e9kony r\u00e9szeinek tartalm\u00e1t, \u00e9s a klinikai d\u00f3zis alapj\u00e1n a vonatkoz\u00f3 szakirodalom szerint \u00e1tv\u00e1ltott\u00e1k az \u00e1llatok in vivo d\u00f3zis\u00e1ra. A kor\u00e1bbi vizsg\u00e1latokban pedig a TFDM (90, 180, 360mg\/kg) kapcsol\u00f3d\u00f3 d\u00f3zisok hat\u00e1smechanizmus\u00e1t PF eg\u00e9rmodellekben a Hh jel\u00e1tviteli \u00fatvonal alapj\u00e1n vizsg\u00e1lt\u00e1k. Meg\u00e1llap\u00edtott\u00e1k, hogy a Hh jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00f3dott a PF eg\u00e9rmodellben, \u00e9s a TFDM a Hh jel\u00e1tviteli \u00fatvonal fontos szab\u00e1lyoz\u00f3 feh\u00e9rj\u00e9iben val\u00f3 beavatkoz\u00e1ssal jav\u00edthatta a PF-t, a TFDM nagy d\u00f3zisain\u00e1l (360mg\/kg) jelent\u0151sebb hat\u00e1st figyeltek meg.
\nEz\u00e9rt a kor\u00e1bbi kutat\u00e1sok alapj\u00e1n ez a cikk a Hh jel\u00e1tviteli \u00fatvonal Cyc \u00e1ltali g\u00e1tl\u00e1s\u00e1nak \u00e9s a TFDM (360mg\/kg) kapcsol\u00f3d\u00f3 hat\u00e1sainak felt\u00e1r\u00e1s\u00e1ra \u00f6sszpontos\u00edt a bleomicin induk\u00e1lta PF egerekben. PF eg\u00e9rmodellt hoztunk l\u00e9tre bleomicin intratrache\u00e1lis instill\u00e1ci\u00f3j\u00e1val. A modell l\u00e9trehoz\u00e1s\u00e1nak m\u00e1sodik napj\u00e1n az egereknek sz\u00e1jon \u00e1t adtuk be a kapcsol\u00f3d\u00f3 gy\u00f3gyszereket, mint a Cyc \u00e9s a TFDM. A Cyc \u00e9s a TFDM gy\u00f3gyszerek oldhatatlans\u00e1ga miatt 0,5% karboximetil-cellul\u00f3z-n\u00e1triumot k\u00e9sz\u00edtett\u00fcnk megfelel\u0151 szuszpenzi\u00f3k\u00e9nt, \u00e9s azt fecskendez\u00e9ssel adtuk be.
\nA PF-modell kialak\u00edt\u00e1s\u00e1nak korai szakasz\u00e1ban a beteg egerek olyan t\u00fcneteket mutattak, mint a fogy\u00e1s, \u00e9tv\u00e1gytalans\u00e1g, a sz\u0151rzet sz\u00edn\u00e9nek rendezetlens\u00e9ge \u00e9s a rossz ment\u00e1lis \u00e1llapot, valamint nagysz\u00e1m\u00fa elhal\u00e1loz\u00e1s. Ugyanakkor a HE \u00e9s Masson fest\u00e9s\u0171 t\u00fcd\u0151sz\u00f6veti patol\u00f3giai metszetek eredm\u00e9nyei alapj\u00e1n arra a k\u00f6vetkeztet\u00e9sre jutottunk, hogy a PF modell fel\u00e9p\u00edt\u00e9se sikeres volt. A folyamatos gy\u00f3gyszeres beavatkoz\u00e1st k\u00f6vet\u0151en az egerek k\u00fcl\u00f6nb\u00f6z\u0151 t\u00fcnetei jelent\u0151sen javultak a PF modell \u00e9p\u00edt\u00e9s\u00e9nek k\u00e9s\u0151bbi szakasz\u00e1ban. A t\u00fcd\u0151sz\u00f6veti patol\u00f3giai metszetek eredm\u00e9nyei azt mutatt\u00e1k, hogy a Cyc csoport \u00e9s a TFDM csoport t\u00fcd\u0151sz\u00f6veti szerkezete norm\u00e1lis volt, \u00e9s a gyullad\u00e1sos sejtek \u00e9s a fibrotikus sz\u00f6vet jelent\u0151sen cs\u00f6kkentek. Ezt k\u00f6vet\u0151en megm\u00e9rt\u00e9k a HYP-tartalmat, \u00e9s a kutat\u00e1si eredm\u00e9nyek azt mutatt\u00e1k, hogy a modellcsoportban a HYP-tartalom n\u0151tt, m\u00edg a Cyc-csoport \u00e9s a TFDM-csoport jelent\u0151sen cs\u00f6kkenteni tudta a HYP-tartalmat. A PF klinikai megnyilv\u00e1nul\u00e1sai a tart\u00f3s sz\u00e1raz k\u00f6h\u00f6g\u00e9s \u00e9s az akut l\u00e9gz\u00e9si distressz, amelyet s\u00falyosbod\u00f3 t\u00fcd\u0151k\u00e1rosod\u00e1s k\u00eds\u00e9r, ami a t\u00fcd\u0151funkci\u00f3 folyamatos cs\u00f6kken\u00e9s\u00e9hez vezet, \u00e9s v\u00e9g\u00fcl hal\u00e1lhoz vezet. A PF a t\u00fcd\u0151funkci\u00f3 cs\u00f6kken\u00e9s\u00e9t okozhatja, amelyet progressz\u00edv l\u00e9gz\u00e9si distressz jellemez, ami g\u00e1zcserezavarokhoz \u00e9s restrikt\u00edv l\u00e9legeztet\u00e9si probl\u00e9m\u00e1khoz vezet. Ez\u00e9rt ebben a vizsg\u00e1latban t\u00fcd\u0151funkci\u00f3s vizsg\u00e1latokat v\u00e9gezt\u00fcnk, \u00e9s meg\u00e1llap\u00edtottuk, hogy a Cyc csoport \u00e9s a TFDM csoport jav\u00edthatja a PF l\u00e9g\u00e1raml\u00e1skorl\u00e1toz\u00e1st \u00e9s enyh\u00edtheti a restrikt\u00edv ventil\u00e1ci\u00f3s zavarokat az RL, RE \u00e9s FEV0.1\/FVC cs\u00f6kkent\u00e9s\u00e9vel, mik\u00f6zben n\u00f6veli a Cdyn, FVC \u00e9s PEF \u00e9rt\u00e9keket, hat\u00e9konyan enyh\u00edtve a bleomicin induk\u00e1lta PF t\u00fcneteit.
\nA Hh \u00fatvonal fontos szerepet j\u00e1tszik a PF folyamat\u00e1ban, p\u00e9ld\u00e1ul az ECM szekr\u00e9ci\u00f3ban \u00e9s az anyagcser\u00e9ben, a PF szab\u00e1lyoz\u00e1s\u00e1ban. A Hh jel\u00e1tviteli \u00fatvonalat a ligandumok szekr\u00e9ci\u00f3ja ind\u00edtja el, \u00e9s a Ptch megsz\u00fcnteti az SMO-ra gyakorolt g\u00e1tl\u00f3 hat\u00e1st, ez\u00e1ltal el\u0151seg\u00edti a Gli1 transzkripci\u00f3s faktor aktiv\u00e1l\u00f3d\u00e1s\u00e1t \u00e9s nukle\u00e1ris transzlok\u00e1ci\u00f3j\u00e1t, ami a Hh c\u00e9lg\u00e9nek, p\u00e9ld\u00e1ul a Gli1 \u00e9s az SMO expresszi\u00f3j\u00e1hoz vezet. Ez\u00e9rt a jelenlegi vizsg\u00e1latban az SMO g\u00e1tl\u00f3 Cyc-t haszn\u00e1ltuk a Hh \u00fatvonal g\u00e1tl\u00e1s\u00e1ra, hogy meghat\u00e1rozzuk a TFDM szerep\u00e9t PF egerekben. Ebben a vizsg\u00e1latban olyan kapcsol\u00f3d\u00f3 feh\u00e9rj\u00e9ket mutattunk ki, mint a Col-1, \u03b1 - SMA, FN1, SHH, SMO, SUFU, Gli1 stb. A Cyc \u00e9s a TFDM g\u00e1tl\u00e1sa a Hh \u00fatvonalban g\u00e1tolhatja az ECM termel\u00e9st \u00e9s az angiogenezist, ami a kapcsol\u00f3d\u00f3 feh\u00e9rj\u00e9k, mint p\u00e9ld\u00e1ul a Col-1, \u03b1 - SMA, FN1, SHH, SMO, Gli1 leszab\u00e1lyoz\u00e1s\u00e1val \u00e9s a SUFU feh\u00e9rje felszab\u00e1lyoz\u00e1s\u00e1val \u00e9rhet\u0151 el. Ez tov\u00e1bb er\u0151s\u00edti, hogy a PF a Hh jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1hoz kapcsol\u00f3dik. Mind a Cyc csoport, mind a TFDM csoport k\u00e9pes volt a t\u00fcd\u0151sz\u00f6veti k\u00e1rosod\u00e1st helyre\u00e1ll\u00edtani, jav\u00edtani a kollag\u00e9n rosttartalmat, le- vagy felszab\u00e1lyozni a Hh jel\u00e1tviteli \u00fatvonalhoz kapcsol\u00f3d\u00f3 feh\u00e9rjetartalmat, ez\u00e1ltal enyh\u00edteni a t\u00fcd\u0151sz\u00f6veti fibr\u00f3zis progresszi\u00f3j\u00e1t. S\u0151t, a Cyc \u00e9s a TFDM kombin\u00e1ci\u00f3ja jobb hat\u00e9konys\u00e1got mutatott.
\n\u00d6sszefoglalva, ez a cikk tov\u00e1bb r\u00e9szletezi a PF el\u0151fordul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s igazolja, hogy a TFDM bizonyos ter\u00e1pi\u00e1s hat\u00e1ssal rendelkezik. A PF-hez kapcsol\u00f3d\u00f3 Hh jel\u00e1tviteli \u00fatvonal hat\u00e1smechanizmus\u00e1ba is belemer\u00fcl, j\u00f3 kutat\u00e1si alapot ny\u00fajtva a PF-hez kapcsol\u00f3d\u00f3 hat\u00e1smechanizmusok tanulm\u00e1nyoz\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"

The effect of the combination therapy of licorice cyclopamine and total flavonoids of fragrant orchid on pulmonary fibrosis mice Pulmonary fibrosis (PF) is a chronic progressive lung disease with obvious histopathological patterns, including a large number of chronic respiratory system lesions, accompanied by the growth of connective tissue in various pulmonary compartments. Among them, interstitial […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nThe effect of the combination therapy of licorice cyclopamine and total flavonoids of fragrant orchid on pulmonary fibrosis mice - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/cyclopamine\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effect of the combination therapy of licorice cyclopamine and total flavonoids of fragrant orchid on pulmonary fibrosis mice - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The effect of the combination therapy of licorice cyclopamine and total flavonoids of fragrant orchid on pulmonary fibrosis mice Pulmonary fibrosis (PF) is a chronic progressive lung disease with obvious histopathological patterns, including a large number of chronic respiratory system lesions, accompanied by the growth of connective tissue in various pulmonary compartments. 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