{"id":4704,"date":"2024-08-04T15:14:34","date_gmt":"2024-08-04T15:14:34","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4704"},"modified":"2024-08-04T15:14:34","modified_gmt":"2024-08-04T15:14:34","slug":"rose-root","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/rose-root\/","title":{"rendered":"A Rosa rugosa gy\u00f6k\u00e9rb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok immunszab\u00e1lyoz\u00f3 hat\u00e1sa a ciklofoszfamid \u00e1ltal kiv\u00e1ltott immunszuppresszi\u00f3ra egerekben"},"content":{"rendered":"

A Rosa davurica Pall. poliszacharidjainak immunmodul\u00e1l\u00f3 hat\u00e1sa a ciklofoszfamid \u00e1ltal kiv\u00e1ltott immunszuppresszi\u00f3ra egerekben. A Rosa davurica Pall. a Rosa davurica Pall. sz\u00e1r\u00edtott gy\u00f6kere, m\u00e1s n\u00e9ven Rosa davurica gy\u00f6k\u00e9r, vadr\u00f3zsa gy\u00f6k\u00e9r \u00e9s m\u00e1lnagy\u00fcm\u00f6lcs gy\u00f6k\u00e9r. A Shan Ci Mei-t sz\u00e9les k\u00f6rben termesztik \u00c9szakkelet-K\u00edn\u00e1ban, \u00e9s vir\u00e1gait, gy\u00fcm\u00f6lcseit \u00e9s gy\u00f6kereit gy\u00f3gyszerk\u00e9nt haszn\u00e1lj\u00e1k. A Rosa rugosa gy\u00f3gyn\u00f6v\u00e9nyre vonatkoz\u00f3 szabv\u00e1nyt Jilin tartom\u00e1ny gy\u00f3gyszernorm\u00e1i tartalmazz\u00e1k. Keser\u0171 \u00e9s \u00f6sszeh\u00faz\u00f3 \u00edz\u0171, enyhe term\u00e9szet\u0171, v\u00e9rz\u00e9scsillap\u00edt\u00f3 \u00e9s antibakteri\u00e1lis hat\u00e1s\u00fa. Menstru\u00e1ci\u00f3s v\u00e9rz\u00e9s, funkcion\u00e1lis m\u00e9hv\u00e9rz\u00e9s, kr\u00f3nikus h\u00f6rghurut, b\u00e9lgyullad\u00e1s, bakteri\u00e1lis v\u00e9rhas, h\u00f3lyaghurut \u00e9s vesegyullad\u00e1s kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k. A mongol orvosl\u00e1sban a t\u00fcsk\u00e9s k\u00f6rtegy\u00f6k\u00e9r mongol gy\u00f3gym\u00f3dj\u00e1nak neve \"Zherelige - Zamuer Yin Wen Du Su\". Hat\u00e9konys\u00e1ga a Xie Ri eloszlat\u00e1sa, a He Yi szab\u00e1lyoz\u00e1sa \u00e9s az \u00e9telek megem\u00e9szt\u00e9se. He Yi Xie Ri szindr\u00f3ma, Badagan Xie Ri szindr\u00f3ma, gyomor Xie Ri szindr\u00f3ma, pulzus betegs\u00e9g, k\u00f6h\u00f6g\u00e9s \u00e9s m\u00e1jm\u00e9rgez\u00e9s tiszt\u00edt\u00e1sa eset\u00e9n haszn\u00e1lj\u00e1k. A kutat\u00e1si jelent\u00e9sek szerint a Rosa rugosa gy\u00f6kere laktonokat, tanninokat, poliszacharidokat, \u00f6sszes glikozidot, flavonoidokat, fenolokat, alkaloidokat, feh\u00e9rj\u00e9ket, antrakinonokat \u00e9s egy\u00e9b \u00f6sszetev\u0151ket tartalmaz, amelyek farmakol\u00f3giai hat\u00e1sai antioxid\u00e1ns, hipoglik\u00e9mi\u00e1s, antibakteri\u00e1lis \u00e9s \u00e9rt\u00e1g\u00edt\u00f3. Han \u00e9s munkat\u00e1rsai arr\u00f3l sz\u00e1moltak be, hogy a Rosa rugosa gy\u00f6k\u00e9rb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok jav\u00edt\u00f3 hat\u00e1ssal vannak az \u00f6reged\u0151 modell egerek immunrendszer\u00e9nek m\u0171k\u00f6d\u00e9s\u00e9re, de a Rosa rugosa gy\u00f6k\u00e9rb\u0151l sz\u00e1rmaz\u00f3 poliszacharidokkal kapcsolatban kev\u00e9s kutat\u00e1s sz\u00fcletett.
\nAz ut\u00f3bbi \u00e9vekben a poliszacharidok egyre nagyobb figyelmet kaptak, mint t\u00f6bbsz\u00f6r\u00f6s biol\u00f3giai aktivit\u00e1ssal rendelkez\u0151 term\u00e9szetes term\u00e9kek. Sz\u00e1mos tanulm\u00e1ny kimutatta, hogy a poliszacharidok k\u00fcl\u00f6nb\u00f6z\u0151 aktivit\u00e1sokkal rendelkeznek, p\u00e9ld\u00e1ul immunszab\u00e1lyoz\u00f3, tumorellenes, v\u00edrusellenes, antioxid\u00e1ns \u00e9s v\u00e9rcukorszint-cs\u00f6kkent\u0151 hat\u00e1s\u00faak. A k\u00ednai n\u00f6v\u00e9nyi poliszacharidok, mint term\u00e9szetes immunmodul\u00e1torok, egy\u00e9rtelm\u0171 hat\u00e9konys\u00e1ggal \u00e9s kev\u00e9s mell\u00e9khat\u00e1ssal rendelkeznek, \u00e9s szab\u00e1lyoz\u00f3 hat\u00e1ssal vannak az immunsejtekre, az immunszervekre \u00e9s a b\u00e9l mikrobi\u00f3t\u00e1ra. K\u00edna \u00e9szakkeleti r\u00e9gi\u00f3ja b\u0151s\u00e9ges vad hegyi t\u00fcskeforr\u00e1sokkal rendelkezik, \u00e9s a gy\u00f3gy\u00e1szatban \u00e9s a funkcion\u00e1lis \u00e9lelmiszerekben v\u00e9gzett kutat\u00e1s \u00e9s fejleszt\u00e9s el\u0151seg\u00edti a helyi gazdas\u00e1gi fejl\u0151d\u00e9st. A r\u00f3zsagy\u00f6keret gyakran haszn\u00e1lj\u00e1k a gy\u00f3gy\u00e1szatban, de alkalmaz\u00e1sa a kapcsol\u00f3d\u00f3 eg\u00e9szs\u00e9g\u00fcgyi term\u00e9kekben vagy \u00e9lelmiszerekben viszonylag korl\u00e1tozott. Ez a cikk kivonja, tiszt\u00edtja \u00e9s elemzi a Rosa rugosa gy\u00f6k\u00e9rb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok szerkezet\u00e9t. Ugyanakkor \u00e9rt\u00e9keli a ciklofoszfamid (CTX) immunrendszeri funkci\u00f3ra gyakorolt szab\u00e1lyoz\u00f3 hat\u00e1s\u00e1t immunhi\u00e1nyos egerekben, \u00e9s felt\u00e1rja a hat\u00e1smechanizmus\u00e1t, k\u00eds\u00e9rleti adatokat szolg\u00e1ltatva a Rosa rugosa gy\u00f6k\u00e9r poliszacharidok j\u00f6v\u0151beli fejleszt\u00e9s\u00e9hez.<\/p>\n

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\nA n\u00f6v\u00e9nyi poliszacharidok k\u00fcl\u00f6nb\u00f6z\u0151 biol\u00f3giai aktivit\u00e1sokkal rendelkeznek, \u00e9s egyre ink\u00e1bb a term\u00e9szetes term\u00e9kek kutat\u00f3inak figyelm\u00e9t is felkeltik. A bioakt\u00edv n\u00f6v\u00e9nyi poliszacharidok fontos szerepet j\u00e1tszanak olyan ter\u00fcleteken, mint a gy\u00f3gyszerek, az \u00e9lelmiszerek, az eg\u00e9szs\u00e9g\u00fcgyi term\u00e9kek \u00e9s a z\u00f6ld term\u00e9kek. A tudom\u00e1ny \u00e9s a technol\u00f3gia folyamatos fejl\u0151d\u00e9s\u00e9vel a n\u00f6v\u00e9nyi poliszacharidok extrakci\u00f3s, tiszt\u00edt\u00e1si \u00e9s szerkezeti azonos\u00edt\u00e1si technik\u00e1i fokozatosan egyre v\u00e1ltozatosabb\u00e1 v\u00e1lnak, mint p\u00e9ld\u00e1ul a forr\u00f3 vizes extrakci\u00f3, l\u00fagos extrakci\u00f3, etanolos ferment\u00e1ci\u00f3s kicsap\u00e1s, enzimekkel t\u00e1mogatott extrakci\u00f3, mikrohull\u00e1m\u00fa extrakci\u00f3, ultrahangos extrakci\u00f3, ultrahangos enzimekkel t\u00e1mogatott extrakci\u00f3, szubkritikus vizes extrakci\u00f3, ultra-nagynyom\u00e1s\u00fa extrakci\u00f3 \u00e9s v\u00e1kuumos extrakci\u00f3. Ezeknek a m\u00f3dszereknek mind megvannak az el\u0151nyei \u00e9s h\u00e1tr\u00e1nyai, amelyek k\u00f6z\u00fcl a forr\u00f3 vizes extrakci\u00f3s m\u00f3dszer, b\u00e1r az extrakci\u00f3s sebess\u00e9g nem t\u00fal magas, a gazdas\u00e1goss\u00e1g, a nem toxicit\u00e1s, a biztons\u00e1g \u00e9s a sejtfalak k\u00e1rosod\u00e1s\u00e1nak elker\u00fcl\u00e9se az el\u0151nye, \u00e9s \u00e1ltal\u00e1ban a poliszacharidok kivon\u00e1s\u00e1ra haszn\u00e1lj\u00e1k. Ebben a tanulm\u00e1nyban a Rosa rugosa gy\u00f6kereib\u0151l a poliszacharidok kivon\u00e1s\u00e1ra a forr\u00f3 vizes extrakci\u00f3s\/etanolos kicsap\u00e1si m\u00f3dszert alkalmaztuk, a deproteiniz\u00e1l\u00e1shoz pedig k\u00e9t m\u00f3dszert haszn\u00e1ltunk. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a TCA m\u00f3dszer jelent\u0151s hat\u00e1ssal volt a deproteiniz\u00e1ci\u00f3ra, de nagyobb volt a cukorvesztes\u00e9g. Ez\u00e9rt a Sevage m\u00f3dszer alkalmasabb a Rosa rugosa gy\u00f6kerekb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok deproteiniz\u00e1l\u00e1s\u00e1ra a TCA m\u00f3dszerhez k\u00e9pest. Az etanolos kicsap\u00e1st k\u00f6vet\u0151en 60% alkoholos kicsap\u00e1ssal egy viszonylag alacsony polidiszperzit\u00e1s\u00fa RDRP poliszacharidot kaptunk, amelynek cukortartalma 94,1% volt. A n\u00f6v\u00e9nyi poliszacharidok szerkezete k\u00f6zvetlen\u00fcl befoly\u00e1solja biol\u00f3giai aktivit\u00e1sukat, \u00e9s a poliszacharidok alapszerkezete a molekulat\u00f6meg-eloszl\u00e1s, az infrav\u00f6r\u00f6s jellegzetes abszorpci\u00f3s cs\u00facsok, a monoszacharid-\u00f6sszet\u00e9tel stb. alapj\u00e1n azonos\u00edthat\u00f3. Ebben a tanulm\u00e1nyban a Rosa rugosa gy\u00f6kerekb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok molekulat\u00f6meg\u00e9nek meghat\u00e1roz\u00e1s\u00e1ra a GPC m\u00f3dszert alkalmazt\u00e1k, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy az RDRP poliszacharidok kever\u00e9ke volt, 13,1 kDa t\u00f6meg\u00e1tlag\u00fa \u00e9s alacsony molekulat\u00f6meg\u0171 (66,7 kDa) poliszacharidokkal. Az infrav\u00f6r\u00f6s detekt\u00e1l\u00e1si eredm\u00e9nyek azt mutatj\u00e1k, hogy a Rosa rugosa gy\u00f6k\u00e9rb\u0151l sz\u00e1rmaz\u00f3 poliszacharid egy semleges, alfa-konfigur\u00e1ci\u00f3t tartalmaz\u00f3 pir\u00e1n poliszacharid. A monoszacharid-\u00f6sszet\u00e9tel elemz\u00e9se azt mutatja, hogy f\u0151k\u00e9nt gl\u00fck\u00f3zb\u00f3l, arabin\u00f3zb\u00f3l, galakt\u00f3zb\u00f3l, mann\u00f3zb\u00f3l \u00e9s xil\u00f3zb\u00f3l \u00e1ll. Monoszacharidj\u00e1nak el\u00e1gaz\u00f3 l\u00e1nc\u00fa kapcsol\u00e1si m\u00f3dszere azonban tov\u00e1bbi m\u00e9lyrehat\u00f3 kutat\u00e1sokat ig\u00e9nyel.
\nAz immunrendszer immunszerveket, immunsejteket \u00e9s immunmolekul\u00e1kat foglal mag\u00e1ban, amelyek egy\u00fcttesen v\u00e9dik a szervezetet a k\u00f3rokoz\u00f3kt\u00f3l. A t\u00edmusz \u00e9s a l\u00e9p a f\u0151 immunszervek, amelyek fontos szerepet j\u00e1tszanak az immunsejtek l\u00e9trehoz\u00e1s\u00e1ban \u00e9s fenntart\u00e1s\u00e1ban. A humor\u00e1lis \u00e9s a sejtes immunit\u00e1s k\u00f6zpontjak\u00e9nt a l\u00e9p a T- \u00e9s B-limfocit\u00e1k f\u0151 megteleped\u00e9si helye, \u00edgy a l\u00e9p indexe t\u00fckr\u00f6zheti a szervezet immunit\u00e1s\u00e1nak szintj\u00e9t. A ciklofoszfamid egyfajta alkil\u00e1l\u00f3 szer, amelyet sz\u00e9les k\u00f6rben alkalmaznak a r\u00e1kkezel\u00e9sben. De nemcsak a r\u00e1kos sejtekre, hanem a gyorsan oszt\u00f3d\u00f3 sejtekre, p\u00e9ld\u00e1ul az immunsejtekre \u00e9s a h\u00e1msejtekre is k\u00fcl\u00f6nb\u00f6z\u0151 toxicit\u00e1sokkal rendelkezik, \u00e9s gyakran haszn\u00e1lj\u00e1k immunszuppressz\u00edv modellek l\u00e9trehoz\u00e1s\u00e1ra. Ebben a vizsg\u00e1latban a ciklofoszfamid intraperitone\u00e1lis bead\u00e1sa ut\u00e1n az egerek testt\u00f6mege, l\u00e9pindexe, t\u00edmusz indexe \u00e9s immunglobulin koncentr\u00e1ci\u00f3j\u00e1nak szintje szignifik\u00e1nsan alacsonyabb volt, mint a vak kontrollcsoport\u00e9 (P<0,01), ami az immunszuppressz\u00edv modell egerek sikeres elk\u00e9sz\u00edt\u00e9s\u00e9t jelzi. A Rosa rugosa gy\u00f6k\u00e9r poliszacharidokb\u00f3l sz\u00e1rmaz\u00f3 RDRP-vel val\u00f3 folyamatos beavatkoz\u00e1s ut\u00e1n 2 h\u00e9tig, a modell-kontrollcsoporthoz k\u00e9pest az RDRP csoportban l\u00e9v\u0151 egerek perif\u00e9ri\u00e1s v\u00e9r\u00e9nek leukocita-, limfocita-, trombocita-, v\u00e9rlemezke-sz\u00e1m\u00e1t, l\u00e9pindex\u00e9t \u00e9s thymus-index\u00e9t szignifik\u00e1nsan megn\u00f6velt\u00e9k (P<0,05 vagy P<0,01), ami azt jelzi, hogy az immunszupprim\u00e1lt egerek immunszerveinek fejl\u0151d\u00e9s\u00e9t el\u0151seg\u00edtheti. A thymus \u00e9s a l\u00e9p patol\u00f3giai v\u00e1ltoz\u00e1sait biol\u00f3giai optikai mikroszk\u00f3p alatt figyelt\u00e9k meg, \u00e9s az eredm\u00e9nyek azt mutatt\u00e1k, hogy a Rosa rugosa poliszacharidok RDRP-csoportja jav\u00edtotta az egerek l\u00e9p\u00e9nek \u00e9s thymus\u00e1nak patol\u00f3giai v\u00e1ltoz\u00e1sait, ami azt jelzi, hogy fokozhatja az immunszervek immunfunkci\u00f3j\u00e1t. Az ELISA kimutat\u00e1s azt mutatta, hogy az IgA, IgG \u00e9s IgM immunglobulinok szintje a Rosa rugosa gy\u00f6k\u00e9r poliszacharidok RDRP csoportj\u00e1ban \u00e9s a shiitake gomba poliszacharidok csoportj\u00e1ban jelent\u0151sen megemelkedett (P<0,01), ami azt jelzi, hogy a Rosa rugosa gy\u00f6k\u00e9r poliszacharidok seg\u00edtenek a szervezet immunfunkci\u00f3j\u00e1nak fokoz\u00e1s\u00e1ban. Ezenk\u00edv\u00fcl a n\u00f6v\u00e9nyi poliszacharidok aktiv\u00e1lhatj\u00e1k a T-limfocit\u00e1kat, B-limfocit\u00e1kat, makrof\u00e1gokat stb., el\u0151seg\u00edthetik a kapcsol\u00f3d\u00f3 citokineket, \u00e9s jav\u00edthatj\u00e1k a szervezet immunfunkci\u00f3j\u00e1t. Ebben a vizsg\u00e1latban mind a Rosa rugosa gy\u00f6k\u00e9r poliszacharidok RDRP adagol\u00e1si csoportja, mind a shiitake gomba poliszacharidok csoportja jelent\u0151sen felszab\u00e1lyozta az IL-2, IFN - \u03b3, TNF - \u03b1 \u00e9s IL-6 szintj\u00e9t az immunhi\u00e1nyos egerek sz\u00e9rum\u00e1ban (P<0.01), ami azt jelzi, hogy a Rosa rugosa gy\u00f6k\u00e9r poliszacharidok szab\u00e1lyozhatj\u00e1k az immunfunkci\u00f3t \u00e9s enyh\u00edthetik a ciklofoszfamid \u00e1ltal kiv\u00e1ltott immunszupresszi\u00f3t az\u00e1ltal, hogy felszab\u00e1lyozz\u00e1k a citokinek szintj\u00e9t az immunhi\u00e1nyos egerek sz\u00e9rum\u00e1ban.
\nJelenleg a poliszacharidok immunmodul\u00e1l\u00f3 mechanizmus\u00e1nak tanulm\u00e1nyoz\u00e1sa is figyelmet kapott. K\u00f6z\u00fcl\u00fck a TLR, az NF - \u03ba B downstream \u00fatvonal\u00e1r\u00f3l sz\u00e1moltak be a legt\u00f6bbet. Ebben a vizsg\u00e1latban Western blotot haszn\u00e1ltunk a TLR4, MyD88, TRAF-6 \u00e9s NF - \u03ba B p65 feh\u00e9rj\u00e9k expresszi\u00f3s szintj\u00e9nek m\u00e9r\u00e9s\u00e9re minden csoportban. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a modellcsoporthoz k\u00e9pest a Rosa rugosa gy\u00f6k\u00e9rb\u0151l sz\u00e1rmaz\u00f3 RDRP magas d\u00f3zis\u00fa csoportj\u00e1ban a TLR4, MyD88 \u00e9s TRAF-6 feh\u00e9rj\u00e9k szignifik\u00e1nsan megn\u00f6vekedtek (P<0,01), az NF - \u03ba B p65 feh\u00e9rje pedig a Rosa rugosa gy\u00f6k\u00e9rb\u0151l sz\u00e1rmaz\u00f3 RDRP minden d\u00f3ziscsoportj\u00e1ban emelked\u0151 tendenci\u00e1t mutatott. Ez az eredm\u00e9ny arra utal, hogy a Rosa rugosa gy\u00f6k\u00e9rb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok aktiv\u00e1lhatj\u00e1k a TLR4 receptorokat, amelyek viszont aktiv\u00e1lj\u00e1k a MyD88-t (myeloid differenci\u00e1l\u00f3d\u00e1si faktor 88), hogy kapcsol\u00f3djon az IRAK-hoz (IL receptorhoz kapcsol\u00f3d\u00f3 kin\u00e1z) a TRAF-6 (TNF receptorhoz kapcsol\u00f3d\u00f3 faktor 6) \u00e9s az I \u03ba B kin\u00e1z komplex deaktiv\u00e1l\u00e1sa \u00e9rdek\u00e9ben, az NF - \u03ba B g\u00e1tolja az I \u03ba B feh\u00e9rje kin\u00e1z foszforil\u00e1ci\u00f3j\u00e1t, n\u00f6veli az olyan citokinek, mint a TNF - \u03b1 \u00e9s az IL-6 szekr\u00e9ci\u00f3j\u00e1t, \u00e9s \u00edgy immunmodul\u00e1l\u00f3 hat\u00e1st fejt ki.
\n\u00d6sszefoglalva, a Rosa rugosa poliszacharidok, amelyek f\u0151k\u00e9nt 13,1 kDa t\u00f6meg\u00e1tlag\u00fa poliszacharidokb\u00f3l \u00e1llnak, n\u00f6velhetik az immunszervek index\u00e9t \u00e9s a perif\u00e9ri\u00e1s v\u00e9r feh\u00e9rv\u00e9rsejtjeinek, limfocit\u00e1inak \u00e9s v\u00e9rlemezk\u00e9inek sz\u00e1m\u00e1t, jav\u00edthatj\u00e1k az immunszervek k\u00f3ros elv\u00e1ltoz\u00e1sait, felszab\u00e1lyozhatj\u00e1k az immunrendszerrel kapcsolatos feh\u00e9rj\u00e9k \u00e9s citokinek expresszi\u00f3s szintj\u00e9t, enyh\u00edthetik a CTX \u00e1ltal okozott immunhi\u00e1nyt, \u00e9s bizonyos immunszab\u00e1lyoz\u00f3 aktivit\u00e1st mutathatnak. Hat\u00e1smechanizmusa a TLR\/NF - \u03ba B csatorn\u00e1khoz kapcsol\u00f3dik. E tanulm\u00e1ny eredm\u00e9nyei \u00e9rt\u00e9kes k\u00eds\u00e9rleti bizony\u00edt\u00e9kokkal szolg\u00e1lnak a Rosa rugosa gy\u00f6kerekb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok fejleszt\u00e9s\u00e9hez \u00e9s alkalmaz\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"

The immunomodulatory effect of polysaccharides from Rosa davurica Pall. on cyclophosphamide induced immunosuppression in mice. Rosa davurica Pall. is the dried root of Rosa davurica Pall., also known as Rosa davurica root, wild rose root, and raspberry fruit root. Shan Ci Mei is widely grown in Northeast China, and its flowers, fruits, and roots are […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nImmune regulatory effects of polysaccharides from Rosa rugosa root on cyclophosphamide induced immunosuppression in mice - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/rose-root\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immune regulatory effects of polysaccharides from Rosa rugosa root on cyclophosphamide induced immunosuppression in mice - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The immunomodulatory effect of polysaccharides from Rosa davurica Pall. on cyclophosphamide induced immunosuppression in mice. 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