{"id":4663,"date":"2024-08-04T15:08:10","date_gmt":"2024-08-04T15:08:10","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4663"},"modified":"2024-08-04T15:08:10","modified_gmt":"2024-08-04T15:08:10","slug":"ombu","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/ombu\/","title":{"rendered":"Tanulm\u00e1ny a tibeti gy\u00f3gyszer, a Weng Bu hat\u00e1smechanizmus\u00e1r\u00f3l a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1sban"},"content":{"rendered":"<p>Tanulm\u00e1ny a tibeti gy\u00f3gyszer, a Weng Bu hat\u00e1smechanizmus\u00e1r\u00f3l a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1sban<br \/>\nA wengbu egy hagyom\u00e1nyos tibeti gy\u00f3gyszer, amely a Myricaria, Tamaricaceae k\u00fcl\u00f6nb\u00f6z\u0151 n\u00f6v\u00e9nyeinek zsenge leveleib\u0151l sz\u00e1rmazik, \u00e9s sz\u00e9les k\u00f6rben elterjedt Xizangban, Qinghaiban, Yunnanban \u00e9s m\u00e1s helyeken. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a Wenbu f\u0151 k\u00e9miai \u00f6sszetev\u0151i flavonoidok \u00e9s polifenolos vegy\u00fcletek. Gy\u00f3gy\u00e1szati r\u00e9szei zsenge \u00e1gak, z\u00f6ld sz\u00edn\u0171ek, lapos jelleg\u0171ek \u00e9s enyh\u00e9n keserny\u00e9s \u00edz\u0171ek. A s\u00e1rga v\u00edz betegs\u00e9g, a bels\u0151 \u00fcregek m\u00e9rgez\u0151 h\u0151s\u00e9g\u00e9nek \u00e9s a sz\u00e9tsz\u00f3rt ki\u00fct\u00e9sek kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k. Olyan betegs\u00e9gekn\u00e9l is alkalmazz\u00e1k, mint a pestis, a v\u00e9rh\u0151s\u00e9g, a m\u00e9rgez\u0151 h\u0151 szindr\u00f3ma, a kanyar\u00f3s \u00e1tl\u00e1tszatlans\u00e1g \u00e9s a torokf\u00e1j\u00e1s. A \"kr\u00f3nikus hasmen\u00e9s\" alapvet\u0151 patogenezise a l\u00e9phi\u00e1ny, a nedves h\u0151 \u00e9s a qi \u00e9s a v\u00e9r k\u00f6z\u00f6tti diszharm\u00f3nia felhalmoz\u00f3d\u00e1sa, m\u00edg a \"v\u00e9rh\u0151\" fontos patog\u00e9n t\u00e9nyez\u0151 a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s akt\u00edv szakasz\u00e1ban. A modern farmakol\u00f3giai kutat\u00e1sok kimutatt\u00e1k, hogy az Onbu antibakteri\u00e1lis, gyullad\u00e1scs\u00f6kkent\u0151, f\u00e1jdalomcsillap\u00edt\u00f3, reumaellenes, f\u00e1radts\u00e1g elleni \u00e9s antioxid\u00e1ns hat\u00e1ssal is rendelkezik.<br \/>\nA fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s (UC) a vastagb\u00e9l kr\u00f3nikus gyullad\u00e1sos betegs\u00e9ge, amelynek etiol\u00f3gi\u00e1ja tiszt\u00e1zatlan. Az elv\u00e1ltoz\u00e1sok a vastagb\u00e9l ny\u00e1lkah\u00e1rty\u00e1j\u00e1ra \u00e9s szubmuk\u00f3z\u00e1j\u00e1ra korl\u00e1toz\u00f3dnak, \u00e9s a f\u0151 t\u00fcnetek a hasi f\u00e1jdalom, hasmen\u00e9s, ny\u00e1lk\u00e1s, gennyes, v\u00e9res sz\u00e9klet stb. Az \u00e1llapot hajlamos a ki\u00fajul\u00e1sra \u00e9s nehezen gy\u00f3gy\u00edthat\u00f3. Az UC kezel\u00e9s\u00e9nek f\u0151 eszk\u00f6zei jelenleg az immunszuppressz\u00e1nsok, a kortikoszteroidok \u00e9s a n\u00e1trium-aminoszalicil\u00e1t k\u00e9sz\u00edtm\u00e9nyek, amelyeknek jelent\u0151s r\u00f6vid t\u00e1v\u00fa kezel\u00e9si hat\u00e1suk van, de vannak probl\u00e9m\u00e1k, mint p\u00e9ld\u00e1ul a nagym\u00e9rt\u00e9k\u0171 mell\u00e9khat\u00e1sok \u00e9s a fenntarthatatlans\u00e1g. M\u00e9g nem vil\u00e1gos, hogy az Onbu ter\u00e1pi\u00e1s hat\u00e1ssal van-e az UC-re. Ennek a tanulm\u00e1nynak a c\u00e9lja, hogy az UHPLC-Q-Exactive-Orbitrap-MS technol\u00f3gi\u00e1val, h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1val, molekul\u00e1ris dokkol\u00e1ssal \u00e9s \u00e1llatk\u00eds\u00e9rletekkel felt\u00e1rja az Ongbu tibeti gy\u00f3gyszer hat\u00e1s\u00e1t \u00e9s mechanizmus\u00e1t az UC kezel\u00e9s\u00e9ben, referenci\u00e1t ny\u00fajtva az Ongbu racion\u00e1lis fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4666\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\" alt=\"\" width=\"455\" height=\"199\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4667\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-70.png\" alt=\"\" width=\"816\" height=\"791\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-70.png 816w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-70-768x744.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-70-743x720.png 743w\" sizes=\"(max-width: 816px) 100vw, 816px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4668\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-66.png\" alt=\"\" width=\"809\" height=\"630\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-66.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-66-768x598.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4669\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-55.png\" alt=\"\" width=\"809\" height=\"256\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-55.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-55-768x243.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4670\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-54.png\" alt=\"\" width=\"807\" height=\"312\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-54.png 807w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-54-768x297.png 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4671\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-50.png\" alt=\"\" width=\"807\" height=\"330\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-50.png 807w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-50-768x314.png 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4672\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-47.png\" alt=\"\" width=\"807\" height=\"389\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-47.png 807w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-47-768x370.png 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4673\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-42.png\" alt=\"\" width=\"807\" height=\"420\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-42.png 807w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-42-768x400.png 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4674\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-36.png\" alt=\"\" width=\"809\" height=\"495\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-36.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-36-768x470.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4675\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-32.png\" alt=\"\" width=\"806\" height=\"264\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-32.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-32-768x252.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4676\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-1.jpg\" alt=\"\" width=\"810\" height=\"372\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-1.jpg 810w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-1-768x353.jpg 768w\" sizes=\"(max-width: 810px) 100vw, 810px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4677\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-25.png\" alt=\"\" width=\"809\" height=\"294\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-25.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-25-768x279.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4678\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-21.png\" alt=\"\" width=\"809\" height=\"315\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-21.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-21-768x299.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4679\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-18.png\" alt=\"\" width=\"806\" height=\"214\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-18.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-18-768x204.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/>Ez a tanulm\u00e1ny az UHPLC-Q-Exactive-Orbitrap-MS technol\u00f3gi\u00e1t haszn\u00e1lta a Wenbu 171 komponens\u00e9nek elemz\u00e9s\u00e9re, \u00e9s a TCMSP platformon kereszt\u00fcl 23 akt\u00edv Wenbu-komponenst sz\u0171rte. A \"Weng Bu Active Ingredient UC\" h\u00e1l\u00f3zati diagram szerint a legt\u00f6bb egyez\u00e9st mutat\u00f3 5 komponens a piretroid, a demetil\u00e1lt piretroid, a rein, az izorhamnetin \u00e9s a csersav. He et al. kutat\u00e1sai azt mutatj\u00e1k, hogy a csersavnak farmakol\u00f3giai hat\u00e1sai vannak, p\u00e9ld\u00e1ul antioxid\u00e1ns \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 tulajdons\u00e1gai. Zheng \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a csersav jelent\u0151sen cs\u00f6kkenti a TNF - \u03b1, IL-1 \u03b2 \u00e9s NO felszabadul\u00e1s\u00e1t az\u00e1ltal, hogy g\u00e1tolja az olyan \u00fatvonalakat, mint a MAPK\/I \u03ba B - \u03b1\/NF - \u03ba B\/COX, ez\u00e1ltal jav\u00edtva az UC-t. A Rhein tumorellenes, antibakteri\u00e1lis \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00fa, \u00e9s vizsg\u00e1latok kimutatt\u00e1k, hogy a c\u00e9lfeh\u00e9rj\u00e9k, p\u00e9ld\u00e1ul a JAK2 g\u00e1tl\u00e1s\u00e1val g\u00e1tolja a gyullad\u00e1sos jelek tov\u00e1bb\u00edt\u00e1s\u00e1t, cs\u00f6kkenti a gyullad\u00e1sos faktorok felszabadul\u00e1s\u00e1t, \u00e9s enyh\u00edti a k\u00f3ros immunfunkci\u00f3 okozta gyullad\u00e1sos v\u00e1laszt az UC-ben. Az izorhamnetin (ISO) egy term\u00e9szetes kis molekul\u00e1j\u00fa flavonoid vegy\u00fclet, amely sz\u00e9les k\u00f6rben jelen van k\u00fcl\u00f6nb\u00f6z\u0151 n\u00f6v\u00e9nyekben, \u00e9s sz\u00e1mos biol\u00f3giai funkci\u00f3val rendelkezik, p\u00e9ld\u00e1ul gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s v\u00edrusellenes hat\u00e1ssal. Az ISO gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s ter\u00e1pi\u00e1s hat\u00e1st gyakorolhat a gyullad\u00e1sos b\u00e9lgyullad\u00e1sra az MPO aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val, a pro-inflammatorikus medi\u00e1torok (TNF - \u03b1, IL-2, IL-6) felszabadul\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val \u00e9s az NF - \u03ba B jel\u00e1tviteli \u00fatvonal leszab\u00e1lyoz\u00e1s\u00e1val. A Scutellaria-lakton k\u00e9pes g\u00e1tolni az NLRP3 inflammasz\u00f3ma aktiv\u00e1l\u00f3d\u00e1s\u00e1t \u00e9s a sejtek piropt\u00f3zis\u00e1t, ez\u00e1ltal in vivo gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st fejt ki.<br \/>\nA h\u00e1l\u00f3zati farmakol\u00f3giai technol\u00f3giai sz\u0171r\u00e9s sor\u00e1n 285 Onbu c\u00e9lpontot azonos\u00edtottak, k\u00f6zt\u00fck 2415 c\u00e9lpontot a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s betegs\u00e9ggel kapcsolatban. A keresztez\u00e9s ut\u00e1n 111 potenci\u00e1lis c\u00e9lpontot kaptunk a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s kezel\u00e9s\u00e9re. Az \"Onbu Active Ingredient UC\" h\u00e1l\u00f3zat fel\u00e9p\u00edt\u00e9s\u00e9vel felt\u00e1rt\u00e1k az Onbu molekul\u00e1ris mechanizmus\u00e1t a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s kezel\u00e9s\u00e9ben; Az Onbu kulcsfontoss\u00e1g\u00fa c\u00e9lpontjainak el\u0151rejelz\u00e9s\u00e9vel a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s kezel\u00e9s\u00e9ben a feh\u00e9rje k\u00f6lcs\u00f6nhat\u00e1si h\u00e1l\u00f3zatokon kereszt\u00fcl a PPI h\u00e1l\u00f3zatelemz\u00e9s kimutatta, hogy az Onbu ter\u00e1pi\u00e1s hat\u00e1st gyakorolhat a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1sra olyan c\u00e9lfeh\u00e9rj\u00e9k szab\u00e1lyoz\u00e1s\u00e1val, mint a TNF, CASP3, EGFR, PTGS2 \u00e9s HSP90AA1. Ezek a g\u00e9nek k\u00f6zvetlen\u00fcl vagy k\u00f6zvetve olyan folyamatokban vesznek r\u00e9szt, mint a sejtgyullad\u00e1s, az apopt\u00f3zis \u00e9s az oxidat\u00edv stressz. A TNF - \u03b1 a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s kezel\u00e9s\u00e9nek kulcsfontoss\u00e1g\u00fa c\u00e9lpontja. Vizsg\u00e1latok kimutatt\u00e1k, hogy a TNF - \u03b1 szintje emelkedett a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1sban szenved\u0151 betegek sz\u00e9kletmint\u00e1iban \u00e9s vastagb\u00e9lny\u00e1lkah\u00e1rtya-biopszi\u00e1s mint\u00e1iban. A TNF - \u03b1 elleni monoklon\u00e1lis antitestek biol\u00f3giai aktivit\u00e1suk blokkol\u00e1s\u00e1val gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st \u00e9rhetnek el. Az anti TNF - \u03b1 monoklon\u00e1lis antitestek j\u00f3 ter\u00e1pi\u00e1s hat\u00e1ssal rendelkeznek a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s kezel\u00e9s\u00e9ben. A kaszp\u00e1zok r\u00e9szt vesznek a sejt apopt\u00f3zisban, \u00e9s a kaszp\u00e1z 3 (CASP3) fontos szerepet j\u00e1tszik a sejt apopt\u00f3zis folyamat\u00e1ban. A fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s el\u0151fordul\u00e1sa szorosan \u00f6sszef\u00fcgg a sejt apopt\u00f3zissal. \u00c1llatk\u00eds\u00e9rletek kimutatt\u00e1k, hogy a CASP3-tartalom a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s modellcsoportj\u00e1nak b\u00e9lny\u00e1lkah\u00e1rty\u00e1j\u00e1ban jelent\u0151sen megn\u00f6vekedett, \u00e9s a hat\u00e9kony gy\u00f3gyszeres kezel\u00e9s ut\u00e1n az expresszi\u00f3s szintje lecs\u00f6kkent, \u00e9s a vastagb\u00e9lsejtek apopt\u00f3zis\u00e1nak ar\u00e1nya jelent\u0151sen cs\u00f6kken. A prosztaciklin-endoperoxid-szint\u00e1z (PTGS2) feh\u00e9rje t\u00f6bb gyullad\u00e1sos jel\u00e1tviteli \u00fatvonalban is r\u00e9szt vesz, \u00e9s ennek a feh\u00e9rj\u00e9nek a g\u00e1tl\u00e1sa cs\u00f6kkentheti a gyullad\u00e1sos medi\u00e1torok termel\u00e9s\u00e9t. Az EGFR jel\u00e1tviteli \u00fatvonal, mint kulcsfontoss\u00e1g\u00fa jel\u00e1tviteli \u00fatvonal az emberi szervezetben, k\u00f6zvet\u00edti a sejtek apopt\u00f3zis\u00e1t \u00e9s prolifer\u00e1ci\u00f3j\u00e1t, \u00e9s \u00f6sszef\u00fcgg a vastagb\u00e9l ny\u00e1lkah\u00e1rtya-k\u00e1rosod\u00e1s\u00e1nak el\u0151fordul\u00e1s\u00e1val. Ez\u00e9rt az EGFR jel\u00e1tviteli \u00fatvonalba val\u00f3 beavatkoz\u00e1s lehet\u0151s\u00e9get ny\u00fajt az UC kezel\u00e9s\u00e9re. Vannak tanulm\u00e1nyok, amelyek azt mutatj\u00e1k, hogy a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s b\u00e9lny\u00e1lkah\u00e1rty\u00e1j\u00e1nak k\u00e1rosod\u00e1sa befoly\u00e1solhatja az EGFR expresszi\u00f3j\u00e1t, ez\u00e1ltal cs\u00f6kkentve a vastagb\u00e9lny\u00e1lkah\u00e1rty\u00e1ra gyakorolt v\u00e9d\u0151 \u00e9s reparat\u00edv hat\u00e1s\u00e1t, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy az EGFR szintje szoros \u00f6sszef\u00fcgg\u00e9sben \u00e1ll az UC ki\u00fajul\u00e1s\u00e1val. A HSP90AA1 szorosan kapcsol\u00f3dik a gyullad\u00e1shoz, \u00e9s szab\u00e1lyozhatja a sejtprolifer\u00e1ci\u00f3t \u00e9s az apopt\u00f3zist. A HSP90AA1 g\u00e1tl\u00e1sa autof\u00e1gi\u00e1t induk\u00e1lhat \u00e9s jav\u00edthatja a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1st.<br \/>\nFelt\u00e9telezhet\u0151, hogy a Weng Bu ter\u00e1pi\u00e1s hat\u00e1st gyakorolhat az UC-re a fent eml\u00edtett \u00f6t c\u00e9lfeh\u00e9rje gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns \u00e9s a sejt apopt\u00f3zis\u00e1nak cs\u00f6kkent\u00e9s\u00e9re ir\u00e1nyul\u00f3 szab\u00e1lyoz\u00e1s\u00e1val. A molekul\u00e1ris dokkol\u00e1si eredm\u00e9nyek azt is kimutatt\u00e1k, hogy a Weng Bu j\u00f3 k\u00f6t\u0151d\u00e9si aktivit\u00e1ssal rendelkezik a fent eml\u00edtett \u00f6t k\u00f6zponti g\u00e9nnel.<br \/>\nA KEGG-eredm\u00e9nyek azt mutatt\u00e1k, hogy a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s Onbu kezel\u00e9s\u00e9nek f\u0151 \u00fatvonalai k\u00f6z\u00e9 tartoznak a cellul\u00e1ris immunol\u00f3giai kutat\u00e1s alapvet\u0151 \u00fatvonalai, mint p\u00e9ld\u00e1ul a T-sejt receptor jel\u00e1tviteli \u00fatvonal, a MAPK jel\u00e1tviteli \u00fatvonal \u00e9s a TNF - \u03b1 jel\u00e1tviteli \u00fatvonal. Az IL-6, a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin-1 b\u00e9ta h\u00e1rom gyakori gyullad\u00e1sos faktor a gyullad\u00e1sos v\u00e1laszban. A TNF - \u03b1 \u00e9s az IL-1 \u03b2 fontos pro-inflammatorikus faktorok az akut UC korai szakasz\u00e1ban. A pro-inflammatorikus faktorok T-sejt apopt\u00f3zisra gyakorolt g\u00e1tl\u00f3 hat\u00e1sa tart\u00f3san pro-inflammatorikus szerepet j\u00e1tszik, ez\u00e1ltal r\u00e9szt vesz az UC kialakul\u00e1s\u00e1ban \u00e9s fejl\u0151d\u00e9s\u00e9ben. Vannak tanulm\u00e1nyok, amelyek azt mutatj\u00e1k, hogy a t\u00fcd\u0151 \u00e9s a b\u00e9lsz\u00f6vetek k\u00f3ros k\u00e1rosod\u00e1sa a TNF - \u03b1\/NF - \u03ba B jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl jav\u00edthat\u00f3, el\u00e9rve a t\u00fcd\u0151 \u00e9s a b\u00e9l egy\u00fcttes kezel\u00e9s\u00e9nek hat\u00e1s\u00e1t. A mitog\u00e9n aktiv\u00e1lt protein kin\u00e1z jel\u00e1tviteli \u00fatvonal mag\u00e1ban foglalja az ERK \u00e9s a p38 MAPK jel\u00e1tviteli \u00fatvonalakat, amelyek r\u00e9szt vehetnek k\u00fcl\u00f6nb\u00f6z\u0151 fiziol\u00f3giai \u00e9s patol\u00f3giai folyamatok szab\u00e1lyoz\u00e1s\u00e1ban, mint p\u00e9ld\u00e1ul a gyullad\u00e1s, az oxidat\u00edv stressz, a sejtdifferenci\u00e1l\u00f3d\u00e1s \u00e9s az apopt\u00f3zis. A MAPK jel\u00e1tvitel-\u00e1tvitel szorosan kapcsol\u00f3dik az UC gyullad\u00e1sos v\u00e1lasz\u00e1hoz.<br \/>\nA TNF - \u03b1 az els\u0151 citokin, amely a szervezetben k\u00e1ros ingerek hat\u00e1s\u00e1ra felszabadul, \u00e9s az IL-1 \u03b2-t a TNF - \u03b1 induk\u00e1lhatja. Az IL-1 \u03b2 n\u00f6veked\u00e9se szinergikusan serkentheti az IL-6 termel\u00e9s\u00e9t a TNF - \u03b1-val egy\u00fctt. Ez\u00e9rt ez a tanulm\u00e1ny h\u00e1l\u00f3zati farmakol\u00f3giai \u00e9s molekul\u00e1ris dokkol\u00e1si technik\u00e1kat haszn\u00e1lt, hogy megj\u00f3solja az Onbu potenci\u00e1lis ter\u00e1pi\u00e1s c\u00e9lpontjait \u00e9s jel\u00e1tviteli \u00fatvonalait a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1sban. A farmakol\u00f3giai \u00e9rt\u00e9kel\u00e9shez a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s eg\u00e9rmodellj\u00e9t a DSS szabad fogyaszt\u00e1s\u00e1val replik\u00e1lt\u00e1k. Az Onbu k\u00e9pes jav\u00edtani a vastagb\u00e9l hossz\u00e1t \u00e9s a vastagb\u00e9l ny\u00e1lkah\u00e1rtya k\u00e1rosod\u00e1s\u00e1t, amelyet a DSS induk\u00e1lt UC egerekben, cs\u00f6kkenti a TNF - \u03b1 \u00e9s az IL-6 szintj\u00e9t a vastagb\u00e9lben \u00e9s a sz\u00e9rumban, \u00e9s enyh\u00edti a fek\u00e9lyes vastagb\u00e9l gyullad\u00e1sos v\u00e1lasz\u00e1t.<br \/>\n\u00d6sszefoglalva, ez a tanulm\u00e1ny szisztematikusan elemezte az Onbu hat\u00e1smechanizmus\u00e1t az UC kezel\u00e9s\u00e9ben h\u00e1l\u00f3zati farmakol\u00f3giai m\u00f3dszerekkel, \u00e9s el\u0151zetesen valid\u00e1lta a c\u00e9lpontj\u00e1t molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1val. Ugyanakkor az Onbu hat\u00e9konys\u00e1g\u00e1t az UC kezel\u00e9s\u00e9ben in vivo k\u00eds\u00e9rletekkel tesztelt\u00fck C57BL-6 egereken. Az el\u0151zetes kutat\u00e1si eredm\u00e9nyek azt mutatj\u00e1k, hogy az Onbu k\u00e9pes az UC kezel\u00e9s\u00e9re a \"multi-target, multi pathway\" ter\u00e1pia r\u00e9v\u00e9n, \u00e9s enyh\u00edti a DSS \u00e1ltal kiv\u00e1ltott gyullad\u00e1sos v\u00e1laszt, de a mechanizmusa m\u00e9g mindig nem vil\u00e1gos. Tov\u00e1bbi kutat\u00e1sokat fognak v\u00e9gezni rajta annak \u00e9rdek\u00e9ben, hogy referenci\u00e1t szolg\u00e1ltassanak az Onbu hat\u00e1smechanizmus\u00e1r\u00f3l a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s kezel\u00e9s\u00e9ben.<\/p>","protected":false},"excerpt":{"rendered":"<p>Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis Wengbu is a traditional Tibetan medicine, which originates from the tender leaves of various plants of Myricaria, Tamaricaceae, and is widely distributed in Xizang, Qinghai, Yunnan and other places. Modern research has shown that the main chemical components of Wenbu are [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/ombu\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis Wengbu is a traditional Tibetan medicine, which originates from the tender leaves of various plants of Myricaria, Tamaricaceae, and is widely distributed in Xizang, Qinghai, Yunnan and other places. Modern research has shown that the main chemical components of Wenbu are [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/hu\/ombu\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T15:08:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Szerz\u0151:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Becs\u00fclt olvas\u00e1si id\u0151\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 perc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/ombu\/\",\"url\":\"https:\/\/longchangextracts.com\/ombu\/\",\"name\":\"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\",\"datePublished\":\"2024-08-04T15:08:10+00:00\",\"dateModified\":\"2024-08-04T15:08:10+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#breadcrumb\"},\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/ombu\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"hu\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tanulm\u00e1ny a hat\u00e1smechanizmus a tibeti gy\u00f3gyszer Weng Bu a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s - K\u00edna Chemical Manufacturer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/hu\/ombu\/","og_locale":"hu_HU","og_type":"article","og_title":"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis - China Chemical Manufacturer","og_description":"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis Wengbu is a traditional Tibetan medicine, which originates from the tender leaves of various plants of Myricaria, Tamaricaceae, and is widely distributed in Xizang, Qinghai, Yunnan and other places. Modern research has shown that the main chemical components of Wenbu are [&hellip;]","og_url":"https:\/\/longchangextracts.com\/hu\/ombu\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T15:08:10+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Szerz\u0151:":"longcha9","Becs\u00fclt olvas\u00e1si id\u0151":"9 perc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/ombu\/","url":"https:\/\/longchangextracts.com\/ombu\/","name":"Tanulm\u00e1ny a hat\u00e1smechanizmus a tibeti gy\u00f3gyszer Weng Bu a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s - K\u00edna Chemical Manufacturer","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/ombu\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/ombu\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png","datePublished":"2024-08-04T15:08:10+00:00","dateModified":"2024-08-04T15:08:10+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/ombu\/#breadcrumb"},"inLanguage":"hu","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/ombu\/"]}]},{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/ombu\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/ombu\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"K\u00edna Vegyi Gy\u00e1rt\u00f3","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4663"}],"collection":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/comments?post=4663"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4663\/revisions"}],"predecessor-version":[{"id":4682,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/4663\/revisions\/4682"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/media?parent=4663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/categories?post=4663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/tags?post=4663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}