{"id":4588,"date":"2024-08-04T14:55:47","date_gmt":"2024-08-04T14:55:47","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4588"},"modified":"2024-08-04T14:55:47","modified_gmt":"2024-08-04T14:55:47","slug":"bairui-granules","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/bairui-granules\/","title":{"rendered":"A Bai Rui granul\u00e1tum v\u00e9rkomponenseinek vizsg\u00e1lata az UHPLC-Q-TOF-MS\/MS technol\u00f3gi\u00e1n alapul\u00f3 UHPLC-Q-TOF-MS\/MS technol\u00f3gia alapj\u00e1n"},"content":{"rendered":"

A Bai Rui granul\u00e1tum v\u00e9rkomponenseinek vizsg\u00e1lata az UHPLC-Q-TOF-MS\/MS technol\u00f3gi\u00e1n alapul\u00f3 UHPLC-Q-TOF-MS\/MS technol\u00f3gia alapj\u00e1n<\/p>\n

A Bai Rui granul\u00e1tum v\u00e9rkomponenseinek vizsg\u00e1lata az UHPLC-Q-TOF-MS\/MS technol\u00f3gi\u00e1n alapul\u00f3 UHPLC-Q-TOF-MS\/MS technol\u00f3gia alapj\u00e1n
\nA Bairui granul\u00e1tum egy szemcs\u00e9s k\u00e9sz\u00edtm\u00e9ny, amely egyetlen gy\u00f3gyn\u00f6v\u00e9nyb\u0151l, a Bairui f\u0171b\u0151l \u00e1ll, amely antibakteri\u00e1lis \u00e9s gyullad\u00e1scs\u00f6kkent\u0151, h\u0151tiszt\u00edt\u00f3 \u00e9s m\u00e9regtelen\u00edt\u0151, valamint k\u00f6h\u00f6g\u00e9scsillap\u00edt\u00f3 hat\u00e1s\u00fa. A modern klinikai gyakorlatban gyakran haszn\u00e1lj\u00e1k gyermekkori mandulagyullad\u00e1s, h\u00f6rghurut \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 l\u00e9g\u00fati fert\u0151z\u00e9sek kezel\u00e9s\u00e9re. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s hat\u00f3anyagai t\u00f6bbnyire a v\u00e9ren mint k\u00f6zegen kereszt\u00fcl jutnak el a c\u00e9lponthoz (a b\u00e9lben t\u00f6rt\u00e9n\u0151 k\u00f6zvetlen hat\u00e1s \u00e9s a k\u00fcls\u0151leges gy\u00f3gyszeres kezel\u00e9s kiv\u00e9tel\u00e9vel), hogy kifejts\u00e9k hat\u00e1sukat. Ez\u00e9rt a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s sz\u00e1jon \u00e1t t\u00f6rt\u00e9n\u0151 bead\u00e1sa ut\u00e1n a szervezetben l\u00e9v\u0151 hat\u00f3anyagok elemz\u00e9se nagyon fontos a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s hat\u00e9konys\u00e1g\u00e1nak anyagi alapjainak tanulm\u00e1nyoz\u00e1s\u00e1hoz. Kutat\u00f3csoportunk kor\u00e1bban folyad\u00e9kkromatogr\u00e1fia-t\u00f6megspektrometri\u00e1s technol\u00f3gi\u00e1t haszn\u00e1lt az Atractylodes macrocephala alkoholos kivonat\u00e1nak szisztematikus elemz\u00e9s\u00e9re, \u00e9s meg\u00e1llap\u00edtotta, hogy az Atractylodes macrocephala-ban sz\u00e1mos hat\u00e9kony \u00f6sszetev\u0151 van, p\u00e9ld\u00e1ul flavonoidok, alkaloidok \u00e9s egy\u00e9b vegy\u00fcletek. A kor\u00e1bbi irodalmi tanulm\u00e1nyok t\u00f6bbnyire az egyes gy\u00f3gyn\u00f6v\u00e9nyek k\u00e9miai \u00f6sszet\u00e9tel\u00e9re \u00e9s min\u0151s\u00e9gellen\u0151rz\u00e9s\u00e9re \u00f6sszpontos\u00edtottak, hi\u00e1nyzik az Atractylodes macrocephala szemcs\u00e9k in vivo v\u00e9rkomponenseinek \u00e9s metabolikus folyamatainak kutat\u00e1sa, \u00e9s a farmakol\u00f3giai anyag alapja m\u00e9g nem vil\u00e1gos.<\/p>\n

A kvadrupolos time-of-flight t\u00f6megspektrometri\u00e1s technol\u00f3gia, nagy \u00e9rz\u00e9kenys\u00e9ge \u00e9s felbont\u00e1sa miatt, gyorsan \u00e9s hat\u00e9konyan elemezheti a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat k\u00e9miai \u00f6sszetev\u0151it, \u00e9s sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat hat\u00e9konys\u00e1g\u00e1nak alapj\u00e1t k\u00e9pez\u0151 anyag kutat\u00e1s\u00e1ban. Ez\u00e9rt a kor\u00e1bbi kutat\u00e1sok alapj\u00e1n kutat\u00f3csoportunk tov\u00e1bbra is az ultra nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1s n\u00e9gyp\u00f3lus\u00fa rep\u00fcl\u00e9si id\u0151 t\u00f6megspektrometri\u00e1s (UHPLC-Q-TOF-MS\/MS) technol\u00f3gi\u00e1t haszn\u00e1lja a v\u00e9rbe bel\u00e9p\u0151 \u00f6sszetev\u0151k \u00e9s a Baisui Granule anyagcsere-folyamat\u00e1nak elemz\u00e9s\u00e9re, amely referenciaalapot biztos\u00edt a hat\u00e9kony anyagok alapkutat\u00e1s\u00e1hoz, \u00e9s nagy jelent\u0151s\u00e9ggel b\u00edr a hagyom\u00e1nyos k\u00ednai szabadalmi gy\u00f3gyszerek \u00e9s egyszer\u0171 k\u00e9sz\u00edtm\u00e9nyek min\u0151s\u00e9gellen\u0151rz\u00e9se, fejleszt\u00e9se \u00e9s felhaszn\u00e1l\u00e1sa szempontj\u00e1b\u00f3l.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nEz a tanulm\u00e1ny az UHPLC-Q-TOF-MS\/MS technol\u00f3gi\u00e1t alkalmazta a Bairui granul\u00e1tumok felsz\u00edv\u00f3dott v\u00e9rkomponenseinek elemz\u00e9s\u00e9re. \u00d6sszesen 20 protot\u00edpusos komponenst \u00e9s 10 metabolitot mutattak ki patk\u00e1nysz\u00e9rumb\u00f3l. A szervezetben elemzett f\u0151 komponensek alkaloidok, mint a kvercetin \u00e9s a szofokarpin, valamint flavonoidok, mint a kaempferol \u00e9s a resveratrol I; A szervezetben l\u00e9v\u0151 f\u0151 metabolikus term\u00e9kek a kaempferol oxid\u00e1ci\u00f3ja \u00e9s gl\u00fckuronid\u00e1ci\u00f3ja, valamint a szofokarpin oxid\u00e1ci\u00f3ja \u00e9s hidrol\u00edzise, ami azt jelzi, hogy az alkaloidok \u00e9s a flavonoidok a szervezetbe jut\u00f3 f\u0151 \u00f6sszetev\u0151k, \u00e9s a gy\u00f3gyszer hat\u00e9konys\u00e1g\u00e1nak potenci\u00e1lis hat\u00f3anyagai is lehetnek.<\/p>\n

A modern farmakol\u00f3giai kutat\u00e1sok kimutatt\u00e1k, hogy a flavonoidok \u00e9s alkaloidok farmakol\u00f3giai funkci\u00f3i, p\u00e9ld\u00e1ul gyullad\u00e1scs\u00f6kkent\u0151, antibakteri\u00e1lis, v\u00edrusellenes \u00e9s antioxid\u00e1ns hat\u00e1s\u00faak. Kor\u00e1bbi tanulm\u00e1nyok arr\u00f3l sz\u00e1moltak be, hogy a Bai Rui Cao-ban l\u00e9v\u0151 resveratrol-sz\u00e1rmaz\u00e9kok gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sa az intracellul\u00e1ris reakt\u00edv oxig\u00e9nfajok termel\u00e9s\u00e9nek \u00e9s a p38 MAPK \u00e9s az aktiv\u00e1tor protein 1 aktiv\u00e1l\u00e1s\u00e1nak hat\u00e9kony g\u00e1tl\u00e1s\u00e1val f\u00fcgg \u00f6ssze. Term\u00e9szetes flavonolk\u00e9nt a resveratrolnak er\u0151s hat\u00e1sa van a gyullad\u00e1sos sejtfunkci\u00f3 g\u00e1tl\u00e1s\u00e1ban \u00e9s a pro-inflammatorikus citokinek \u00e9s kemokinek expresszi\u00f3j\u00e1nak elfojt\u00e1s\u00e1ban. A Bairuicao I az NF - \u03ba B \u00e9s a MAPK \u00fatvonalakra hatva g\u00e1tolni tudja a TNF - \u03b1, IL-6, IL-1 \u03b2 stb. gyullad\u00e1sos citokinek expresszi\u00f3j\u00e1t, ez\u00e1ltal jav\u00edtja a t\u00fcd\u0151\u00f6d\u00e9m\u00e1t t\u00fcd\u0151gyullad\u00e1ssal fert\u0151z\u00f6tt egerekben. Az alkaloidok jelent\u0151sen g\u00e1tolhatj\u00e1k az olyan mikroorganizmusok n\u00f6veked\u00e9s\u00e9t, mint az Escherichia coli \u00e9s a Staphylococcus aureus. A szofokarpin er\u0151s gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1ssal rendelkezik, \u00e9s az NF - \u03ba B jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val cs\u00f6kkentheti a gyullad\u00e1st. Az oxymatrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st fejthet ki az NF - \u03ba B jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val \u00e9s az IL-6 \u00e9s IL-8 gyullad\u00e1sos faktorok expresszi\u00f3j\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel.<\/p>\n

\u00d6sszefoglalva, ez a tanulm\u00e1ny a Bairui granul\u00e1tum v\u00e9rkomponenseit \u00e9s metabolitjait tiszt\u00e1zta az UHPLC-Q-TOFMS\/MS technol\u00f3gia seg\u00edts\u00e9g\u00e9vel. Ezek a vegy\u00fcletek szorosan kapcsol\u00f3dhatnak a Bairui granul\u00e1tum gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s antibakteri\u00e1lis hat\u00e1saihoz, ami nagy jelent\u0151s\u00e9ggel b\u00edr a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat hat\u00e9konys\u00e1g\u00e1nak anyagi alapjainak tiszt\u00e1z\u00e1sa \u00e9s a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat min\u0151s\u00e9gi szabv\u00e1nyainak jav\u00edt\u00e1sa szempontj\u00e1b\u00f3l. Referenciaalapot biztos\u00edt a hat\u00e1smechanizmus \u00e9s a klinikai alkalmaz\u00e1s tov\u00e1bbi meg\u00e9rt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Bairui granules are a granular preparation composed of single herb Bairui grass, which has the effects of antibacterial and anti-inflammatory, clearing heat and detoxifying, and relieving cough. They are […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/bairui-granules\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Bairui granules are a granular preparation composed of single herb Bairui grass, which has the effects of antibacterial and anti-inflammatory, clearing heat and detoxifying, and relieving cough. 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