{"id":4566,"date":"2024-08-04T14:53:22","date_gmt":"2024-08-04T14:53:22","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4566"},"modified":"2024-08-04T14:53:22","modified_gmt":"2024-08-04T14:53:22","slug":"callicarpa-nudiflora","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/callicarpa-nudiflora\/","title":{"rendered":"Az UPLC-Q-Exactive-Orbitrap-MS, a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a k\u00eds\u00e9rleti valid\u00e1ci\u00f3 alapj\u00e1n a Naked Purple Beads H1N1-ellenes akt\u00edv \u00f6sszetev\u0151inek \u00e9s mechanizmusainak felt\u00e1r\u00e1sa"},"content":{"rendered":"<p>Az UPLC-Q-Exactive-Orbitrap-MS, a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a k\u00eds\u00e9rleti valid\u00e1ci\u00f3 alapj\u00e1n a Naked Purple Beads H1N1-ellenes akt\u00edv \u00f6sszetev\u0151inek \u00e9s mechanizmusainak felt\u00e1r\u00e1sa<br \/>\nA hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer, a Callicarpa nudiflora Hook.&amp;Arn. a Verbenaceae csal\u00e1dba tartoz\u00f3 Callicarpa nudiflora Hook.&amp;Arn. n\u00f6v\u00e9ny sz\u00e1r\u00edtott levele. A meztelen lila gy\u00f6ngy\u00f6k f\u0151k\u00e9nt Hainan, Guangxi, Guangdong \u00e9s m\u00e1s r\u00e9gi\u00f3kban terjednek el, a hiteles term\u0151ter\u00fclet a Hainan tartom\u00e1nybeli Wuzhishan k\u00f6rzet. A Meztelen Vir\u00e1g B\u00edbor Gy\u00f6ngy az egyetlen \u00fajonnan hozz\u00e1adott hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer a K\u00ednai N\u00e9pk\u00f6zt\u00e1rsas\u00e1g gy\u00f3gyszerk\u00f6nyv\u00e9nek 2020-as kiad\u00e1s\u00e1ban. Egyoldal\u00fa k\u00e9sz\u00edtm\u00e9nyei, a Meztelen Vir\u00e1g B\u00edbor Gy\u00f6ngy Tabletta \u00e9s a Meztelen Vir\u00e1g B\u00edbor Gy\u00f6ngy Kapszula sz\u00e9les k\u00f6rben haszn\u00e1latosak a l\u00e9g\u00fati \u00e9s em\u00e9szt\u0151rendszeri v\u00e9rz\u00e9sek, valamint a t\u00falzott v\u00e9rh\u0151m\u00e9rs\u00e9klet \u00e9s toxicit\u00e1s okozta bakteri\u00e1lis fert\u0151z\u00e9ses gyullad\u00e1sok kezel\u00e9s\u00e9re. A fitok\u00e9mikusok t\u00f6bb mint 300 vegy\u00fcletet azonos\u00edtottak a meztelen vir\u00e1g\u00fa lila gy\u00f6ngyb\u0151l, k\u00f6zt\u00fck fenilpropanoidokat, flavonoidokat, triterpenoidokat, diterp\u00e9neket, iridoidokat, ill\u00f3olajokat \u00e9s m\u00e9g sok m\u00e1st. A modern farmakol\u00f3giai kutat\u00e1sok meger\u0151s\u00edtett\u00e9k, hogy a meztelen vir\u00e1g\u00fa lila gy\u00f6ngy gyullad\u00e1scs\u00f6kkent\u0151, antitrombotikus, daganatellenes, antibakteri\u00e1lis \u00e9s m\u00e1jv\u00e9d\u0151 hat\u00e1s\u00fa. A v\u00edrusellenes aktivit\u00e1ssal rendelkez\u0151 hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerek sz\u0171r\u00e9se sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy a meztelen vir\u00e1g lila gy\u00f6ngy kivonat\u00e1nak j\u00f3 v\u00edrusellenes aktivit\u00e1sa van (p\u00e9ld\u00e1ul H1N1 influenzav\u00edrus, 71-es enterov\u00edrus stb.). Az influenza A v\u00edrusfert\u0151z\u00e9s a t\u00fcd\u0151gyullad\u00e1ssal \u00f6sszef\u00fcgg\u0151 hal\u00e1lesetek gyakori oka. Az influenza A v\u00edrus s\u00falyos fert\u0151z\u00e9se k\u00e9toldali t\u00fcd\u0151infiltr\u00e1ci\u00f3t \u00e9s hipox\u00e9mi\u00e1t okozhat, amely akut l\u00e9gz\u00e9si distressz szindr\u00f3mak\u00e9nt ismert, \u00e9s amely az influenza A v\u00edrus okozta hal\u00e1loz\u00e1s egyik f\u0151 oka. Ez a k\u00eds\u00e9rlet a meztelen vir\u00e1g\u00fa lila gy\u00f6ngy\u00f6k H1N1-ellenes aktivit\u00e1s\u00e1ra \u00f6sszpontos\u00edt. A meztelen vir\u00e1g lila gy\u00f6ngy hat\u00e9kony r\u00e9szeinek k\u00e9miai \u00f6sszet\u00e9tel\u00e9t ultra-nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1s kvadrupolos elektrosztatikus mez\u0151 orbitrap MS seg\u00edts\u00e9g\u00e9vel azonos\u00edtott\u00e1k, \u00e9s a meztelen vir\u00e1g lila gy\u00f6ngy H1N1-ellenes mechanizmus\u00e1t megj\u00f3solt\u00e1k \u00e9s k\u00eds\u00e9rletileg igazolt\u00e1k a h\u00e1l\u00f3zati farmakol\u00f3gia seg\u00edts\u00e9g\u00e9vel. El\u0151zetesen felt\u00e1rt\u00e1k a meztelen vir\u00e1gos lila gy\u00f6ngy H1N1 elleni hat\u00e1smechanizmus\u00e1t.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4570\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-73.png\" alt=\"\" width=\"340\" height=\"709\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4571\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-63.png\" alt=\"\" width=\"340\" height=\"234\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4572\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-60.png\" alt=\"\" width=\"600\" height=\"621\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4573\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-50.png\" alt=\"\" width=\"600\" height=\"660\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4574\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-2.jpg\" alt=\"\" width=\"539\" height=\"748\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-2.jpg 539w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-2-519x720.jpg 519w\" sizes=\"(max-width: 539px) 100vw, 539px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4575\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-44.png\" alt=\"\" width=\"539\" height=\"272\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4576\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-42.png\" alt=\"\" width=\"600\" height=\"784\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-42.png 600w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-42-551x720.png 551w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4577\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-36.png\" alt=\"\" width=\"600\" height=\"539\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4578\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-31.png\" alt=\"\" width=\"600\" height=\"304\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4579\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-27.png\" alt=\"\" width=\"600\" height=\"244\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4580\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-25.png\" alt=\"\" width=\"340\" height=\"219\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4581\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-21.png\" alt=\"\" width=\"340\" height=\"546\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4582\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-18.png\" alt=\"\" width=\"600\" height=\"271\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4583\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-15.png\" alt=\"\" width=\"600\" height=\"327\" \/>callicarpa nudiflora<br \/>\nAz influenza A-v\u00edrus k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e9rt\u00e9kben rezisztens az \u00e1ltal\u00e1nosan haszn\u00e1lt M2-csatorna-g\u00e1tl\u00f3kkal \u00e9s NA-g\u00e1tl\u00f3kkal szemben. Ez\u00e9rt az A influenza elleni \u00faj gy\u00f3gyszerek vagy kezel\u00e9si m\u00f3dszerek megtal\u00e1l\u00e1sa s\u00fcrg\u0151sen megoldand\u00f3 probl\u00e9m\u00e1v\u00e1 v\u00e1lt. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s fontos szerepet j\u00e1tszott az influenza A v\u00edrus klinikai kezel\u00e9s\u00e9ben. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s elm\u00e9let\u00e9nek holisztikus koncepci\u00f3ja szisztematikusan szab\u00e1lyozza a betegeket mint szerves eg\u00e9szet, m\u00edg a h\u00e1l\u00f3zati farmakol\u00f3gia a h\u00e1l\u00f3zat egyes csom\u00f3pontjainak biol\u00f3giai funkci\u00f3i \u00e9s a betegs\u00e9gek k\u00f6z\u00f6tti k\u00f6lcs\u00f6nhat\u00e1st vizsg\u00e1lja a gy\u00f3gyszer\u00f6sszetev\u0151 c\u00e9l\u00fatvonal betegs\u00e9gh\u00e1l\u00f3zat\u00e1nak fel\u00e9p\u00edt\u00e9s\u00e9vel, amely \u00f6sszhangban van a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s holisztikus koncepci\u00f3j\u00e1val. Ez a k\u00eds\u00e9rlet el\u0151sz\u00f6r a hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer, a Naked Flower Purple Pearl Naked Flower Purple Pearl f\u0151 H1N1-ellenes akt\u00edv helyeit sz\u0171rte, \u00e9s 34 k\u00e9miai komponens azonos\u00edt\u00e1sa \u00e9rdek\u00e9ben elemezte a helyeket. Az irodalom \u00e9s az adatb\u00e1zisok kombin\u00e1l\u00e1s\u00e1val 67 \u00e1tfed\u0151 gy\u00f3gyszer- \u00e9s betegs\u00e9gc\u00e9lpontot azonos\u00edtottak. A keresztc\u00e9lpontok gazdagod\u00e1si elemz\u00e9se r\u00e9v\u00e9n felt\u00e9telezz\u00fck, hogy az EACN H1N1 elleni fontos biol\u00f3giai folyamata a feh\u00e9rje foszforil\u00e1ci\u00f3 \u00e9s az oxidat\u00edv stresszre adott v\u00e1lasz pozit\u00edv szab\u00e1lyoz\u00e1sa lehet. A KEGG gazdagod\u00e1si elemz\u00e9s eredm\u00e9nyei azt mutatt\u00e1k, hogy az EACN 19 vegy\u00fclete 11 c\u00e9lponton kereszt\u00fcl hat az influenza A v\u00edrus \u00fatvonal\u00e1ra. A hat\u00f3anyag a PLG \u00e9s a PRSS1 hat\u00e1s\u00e1ra befoly\u00e1solja a H1N1 v\u00edrus M2 csatorn\u00e1j\u00e1t, \u00e9s a PLG-n kereszt\u00fcl a neuraminid\u00e1z (NA) \u00fatvonalra hatva a v\u00edrus felszabadul\u00e1si folyamat\u00e1t is befoly\u00e1solhatja. A PLG \u00e9s a PRSS1 kulcsfontoss\u00e1g\u00fa c\u00e9lpontok lehetnek az EACN sz\u00e1m\u00e1ra a H1N1 v\u00edrusra val\u00f3 k\u00f6zvetlen hat\u00e1s \u00e9rdek\u00e9ben. Az EACN g\u00e1tolhatja a H1N1 prolifer\u00e1ci\u00f3j\u00e1t az\u00e1ltal, hogy befoly\u00e1solja a lev\u00e1l\u00e1si \u00e9s felszabadul\u00e1si folyamatokat. A hat\u00f3anyag-\u00f6sszetev\u0151 c\u00e9lpont\u00fatvonal betegs\u00e9gh\u00e1l\u00f3zat\u00e1ban a RELA \u00e9s az NF - \u03ba B1 a k\u00e9t legmagasabb fok\u00fa c\u00e9lpont. Az NF - \u03ba B jel\u00e1tviteli \u00fatvonal, amelyben ezek tal\u00e1lhat\u00f3k, el\u0151seg\u00edtheti az olyan faktorok kifejez\u0151d\u00e9s\u00e9t, mint az IL1 \u03b2, TNF - \u03b1, IL-6, \u00e9s el\u0151seg\u00edtheti a gyullad\u00e1sos v\u00e1laszt, ami arra utal, hogy az EACN olyan kulcsfontoss\u00e1g\u00fa c\u00e9lpontokra hathat, mint a RELA \u00e9s az NF - \u03ba B1, hogy szab\u00e1lyozza az NF - \u03ba B jel\u00e1tviteli \u00fatvonalat \u00e9s cs\u00f6kkentse a gyullad\u00e1s \u00e1ltal a szervezetben okozott k\u00e1rokat. A h\u00e1l\u00f3zati farmakol\u00f3gia \u00e1ltal el\u0151re jelzett eredm\u00e9nyek szerint az EACN szab\u00e1lyozhatja a T-sejtek jel\u00e1tviteli \u00fatvonalait, befoly\u00e1solhatja a Th1 \u00e9s Th2 differenci\u00e1l\u00f3d\u00e1st, \u00e9s immunszab\u00e1lyoz\u00f3 hat\u00e1st fejthet ki. Ez\u00e9rt ebben a tanulm\u00e1nyban \u00e1llatk\u00eds\u00e9rleteket v\u00e9gezt\u00fcnk az EACN H1N1 prolifer\u00e1ci\u00f3ra gyakorolt g\u00e1tl\u00f3, gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s immunszab\u00e1lyoz\u00f3 hat\u00e1s\u00e1nak ellen\u0151rz\u00e9s\u00e9re. A k\u00eds\u00e9rleti eredm\u00e9nyek azt mutatt\u00e1k, hogy az EACN jav\u00edthatja a H1N1 fert\u0151z\u00e9s okozta s\u00falycs\u00f6kken\u00e9st \u00e9s a t\u00fcd\u0151index n\u00f6veked\u00e9s\u00e9t, cs\u00f6kkentheti a v\u00edrusterhel\u00e9st az eg\u00e9r t\u00fcd\u0151sz\u00f6vet\u00e9ben, enyh\u00edtheti az eg\u00e9r t\u00fcd\u0151sz\u00f6vet\u00e9nek k\u00f3ros k\u00e1rosod\u00e1s\u00e1t, cs\u00f6kkentheti a TNF - \u03b1, IFN - \u03b3, IL-1 \u03b2 szintj\u00e9t a perif\u00e9ri\u00e1s v\u00e9rsz\u00e9rumban, \u00e9s n\u00f6velheti a sz\u00e9rum IgG antitest szintj\u00e9t. Ez a tanulm\u00e1ny el\u0151sz\u00f6r in vitro k\u00eds\u00e9rleteket haszn\u00e1lt a Naked Purple Pearl H1N1 elleni akt\u00edv kivon\u00e1si helyeinek sz\u0171r\u00e9s\u00e9re, \u00e9s az EACN H1N1 elleni akt\u00edv \u00f6sszetev\u0151it az UPLC-Q-Hexactive-Orbitrap-MS \u00e9s a h\u00e1l\u00f3zati farmakol\u00f3gia seg\u00edts\u00e9g\u00e9vel j\u00f3solta meg. A megj\u00f3solt eredm\u00e9nyeket \u00e1llatk\u00eds\u00e9rletekkel igazolt\u00e1k, \u00e9s az EACN H1N1 elleni potenci\u00e1lis hat\u00f3anyagait, k\u00f6zt\u00fck a kvercetin, a miricetin, a luteolin, a kaempferol, a kvercetin, az apigenin \u00e9s az acacetin hat\u00f3anyagokat is \u00e1tvil\u00e1g\u00edtott\u00e1k. El\u0151zetesen kimutatt\u00e1k, hogy a Naked Purple Pearl t\u00f6bbf\u00e9le \u00faton, p\u00e9ld\u00e1ul k\u00f6zvetlen v\u00edrusg\u00e1tl\u00e1son, gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1son \u00e9s immunszab\u00e1lyoz\u00e1son kereszt\u00fcl k\u00e9pes H1N1-ellenes hat\u00e1st kifejteni. A tov\u00e1bbi k\u00eds\u00e9rletek sor\u00e1n in vitro \u00e9s in vivo k\u00eds\u00e9rleteket kell v\u00e9gezni a kiv\u00e1lasztott monomer vegy\u00fcletek valid\u00e1l\u00e1sa \u00e9s az EACN H1N1-ellenes hat\u00e1s\u00e1nak mechanizmus\u00e1nak tov\u00e1bbi vizsg\u00e1lata \u00e9rdek\u00e9ben mRNS- \u00e9s feh\u00e9rjeszinten.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the Anti H1N1 Active Components and Mechanisms of Naked Purple Beads Based on UPLC-Q-Exactive-Orbitrap-MS, Network Pharmacology, and Experimental Validation The traditional Chinese medicine, Callicarpa nudiflora Hook.&amp;Arn., is a dried leaf of the plant Callicarpa nudiflora Hook.&amp;Arn. in the family Verbenaceae. Naked Purple Beads are mainly distributed in Hainan, Guangxi, Guangdong and other regions, with [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exploring the Anti H1N1 Active Components and Mechanisms of Naked Purple Beads Based on UPLC-Q-Exactive-Orbitrap-MS, Network Pharmacology, and Experimental Validation - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/callicarpa-nudiflora\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the Anti H1N1 Active Components and Mechanisms of Naked Purple Beads Based on UPLC-Q-Exactive-Orbitrap-MS, Network Pharmacology, and Experimental Validation - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the Anti H1N1 Active Components and Mechanisms of Naked Purple Beads Based on UPLC-Q-Exactive-Orbitrap-MS, Network Pharmacology, and Experimental Validation The traditional Chinese medicine, Callicarpa nudiflora Hook.&amp;Arn., is a dried leaf of the plant Callicarpa nudiflora Hook.&amp;Arn. in the family Verbenaceae. 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