{"id":4523,"date":"2024-08-04T14:39:26","date_gmt":"2024-08-04T14:39:26","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4523"},"modified":"2024-08-04T14:39:26","modified_gmt":"2024-08-04T14:39:26","slug":"corydalis-fangshanensis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/corydalis-fangshanensis\/","title":{"rendered":"A Corydalis Fangshanensis f\u00f6ld feletti r\u00e9sz\u00e9nek k\u00e9miai \u00f6sszetev\u0151inek \u00e9s az eml\u0151r\u00e1kos sejtekre gyakorolt antiprolifer\u00e1ci\u00f3s hat\u00e1s\u00e1nak vizsg\u00e1lata"},"content":{"rendered":"<p>A Corydalis Fangshanensis f\u00f6ld feletti r\u00e9sz\u00e9nek k\u00e9miai \u00f6sszetev\u0151inek \u00e9s az eml\u0151r\u00e1kos sejtekre gyakorolt antiprolifer\u00e1ci\u00f3s hat\u00e1s\u00e1nak vizsg\u00e1lata<br \/>\nA Corydalis fangshanensis a Papaveraceae csal\u00e1dba tartoz\u00f3 Corydalis nemzets\u00e9gbe tartoz\u00f3 egy\u00e9ves l\u00e1gysz\u00e1r\u00fa n\u00f6v\u00e9ny. F\u0151k\u00e9nt Fangshan, Peking, Shanxi, Henan, Hebei \u00e9s m\u00e1s helyeken elterjedt, \u00e9s m\u00e9szk\u0151- \u00e9s szikl\u00e1s lejt\u0151k\u00f6n n\u0151 500-1600 m magass\u00e1gban. A lila ibolya gy\u00f3gyn\u00f6v\u00e9nyeket t\u00f6bbnyire eg\u00e9sz gy\u00f3gyn\u00f6v\u00e9nyk\u00e9nt haszn\u00e1lj\u00e1k, f\u0151 \u00f6sszetev\u0151i \u00e9des \u00e9s hideg \u00edz\u0171ek. H\u0151tiszt\u00edt\u00f3 \u00e9s m\u00e9regtelen\u00edt\u0151 hat\u00e1suk van, \u00e9s gyakran haszn\u00e1lj\u00e1k olyan betegs\u00e9gek kezel\u00e9s\u00e9re, mint a megf\u00e1z\u00e1s, l\u00e1z, fek\u00e9lyek \u00e9s fek\u00e9lyek. Kor\u00e1bbi tanulm\u00e1nyok meg\u00e1llap\u00edtott\u00e1k, hogy ez a n\u00f6v\u00e9nynemzets\u00e9g olyan k\u00e9miai \u00f6sszetev\u0151ket tartalmaz, mint az alkaloidok, flavonoidok, kumarinok \u00e9s szerves savak, amelyek k\u00f6z\u00fcl az alkaloidok a f\u0151 farmakol\u00f3giai hat\u00f3anyagok. A modern farmakol\u00f3giai kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy az ebben a nemzets\u00e9gben tal\u00e1lhat\u00f3 alkaloidok k\u00fcl\u00f6nb\u00f6z\u0151 aktivit\u00e1sokkal rendelkeznek, p\u00e9ld\u00e1ul tumorellenes, gyullad\u00e1scs\u00f6kkent\u0151, sz\u00edvizom iszk\u00e9mi\u00e1t g\u00e1tl\u00f3, antibakteri\u00e1lis \u00e9s m\u00e1jv\u00e9d\u0151 hat\u00e1ssal. A K\u00ednai N\u00e9pk\u00f6zt\u00e1rsas\u00e1g gy\u00f3gyszerk\u00f6nyv\u00e9nek 2020-as kiad\u00e1sa a C. yanhusuo-t a Corydalis yanhusuo\u3001 ny\u00e1r n\u00e9lk\u00fcl C decumbens\u3001 Kudi Ding C nemzets\u00e9gbe sorolja A klinikai gyakorlatban olyan gy\u00f3gyn\u00f6v\u00e9nyeket haszn\u00e1ltak, mint a Bungeana, a vegyes Corydalis yanhusuo tablett\u00e1k \u00e9s a ny\u00e1r n\u00e9lk\u00fcl injekci\u00f3. Jelenleg olyan t\u00e9nyez\u0151k miatt, mint a n\u00f6veked\u00e9si k\u00f6rnyezet \u00e9s a term\u00e9shozam, kev\u00e9s jelent\u00e9s van a Fangshan lila ibolya k\u00e9miai \u00f6sszet\u00e9tel\u00e9r\u0151l vagy farmakol\u00f3giai aktivit\u00e1s\u00e1r\u00f3l, ami akad\u00e1lyozza a gy\u00f3gy\u00e1szati \u00f6sszetev\u0151inek felt\u00e1r\u00e1s\u00e1t. Ez\u00e9rt ez a tanulm\u00e1ny szisztematikusan tanulm\u00e1nyozta a Shanxi tartom\u00e1ny Zuoquan megy\u00e9j\u00e9b\u0151l gy\u0171jt\u00f6tt Corydalis fangshan k\u00e9miai \u00f6sszet\u00e9tel\u00e9t \u00e9s in vitro citotoxicit\u00e1s\u00e1t. K\u00fcl\u00f6nb\u00f6z\u0151 kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si technik\u00e1kat alkalmaztunk a 80% etanol nyers kivonat szisztematikus elv\u00e1laszt\u00e1s\u00e1ra, \u00e9s az elv\u00e1lasztott vegy\u00fcleteket melldaganatsejt-g\u00e1tl\u00e1s szempontj\u00e1b\u00f3l vizsg\u00e1ltuk, hogy alapot biztos\u00edtsunk ennek a gy\u00f3gyszernek a mellr\u00e1k elleni alkalmaz\u00e1s\u00e1hoz \u00e9s k\u00e9s\u0151bbi min\u0151s\u00e9gellen\u0151rz\u00e9si kutat\u00e1s\u00e1hoz.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4526\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-69.png\" alt=\"\" width=\"700\" height=\"560\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4527\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-59.png\" alt=\"\" width=\"802\" height=\"564\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-59.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-59-768x540.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4528\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-56.png\" alt=\"\" width=\"802\" height=\"334\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-56.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-56-768x320.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/>Ebben a k\u00eds\u00e9rletben \u00f6sszesen 17 monomer vegy\u00fcletet izol\u00e1ltak a Fangshan lila ibolya 80% etanolos kivonat\u00e1b\u00f3l (etil-acet\u00e1t \u00e9s n-butanol). Az 1-10 vegy\u00fcletek izokinolin alkaloidok, a 11. \u00e9s 12. vegy\u00fcletek egy\u00e9b alkaloidok, a 13. \u00e9s 14. vegy\u00fcletek fenilpropanoidok, a 15. vegy\u00fcletek flavonok, a 16. \u00e9s 17. vegy\u00fcletek lign\u00e1nok voltak. K\u00f6z\u00fcl\u00fck az 1. vegy\u00fcletet el\u0151sz\u00f6r jelentett\u00e9k term\u00e9szetes term\u00e9kk\u00e9nt, a 2-17 vegy\u00fcleteket pedig el\u0151sz\u00f6r izol\u00e1lt\u00e1k a Fangshan lila iboly\u00e1b\u00f3l. A fent izol\u00e1lt vegy\u00fcletek alapvet\u0151en \u00f6sszhangban vannak az irodalomban a Corydalis nemzets\u00e9gb\u0151l ismertetett \u00f6sszet\u00e9teli t\u00edpusokkal. A mellr\u00e1ksejtek prolifer\u00e1ci\u00f3j\u00e1nak in vitro g\u00e1tl\u00e1s\u00e1ra vonatkoz\u00f3 aktivit\u00e1si tesztek eredm\u00e9nyei azt mutatt\u00e1k, hogy a 3, 4, 7 \u00e9s 10 vegy\u00fcletek nyilv\u00e1nval\u00f3 g\u00e1tl\u00f3 hat\u00e1ssal rendelkeztek az MDA-MB-231, a 4 \u00e9s 17 vegy\u00fcletek nyilv\u00e1nval\u00f3 g\u00e1tl\u00f3 hat\u00e1ssal rendelkeztek az MCF-7 sejtekkel szemben, a t\u00f6bbi vegy\u00fcletnek pedig nem volt g\u00e1tl\u00f3 hat\u00e1sa a fenti mellr\u00e1kos daganatsejtekre. Az aktivit\u00e1svizsg\u00e1lati eredm\u00e9nyek szerint a legt\u00f6bb benzil-izokinolin alkaloid komponensnek van bizonyos g\u00e1tl\u00f3 hat\u00e1sa, de az izol\u00e1lt alkaloid vegy\u00fcletek \u00e1ltal\u00e1ban kevesen vannak, ami megnehez\u00edti a szerkezet-aktivit\u00e1s \u00f6sszef\u00fcgg\u00e9sek hat\u00e9kony \u00f6sszefoglal\u00e1s\u00e1t. A k\u00e9s\u0151bbi munka m\u00f3dos\u00edthatja n\u00e9h\u00e1ny benzilizokinolin alkaloid komponens szerkezet\u00e9t nagy mennyis\u00e9gben, \u00e9s \u00f6sszefoglalhatja szerkezet-aktivit\u00e1s \u00f6sszef\u00fcgg\u00e9seiket. E tanulm\u00e1ny eredm\u00e9nyei bizonyos referencia\u00e9rt\u00e9kkel b\u00edrnak a farmakol\u00f3giai anyagalapok tiszt\u00e1z\u00e1s\u00e1hoz, a min\u0151s\u00e9gellen\u0151rz\u00e9shez \u00e9s a Fangshan Purple Osmanthus farmakol\u00f3giai hat\u00e1sainak tov\u00e1bbi m\u00e9lyrehat\u00f3 kutat\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"<p>Studies on the Chemical Constituents of the Aboveground Part of Corydalis Fangshanensis and Its Anti proliferation Effect on breast cancer Cells Corydalis fangshanensis is an annual herbaceous plant of the genus Corydalis in the Papaveraceae family. It is mainly distributed in Fangshan, Beijing, Shanxi, Henan, Hebei and other places, and grows on limestone and rocky [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Studies on the Chemical Constituents of the Aboveground Part of Corydalis Fangshanensis and Its Anti proliferation Effect on breast cancer Cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/corydalis-fangshanensis\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Studies on the Chemical Constituents of the Aboveground Part of Corydalis Fangshanensis and Its Anti proliferation Effect on breast cancer Cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Studies on the Chemical Constituents of the Aboveground Part of Corydalis Fangshanensis and Its Anti proliferation Effect on breast cancer Cells Corydalis fangshanensis is an annual herbaceous plant of the genus Corydalis in the Papaveraceae family. 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