{"id":4263,"date":"2024-08-04T09:03:00","date_gmt":"2024-08-04T09:03:00","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4263"},"modified":"2024-08-04T09:03:00","modified_gmt":"2024-08-04T09:03:00","slug":"fennel-root-bark","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/fennel-root-bark\/","title":{"rendered":"Az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg hat\u00e9kony \u00f6sszetev\u0151inek sz\u0171r\u00e9se a m\u00e1jfibr\u00f3zis ellen a spektr\u00e1lis hat\u00e1s \u00f6sszef\u00fcgg\u00e9s alapj\u00e1n \u00e9s a mechanizmus felt\u00e1r\u00e1sa"},"content":{"rendered":"

Az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg hat\u00e9kony \u00f6sszetev\u0151inek sz\u0171r\u00e9se a m\u00e1jfibr\u00f3zis ellen a spektr\u00e1lis hat\u00e1s \u00f6sszef\u00fcgg\u00e9s alapj\u00e1n \u00e9s a mechanizmus felt\u00e1r\u00e1sa
\nA m\u00e1jfibr\u00f3zis a m\u00e1jzsugorod\u00e1s, s\u0151t a m\u00e1jr\u00e1k f\u0151 oka, \u00e9s a m\u00e1jr\u00e1k mintegy 90%-je m\u00e1jfibr\u00f3zis vagy m\u00e1jzsugorod\u00e1s alapj\u00e1n alakul ki. Ez\u00e9rt a m\u00e1jfibr\u00f3zis kezel\u00e9se k\u00fcl\u00f6n\u00f6sen fontos. A m\u00e1jfibr\u00f3zis klinikai el\u0151fordul\u00e1sa \u00e9vr\u0151l \u00e9vre n\u0151, ami s\u00falyosan vesz\u00e9lyezteti az emberek \u00e9letbiztons\u00e1g\u00e1t. A m\u00e1jfibr\u00f3zis f\u0151 okai k\u00f6z\u00e9 tartozik a kr\u00f3nikus hepatitisv\u00edrus-fert\u0151z\u00e9s, az alkoholfogyaszt\u00e1s \u00e9s a nem alkoholos zs\u00edrm\u00e1jbetegs\u00e9g. A m\u00e1jfibr\u00f3zis jellemz\u0151je az extracellul\u00e1ris m\u00e1trix t\u00falzott felhalmoz\u00f3d\u00e1sa, amelyet az extracellul\u00e1ris m\u00e1trix fokozott szint\u00e9zise \u00e9s lerak\u00f3d\u00e1sa, valamint az extracellul\u00e1ris m\u00e1trix cs\u00f6kkent vagy egy\u00e1ltal\u00e1n nem t\u00f6rt\u00e9n\u0151 leboml\u00e1sa okoz. A m\u00e1jfibr\u00f3zisban kulcsfontoss\u00e1g\u00fa l\u00e1ncszemnek tekintik a m\u00e1j csillagsejtek aktiv\u00e1l\u00f3d\u00e1s\u00e1t, \u00e9s ez a f\u0151 oka az extracellul\u00e1ris m\u00e1trix feh\u00e9rj\u00e9k t\u00falzott felhalmoz\u00f3d\u00e1s\u00e1nak a m\u00e1jban.
\nAz \u00e9desk\u00f6m\u00e9ny gy\u00f6k\u00e9rk\u00e9reg a Foeniculum vulgare Mill. Benne van a standard ujgur gy\u00f3gyszerk\u00f6nyvben, \u00e9s nedves hideg vagy ny\u00e1lk\u00e1s betegs\u00e9gek, p\u00e9ld\u00e1ul nedves hideg okozta k\u00fcl\u00f6nb\u00f6z\u0151 gyullad\u00e1sok \u00e9s duzzanatok, k\u00e9toldali hidegf\u00e1jdalom, der\u00e9kf\u00e1j\u00e1s, h\u00e1tf\u00e1j\u00e1s, amenorrhoea, vizeletelz\u00e1r\u00f3d\u00e1s \u00e9s r\u00e9gi b\u00e9lelz\u00e1r\u00f3d\u00e1s kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k. A Hugan Buzu Re Granules a hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban a m\u00e1j v\u00e9delm\u00e9re szolg\u00e1l\u00f3 klasszikus formula. Zellermagb\u00f3l, zellergy\u00f6k\u00e9rb\u0151l, krizant\u00e9mmagb\u00f3l, cickafarkmagb\u00f3l, cik\u00f3riagy\u00f6k\u00e9rb\u0151l, \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9rg\u00e9b\u0151l \u00e9s \u00e9desk\u00f6m\u00e9nyb\u0151l \u00e1ll, \u00e9s a m\u00e1jat t\u00e1pl\u00e1l\u00f3 \u00e9s az epe\u00e1raml\u00e1st el\u0151seg\u00edt\u0151 hat\u00e1s\u00fa. A kutat\u00f3csoport el\u0151zetes kutat\u00e1sai szerint a Hugan BuZuRe granul\u00e1tum patk\u00e1nyokban v\u00e9delmet ny\u00fajt a CCI4 \u00e1ltal kiv\u00e1ltott m\u00e1jfibr\u00f3zissal szemben. Medina Saifudin \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban haszn\u00e1lt \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg bizonyos m\u00e9rt\u00e9kben el\u0151seg\u00edti a m\u00e1jsz\u00f6vetek helyre\u00e1ll\u00edt\u00e1s\u00e1t \u00e9s v\u00e9di a m\u00e1jsejtmembr\u00e1nokat. Ez\u00e9rt az \u00e9desk\u00f6m\u00e9ny gy\u00f6k\u00e9rk\u00e9regnek m\u00e1jfibr\u00f3zis elleni hat\u00e1sa lehet.
\nA gy\u00f3gyszer-spektrum-hat\u00e1s \u00f6sszef\u00fcgg\u00e9s vizsg\u00e1lata olyan m\u00f3dszer, amely a k\u00e9miai \u00f6sszet\u00e9telt \u00e9s a farmakol\u00f3giai kutat\u00e1st egyes\u00edti a hat\u00e9kony k\u00e9miai \u00f6sszetev\u0151k elemz\u00e9s\u00e9re. A spektrumok tanulm\u00e1nyoz\u00e1sa alapj\u00e1n maximaliz\u00e1lja a hasznos k\u00e9miai inform\u00e1ci\u00f3k megszerz\u00e9s\u00e9t, \u00f6sszekapcsolja a spektrumokat a farmakol\u00f3giai eredm\u00e9nyekkel, line\u00e1ris vagy nemline\u00e1ris matematikai feldolgoz\u00e1ssal l\u00e9trehoz egy \"spektrumhat\u00e1s\" matematikai modellt, \u00e9s meghat\u00e1rozza a farmakol\u00f3giai hat\u00e1sokkal kapcsolatos vegy\u00fcletcsoportokat. Az ismert \u00e9s ismeretlen komponensek elemz\u00e9s\u00e9vel a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat \u00f6sszetett vegyes rendszereiben tal\u00e1lhat\u00f3 k\u00e9miai komponensek t\u00edpusai \u00e9s tartalma maxim\u00e1lisan t\u00fckr\u00f6z\u0151dhetnek, ez\u00e1ltal \u00e1tfog\u00f3 le\u00edr\u00e1st \u00e9s \u00e9rt\u00e9kel\u00e9st adva a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat min\u0151s\u00e9g\u00e9r\u0151l. Ez\u00e9rt ebben a tanulm\u00e1nyban ultranagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fia-t\u00f6megspektrometri\u00e1t alkalmaztunk a k\u00ednai gy\u00f3gyn\u00f6v\u00e9ny \u00e9desk\u00f6m\u00e9ny gy\u00f6k\u00e9rk\u00e9reg k\u00e9miai \u00f6sszetev\u0151inek vizsg\u00e1lat\u00e1ra. Az etanolos extrakci\u00f3, a petr\u00f3leum\u00e9teres extrakci\u00f3, az etil-acet\u00e1tos extrakci\u00f3, az n-butanolos extrakci\u00f3 \u00e9s a vizes extrakci\u00f3 HSC-T6 sejtprolifer\u00e1ci\u00f3ra gyakorolt hat\u00e1s\u00e1t UPLC-Orbitrap-MS\/MS-sel kombin\u00e1ltuk az \u00e9desk\u00f6m\u00e9ny gy\u00f6k\u00e9rk\u00e9reg k\u00e9miai \u00f6sszetev\u0151inek sz\u0171r\u00e9s\u00e9re, r\u00e9szleges legkisebb n\u00e9gyzetek \u00e9s sz\u00fcrke rel\u00e1ci\u00f3s elemz\u00e9s seg\u00edts\u00e9g\u00e9vel. Az in vitro k\u00eds\u00e9rleteket az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg hat\u00e9kony \u00f6sszetev\u0151inek m\u00e1jfibr\u00f3zis elleni hat\u00e1s\u00e1nak \u00e9s mechanizmus\u00e1nak ellen\u0151rz\u00e9s\u00e9re v\u00e9gezt\u00fck, tudom\u00e1nyos alapot ny\u00fajtva a n\u00e9pi gy\u00f3gy\u00e1szat kutat\u00e1s\u00e1hoz \u00e9s fejleszt\u00e9s\u00e9hez.<\/p>\n

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A hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban a t\u00f6bb c\u00e9lpont \u00e9s \u00f6sszetev\u0151 szinergikus hat\u00e1sa a kutat\u00e1s egyik legforr\u00f3bb t\u00e9m\u00e1j\u00e1v\u00e1 v\u00e1lt. A hat\u00f3anyagok vizsg\u00e1lata a gy\u00f3gyszerkutat\u00e1s alapja, \u00e9s a hat\u00f3anyagokat \u00e9s hat\u00e1sm\u00f3dokat \u00f6sszetetts\u00e9g jellemzi. Li Rong 2002-ben javasolta a spektr\u00e1lis hat\u00e1skapcsolat elm\u00e9let\u00e9t, amely \u00faj kutat\u00e1si ir\u00e1nyt mutatott a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat hat\u00e9konys\u00e1g\u00e1nak vizsg\u00e1lat\u00e1ra. Az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg alkoholos kivonat\u00e1nak \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 kivonatainak UPLC-Orbitrap-MS\/MS spektrum\u00e1ban l\u00e9v\u0151 k\u00f6z\u00f6s cs\u00facsok \u00e9s a m\u00e1jfibr\u00f3zis elleni hat\u00e1suk sz\u00e1mszer\u0171s\u00edt\u00e9se alapj\u00e1n ez a tanulm\u00e1ny r\u00e9szleges legkisebb n\u00e9gyzetek \u00e9s sz\u00fcrke korrel\u00e1ci\u00f3s anal\u00edzis seg\u00edts\u00e9g\u00e9vel vizsg\u00e1lta az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg teljes ion\u00e1raml\u00e1si spektrum\u00e1ban l\u00e9v\u0151 k\u00f6z\u00f6s cs\u00facsok \u00e9s a m\u00e1jfibr\u00f3zis elleni hat\u00e1suk k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9st. Ez nagym\u00e9rt\u00e9kben t\u00fckr\u00f6zheti az \u00f6sszetev\u0151k hozz\u00e1j\u00e1rul\u00e1s\u00e1t a farmakol\u00f3giai hat\u00e1shoz.
\nEz a tanulm\u00e1ny az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg alkoholos, petr\u00f3leum\u00e9teres, etil-acet\u00e1tos, n-butanolos \u00e9s vizes r\u00e9sz\u00e9vel foglalkozik. Nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fia-t\u00f6megspektrometri\u00e1s elemz\u00e9st v\u00e9gezt\u00fcnk az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg folyad\u00e9kkromatogr\u00e1fia-t\u00f6megspektrometri\u00e1s (LC-MS) spektrum\u00e1nak \u00f6ssze\u00e1ll\u00edt\u00e1s\u00e1hoz. \u00d6sszesen 58 k\u00f6z\u00f6s cs\u00facsot kalibr\u00e1ltunk pozit\u00edv \u00e9s negat\u00edv ionm\u00f3dban, \u00e9s elemezt\u00fck a spektrumokat. L\u00e1that\u00f3, hogy az egyes mint\u00e1k k\u00f6z\u00f6s cs\u00facster\u00fcletei elt\u00e9r\u0151ek, ami felhaszn\u00e1lhat\u00f3 a spektr\u00e1lis hat\u00e9konys\u00e1gi kapcsolat kutat\u00e1s\u00e1hoz. A spektr\u00e1lis hat\u00e1skapcsolati elemz\u00e9s azt mutatta, hogy 11 komponens jelent\u0151sen hozz\u00e1j\u00e1rult a m\u00e1jfibr\u00f3zis elleni hat\u00e1shoz (VIP>1 \u00e9s regresszi\u00f3s egy\u00fctthat\u00f3>0). K\u00f6z\u00fcl\u00fck a szakirodalomban m\u00e1jfibr\u00f3zis-ellenes hat\u00e1s\u00fa vegy\u00fcletek k\u00f6z\u00e9 tartozik a galluszsav, az apigenin, a kaempferol, a kvercetin, a szkopoletint \u00e9s a rein, ami t\u00fckr\u00f6zi az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg t\u00f6bbkomponens\u0171 \u00e9s t\u00f6bbc\u00e9l\u00fa m\u00e1jfibr\u00f3zis-ellenes hat\u00e1s\u00e1nak jellemz\u0151it. A dihidro-kamptotecin, a dihidro-kapszaicin \u00e9s a szkopolamin olyan vegy\u00fcletek, amelyek viszonylag magas tartalommal \u00e9s j\u00f3 m\u00e1jfibr\u00f3zis-ellenes hat\u00e1ssal rendelkeznek, \u00e9s amelyeket el\u0151sz\u00f6r tal\u00e1ltak az \u00e9desk\u00f6m\u00e9ny gy\u00f6k\u00e9rk\u00e9regben, \u00e9s amelyek potenci\u00e1lis min\u0151s\u00e9gi markerek lehetnek. K\u00f6z\u00fcl\u00fck a dehidrokamelbin jav\u00edthatja az Echinococcus granulosus m\u00e1sodlagos fert\u0151z\u00e9se \u00e1ltal okozott eg\u00e9r t\u00fcd\u0151sz\u00f6veti fibr\u00f3zist az\u00e1ltal, hogy cs\u00f6kkenti a TGF - \u03b2 1, Smad3 \u00e9s NF kB p65 expresszi\u00f3j\u00e1t a t\u00fcd\u0151sz\u00f6vetben. A dihidrokapszaicin \u00e9s a szkopolamin m\u00e1jfibr\u00f3zis elleni hat\u00e1s\u00e1r\u00f3l nem \u00e9rkezett jelent\u00e9s.
\nA Bcl-2 az antiapoptotikus g\u00e9nhez tartozik, \u00e9s kulcsfontoss\u00e1g\u00fa t\u00e9nyez\u0151 a sejtek \u00e9let\u00e9nek \u00e9s hal\u00e1l\u00e1nak koordin\u00e1l\u00e1s\u00e1ban, m\u00edg a Bax a proapoptotikus g\u00e9nhez tartozik, \u00e9s a Bcl-2 csal\u00e1d proapoptotikus feh\u00e9rj\u00e9je. A kaszp\u00e1z3 a sejt apopt\u00f3zis fontos effektor faktorak\u00e9nt az apoptotikus prote\u00e1zok kaszk\u00e1dreakci\u00f3j\u00e1nak sz\u00fcks\u00e9ges \u00fatvonala. Aktiv\u00e1l\u00f3d\u00e1sa azt jelzi, hogy az apopt\u00f3zis irreverzibilis szakaszba l\u00e9pett. Az apopt\u00f3zisban a Bax\/Bcl-2 ar\u00e1ny fontos indik\u00e1tor a mitokondri\u00e1lis \u00fatvonalon kereszt\u00fcl t\u00f6rt\u00e9n\u0151 sejt apopt\u00f3zis m\u00e9r\u00e9s\u00e9re. Ha a Bax\/Bcl-2 ar\u00e1ny n\u0151, az apopt\u00f3zis n\u00f6vekszik; ellenkez\u0151leg, az apopt\u00f3zis cs\u00f6kken. Amikor a sejtek apoptotikus jeleket \u00e9rz\u00e9kelnek, az apoptotikus faktorok, p\u00e9ld\u00e1ul a Bcl-2 \u00e9s a Bax expresszi\u00f3j\u00e1nak szab\u00e1lyoz\u00e1s\u00e1val aktiv\u00e1lhatj\u00e1k a kaszp\u00e1z-9-et (Caspase9), ez\u00e1ltal aktiv\u00e1lj\u00e1k a Caspase3-at \u00e9s elind\u00edtj\u00e1k a kaszp\u00e1z csal\u00e1d kaszk\u00e1dreakci\u00f3j\u00e1t, ez\u00e1ltal kiv\u00e1ltva a sejt apopt\u00f3zis\u00e1t. Ez a tanulm\u00e1ny k\u00eds\u00e9rletekkel igazolta, hogy a dehidrokamptotetocin \u00e9s a dihidrokapszaicin cs\u00f6kkentheti a mitokondriumok m\u0171k\u00f6d\u00e9s\u00e9t \u00e9s megzavarhatja a mitokondri\u00e1lis membr\u00e1npotenci\u00e1l egyens\u00faly\u00e1t aktiv\u00e1lt m\u00e1j-sztengelysejtekben, ami a proapoptotikus faktor (Bax) nagym\u00e9rt\u00e9k\u0171 felszabadul\u00e1s\u00e1hoz vezet, \u00e9s v\u00e9g\u00fcl sejtapopt\u00f3zist okoz, cs\u00f6kkenti a m\u00e1j-sztengelysejtek prolifer\u00e1ci\u00f3j\u00e1t, g\u00e1tolja az extracellul\u00e1ris m\u00e1trix \u00e9s az \u03b1 - simaizom aktiv\u00e1tor feh\u00e9rje expresszi\u00f3j\u00e1t, \u00e9s ez\u00e1ltal enyh\u00edti a m\u00e1jfibr\u00f3zist. A k\u00e9s\u0151bbi k\u00eds\u00e9rletek sor\u00e1n in vivo k\u00eds\u00e9rleteket kell v\u00e9gezni a kiv\u00e1lasztott monomer vegy\u00fcletek valid\u00e1l\u00e1s\u00e1ra, \u00e9s tov\u00e1bb kell vizsg\u00e1lni az \u00e9desk\u00f6m\u00e9nygy\u00f6k\u00e9r k\u00e9reg monomer vegy\u00fcleteinek mRNS- \u00e9s feh\u00e9rjeszint\u0171 m\u00e1jfibr\u00f3zis-ellenes mechanizmus\u00e1t.
\n\u00d6sszefoglalva, ez a tanulm\u00e1ny az UPLC Orbitrap MS\/MS technol\u00f3gi\u00e1t haszn\u00e1lta a parci\u00e1lis legkisebb n\u00e9gyzetek \u00e9s a sz\u00fcrke korrel\u00e1ci\u00f3s elemz\u00e9ssel kombin\u00e1lva az \u00e9desk\u00f6m\u00e9ny gy\u00f6k\u00e9rk\u00e9reg m\u00e1jfibr\u00f3zis elleni lehets\u00e9ges \u00f6sszetev\u0151inek tiszt\u00e1z\u00e1s\u00e1ra, ami t\u00fckr\u00f6zi az \u00e9desk\u00f6m\u00e9ny gy\u00f6k\u00e9rk\u00e9reg t\u00f6bbkomponens\u0171 \u00e9s t\u00f6bbc\u00e9l\u00fa m\u00e1jfibr\u00f3zis elleni hat\u00e1s\u00e1nak jellemz\u0151it. Ez nagy jelent\u0151s\u00e9ggel b\u00edr a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat hat\u00e9konys\u00e1g\u00e1nak anyagi alapjainak tiszt\u00e1z\u00e1sa \u00e9s a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat min\u0151s\u00e9gi szabv\u00e1nyainak jav\u00edt\u00e1sa szempontj\u00e1b\u00f3l, hivatkoz\u00e1si alapot ny\u00fajtva a hat\u00e1smechanizmus \u00e9s a klinikai alkalmaz\u00e1s tov\u00e1bbi meg\u00e9rt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Screening of effective ingredients in fennel root bark for anti liver fibrosis based on spectral effect relationship and exploration of its mechanism Liver fibrosis is the main cause of liver cirrhosis and even liver cancer, and about 90% of liver cancer develops on the basis of liver fibrosis or cirrhosis. Therefore, the treatment of liver […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nScreening of effective ingredients in fennel root bark for anti liver fibrosis based on spectral effect relationship and exploration of its mechanism - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/fennel-root-bark\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Screening of effective ingredients in fennel root bark for anti liver fibrosis based on spectral effect relationship and exploration of its mechanism - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Screening of effective ingredients in fennel root bark for anti liver fibrosis based on spectral effect relationship and exploration of its mechanism Liver fibrosis is the main cause of liver cirrhosis and even liver cancer, and about 90% of liver cancer develops on the basis of liver fibrosis or cirrhosis. 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