{"id":4220,"date":"2024-08-04T08:53:16","date_gmt":"2024-08-04T08:53:16","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4220"},"modified":"2024-08-04T08:53:16","modified_gmt":"2024-08-04T08:53:16","slug":"astragalus-membranaceus","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/astragalus-membranaceus\/","title":{"rendered":"A Huangqi kivonat mechanizmus\u00e1nak tanulm\u00e1nyoz\u00e1sa az ischaemi\u00e1s hipoxi\u00e1s encephalopathia kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1si technol\u00f3gia \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n"},"content":{"rendered":"

A Huangqi kivonat mechanizmus\u00e1nak tanulm\u00e1nyoz\u00e1sa az ischaemi\u00e1s hipoxi\u00e1s encephalopathia kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1si technol\u00f3gia \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n
\nAz \u00fajsz\u00fcl\u00f6ttkori ischaemi\u00e1s enkefalop\u00e1tia (HIE) egy olyan betegs\u00e9gt\u00edpus, amely az \u00fajsz\u00fcl\u00f6ttek \u00e9s csecsem\u0151k idegeinek n\u00f6veked\u00e9s\u00e9t \u00e9s fejl\u0151d\u00e9s\u00e9t befoly\u00e1solja. A t\u00fal\u00e9l\u0151k gyakran k\u00fcl\u00f6nb\u00f6z\u0151 neurol\u00f3giai k\u00f6vetkezm\u00e9nyeket hagynak maguk ut\u00e1n, amelyek s\u00falyos terhet r\u00f3nak az \u00e9rintett gyermekekre \u00e9s csal\u00e1djukra. A klinikai gyakorlatban jelenleg nincs specifikus gy\u00f3gyszer a HIE kezel\u00e9s\u00e9re, \u00e9s a HIE patofiziol\u00f3giai mechanizmusainak tanulm\u00e1nyoz\u00e1sa nagy jelent\u0151s\u00e9ggel b\u00edr a hat\u00e9konyabb kezel\u00e9si tervek megtal\u00e1l\u00e1sa szempontj\u00e1b\u00f3l. A kutat\u00e1sok kimutatt\u00e1k, hogy az oxidat\u00edv stressz, a kalcium be\u00e1raml\u00e1sa, a szabadgy\u00f6k-termel\u00e9s, az acid\u00f3zis, az ionegyens\u00falyhi\u00e1ny, a gyullad\u00e1s, az apopt\u00f3zis, az autof\u00e1gia, a nekr\u00f3zis \u00e9s m\u00e1s t\u00e9nyez\u0151k mind fontos szerepet j\u00e1tszanak a HIE patogenezis\u00e9ben. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s ter\u00fclet\u00e9n arr\u00f3l sz\u00e1moltak be, hogy a Huangqi \u00e9s k\u00e9sz\u00edtm\u00e9nyei j\u00f3 hat\u00e1st mutatnak a HIE kezel\u00e9s\u00e9ben. A modern farmakol\u00f3gia meger\u0151s\u00edtette, hogy a Huangqi-kivonat az oxig\u00e9n szabad gy\u00f6k\u00f6k tiszt\u00edt\u00e1s\u00e1ra, a fert\u0151z\u00e9s elleni v\u00e9delemre \u00e9s az \u00e9rrendszeri endothelium v\u00e9delm\u00e9re k\u00e9pes. A klinikai gyakorlatban sz\u00e9les k\u00f6rben alkalmazz\u00e1k a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gek kezel\u00e9s\u00e9re. E tanulm\u00e1ny c\u00e9lja, hogy elemezze a Huangqi kivonat hat\u00e1smechanizmus\u00e1t a HIE kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a molekul\u00e1ris dokkol\u00e1si technik\u00e1k seg\u00edts\u00e9g\u00e9vel, referenci\u00e1t ny\u00fajtva a klinikai alkalmaz\u00e1s el\u0151seg\u00edt\u00e9s\u00e9hez.<\/p>\n

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A HIE f\u0151 patofiziol\u00f3giai mechanizmusa az agysz\u00f6vet iszk\u00e9mi\u00e1ja \u00e9s hipoxi\u00e1ja. Az agysz\u00f6veti iszk\u00e9mia \u00e9s hipoxia egy sor patol\u00f3giai \u00e9s fiziol\u00f3giai v\u00e1ltoz\u00e1st okozhat, els\u0151sorban a sejtek apopt\u00f3zis\u00e1t, a gyullad\u00e1sos v\u00e1laszt \u00e9s az oxidat\u00edv stresszv\u00e1laszt. Az iszk\u00e9mi\u00e1s \u00e9s hipoxi\u00e1s idegk\u00e1rosod\u00e1s k\u00fcl\u00f6nb\u00f6z\u0151 szakaszait mind a fent eml\u00edtett h\u00e1rom fiziol\u00f3giai v\u00e1ltoz\u00e1s k\u00f6lcs\u00f6nhat\u00e1sa okozza. Az \u00fajsz\u00fcl\u00f6ttkori HIE kezel\u00e9se mindig is forr\u00f3 \u00e9s neh\u00e9z t\u00e9ma volt a klinikai kutat\u00e1sban. A hagyom\u00e1nyos \"h\u00e1rom t\u00e1mogat\u00f3\" \u00e9s \"h\u00e1rom t\u00fcneti\" ter\u00e1pi\u00e1t k\u00fcl\u00f6nb\u00f6z\u0151 t\u00e9nyez\u0151k, p\u00e9ld\u00e1ul a terhess\u00e9gi kor, az id\u0151 \u00e9s az orvosi l\u00e9tes\u00edtm\u00e9nyek korl\u00e1tozz\u00e1k, ami korl\u00e1tozott ter\u00e1pi\u00e1s hat\u00e1st eredm\u00e9nyez a HIE eset\u00e9ben. Klinikai szempontb\u00f3l s\u00fcrg\u0151sen keresik a kieg\u00e9sz\u00edt\u0151 vagy alternat\u00edv ter\u00e1pi\u00e1kat a HIE kezel\u00e9s\u00e9re. A Huangqi, mint hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat, az elm\u00falt \u00e9vekben jelent\u0151s el\u0151rel\u00e9p\u00e9st \u00e9rt el a Huangqi hat\u00f3anyagainak hat\u00e1saira vonatkoz\u00f3 modern farmakol\u00f3giai kutat\u00e1sok r\u00e9v\u00e9n. A kutat\u00e1sok kimutatt\u00e1k, hogy az Astragalus membranaceus fokozza a szervezet immunit\u00e1s\u00e1t, ellen\u00e1ll a hipoxi\u00e1nak \u00e9s az oxidat\u00edv stressznek, \u00e9s jav\u00edtja az \u00e9rrendszeri endothelfunkci\u00f3t. \u00c1llatk\u00eds\u00e9rletek kimutatt\u00e1k, hogy az Astragalus membranaceus k\u00e9pes felszab\u00e1lyozni a B-lymphotumor-2 feh\u00e9rje expresszi\u00f3s szintj\u00e9t patk\u00e1nyok agysz\u00f6vet\u00e9ben, g\u00e1tolja a neuron\u00e1lis apopt\u00f3zist, \u00e9s enyh\u00edti az iszk\u00e9mia \u00e9s hipoxia \u00e1ltal okozott agyk\u00e1rosod\u00e1st. Az Astragalus membranaceus f\u0151 hat\u00f3anyagai \u00e9s hat\u00e1smechanizmusai a klinikai gyakorlatban azonban m\u00e9g nem tiszt\u00e1zottak. A h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a molekul\u00e1ris dokkol\u00e1s az ut\u00f3bbi \u00e9vekben a nagy adatb\u00e1zisokon alapul\u00f3 farmakol\u00f3giai kutat\u00e1s \u00fajonnan megjelen\u0151 technol\u00f3gi\u00e1i. A nagy adatokon kereszt\u00fcl megkapjuk a kapcsol\u00f3d\u00f3 gy\u00f3gyszerek f\u0151 hat\u00f3anyagait \u00e9s c\u00e9lpontjait, \u00e9s molekul\u00e1ris dokkol\u00e1st v\u00e9gz\u00fcnk a betegs\u00e9g c\u00e9lpontjaival a gy\u00f3gyszerek specifikus hat\u00e1smechanizmus\u00e1nak elemz\u00e9se \u00e9rdek\u00e9ben. A TCMSP adatb\u00e1zis szerint a Huangqi kivonatb\u00f3l \u00f6sszesen 70 hat\u00f3anyagot kaptunk. \u00d6sszesen 350 relev\u00e1ns c\u00e9lpontot kaptunk, \u00e9s a duplik\u00e1lt c\u00e9lpontok \u00e9s g\u00e9nmegjegyz\u00e9sek elt\u00e1vol\u00edt\u00e1sa ut\u00e1n v\u00e9g\u00fcl a \"Huangqi kivonat\" hat\u00f3anyagainak 120 c\u00e9lpontj\u00e1t kaptuk meg.
\nA topol\u00f3giai elemz\u00e9ssel kapott vegy\u00fcleth\u00e1l\u00f3zati c\u00e9lt\u00e9rk\u00e9p azt mutatja, hogy az Astragalus membranaceus f\u0151 hat\u00f3anyagai a HIE kezel\u00e9s\u00e9ben a 4-hidroxifah\u00e9jsav, a cisz-avionsav, az asztragalozid, a hederagenin \u00e9s a galangin. A 4-hidroxifah\u00e9jsav bizony\u00edtottan k\u00e9pes az oxig\u00e9n szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. \u00c1llatk\u00eds\u00e9rletek kimutatt\u00e1k, hogy a 4-hidroxifah\u00e9jsav k\u00e9pes enyh\u00edteni a neurop\u00e1ti\u00e1s f\u00e1jdalmat patk\u00e1nyokban. Egy Xizangban v\u00e9gzett vizsg\u00e1lat kimutatta, hogy a cisz-acitretin hat\u00e9konyan jav\u00edthatja a szervezet oxig\u00e9ntel\u00edtetts\u00e9g\u00e9t \u00e9s enyh\u00edtheti a hipoxia \u00e1ltal okozott k\u00e1ros t\u00fcneteket; \u00c9s a hat\u00f3anyag el\u0151seg\u00edtheti az asztragalozid IV felsz\u00edv\u00f3d\u00e1s\u00e1t a szervezetben. Az asztragalozid IV-et sz\u00e9les k\u00f6rben tanulm\u00e1nyozt\u00e1k \u00e9s bizony\u00edtott\u00e1k, hogy gyullad\u00e1scs\u00f6kkent\u0151, antiapoptotikus \u00e9s immunmodul\u00e1l\u00f3 biol\u00f3giai tev\u00e9kenys\u00e9ggel rendelkezik, ami fontos neuroprotekt\u00edv anyagg\u00e1 teszi. Az asztragalozid r\u00f3zsafa glikozid az Astragalus membranaceusb\u00f3l izol\u00e1lt vegy\u00fclet, amely k\u00e9pes g\u00e1tolni az extracellul\u00e1risan szab\u00e1lyozott feh\u00e9rje kin\u00e1zok 1\/2 (ERK1\/2) aktiv\u00e1l\u00f3d\u00e1s\u00e1t, amelyet a hum\u00e1n trombocita eredet\u0171 BB n\u00f6veked\u00e9si faktor (PDGF-BB) stimul\u00e1ci\u00f3ja induk\u00e1l, \u00e9s g\u00e1tolja a mitog\u00e9n aktiv\u00e1l\u00f3 protein (MAP) kin\u00e1z foszforil\u00e1ci\u00f3j\u00e1t; Az ERK1\/2MAP-kin\u00e1z kaszk\u00e1d \u00fatvonal elnyom\u00e1sa r\u00e9v\u00e9n g\u00e1tolhatja az \u00e9rrendszeri simaizomsejtek PDGF-BB \u00e1ltal induk\u00e1lt prolifer\u00e1ci\u00f3j\u00e1t is. H\u00e1l\u00f3zati farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy a Huangqi hat\u00f3anyaga, a Hualiangjiangsu, ter\u00e1pi\u00e1s hat\u00e1st gyakorolhat a t\u00e9rd osteoarthritisre a PDK Akt jel\u00e1tviteli \u00fatvonalon, a tumor nekr\u00f3zis faktoron \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl.
\nA 120 c\u00e9lpont felt\u00e9rk\u00e9pez\u00e9se ut\u00e1n 242 HIE c\u00e9lponttal 18 potenci\u00e1lis c\u00e9lpontot kaptunk. A tov\u00e1bbi PPI-h\u00e1l\u00f3zati elemz\u00e9s felt\u00e1rta, hogy a NOS2, PTGS2, SOD1, MAPK4 \u00e9s CASP8 a Huangqi k\u00f6zponti c\u00e9lpontjai a HIE kezel\u00e9s\u00e9ben. A gyullad\u00e1st a HIE fontos patog\u00e9n t\u00e9nyez\u0151j\u00e9nek tekintik, \u00e9s a nagy mennyis\u00e9g\u0171 gyullad\u00e1sos faktorok felgyors\u00edthatj\u00e1k a neuron\u00e1lis sejtek apopt\u00f3zis\u00e1t \u00e9s nekr\u00f3zis\u00e1t. A NOS2 el\u0151seg\u00edtheti a nitrog\u00e9n-oxid termel\u00e9s\u00e9t a k\u00f6zponti \u00e9s a perif\u00e9ri\u00e1s idegrendszer idegsz\u00f6veteiben, \u00e9s r\u00e9szt vehet a gyullad\u00e1sban \u00e9s az oxidat\u00edv stresszre adott v\u00e1laszokban. \u00c1llatk\u00eds\u00e9rletek kimutatt\u00e1k, hogy a patk\u00e1ny NOS2 g\u00e9n ki\u00fct\u00e9se g\u00e1tolhatja a Rac1 szint\u00e9zis\u00e9t, ez\u00e1ltal elnyomja a tumor nekr\u00f3zis faktor alfa gyullad\u00e1skelt\u0151 hat\u00e1s\u00e1t. A SOD1 f\u0151 funkci\u00f3ja, hogy antioxid\u00e1ns hat\u00e1st fejt ki a szervezetben. A SOD1 fontos szerepet j\u00e1tszik a szervezet oxidat\u00edv stresszv\u00e1lasz\u00e1ban, mivel el\u0151seg\u00edtheti a hidrog\u00e9n-peroxid lebont\u00e1s\u00e1t a sejtekben, cs\u00f6kkentheti az oxig\u00e9n szabad gy\u00f6k\u00f6k termel\u00e9s\u00e9t, \u00e9s fenntartja a szervezet oxidat\u00edv antioxid\u00e1ns rendszer\u00e9nek egyens\u00faly\u00e1t. In vitro sejtk\u00eds\u00e9rletek kimutatt\u00e1k, hogy a PTGS2 t\u00falterjed\u00e9se s\u00falyosb\u00edthatja a sejtk\u00e1rosod\u00e1st PC12 sejtekben gl\u00fck\u00f3zmegvon\u00e1sos modellben. Ha helyi iszk\u00e9mia \u00e9s hipoxia l\u00e9p fel \u00e9s citokineket szabad\u00edt fel, az aktiv\u00e1lhatja a MAPK4 \u00fatvonalat, ami tov\u00e1bb stimul\u00e1lja az immunsejteket pro-inflammatorikus citokinek felszabad\u00edt\u00e1s\u00e1ra \u00e9s s\u00falyosb\u00edtja a helyi gyullad\u00e1sos reakci\u00f3kat. A CASP8 a sejtek apopt\u00f3zis\u00e1nak \u00e9s nekrotikus apopt\u00f3zis\u00e1nak kulcsfontoss\u00e1g\u00fa szab\u00e1lyoz\u00f3 t\u00e9nyez\u0151je, valamint dimeriz\u00e1ci\u00f3ja \u00e9s enzimaktivit\u00e1sa r\u00e9v\u00e9n a gyullad\u00e1sos v\u00e1lasz szab\u00e1lyoz\u00e1s\u00e1ban is kulcsszerepet j\u00e1tszik. Tartalm\u00e1nak n\u00f6veked\u00e9se a helyi gyullad\u00e1sos v\u00e1lasz fokoz\u00f3d\u00e1s\u00e1t jelzi. A fenti elemz\u00e9sb\u0151l l\u00e1thatjuk, hogy az Astragalus membranaceus f\u0151 hat\u00f3anyagai a fent eml\u00edtett c\u00e9lpontokra hatva fejtik ki ter\u00e1pi\u00e1s hat\u00e1sukat a HIE-re, \u00e9s a biol\u00f3giai folyamatok gyullad\u00e1sos reakci\u00f3kat, oxidat\u00edv stressz sejteket, k\u00e1rosod\u00e1sjav\u00edt\u00e1st stb. \u00e9rinthetnek.
\nA molekul\u00e1ris dokkol\u00e1si eredm\u00e9nyek azt mutatt\u00e1k, hogy az Astragalus membranaceus h\u00e1rom hat\u00f3anyaga, a 4-hidroxifah\u00e9jsav, a cisz-avionsav \u00e9s az asztragalozid j\u00f3 k\u00f6t\u0151d\u00e9si aktivit\u00e1ssal rendelkezik a kulcsfontoss\u00e1g\u00fa c\u00e9lpontokkal, \u00e9s els\u0151sorban a hidrof\u00f3b vagy hidrog\u00e9nk\u00f6t\u00e9sre t\u00e1maszkodva gyakorol ter\u00e1pi\u00e1s hat\u00e1st a HIE-re. A k\u00f6t\u00e9si energi\u00e1t tekintve a SOD1 \u00e9s az Astragalus membranaceus r\u00f3zsafa glikozid k\u00f6z\u00f6tt a legalacsonyabb k\u00f6t\u00e9si energia -8,9 kcal\/mol. Az \u00e1llatk\u00eds\u00e9rletes ellen\u0151rz\u00e9s eredm\u00e9nyei azt mutatt\u00e1k, hogy a NOS2 \u00e9s PTGS2 feh\u00e9rj\u00e9k expresszi\u00f3s szintje a kezelt csoport patk\u00e1nyainak hippokampusz\u00e1ban alacsonyabb volt, mint a modellcsoportban, \u00e9s a SOD1 feh\u00e9rje expresszi\u00f3s szintje magasabb volt, mint a modellcsoportban. A NOS2 \u00e9s a PTGS2 feh\u00e9rj\u00e9k expresszi\u00f3s szintje a l\u00e1tszatm\u0171t\u00e9ti csoport patk\u00e1nyainak hippokampusz\u00e1ban alacsonyabb volt, mint a kezel\u00e9si csoportban \u00e9s a modellcsoportban, \u00e9s a SOD1 expresszi\u00f3s szintje magasabb volt, mint a kezel\u00e9si csoportban \u00e9s a modellcsoportban, ami tov\u00e1bb er\u0151s\u00edti a Huangqi kivonat megb\u00edzhat\u00f3 szerep\u00e9t a HIE kezel\u00e9s\u00e9ben. Kapcsol\u00f3d\u00f3 tanulm\u00e1nyok kimutatt\u00e1k, hogy az astragalus szaponinok aktiv\u00e1lhatj\u00e1k az Nrf2\/HO jel\u00e1tviteli \u00fatvonalat, felszab\u00e1lyozhatj\u00e1k a downstream antioxid\u00e1ns g\u00e9n HO-1 expresszi\u00f3j\u00e1t, g\u00e1tolhatj\u00e1k a nitrog\u00e9n-oxid termel\u00e9st, n\u00f6velhetik a SOD aktivit\u00e1st \u00e9s fokozhatj\u00e1k az agysz\u00f6vet antioxid\u00e1ns kapacit\u00e1s\u00e1t. A modern farmakol\u00f3gia azt is meger\u0151s\u00edtette, hogy a Huangqi a szabad gy\u00f6k\u00f6k elnyel\u00e9s\u00e9re val\u00f3 er\u0151s k\u00e9pess\u00e9ge mellett flavonoidokat is tartalmaz, amelyek cs\u00f6kkenthetik a v\u00e9rlemezk\u00e9k aktivit\u00e1s\u00e1t az agyi iszk\u00e9mia-reperf\u00fazi\u00f3 sor\u00e1n, g\u00e1tolj\u00e1k a ciklooxigen\u00e1z-2 expresszi\u00f3j\u00e1t, \u00e9s enyh\u00edtik az agyi iszk\u00e9mia-reperf\u00fazi\u00f3s s\u00e9r\u00fcl\u00e9st.
\n\u00d6sszefoglalva, ez a cikk h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t \u00e9s molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1t alkalmaz az Astragalus membranaceus kivonat f\u0151 hat\u00f3anyagainak mechanizmus\u00e1nak elemz\u00e9s\u00e9re a HIE kezel\u00e9s\u00e9ben. Arra a k\u00f6vetkeztet\u00e9sre jutottunk, hogy az Astragalus membranaceus kivonat h\u00e1rom f\u0151 \u00f6sszetev\u0151je a HIE kezel\u00e9s\u00e9ben a 4-hidroxifah\u00e9jsav, a cisz-avionsav \u00e9s az Astragalus membranaceus r\u00f3zsafa glikozid, amelyek a kulcsfontoss\u00e1g\u00fa c\u00e9lpontokra, p\u00e9ld\u00e1ul a NOS2-re, PTGS2-re, SOD1-re, MAPK4-re \u00e9s CASP8-ra hatva fejtik ki ter\u00e1pi\u00e1s hat\u00e1sukat a HIE-re. A h\u00e1l\u00f3zati farmakol\u00f3giai elemz\u00e9s azt is meger\u0151s\u00edtette, hogy ez a folyamat t\u00f6bb komponens, c\u00e9lpont \u00e9s \u00fatvonal szinergikus hat\u00e1s\u00e1nak eredm\u00e9nye.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification Neonatal ischemic encephalopathy (HIE) is a type of disease that affects the nerve growth and development of newborns and infants. Survivors often leave behind various neurological sequelae, which impose a heavy burden on […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/astragalus-membranaceus\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification Neonatal ischemic encephalopathy (HIE) is a type of disease that affects the nerve growth and development of newborns and infants. 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