{"id":4179,"date":"2024-08-04T08:48:04","date_gmt":"2024-08-04T08:48:04","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4179"},"modified":"2024-08-04T08:48:04","modified_gmt":"2024-08-04T08:48:04","slug":"qianhu-medicinal-materials","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/qianhu-medicinal-materials\/","title":{"rendered":"A HPLC-ujjlenyomat, a k\u00e9miai mintafelismer\u00e9s \u00e9s a Houttuynia cordata gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9g\u00e9nek t\u00f6bb indexkomponens\u0171 kvantitat\u00edv \u00e9rt\u00e9kel\u00e9se a HPLC-ujjlenyomat alapj\u00e1n"},"content":{"rendered":"

A HPLC-ujjlenyomat, a k\u00e9miai mintafelismer\u00e9s \u00e9s a Houttuynia cordata gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9g\u00e9nek t\u00f6bb indexkomponens\u0171 kvantitat\u00edv \u00e9rt\u00e9kel\u00e9se a HPLC-ujjlenyomat alapj\u00e1n
\nA Peucedamum praeruptorum Dunn gy\u00f3gyn\u00f6v\u00e9nyt az Umbelliferae csal\u00e1dba tartoz\u00f3 feh\u00e9r vir\u00e1g\u00fa Peucedamum praeruptorum Dunn n\u00f6v\u00e9ny sz\u00e1r\u00edtott gy\u00f6ker\u00e9b\u0151l nyerik. El\u0151sz\u00f6r a \"H\u00edres orvosok feljegyz\u00e9sei\" c\u00edm\u0171 k\u00f6nyvben jelent meg, \u00e9s a sz\u00e9lh\u0151 eloszlat\u00e1s\u00e1ra, a qi cs\u00f6kkent\u00e9s\u00e9re \u00e9s a v\u00e1lad\u00e9k felold\u00e1s\u00e1ra van hat\u00e1ssal. \u00c1ltal\u00e1ban olyan t\u00fcnetekre haszn\u00e1lj\u00e1k, mint a v\u00e1lad\u00e9kh\u0151 k\u00f6h\u00f6g\u00e9s \u00e9s asztma, s\u00e1rga s\u0171r\u0171 v\u00e1lad\u00e9k, sz\u00e9lh\u0151 k\u00f6h\u00f6g\u00e9s \u00e9s t\u00falzott v\u00e1lad\u00e9k. A modern k\u00e9miai \u00f6sszet\u00e9tel \u00e9s a klinikai alkalmaz\u00e1sok szempontj\u00e1b\u00f3l a Peucedanum praeruptorum hat\u00f3anyagai f\u0151k\u00e9nt szarv t\u00edpus\u00fa kumarinok, bele\u00e9rtve a Peucedanum praeruptorum A, Peucedanum praeruptorum B, Peucedanum praeruptorum Ding stb., amelyek farmakol\u00f3giai hat\u00e1sai k\u00f6z\u00e9 tartozik a k\u00f6ptet\u0151, sz\u00edvel\u00e9gtelens\u00e9g elleni, v\u00e9rnyom\u00e1scs\u00f6kkent\u0151 \u00e9s gyullad\u00e1scs\u00f6kkent\u0151. Az \u0151si id\u0151k \u00f3ta a Qianhu gy\u00f3gyn\u00f6v\u00e9nye f\u0151k\u00e9nt vadon term\u0151 forr\u00e1sok, amelyek Anhui, Hunan, Jiangxi, Zhejiang, Jiangsu \u00e9s m\u00e1s helyeken terjedtek el. Az ut\u00f3bbi \u00e9vekben az er\u0151forr\u00e1s ir\u00e1nti kereslet megugr\u00e1sa miatt a mesters\u00e9ges termeszt\u00e9s fokozatosan felv\u00e1ltotta a vadon termeszt\u00e9st. F\u0151 termeszt\u00e9si ter\u00fcletei: Ningguo Anhui-ban, Huarong Hunan-ban, Zunyi Guizhou-ban, Fengjie Chongqing-ban \u00e9s m\u00e1s helyeken. A feh\u00e9r vir\u00e1g\u00fa Peucedanum praeruptorum mesters\u00e9ges termeszt\u00e9se ut\u00e1n k\u00fcl\u00f6nb\u00f6z\u0151 term\u0151ter\u00fcletek vezett\u00e9k be \u00e9s telep\u00edtett\u00e9k, a keleti Zhejiangt\u00f3l a nyugati Yunnanig \u00e9s Sichuanig. A termel\u00e9si k\u00f6rnyezetek k\u00f6z\u00f6tti nagy k\u00fcl\u00f6nbs\u00e9gek miatt azonban a Peucedanum praeruptorum gy\u00f3gyn\u00f6v\u00e9nyek min\u0151s\u00e9g\u00e9ben jelent\u0151s k\u00fcl\u00f6nbs\u00e9gek vannak, \u00e9s a min\u0151s\u00e9g\u00fck is elt\u00e9r\u0151. Ezenk\u00edv\u00fcl a feh\u00e9r vir\u00e1g\u00fa Peucedanum praeruptorum mesters\u00e9ges \u00fcltet\u00e9se hajlamos olyan probl\u00e9m\u00e1kra, mint a korai bimb\u00f3sod\u00e1s, ami a Peucedanum praeruptorum gy\u00f3gyn\u00f6v\u00e9nyek korai betakar\u00edt\u00e1s\u00e1t k\u00e9nyszer\u00edti ki. Az el\u00e9gtelen n\u00f6veked\u00e9si id\u0151szak a gy\u00f3gy\u00e1szati anyagok min\u0151s\u00edthetetlen ar\u00e1ny\u00e1nak jelent\u0151s n\u00f6veked\u00e9s\u00e9hez vezet. A K\u00ednai Gy\u00f3gyszerk\u00f6nyv 2020-as kiad\u00e1sa el\u0151\u00edrja, hogy \"a Peucedanum praeruptorum A tartalma nem lehet kevesebb, mint 0,90%, \u00e9s a Peucedanum praeruptorum B tartalma nem lehet kevesebb, mint 0,24%\". A Peucedanum praeruptorum gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9gi megfelel\u00e9si ar\u00e1nya a piacon azonban csak 26%, \u00e9s a nem min\u0151s\u00edtett Peucedanum praeruptorum gy\u00f3gy\u00e1szati anyagok el\u00e1rasztj\u00e1k a piacot. A kiv\u00e1l\u00f3 min\u0151s\u00e9g\u0171 \u00faj fajt\u00e1k termeszt\u00e9se, a megfelel\u0151 \u00fcltet\u00e9si technik\u00e1k kialak\u00edt\u00e1sa \u00e9s a kezdeti feldolgoz\u00e1s szabv\u00e1nyos\u00edt\u00e1sa mellett a termel\u00e9si ter\u00fcleteken az objekt\u00edv, tudom\u00e1nyos \u00e9s \u00e9sszer\u0171 min\u0151s\u00e9g\u00e9rt\u00e9kel\u00e9si m\u00f3dszerek \u00e9s szabv\u00e1nyok is fontos szempontok a Qianhu gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9g\u00e9nek biztos\u00edt\u00e1s\u00e1ban. Jelenleg a Houttuynia cordata gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9g\u00e9rt\u00e9kel\u00e9s\u00e9nek kulcsa a feh\u00e9r vir\u00e1g\u00fa Houttuynia cordata berberin \u00e9s berberin tartalma. Ez azonban gyakran nem k\u00e9pes \u00e1tfog\u00f3an \u00e9rt\u00e9kelni a Houttuynia cordata gy\u00f3gy\u00e1szati anyagok bels\u0151 min\u0151s\u00e9g\u00e9t, \u00e9s k\u00f6zvetlen\u00fcl befoly\u00e1solja a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s klinikai alkalmaz\u00e1s\u00e1t.<\/p>\n

A HPLC-ujjlenyomat \u00e1tfog\u00f3an k\u00e9pes t\u00fckr\u00f6zni a gy\u00f3gy\u00e1szati anyagok bels\u0151 min\u0151s\u00e9g\u00e9t, \u00e9s sz\u00e9les k\u00f6rben elismert min\u0151s\u00e9gellen\u0151rz\u00e9si m\u00f3dszer. A t\u00f6bbindexes tartalom meghat\u00e1roz\u00e1s\u00e1val kombin\u00e1lva a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9gellen\u0151rz\u00e9s\u00e9nek f\u0151\u00e1ram\u00e1v\u00e1 v\u00e1lt. A fel\u00fcgyelet n\u00e9lk\u00fcli m\u00f3dszerek, mint a hierarchikus klaszterelemz\u00e9s (HCA) \u00e9s a f\u0151komponens-elemz\u00e9s (PCA), valamint a fel\u00fcgyelt k\u00e9miai modellez\u00e9si m\u00f3dszerek, mint a r\u00e9szleges legkisebb n\u00e9gyzetek (PLS) \u00e9s a mesters\u00e9ges neur\u00e1lis h\u00e1l\u00f3zatok, jobban t\u00fckr\u00f6zik a gy\u00f3gy\u00e1szati anyagok bels\u0151 min\u0151s\u00e9g\u00e9t, \u00e9s az ut\u00f3bbi \u00e9vekben sz\u00e9les k\u00f6rben haszn\u00e1lt \u00faj m\u00f3dszerek. Ez a tanulm\u00e1ny a kor\u00e1bbi alapokra \u00e9p\u00fcl, HPLC-ujjlenyomatot hoz l\u00e9tre, \u00e9s olyan k\u00e9miai modellez\u00e9si m\u00f3dszereket kombin\u00e1l, mint a klaszterelemz\u00e9s, a f\u0151komponens-elemz\u00e9s \u00e9s a r\u00e9szleges legkisebb n\u00e9gyzetek regresszi\u00f3elemz\u00e9se, hogy \u00e1tfog\u00f3an \u00e9rt\u00e9kelje a Houttuynia cordata k\u00fcl\u00f6nb\u00f6z\u0151 eredet\u0171 gy\u00f3gy\u00e1szati anyagait; Ugyanakkor n\u00e9gy kumarin komponens, nevezetesen a bergamott-lakton, a paeoniflorin, a paeoniflorin \u00e9s a paeoniflorin E tartalm\u00e1t kvantitat\u00edv m\u00f3don hat\u00e1rozt\u00e1k meg, hogy tiszt\u00e1zz\u00e1k a k\u00fcl\u00f6nb\u00f6z\u0151 r\u00e9gi\u00f3kb\u00f3l sz\u00e1rmaz\u00f3 paeoniflorin \u00f6sszet\u00e9telbeli k\u00fcl\u00f6nbs\u00e9geit, referenci\u00e1t biztos\u00edtva a paeoniflorin min\u0151s\u00e9gi szabv\u00e1nyainak kidolgoz\u00e1s\u00e1hoz.<\/p>\n

\"\"\"\"
\nA Houttuynia cordata HPLC-ujjlenyomat\u00e1nak kromatogr\u00e1fi\u00e1s k\u00f6r\u00fclm\u00e9nyeinek optimaliz\u00e1l\u00e1sa \u00e9rdek\u00e9ben ez a tanulm\u00e1ny a kor\u00e1bbi kutat\u00e1sok alapj\u00e1n optimaliz\u00e1lta a detekt\u00e1l\u00e1si hull\u00e1mhosszt, a mobilf\u00e1zist \u00e9s az \u00e1raml\u00e1si sebess\u00e9get. Az elemz\u00e9st teljes hull\u00e1mhossz\u00fa p\u00e1szt\u00e1z\u00f3 m\u00f3dszerrel v\u00e9gezt\u00fck, \u00e9s az eredm\u00e9nyek 190-245 nm \u00e9s 290-340 nm hull\u00e1mhosszon mutattak abszorpci\u00f3t. A 321 nm-es detekt\u00e1l\u00e1si hull\u00e1mhossz kiv\u00e1laszt\u00e1sa nagy mennyis\u00e9g\u0171 inform\u00e1ci\u00f3val, j\u00f3 v\u00e1lasz\u00e9rt\u00e9kkel \u00e9s kevesebb szennyez\u0151d\u00e9sb\u0151l sz\u00e1rmaz\u00f3 interferenci\u00e1val j\u00e1r. Ez\u00e9rt a 321 nm-t hat\u00e1roztuk meg detekt\u00e1l\u00e1si hull\u00e1mhosszk\u00e9nt. Az \"acetonitril v\u00edz\" \u00e9s a \"metanol v\u00edz\" mobilf\u00e1zisok vizsg\u00e1lata azt mutatta, hogy a \"metanol v\u00edz\" elv\u00e1laszt\u00f3 hat\u00e1sa jobb volt, \u00e9s a 0,5% hangyasavas v\u00edzzel jobb cs\u00facsform\u00e1kat lehetett el\u00e9rni. Ez\u00e9rt a \"metanol-0,5% hangyasavas v\u00edz\" f\u00e1zist hat\u00e1rozt\u00e1k meg mozg\u00f3f\u00e1zisk\u00e9nt. Ezenk\u00edv\u00fcl vizsg\u00e1latokat v\u00e9geztek az \u00e1raml\u00e1s \"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"1, 0,8 \u00e9s 0,5 ml\/perc sebess\u00e9ggel, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy a 0,5 ml\/perc jobb elv\u00e1laszt\u00e1si hat\u00e9konys\u00e1ggal rendelkezik. Ez\u00e9rt a m\u00f3dszerhez 0,5 ml\/perc \u00e1raml\u00e1si sebess\u00e9get hat\u00e1roztunk meg.<\/p>\n

Ebben a tanulm\u00e1nyban HPLC-ujjlenyomat-elemz\u00e9ssel elemezt\u00e9k a Hunan, Anhui, Chongqing, Hubei, Guizhou, Yunnan \u00e9s m\u00e1s term\u0151ter\u00fcletekr\u0151l sz\u00e1rmaz\u00f3 mint\u00e1kat. A 16 k\u00ednai gy\u00f3gyn\u00f6v\u00e9nyt\u00e9tel ujjlenyomata nagyfok\u00fa hasonl\u00f3s\u00e1got mutatott, \u00f6sszesen 21 k\u00f6z\u00f6s cs\u00facsot \u00e9s 7 komponenst azonos\u00edtottak. A k\u00e9miai mintaelemz\u00e9s sor\u00e1n a 16 t\u00e9tel mint\u00e1t h\u00e1rom kateg\u00f3ri\u00e1ba sorolt\u00e1k. A szakirodalmi referenci\u00e1k alapj\u00e1n h\u00e1rom kateg\u00f3ri\u00e1ba sorolhat\u00f3k: autentikus term\u0151ter\u00fcletek, mint p\u00e9ld\u00e1ul Ningguo \u00e9s Bozhou Anhui-ban, Qianhu f\u0151k\u00e9nt Hunanban, Guizhou, Chongqing \u00e9s a magasan fekv\u0151 term\u0151ter\u00fcletek Yunnanban. A f\u0151komponens \u00e9s a PLS-DA elemz\u00e9s r\u00e9v\u00e9n a hat f\u0151komponens kumulat\u00edv variancia-hozz\u00e1j\u00e1rul\u00e1si ar\u00e1nya 86,213% volt. A tov\u00e1bbi elemz\u00e9s nyolc k\u00f6z\u00f6s cs\u00facsot azonos\u00edtott, amelyek megk\u00fcl\u00f6nb\u00f6ztetik a sz\u00e1rmaz\u00e1st, \u00e9s amelyek a sz\u00e1rmaz\u00e1s f\u0151 jellemz\u0151 \u00f6sszetev\u0151ik\u00e9nt haszn\u00e1lhat\u00f3k. A berberin \u00e9s a bergamott tartalma a magasan fekv\u0151 Yunnan term\u0151ter\u00fclet\u00e9r\u0151l sz\u00e1rmaz\u00f3 Houttuynia cordata mint\u00e1kban szignifik\u00e1nsan magasabb, mint m\u00e1s term\u0151ter\u00fcleteken, m\u00edg a berberin\u00e9 kiss\u00e9 magasabb, mint m\u00e1s term\u0151ter\u00fcleteken. Felt\u00e9telezz\u00fck, hogy a nagy tengerszint feletti magass\u00e1g el\u0151seg\u00edti a bergamott-lakton, a berberin \u00e9s a berberin felhalmoz\u00f3d\u00e1s\u00e1t a Houttuynia cordata gy\u00f3gy\u00e1szati anyagokban. Yang \u00e9s munkat\u00e1rsai \u00fagy v\u00e9lik, hogy a nagy tengerszint feletti magass\u00e1g el\u0151seg\u00edti a Peucedanum praeruptorum \u00e9s a Peucedanum praeruptorum keletkez\u00e9s\u00e9t \u00e9s felhalmoz\u00f3d\u00e1s\u00e1t, m\u00edg Luo \u00e9s munkat\u00e1rsai \u00fagy v\u00e9lik, hogy a tengerszint feletti magass\u00e1g nagyobb hat\u00e1ssal van a Peucedanum praeruptorum tartalm\u00e1ra, mint a Peucedanum praeruptorum\u00e9ra. B\u00e1r ez a tanulm\u00e1ny elt\u00e9r a kor\u00e1bbi kutat\u00e1sokt\u00f3l, tiszt\u00e1zhat\u00f3, hogy a magaslati k\u00f6rnyezet jobban el\u0151seg\u00edti a Houttuynia cordata gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9g\u00e9nek kialakul\u00e1s\u00e1t.<\/p>\n

A multiindex komponens tartalom meghat\u00e1roz\u00e1s\u00e1nak elemz\u00e9se sor\u00e1n a Peucedanum praeruptorum mint\u00e1k \u00f6sszesen 9 t\u00e9tele felelt meg a K\u00ednai Gy\u00f3gyszerk\u00f6nyv Peucedanum praeruptorum A-ra vonatkoz\u00f3 k\u00f6vetelm\u00e9nyeinek, ami 56,25%-t tett ki. Egyetlen t\u00e9tel sem felelt meg azonban a Peucedanum praeruptorum B-re vonatkoz\u00f3 hat\u00e1r\u00e9rt\u00e9kk\u00f6vetelm\u00e9nyeknek, a legmagasabb \u00e9rt\u00e9k mind\u00f6ssze 2,01 mg\/g volt. Xu et al. \u00e9s Liu et al. azt is meg\u00e1llap\u00edtotta, hogy a Houttuynia cordata gy\u00f3gyn\u00f6v\u00e9ny eset\u00e9ben a feh\u00e9r vir\u00e1g\u00fa Houttuynia cordata A nagyobb val\u00f3sz\u00edn\u0171s\u00e9ggel felel meg a szabv\u00e1nynak, m\u00edg a feh\u00e9r vir\u00e1g\u00fa Houttuynia cordata B eset\u00e9ben gyakoribb az a jelens\u00e9g, hogy nem felel meg a szabv\u00e1nynak. A feh\u00e9r vir\u00e1g\u00fa Houttuynia cordata egy \u00e9vel\u0151 n\u00f6v\u00e9ny, amely egyszer vir\u00e1gzik. A nagy\u00fczemi \u00fcltetv\u00e9nyek egyny\u00e1ri fajt\u00e1v\u00e1 v\u00e1ltak, \u00e9s a Houttuynia cordata gy\u00f3gyn\u00f6v\u00e9ny min\u0151s\u00e9g\u00e9nek roml\u00e1s\u00e1ban fontos szerepet j\u00e1tszik az el\u00e9gtelen \u00e9letkor. Ezenk\u00edv\u00fcl a feh\u00e9r vir\u00e1g\u00fa Houttuynia cordata hajlamos a korai elvir\u00e1gz\u00e1sra, \u00e9s a \"puskaporos magok\" (egyny\u00e1ri magok) el\u00e1rasztj\u00e1k a piacot. A hossz\u00fa t\u00e1v\u00fa iterat\u00edv szelekci\u00f3 r\u00e9v\u00e9n a Houttuynia cordata gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9ge \u00e9vr\u0151l \u00e9vre mesters\u00e9gesen szelekt\u00edven romlik. Tov\u00e1bbi kutat\u00e1sokra van sz\u00fcks\u00e9g annak meg\u00e1llap\u00edt\u00e1s\u00e1ra, hogy a Qianhu gy\u00f3gyn\u00f6v\u00e9nyek min\u0151s\u00e9g\u00e9nek sz\u00e9les k\u00f6r\u0171 roml\u00e1sa befoly\u00e1solja-e a klinikai hat\u00e9konys\u00e1got.<\/p>\n

A szakirodalmi jelent\u00e9sek szerint a Peucedanum praeruptorum A \u00e9s a Peucedanum praeruptorum B tartalma k\u00f6z\u00f6tt bizonyos fok\u00fa negat\u00edv korrel\u00e1ci\u00f3 van. Ez a tanulm\u00e1ny is ezt a tendenci\u00e1t tal\u00e1lta, de a konkr\u00e9t okokat tov\u00e1bb kell er\u0151s\u00edteni. A piacon l\u00e9v\u0151 k\u00ednai gy\u00f3gyn\u00f6v\u00e9nyek rossz min\u0151s\u00e9g\u00e9nek okai az \u00f6kol\u00f3giai k\u00f6rnyezet, a genetikai t\u00e9nyez\u0151k \u00e9s a mesters\u00e9ges beavatkoz\u00e1s mellett szorosan \u00f6sszef\u00fcgghetnek a jelenlegi min\u0151s\u00e9g\u00e9rt\u00e9kel\u00e9ssel is. A jelenlegi szabv\u00e1nyok szerint a piacon l\u00e9v\u0151 Hu gy\u00f3gy\u00e1szati anyagok \u00e9rt\u00e9kes\u00edt\u00e9s el\u0151tti min\u0151s\u00edt\u00e9si ar\u00e1nya rendk\u00edv\u00fcl alacsony, k\u00fcl\u00f6n\u00f6sen a Baihua Qianhu Yi tartalm\u00e1nak megfelel\u0151s\u00e9gi ar\u00e1nya, ami m\u00e1r nincs \u00f6sszhangban a Qianhu gy\u00f3gy\u00e1szati anyagok klinikai felhaszn\u00e1l\u00e1s\u00e1val \u00e9s ipari fejl\u0151d\u00e9s\u00e9vel. Ebben az \u00f6sszef\u00fcgg\u00e9sben Qiu et al. felt\u00e1rta a Peucedanum praeruptorum A \u00e9s a Peucedanum praeruptorum B ar\u00e1ny\u00e1nak vagy \u00f6sszeg\u00e9nek haszn\u00e1lat\u00e1t a Peucedanum praeruptorum gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9g\u00e9nek \u00e1tfog\u00f3 \u00e9rt\u00e9kel\u00e9s\u00e9re. Liu et al., Xiao et al., Shi et al. mindannyian k\u00fcl\u00f6nb\u00f6z\u0151 szempontokb\u00f3l v\u00e9geztek \u00e9rt\u00e9kel\u0151 vizsg\u00e1latokat a Peucedanum praeruptorum gy\u00f3gy\u00e1szati anyagok ujjlenyomat-spektrum\u00e1r\u00f3l, \u00e9s j\u00f3 eredm\u00e9nyeket \u00e9rtek el.<\/p>\n

Ez a tanulm\u00e1ny az ujjlenyomat-elemz\u00e9s, a t\u00f6bbindexes komponenselemz\u00e9s \u00e9s a k\u00e9miai modellelemz\u00e9s kombin\u00e1ci\u00f3j\u00e1t haszn\u00e1lta a gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9g\u00e9nek elemz\u00e9s\u00e9re \u00e9s \u00e9rt\u00e9kel\u00e9s\u00e9re, ami fontos referenciak\u00e9nt szolg\u00e1l a Qianhu gy\u00f3gy\u00e1szati anyagok min\u0151s\u00e9g\u00e9rt\u00e9kel\u00e9si szabv\u00e1nyainak megfogalmaz\u00e1s\u00e1hoz. Hi\u00e1nyoss\u00e1ga azonban, hogy a tanulm\u00e1nyban gy\u0171jt\u00f6tt mint\u00e1k f\u0151k\u00e9nt piacokr\u00f3l, \u00fcltetv\u00e9nyekr\u0151l \u00e9s egy\u00e9b forr\u00e1sokb\u00f3l sz\u00e1rmaznak, a cs\u00edraplazma, az \u00f6kol\u00f3giai k\u00f6rnyezet, az \u00fcltet\u00e9si technik\u00e1k \u00e9s egy\u00e9b inform\u00e1ci\u00f3k r\u00e9szletes nyilv\u00e1ntart\u00e1sa n\u00e9lk\u00fcl. A mint\u00e1k konzisztenci\u00e1j\u00e1nak korl\u00e1toz\u00e1sa hat\u00e1ssal lehet erre a tanulm\u00e1nyra. A k\u00e9s\u0151bbi kutat\u00e1s sor\u00e1n er\u0151fesz\u00edt\u00e9seket kell tenni az \u00f6kol\u00f3giai k\u00f6rnyezetnek a Houttuynia cordata min\u0151s\u00e9g\u00e9re gyakorolt hat\u00e1s\u00e1nak vizsg\u00e1lat\u00e1ra, a feh\u00e9r vir\u00e1g\u00fa Houttuynia cordata korai elvir\u00e1gz\u00e1s\u00e1nak alapvet\u0151 k\u00e9rd\u00e9s\u00e9re, a min\u0151s\u00e9gi szabv\u00e1nyok kutat\u00e1s\u00e1nak mintam\u00e9ret\u00e9nek n\u00f6vel\u00e9s\u00e9re, valamint a piaci elv\u00e1r\u00e1soknak megfelel\u0151 \u00e9s az \u00e1gazat fenntarthat\u00f3 fejl\u0151d\u00e9s\u00e9t el\u0151seg\u00edt\u0151 min\u0151s\u00e9g\u00e9rt\u00e9kel\u00e9si szabv\u00e1nyok kidolgoz\u00e1s\u00e1ra.<\/p>","protected":false},"excerpt":{"rendered":"

Based on HPLC fingerprint combined with chemical pattern recognition and multi index component quantitative evaluation of the quality of Houttuynia cordata medicinal materials The medicinal herb of Peucedamum praeruptorum Dunn is derived from the dried roots of the white flowered Peucedamum praeruptorum Dunn plant in the Umbelliferae family. It was first recorded in the “Record […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nBased on HPLC fingerprint combined with chemical pattern recognition and multi index component quantitative evaluation of the quality of Houttuynia cordata medicinal materials - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/qianhu-medicinal-materials\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Based on HPLC fingerprint combined with chemical pattern recognition and multi index component quantitative evaluation of the quality of Houttuynia cordata medicinal materials - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Based on HPLC fingerprint combined with chemical pattern recognition and multi index component quantitative evaluation of the quality of Houttuynia cordata medicinal materials The medicinal herb of Peucedamum praeruptorum Dunn is derived from the dried roots of the white flowered Peucedamum praeruptorum Dunn plant in the Umbelliferae family. 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