{"id":4033,"date":"2024-08-04T08:13:19","date_gmt":"2024-08-04T08:13:19","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4033"},"modified":"2024-08-04T08:13:19","modified_gmt":"2024-08-04T08:13:19","slug":"chaihu-white-peony","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/chaihu-white-peony\/","title":{"rendered":"A Chaihu Baiyaoyao formula granul\u00e1tum ujjlenyomat-spektrum\u00e1nak meg\u00e1llap\u00edt\u00e1sa \u00e9s a multi index komponens tartalom meghat\u00e1roz\u00e1sa"},"content":{"rendered":"

A Chaihu Baiyaoyao formula granul\u00e1tum ujjlenyomat-spektrum\u00e1nak meg\u00e1llap\u00edt\u00e1sa \u00e9s a multi index komponens tartalom meghat\u00e1roz\u00e1sa
\nA Chaihu, amelyet el\u0151sz\u00f6r a Shennong Bencao Jing-ben jegyeztek fel, a Bupleurum scorzonerifolium Willd. vagy Bupleurum chinense DC. eg\u00e9sz n\u00f6v\u00e9nye vagy sz\u00e1r\u00edtott gy\u00f6kere, amely az Umbelliferae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9ny. Keser\u0171 \u00e9s cs\u00edp\u0151s \u00edze van, enyh\u00e9n hideg, \u00e9s a m\u00e1j, az epeh\u00f3lyag \u00e9s a t\u00fcd\u0151 meridi\u00e1nokhoz tartozik. A m\u00e1jat nyugtat\u00f3, a depresszi\u00f3t enyh\u00edt\u0151, a l\u00e1zat eloszlat\u00f3 \u00e9s a jang qi-t el\u0151seg\u00edt\u0151 hat\u00e1sa van. A modern term\u00e9szetes gy\u00f3gyszerk\u00e9mia fejl\u0151d\u00e9s\u00e9vel a Bupleurum chinense-ben k\u00fcl\u00f6nb\u00f6z\u0151 \u00e9rt\u00e9kes \u00e9s fontos hat\u00e1sokat fedeztek fel, mint p\u00e9ld\u00e1ul gyullad\u00e1scs\u00f6kkent\u0151, daganatellenes, antidepressz\u00e1ns, v\u00edrusellenes, immunszab\u00e1lyoz\u00f3 \u00e9s idegrendszeri szab\u00e1lyoz\u00f3. A Paeonia lactiflora Pall. a Ranunculaceae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9ny, a Paeonia lactiflora Pall. sz\u00e1r\u00edtott gy\u00f6kere. Keserny\u00e9s, savany\u00fa \u00edz\u0171 \u00e9s enyh\u00e9n hideg jelleg\u0171. F\u0151leg Shandongban, Hunanban \u00e9s m\u00e1s helyeken termesztik. Jelenleg Bozhou-ban termelik a legt\u00f6bb Paeonia lactiflora-t, amely h\u00edres hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer K\u00edn\u00e1ban. A m\u00e1jat nyugtatja \u00e9s enyh\u00edti a f\u00e1jdalmat, t\u00e1pl\u00e1lja a v\u00e9rt \u00e9s szab\u00e1lyozza a meridi\u00e1nokat, valamint cs\u00f6kkenti a jin-t \u00e9s az izzad\u00e1st. A modern farmakol\u00f3giai kutat\u00e1sok kimutatt\u00e1k, hogy a Paeonia lactiflora gyullad\u00e1scs\u00f6kkent\u0151, f\u00e1jdalomcsillap\u00edt\u00f3, daganatellenes \u00e9s antioxid\u00e1ns hat\u00e1s\u00fa. A Chaihu Bai Shaoyao p\u00e1ros, mint a m\u00e1j nyugtat\u00e1s\u00e1ra \u00e9s a depresszi\u00f3 enyh\u00edt\u00e9s\u00e9re szolg\u00e1l\u00f3 alapgy\u00f3gyszer, el\u0151sz\u00f6r a Han-dinasztia \"\u00c9rtekez\u00e9s a hidegk\u00e1rosod\u00e1sr\u00f3l\" c\u00edm\u0171 m\u0171v\u00e9ben jelent meg. Az olyan formul\u00e1k, mint a Sini San, a Xiaoyao San, a Chaihu Shugan San \u00e9s az Anshen Jieyu Tang mind a Chaihu-t haszn\u00e1lj\u00e1k f\u0151 gy\u00f3gyszerk\u00e9nt \u00e9s a Bai Shaoyao-t al\u00e1rendelt gy\u00f3gyszerk\u00e9nt. A k\u00e9t gy\u00f3gyszert kombin\u00e1ci\u00f3ban haszn\u00e1lj\u00e1k, az egyik sz\u00e9toszlatja, a m\u00e1sik pedig \u00f6sszefolyik, ami megfelel a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s elm\u00e9let\u00e9ben a m\u00e1jgy\u00f3gy\u00e1szat jellemz\u0151inek.
\nA k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9ny granul\u00e1tumokat egyetlen k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9ny f\u0151zetdarabjaib\u00f3l k\u00e9sz\u00edtik, modern gy\u00f3gyszertechnol\u00f3gia alkalmaz\u00e1s\u00e1val, \u00e9s v\u00edzmeleg\u00edt\u00e9ssel extrah\u00e1lj\u00e1k, sz\u00e9tv\u00e1lasztj\u00e1k, koncentr\u00e1lj\u00e1k, sz\u00e1r\u00edtj\u00e1k \u00e9s granul\u00e1lj\u00e1k. Az alacsony adagol\u00e1s, a k\u00f6nny\u0171 hordozhat\u00f3s\u00e1g \u00e9s a t\u00fcneteknek megfelel\u0151 be\u00e1ll\u00edt\u00e1s el\u0151nyei sz\u00e9lesk\u00f6r\u0171 fejl\u0151d\u00e9si kil\u00e1t\u00e1sokkal ruh\u00e1zz\u00e1k fel a k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9ny granul\u00e1tumokat. \u00c9s a hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9ny granul\u00e1tumok m\u00e1r nem korl\u00e1toz\u00f3dnak az egy \u00f6sszetev\u0151b\u0151l \u00e1ll\u00f3 f\u0151zetdarabok fejleszt\u00e9s\u00e9re, mint p\u00e9ld\u00e1ul a lonc Forsythia suspensa, efedra mandula, efedra cassia gally, Danshen s\u00e1fr\u00e1ny, Huanglian wuzhuyu \u00e9s m\u00e1s gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9ny granul\u00e1tumokat fokozatosan sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k a klinikai kompatibilit\u00e1si alkalmaz\u00e1sokban. A Chaihu egy \u00f6sszetev\u0151j\u0171 formula granul\u00e1tum kivon\u00e1si ar\u00e1nya viszonylag alacsony. Ugyanakkor a feh\u00e9r bazsar\u00f3zsa \u00e9s a Chaihu kombin\u00e1ci\u00f3ja n\u00f6velheti a paeoniflorin f\u0151z\u00e9si mennyis\u00e9g\u00e9t \u00e9s cs\u00f6kkentheti a toxikus komponens benzoesav f\u0151z\u00e9si mennyis\u00e9g\u00e9t, ami fokozhatja a hat\u00f3anyagok oldhat\u00f3s\u00e1g\u00e1t, kik\u00fcsz\u00f6b\u00f6lheti vagy cs\u00f6kkentheti a toxikus mell\u00e9khat\u00e1sokat, \u00e9s biztos\u00edthatja a klinikai gy\u00f3gyszeradagol\u00e1s pontoss\u00e1g\u00e1t. Jelenleg nincsenek jelent\u00e9sek a Chaihu Baiyaoyao formula granul\u00e1tumair\u00f3l. Ez\u00e9rt ez a tanulm\u00e1ny HPLC-ujjlenyomatot, k\u00e9miai mintafelismer\u00e9si technol\u00f3gi\u00e1t \u00e9s a Chaihu Baiyaoyao formula granul\u00e1tum n\u00e9gy \u00f6sszetev\u0151j\u00e9nek egyidej\u0171 meghat\u00e1roz\u00e1s\u00e1t hozza l\u00e9tre, hogy jav\u00edtsa a Chaihu Baiyaoyao formula granul\u00e1tum min\u0151s\u00e9g\u00e9rt\u00e9kel\u00e9si rendszer\u00e9t, \u00e9s referenci\u00e1t ny\u00fajtson a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s klinikai alkalmaz\u00e1s\u00e1hoz.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nEz a tanulm\u00e1ny HPLC-t haszn\u00e1lt a Chaihu Baiyaoyao formula r\u00e9szecsk\u00e9inek ujjlenyomat-spektrum\u00e1nak meg\u00e1llap\u00edt\u00e1s\u00e1ra. K\u00fcl\u00f6nb\u00f6z\u0151 mozg\u00f3f\u00e1zis-rendszereket (acetonitril-v\u00edz, acetonitril-0,1% foszforsavas v\u00edz, acetonitril-0,1% hangyasavas v\u00edz \u00e9s metanol-0,1% foszforsavas v\u00edz) vizsg\u00e1ltak, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy az acetonitril-0.1% foszforsavas v\u00edz jobb kurt\u00f3zissal \u00e9s magasabb v\u00e1lasz\u00e9rt\u00e9kekkel rendelkezett, amikor v\u00edzzel most\u00e1k; Az extrakci\u00f3s old\u00f3szereket v\u00edz, metanol, etanol, 5% koncentr\u00e1lt amm\u00f3nia-metanol \u00e9s 5% koncentr\u00e1lt amm\u00f3nia-etanol oldat eset\u00e9ben vizsg\u00e1lt\u00e1k. Meg\u00e1llap\u00edtott\u00e1k, hogy az 5% koncentr\u00e1lt amm\u00f3nia-metanolos oldat haszn\u00e1lata eset\u00e9n a kromatogr\u00e1fi\u00e1s cs\u00facsok \u00e9pek voltak; A Chaihu Baiyaoyao formula granul\u00e1tum tesztoldat\u00e1nak k\u00e9t hull\u00e1mhosszon (210 nm, 230 nm) t\u00f6rt\u00e9n\u0151 szkennel\u00e9se azt mutatta, hogy 210 nm-en az ujjlenyomat spektrum\u00e1ban t\u00f6bb kromatogr\u00e1fi\u00e1s cs\u00facs volt \u00e9s stabil alapvonal; Ugyanakkor a kromatogr\u00e1fi\u00e1s oszlopok (COSMOSIL 5C18-MS-II oszlop, WONDASIL C18, Amethyst C18-H (4.6mm \u00d7 250mm, 5 \u03bc m, 120 \u00c5)) \u00e9s az oszloph\u0151m\u00e9rs\u00e9kleteket (20 \u2103, 25 \u2103, 30 \u2103) hasonl\u00edtottuk \u00f6ssze. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a COSMOSIL 5C18-MS-II oszlop jobb elv\u00e1laszt\u00e1si hat\u00e9konys\u00e1ggal rendelkezett, amikor 30 \u2103-on detekt\u00e1lt\u00e1k.
\nA Chaihu White Peony Formula Granules a Chaihu White Peony f\u0151zet darabjaib\u00f3l standardiz\u00e1lt folyamatok, p\u00e9ld\u00e1ul extrakci\u00f3, sz\u00e9tv\u00e1laszt\u00e1s, koncentr\u00e1l\u00e1s, sz\u00e1r\u00edt\u00e1s \u00e9s granul\u00e1l\u00e1s \u00fatj\u00e1n el\u0151\u00e1ll\u00edtott granul\u00e1tum. \u00d6sszet\u00e9tel\u00fck \u00e9s farmakol\u00f3gi\u00e1juk hasonl\u00f3 a Chaihu Feh\u00e9r Bazsar\u00f3zsa formul\u00e1hoz, \u00e9s a f\u0151zetdarabok \u00faj form\u00e1ja. A Chaihu szaponin a, a Chaihu szaponin d \u00e9s a paeoniflorin a K\u00ednai Gy\u00f3gyszerk\u00f6nyv 2020-as kiad\u00e1s\u00e1ban a Chaihu \u00e9s a Paeonia lactiflora min\u0151s\u00e9g\u00e9nek ellen\u0151rz\u00e9s\u00e9re szolg\u00e1l\u00f3 f\u0151 kimutat\u00e1si mutat\u00f3k. Kutat\u00e1sok kimutatt\u00e1k, hogy mind a saikosaponin a, mind a saikosaponin d jav\u00edthatja a patk\u00e1nyok depressz\u00edv viselked\u00e9s\u00e9t a p-CREB\/BDNF \u00fatvonal g\u00e1tl\u00e1s\u00e1val, ez\u00e1ltal elnyomva a hippokampusz neuron\u00e1lis apopt\u00f3zist \u00e9s a mikroglia aktiv\u00e1ci\u00f3t. A paeoniflorin enyh\u00edtheti a CFA \u00e1ltal kiv\u00e1ltott gyullad\u00e1sos f\u00e1jdalmat a TRPV1 \u00e9s a borosty\u00e1nk\u0151sav\/SUCNR1-HIF-1 \u03b1\/NLPR3 \u00fatvonalak g\u00e1tl\u00e1s\u00e1val. Az oxid\u00e1lt paeoniflorin aktiv\u00e1lhatja a receptorokat a peroxisz\u00f3ma prolifer\u00e1tor alfa feh\u00e9rje expresszi\u00f3j\u00e1nak felszab\u00e1lyoz\u00e1s\u00e1val, el\u0151seg\u00edtheti az ATP-k\u00f6t\u0151 transzporter A1 g\u00e9n expresszi\u00f3j\u00e1t \u00e9s jav\u00edthatja a lipideloszl\u00e1st. A fentiek a Chaihu Baiyaoyao formula granul\u00e1tum f\u0151 hat\u00f3anyagai, \u00e9s e n\u00e9gy \u00f6sszetev\u0151 tartalm\u00e1nak meghat\u00e1roz\u00e1sa nagy jelent\u0151s\u00e9ggel b\u00edr a Chaihu Baiyaoyao formula granul\u00e1tum min\u0151s\u00e9gellen\u0151rz\u00e9se szempontj\u00e1b\u00f3l. Ezenk\u00edv\u00fcl az ujjlenyomat-spektrumok \u00e1tfog\u00f3an t\u00fckr\u00f6zhetik a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s anyagi alapjait. Ez\u00e9rt ez a tanulm\u00e1ny kombin\u00e1lja az ujjlenyomat-spektrumot a tartalom meghat\u00e1roz\u00e1s\u00e1val, hogy referenci\u00e1t ny\u00fajtson a Chaihu Bai Shaoo formula granul\u00e1tum min\u0151s\u00e9gi szabv\u00e1nyainak jav\u00edt\u00e1s\u00e1hoz.
\nAz ujjlenyomat-spektrumot a k\u00e9miai mintafelismer\u00e9si technol\u00f3gi\u00e1val kombin\u00e1lva sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat, a k\u00ednai gy\u00f3gyn\u00f6v\u00e9nyes f\u0151zetdarabok \u00e9s a k\u00e9pletszemcs\u00e9k min\u0151s\u00e9g\u00e9nek \u00e9rt\u00e9kel\u00e9s\u00e9re. A m\u00f3dszer alkalmaz\u00e1sa ebben a tanulm\u00e1nyban intuit\u00edv m\u00f3don m\u00e9rheti a k\u00fcl\u00f6nb\u00f6z\u0151 eredet\u0171 Chaihu Baiyaoyao k\u00e9pletszemcs\u00e9k mint\u00e1i k\u00f6z\u00f6tti ujjlenyomat-mint\u00e1zat v\u00e1ltoz\u00e1sainak hasonl\u00f3s\u00e1g\u00e1t. Az ujjlenyomat-spektrumok hasonl\u00f3s\u00e1gi \u00e9rt\u00e9kel\u00e9si eredm\u00e9nyei azt mutatt\u00e1k, hogy a Chaihu Baiyaoyao 15 t\u00e9tel\u00e9nek k\u00e9pletszemcs\u00e9i \u00e9s a kontroll ujjlenyomat-spektrumai k\u00f6z\u00f6tti hasonl\u00f3s\u00e1g nagyobb volt, mint 0,90, ami azt jelzi, hogy a k\u00fcl\u00f6nb\u00f6z\u0151 eredet\u0171 Chaihu Baiyaoyao jobb \u00e1ltal\u00e1nos teljes\u00edtm\u00e9nyt ny\u00fajtott a k\u00e9pletszemcs\u00e9kben, de az indik\u00e1tor komponensek tartalm\u00e1ban k\u00fcl\u00f6nbs\u00e9gek voltak. Az elemz\u00e9s a k\u00fcl\u00f6nb\u00f6z\u0151 eredet\u0171 gy\u00f3gy\u00e1szati anyagok feldolgoz\u00e1s\u00e1nak, betakar\u00edt\u00e1si m\u00f3dszereinek \u00e9s gy\u00e1rt\u00e1si folyamatainak tudhat\u00f3 be. A f\u0151komponens-elemz\u00e9s \u00e9s a klaszterelemz\u00e9s eredm\u00e9nyei k\u00f6lcs\u00f6n\u00f6sen meger\u0151s\u00edtik egym\u00e1st, ami a gy\u00f3gy\u00e1szati anyagok eredet\u00e9nek szab\u00e1lyszer\u0171s\u00e9g\u00e9t mutatja. A kutat\u00f3int\u00e9zet \u00e1ltal gy\u0171jt\u00f6tt mint\u00e1k eredete \u00e9s t\u00e9tele korl\u00e1tozott, \u00e9s a k\u00e9s\u0151bbi szakaszban tov\u00e1bbi fejleszt\u00e9sre van sz\u00fcks\u00e9g.
\n\u00d6sszefoglalva, ez a tanulm\u00e1ny 15 t\u00e9tel ujjlenyomat-spektrum\u00e1t \u00e9s a Chaihu Baiyaoyao formula granul\u00e1tum n\u00e9gy indik\u00e1torkomponens\u00e9nek egyidej\u0171 meghat\u00e1roz\u00e1s\u00e1t \u00e1llap\u00edtotta meg HPLC-m\u00f3dszerrel. A Chaihu Baiyaoyao formula granul\u00e1tum min\u0151s\u00e9g\u00e9nek \u00e9rt\u00e9kel\u00e9s\u00e9re \u00e9s oszt\u00e1lyoz\u00e1s\u00e1ra hasonl\u00f3s\u00e1gi \u00e9rt\u00e9kel\u00e9st, klaszterelemz\u00e9st \u00e9s f\u0151komponens-elemz\u00e9st alkalmaztunk. Ez a m\u00f3dszer k\u00f6nnyen kezelhet\u0151, j\u00f3l ism\u00e9telhet\u0151, pontos \u00e9s megb\u00edzhat\u00f3 eredm\u00e9nyekkel rendelkezik, \u00e9s tudom\u00e1nyos alapot biztos\u00edthat a Chaihu Baiyaoyao formula granul\u00e1tum min\u0151s\u00e9g\u00e9nek \u00e1tfog\u00f3 ellen\u0151rz\u00e9s\u00e9hez \u00e9s \u00e9rt\u00e9kel\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Establishment of fingerprint spectrum and determination of multi index component content of Chaihu Baiyaoyao formula granules Chaihu, first recorded in the Shennong Bencao Jing, is the whole plant or dried root of Bupleurum scorzonerifolium Willd. or Bupleurum chinense DC., a plant in the Umbelliferae family. It has a bitter and pungent taste, a slight coldness, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nEstablishment of fingerprint spectrum and determination of multi index component content of Chaihu Baiyaoyao formula granules - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/chaihu-white-peony\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Establishment of fingerprint spectrum and determination of multi index component content of Chaihu Baiyaoyao formula granules - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Establishment of fingerprint spectrum and determination of multi index component content of Chaihu Baiyaoyao formula granules Chaihu, first recorded in the Shennong Bencao Jing, is the whole plant or dried root of Bupleurum scorzonerifolium Willd. or Bupleurum chinense DC., a plant in the Umbelliferae family. 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