{"id":3898,"date":"2024-08-03T08:34:30","date_gmt":"2024-08-03T08:34:30","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3898"},"modified":"2024-08-03T08:34:30","modified_gmt":"2024-08-03T08:34:30","slug":"prevention-and-treatment-of-atherosclerosis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/prevention-and-treatment-of-atherosclerosis\/","title":{"rendered":"A Buyang Huanwu f\u0151zet mechanizmus\u00e1nak vizsg\u00e1lata az ateroszkler\u00f3zis megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben az Nrf2 \/ ARE jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl"},"content":{"rendered":"

A Buyang Huanwu f\u0151zet mechanizmus\u00e1nak vizsg\u00e1lata az ateroszkler\u00f3zis megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben az Nrf2 \/ ARE jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl
\nAz \u00e9relmeszesed\u00e9s (AS) kr\u00f3nikus gyullad\u00e1sos betegs\u00e9g. Az AS-betegek korai kezdete alattomos, \u00e9s nincsenek nyilv\u00e1nval\u00f3 klinikai t\u00fcnetek, de a betegs\u00e9g el\u0151rehaladt\u00e1val a k\u00e9s\u0151bbi szakaszokban a c\u00e9lszervek, p\u00e9ld\u00e1ul a sz\u00edv \u00e9s az agy is \u00e9rintett\u00e9 v\u00e1lhatnak. Az Eg\u00e9szs\u00e9g\u00fcgyi Vil\u00e1gszervezet (WHO) felm\u00e9r\u00e9se szerint a k\u00f6z\u00e9pkor\u00faak \u00e9s az id\u0151sek m\u00e9g mindig a sz\u00edv- \u00e9s \u00e9rrendszeri mell\u00e9khat\u00e1sok f\u0151 csoportj\u00e1t jelentik, a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gben szenved\u0151 betegek mintegy 81%-je 65 \u00e9ves vagy ann\u00e1l id\u0151sebb korban hal meg. Az ut\u00f3bbi \u00e9vekben azonban az AS-betegek popul\u00e1ci\u00f3ja is ink\u00e1bb fiatalabb lett. K\u00edn\u00e1ban k\u00f6zel 300 milli\u00f3 ember szenved sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gekben. B\u00e1r az AS modern orvosi kezel\u00e9se bizonyos hat\u00e9konys\u00e1ggal rendelkezik, m\u00e9g mindig nem k\u00e9pes cs\u00f6kkenteni az AS magas el\u0151fordul\u00e1si ar\u00e1ny\u00e1t, \u00e9s a hossz\u00fa t\u00e1v\u00fa alkalmaz\u00e1s ut\u00e1n sz\u00e1mos mell\u00e9khat\u00e1s jelentkezik. Ez\u00e9rt az AS el\u0151fordul\u00e1s\u00e1nak cs\u00f6kkent\u00e9se a legf\u0151bb priorit\u00e1s \u00e9s a f\u0151\u00e1ram\u00fa kutat\u00e1si ir\u00e1ny. Az oxidat\u00edv stressz az egyik fontos t\u00e9nyez\u0151, amely az ateroszkler\u00f3zis kialakul\u00e1s\u00e1hoz vezet. A fejlett oxidat\u00edv feh\u00e9rjeterm\u00e9kek (AOPP) korai biomarkerekk\u00e9nt \u00e9s az ateroszkler\u00f3zis f\u00fcggetlen, er\u0151s el\u0151rejelz\u0151jek\u00e9nt szolg\u00e1lhatnak, m\u00edg a reakt\u00edv oxig\u00e9nfajok (ROS) el\u0151seg\u00edthetik a feh\u00e9r feh\u00e9rj\u00e9k AOPP-v\u00e9 t\u00f6rt\u00e9n\u0151 oxid\u00e1ci\u00f3j\u00e1t, ami az oxidat\u00edv stressz kit\u00f6r\u00e9s\u00e9hez vezet; a malondialdehid (MDA), a szuperoxid-dizmut\u00e1z (SOD) \u00e9s a glutation-peroxid\u00e1z (GSH Px) az oxidat\u00edv stresszre adott v\u00e1lasz fontos biomarkerei, amelyek alapvet\u0151en t\u00fckr\u00f6zhetik a szervezet oxidat\u00edv stressz \u00e1llapot\u00e1t. A h\u00e1rom gyakran k\u00f6lcs\u00f6nhat\u00e1sba l\u00e9p egym\u00e1ssal, ami az \u00e9rrendszeri endothelium \u00e9s a sz\u00f6veti sejtek oxidat\u00edv k\u00e1rosod\u00e1s\u00e1hoz vezet, ami az \u00e9relmeszesed\u00e9s kialakul\u00e1s\u00e1hoz vezet. A kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a nukle\u00e1ris faktor E2-hez kapcsol\u00f3d\u00f3 2-es faktor (Nrf2)\/antioxid\u00e1ns v\u00e1laszelem (ARE) jel\u00e1tviteli \u00fatvonal egy kulcsfontoss\u00e1g\u00fa nukle\u00e1ris transzkripci\u00f3s faktor, amely szab\u00e1lyozza az oxidat\u00edv stresszt. Sz\u00e1mos antioxid\u00e1ns feh\u00e9rj\u00e9t k\u00e9pes aktiv\u00e1lni, \u00e9s r\u00e9szt vesz k\u00fcl\u00f6nb\u00f6z\u0151 biol\u00f3giai folyamatokban, p\u00e9ld\u00e1ul a sejtek \u00f6reged\u00e9s\u00e9ben, az apopt\u00f3zisban \u00e9s a prolifer\u00e1ci\u00f3ban.
\nA hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u00e1ltal\u00e1ban \u00fagy v\u00e9li, hogy az AS f\u0151 patogenezise a pozit\u00edv qi hi\u00e1ny\u00e1ban rejlik, amely a betegs\u00e9g gy\u00f6kere; a flegma, a v\u00e9r pang\u00e1sa \u00e9s m\u00e1s patog\u00e9n t\u00e9nyez\u0151k fontos patog\u00e9n t\u00e9nyez\u0151k \u00e9s a betegs\u00e9g kialakul\u00e1s\u00e1nak mutat\u00f3i. Ez\u00e9rt az AS patogenezis\u00e9re v\u00e1laszul ez a tanulm\u00e1ny a \"sz\u00edv t\u00e1pl\u00e1l\u00e1s\u00e1nak, a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9nek \u00e9s a flegma felold\u00e1s\u00e1nak\" alapvet\u0151 m\u00f3dszer\u00e9t alkalmazza, \u00e9s a m\u00f3dos\u00edtott Buyang Huanwu Tangot haszn\u00e1lja az AS megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re. A Buyang Huanwu Tang egy klasszikus formula a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a qi toniz\u00e1l\u00e1s\u00e1ra Wang Qingren \"Yi Lin Gai Cuo\" c\u00edm\u0171 m\u0171v\u00e9b\u0151l a Qing-dinasztia idej\u00e9b\u0151l. Ezt kombin\u00e1lj\u00e1k a Gualou Xiebai Banxia Tanggal, amely \u00f6sszhangban van az AS patogenezis\u00e9vel. R\u00e1ad\u00e1sul a kett\u0151nek jelent\u0151s ter\u00e1pi\u00e1s hat\u00e1sa van az AS-hez kapcsol\u00f3d\u00f3 betegs\u00e9gekre a klinikai gyakorlatban, nyilv\u00e1nval\u00f3 mell\u00e9khat\u00e1sok n\u00e9lk\u00fcl. Ez\u00e9rt ez a tanulm\u00e1ny a Buyang Huanwu Tang megfelel\u0151 m\u00f3dos\u00edt\u00e1s\u00e1t v\u00e1lasztotta. Az el\u0151zetes k\u00eds\u00e9rleti eredm\u00e9nyek azt mutatt\u00e1k, hogy a m\u00f3dos\u00edtott Buyang Huanwu Tang bizonyos hat\u00e1st gyakorol az AS megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re az\u00e1ltal, hogy szab\u00e1lyozza az immunrendszer gyullad\u00e1sos v\u00e1lasz\u00e1t, az endoplazmatikus retikulum stresszt, \u00e9s befoly\u00e1solja az olyan jel\u00e1tviteli \u00fatvonalakat, mint a HMGB1 \u00e9s a Wnt1, cs\u00f6kkenti a plakk ter\u00fclet\u00e9t, \u00e9s enyh\u00edti az AS elv\u00e1ltoz\u00e1sokat. A specifikus hat\u00e1smechanizmus azonban m\u00e9g nem tiszt\u00e1zott. Ez\u00e9rt ez a tanulm\u00e1ny az oxidat\u00edv stresszt veszi kiindul\u00f3pontnak, hogy felt\u00e1rja a m\u00f3dos\u00edtott Buyang Huanwu Tang hat\u00e1s\u00e1t az ateroszklerotikus plakkok kialakul\u00e1s\u00e1ra, \u00e9s hogy felt\u00e1rja azt a specifikus mechanizmust, amellyel a m\u00f3dos\u00edtott Buyang Huanwu Tang szab\u00e1lyozza az ateroszklerotikus plakkokat az Nrf2\/ARE jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl.<\/p>\n

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\nA modern orvostudom\u00e1ny betegs\u00e9gnevek\u00e9nt a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u0151si k\u00f6nyveiben nem szerepel az \"ateroszkler\u00f3zis\", amely els\u0151sorban a v\u00e9rkering\u00e9s akad\u00e1lyoz\u00e1s\u00e1ban nyilv\u00e1nul meg, mint p\u00e9ld\u00e1ul a lumen sz\u0171k\u00fcl\u00e9se, az \u00e9rfal cs\u00f6kkent rugalmass\u00e1ga stb., \u00edgy a \"mellkasi f\u00e1jdalom, sz\u00e9d\u00fcl\u00e9s, pulzus elz\u00e1r\u00f3d\u00e1sa\" \u00e9s m\u00e1s kateg\u00f3ri\u00e1kba sorolj\u00e1k. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u00fagy v\u00e9li, hogy patogenezise a szervezet igaz qi hi\u00e1ny\u00e1ban rejlik, ami a qi \u00e9s a v\u00e9r rossz kering\u00e9s\u00e9hez vezet. Amint azt a \"Yi Lin Gai Cuo\" c\u00edm\u0171 k\u00f6nyvben olvashatjuk: \"Ha a qi gyenge, nem tud eljutni az erekbe. Ha nincs qi az erekben, akkor ott marad \u00e9s stagn\u00e1l.\" A \"Compendium of Medicine\" feljegyzi, hogy \"a stroke-ot a kedvez\u0151tlen impulzuscsatorn\u00e1k \u00e9s a v\u00e9rg\u00e1zok elz\u00e1r\u00f3d\u00e1sa okozza\", elm\u00e9leti alapot szolg\u00e1ltatva az \u00e9relmeszesed\u00e9s v\u00e9rstasis \u00e1ltali kiv\u00e1lt\u00e1s\u00e1hoz. A sz\u00edvhi\u00e1ny k\u00fcl\u00f6n\u00f6sen fontos a pozit\u00edv qi hi\u00e1ny\u00e1ban; Az olyan k\u00f3ros t\u00e9nyez\u0151k, mint a v\u00e9r pang\u00e1sa \u00e9s a v\u00e1lad\u00e9k zavaross\u00e1ga, a betegs\u00e9g kialakul\u00e1s\u00e1ra utalnak. Ez a tanulm\u00e1ny a \"sz\u00edv t\u00e1pl\u00e1l\u00e1sa, a v\u00e9r pang\u00e1s\u00e1nak eloszlat\u00e1sa \u00e9s a flegma felold\u00e1sa\" alapelv\u00e9n alapul az AS patogenezis\u00e9re vonatkoz\u00f3an. A formula Huangqi, Danggui Wei, Chishao, Chuanxiong, Taoren, Honghua, Dilong, Gualou, Xiebai, Banxia, Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis \u00e9s m\u00e1s gy\u00f3gyszerekb\u0151l \u00e1ll. A Huangqi a kir\u00e1ly gy\u00f3gyszere, Codonopsis pilosul\u00e1val, Ophiopogon japonicusszal \u00e9s Schisandra chinensisszel kombin\u00e1lva a qi t\u00e1pl\u00e1l\u00e1s\u00e1ra. C\u00e9lja a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9se, ha a qi er\u0151s, a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9se, ha a v\u00e9rkering\u00e9s er\u0151s, \u00e9s a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9se, ha a v\u00e9r pang\u00e1sa megsz\u0171nik; a Danggui a qi-t \u00e9s a v\u00e9rt t\u00e1pl\u00e1l\u00f3 gy\u00f3gyn\u00f6v\u00e9ny. F\u00f6ldigiliszt\u00e1val, v\u00f6r\u00f6s barackvir\u00e1ggal, barackmaggal, v\u00f6r\u00f6s vir\u00e1ggal \u00e9s Chuanxionggal egy\u00fctt a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a kollater\u00e1lisok felold\u00e1s\u00e1ra szolg\u00e1l; a Gualou, Xiebai \u00e9s Banxia a mellkas kit\u00e1g\u00edt\u00e1s\u00e1ra, a csom\u00f3k eloszlat\u00e1s\u00e1ra, a v\u00e1lad\u00e9k elt\u00e1vol\u00edt\u00e1s\u00e1ra \u00e9s a kollater\u00e1lisok felold\u00e1s\u00e1ra szolg\u00e1l. A k\u00fcl\u00f6nb\u00f6z\u0151 gy\u00f3gyszerek kombin\u00e1lt alkalmaz\u00e1sa a qi t\u00e1pl\u00e1l\u00e1s\u00e1ra, a sz\u00edv t\u00e1pl\u00e1l\u00e1s\u00e1ra, a zavarosod\u00e1s megsz\u00fcntet\u00e9s\u00e9re \u00e9s a kollater\u00e1lisok felold\u00e1s\u00e1ra hat. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a Buyang Huanwu Tang anti AS hat\u00e1st fejt ki antioxid\u00e1ns stressz, gyullad\u00e1scs\u00f6kkent\u0151, endot\u00e9lsejtk\u00e1rosod\u00e1s elleni, apopt\u00f3zis elleni \u00e9s egy\u00e9b aspektusokon kereszt\u00fcl. A Gualou, Xiebai \u00e9s Banxia a Gualou Xiebai Banxia Tangb\u00f3l sz\u00e1rmazik. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a Gualou Xiebai Banxia Tang az oxidat\u00edv stressz g\u00e1tl\u00e1s\u00e1val, a lipidanyagcsere szab\u00e1lyoz\u00e1s\u00e1val \u00e9s a gyullad\u00e1sos reakci\u00f3k cs\u00f6kkent\u00e9s\u00e9vel megel\u0151zheti \u00e9s kezelheti az AS-t.
\nAz ApoE g\u00e9n ki\u00fct\u00e9ses (ApoE -\/-) egereket 1992-ben sikeresen teny\u00e9sztette ki az \u00c9szak-Karolinai Egyetem patol\u00f3giai genetikai laborat\u00f3riuma \u00e9s a Rockefeller Egyetem biok\u00e9miai genetikai \u00e9s anyagcsere laborat\u00f3riuma az Egyes\u00fclt \u00c1llamokban. Az ApoE a chylomikronok, a rendk\u00edv\u00fcl alacsony s\u0171r\u0171s\u00e9g\u0171 lipoprotein \u00e9s a nagy s\u0171r\u0171s\u00e9g\u0171 lipoprotein fontos \u00f6sszetev\u0151je, amely d\u00f6nt\u0151 szerepet j\u00e1tszik az oxidat\u00edv stressz, a lipidanyagcsere, a jel\u00e1tvitel \u00e9s m\u00e1s aspektusok szab\u00e1lyoz\u00e1s\u00e1ban. Az ApoE -\/- egerek patol\u00f3giai v\u00e1ltoz\u00e1sai nagyon hasonl\u00edtanak az emberek\u00e9hez. Term\u00e9szetes t\u00e1pl\u00e1lkoz\u00e1s mellett spont\u00e1n kialakulhatnak rostos plakkok \u00e9s \u00f6sszetett plakkok, \u00e9s s\u00falyos hyperlipidaemia alakulhat ki n\u00e1luk. A h\u00edmekn\u00e9l nagyobb val\u00f3sz\u00edn\u0171s\u00e9ggel alakulnak ki AS elv\u00e1ltoz\u00e1sok, \u00e9s az SD patk\u00e1nyokhoz k\u00e9pest az ApoE -\/- egerek gyorsabban modelleznek. Amikor 8 h\u00e9ten kereszt\u00fcl magas zs\u00edrtartalm\u00fa di\u00e9t\u00e1val (0,15% koleszterin, 18% hidrog\u00e9nezett kaka\u00f3vaj) etett\u00e9k \u0151ket, a v\u00e9letlenszer\u0171en boncolt egerek aort\u00e1j\u00e1ban lipid plakkokat \u00e9s gyullad\u00e1sos infiltr\u00e1ci\u00f3t tal\u00e1ltak, ami meger\u0151s\u00edtette a sikeres modellez\u00e9st. Ez\u00e9rt a k\u00eds\u00e9rlethez \u00e1ltal\u00e1ban h\u00edm ApoE -\/- egereket v\u00e1lasztanak kutat\u00e1si alanyk\u00e9nt. A v\u00e9r lipidszintje pozit\u00edvan korrel\u00e1l az AS megjelen\u00e9s\u00e9vel. K\u00f3ros k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt a lipid lerak\u00f3dik az art\u00e9ri\u00e1s falban, a monocita makrof\u00e1gok oxid\u00e1l\u00f3dnak \u00e9s habsejtekk\u00e9 fagocit\u00e1l\u00f3dnak, ez\u00e1ltal cs\u00f6kkentik a rostos plakk stabilit\u00e1s\u00e1t \u00e9s felgyors\u00edtj\u00e1k az AS folyamat\u00e1t. A vizsg\u00e1lat eredm\u00e9nyei azt mutatt\u00e1k, hogy a Buyang Huanwu Tang csoportban a TC, TG \u00e9s LDL-C szintje az AS plakkokban alacsonyabb volt, mint a modellcsoportban, \u00e9s az aorta gy\u00f6ker\u00e9ben nem volt megfigyelhet\u0151 jelent\u0151s lipidlerak\u00f3d\u00e1s vagy plakkk\u00e9pz\u0151d\u00e9s, ami tov\u00e1bb er\u0151s\u00edtette a Buyang Huanwu Tang AS-ellenes \u00e9s plakkstabiliz\u00e1l\u00f3 hat\u00e1s\u00e1t.
\nAz oxidat\u00edv stressz okozta k\u00e1rosod\u00e1s a szervezetben keletkez\u0151 ROS-ok \u00e9s az antioxid\u00e1ns enzimrendszer \u00e1ltal t\u00f6rt\u00e9n\u0151 elt\u00e1vol\u00edt\u00e1suk k\u00f6z\u00f6tti egyens\u00falyhi\u00e1nyra utal, ami a ROS-ok felhalmoz\u00f3d\u00e1s\u00e1nak n\u00f6veked\u00e9s\u00e9hez vezet, \u00e9s oxidat\u00edv k\u00e1rosod\u00e1st okoz a szervezetben. Ha t\u00fal sok ROS halmoz\u00f3dik fel az art\u00e9ri\u00e1ban, az oxidat\u00edv k\u00e1rosod\u00e1st okoz az \u00e9rfalban, el\u0151seg\u00edti a habsejtek termel\u0151d\u00e9s\u00e9t, v\u00e9g\u00fcl kiv\u00e1ltja vagy s\u00falyosb\u00edtja az AS-t, \u00e9s m\u00e9g az AS-plakk megreped\u00e9s\u00e9t is el\u0151seg\u00edti, ami s\u00falyosan befoly\u00e1solja az emberek \u00e9letmin\u0151s\u00e9g\u00e9t. Az AOPP k\u00fcl\u00f6nb\u00f6z\u0151 mechanizmusokon kereszt\u00fcl r\u00e9szt vehet az AS kialakul\u00e1s\u00e1ban \u00e9s fejl\u0151d\u00e9s\u00e9ben. Egyr\u00e9szt oxidat\u00edv metabolizmusa szuperoxid (H2O2, O-2, OH -) termel\u00e9s\u00e9t okozhatja, ami endothelialis diszfunkci\u00f3hoz vezet; m\u00e1sr\u00e9szt az AOPP el\u0151seg\u00edtheti a gyullad\u00e1sos faktorok szint\u00e9zis\u00e9t \u00e9s felszabadul\u00e1s\u00e1t, kiv\u00e1lthatja \u00e9s s\u00falyosb\u00edthatja az AS progresszi\u00f3j\u00e1t. Ez\u00e9rt az antioxid\u00e1ns reakci\u00f3k k\u00fcl\u00f6n\u00f6sen fontosak az AS megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben. Az Nrf2 jel\u00e1tviteli \u00fatvonal szorosan kapcsol\u00f3dik az antioxid\u00e1ns stresszhez. A szervezetben l\u00e9v\u0151 ROS-t\u00falterhel\u00e9s aktiv\u00e1lhatja az Nrf2\/HO jel\u00e1tviteli \u00fatvonalat, aminek hat\u00e1s\u00e1ra az Nrf2 disszoci\u00e1l a Keap1-gyel alkotott komplexb\u0151l, \u00e9s szabad \u00e1llapotban felhalmoz\u00f3dik a citoplazm\u00e1ban. Ugyanakkor foszforil\u00e1l\u00f3dik \u00e9s a sejtmagba ker\u00fcl, el\u0151seg\u00edtve a HO-1 g\u00e9n expresszi\u00f3j\u00e1t \u00e9s fokozva a sejtek antioxid\u00e1ns stresszel szembeni ellen\u00e1ll\u00f3 k\u00e9pess\u00e9g\u00e9t, ez\u00e1ltal v\u00e9d\u0151 hat\u00e1st gyakorolva a sejtekre. Az Nrf2 g\u00e9n egy alkalikus leucin cipz\u00e1r transzkripci\u00f3s faktor, amely sz\u00e9les k\u00f6rben jelen van az oxig\u00e9nfogyaszt\u00f3 szervekben. K\u00f6zvet\u00edtheti az antioxid\u00e1ns v\u00e1lasz\u00fatvonalakat, fenntarthatja a sejtek redox-homeoszt\u00e1zis\u00e1t, szab\u00e1lyozhatja a k\u00fcl\u00f6nb\u00f6z\u0151 antioxid\u00e1ns feh\u00e9rje g\u00e9neket, \u00e9s kulcsszerepet j\u00e1tszik a sejtek oxidat\u00edv stressz\u00e9ben. Az Nrf2\/ARE jel\u00e1tviteli \u00fatvonal jelenleg a legfontosabb endog\u00e9n antioxid\u00e1ns \u00fatvonalk\u00e9nt ismert, amely r\u00e9szt vesz a sejtes homeoszt\u00e1zis, a lipidk\u00e9pz\u0151d\u00e9s \u00e9s a gyullad\u00e1sos citokin felszabadul\u00e1s szab\u00e1lyoz\u00e1s\u00e1ban. A kutat\u00e1sok kimutatt\u00e1k, hogy az Nrf2 az \u00e1ltala k\u00f6zvet\u00edtett antioxid\u00e1ns \u00fatvonalon kereszt\u00fcl cs\u00f6kkentheti az oxidat\u00edv stressz okozta k\u00e1rosod\u00e1sokat, enyh\u00edtheti a gyullad\u00e1sos reakci\u00f3kat, v\u00e9dheti a sejteket, \u00e9s szab\u00e1lyozhatja a k\u00fcl\u00f6nb\u00f6z\u0151 antioxid\u00e1ns enzimaktivit\u00e1sokat. Az NQO-1 cs\u00f6kkentheti a NADPH-oxid\u00e1z, a ROS-szintet \u00e9s az oxidat\u00edv stressz okozta k\u00e1rosod\u00e1sok el\u0151fordul\u00e1s\u00e1t. A HO-1 egy rendk\u00edv\u00fcl fontos antioxid\u00e1ns enzim, amelyr\u0151l kider\u00fclt, hogy el\u0151seg\u00edti a hemoglobin lebont\u00e1s\u00e1t olyan anyagokra, mint a CO, a bilirubin \u00e9s a biliverdin, \u00e9s j\u00f3 megel\u0151z\u0151 hat\u00e1ssal van az ateroszkler\u00f3zis el\u0151fordul\u00e1s\u00e1ra. Ez a tanulm\u00e1ny meg\u00e1llap\u00edtotta, hogy a Buyang Huanwu Tang k\u00e9pes n\u00f6velni az Nrf2, az ARE, az NQO-1 \u00e9s a HO-1 expresszi\u00f3j\u00e1t az AS modell egerek aort\u00e1j\u00e1ban. Felt\u00e9telezhet\u0151, hogy a Buyang Huanwu Tang aktiv\u00e1lhatja az Nrf2\/ARE jel\u00e1tviteli \u00fatvonalat, hogy megv\u00e9dje az AS modell egerek aort\u00e1j\u00e1t az oxidat\u00edv stressz okozta k\u00e1rosod\u00e1st\u00f3l. Kutat\u00f3csoportunk tov\u00e1bbi vizsg\u00e1latokat v\u00e9gzett, \u00e9s meg\u00e1llap\u00edtotta, hogy a Buyang Huanwu Tang n\u00f6velheti az Nrf2 \u00e9s az ARE feh\u00e9rj\u00e9k, valamint az NQO-1, HO-1 feh\u00e9rj\u00e9k \u00e9s mRNS-\u00fck expresszi\u00f3j\u00e1t az egerek aort\u00e1j\u00e1ban. Ez azt jelzi, hogy a Buyang Huanwu Tang aktiv\u00e1lhatja az Nrf2\/ARE jel\u00e1tviteli \u00fatvonalat \u00e9s AS-ellenes hat\u00e1st fejthet ki. A SOD egy antioxid\u00e1ns enzim, amely az oxig\u00e9n szabad gy\u00f6k\u00f6k elkap\u00e1s\u00e1val antioxid\u00e1ns hat\u00e1st fejthet ki, \u00e9s k\u00f6zvetlen hat\u00e1ssal van az oxidat\u00edv stressz szintj\u00e9re. Az MDA az egyik legfontosabb term\u00e9k a membr\u00e1n lipidperoxid\u00e1ci\u00f3 folyamat\u00e1ban, amely pozit\u00edvan korrel\u00e1l az oxidat\u00edv stressz szintj\u00e9vel, \u00e9s t\u00fckr\u00f6zheti a szervezet oxidat\u00edv stressz \u00e1llapot\u00e1t. A GSH Px fontos antioxid\u00e1ns a szervezetben, amely negat\u00edvan korrel\u00e1l az oxidat\u00edv stressz m\u00e9rt\u00e9k\u00e9vel, \u00e9s k\u00e9pes a ROS-t ki\u00fcr\u00edteni, hogy antioxid\u00e1ns hat\u00e1st fejtsen ki. A vizsg\u00e1lat eredm\u00e9nyei azt mutatt\u00e1k, hogy a Buyang Huanwu Tang csoport n\u00f6velni tudta a GSH Px \u00e9s a SOD expresszi\u00f3s szintj\u00e9t az eg\u00e9rplazm\u00e1ban, \u00e9s cs\u00f6kkentette az MDA expresszi\u00f3s szintj\u00e9t; Cs\u00f6kkentette az AOPP \u00e9s a ROS expresszi\u00f3s szintj\u00e9t. A fentiek tov\u00e1bb er\u0151s\u00edtik, hogy a Buyang Huanwu Tang antioxid\u00e1ns \u00e9s stresszold\u00f3 hat\u00e1ssal rendelkezik.<\/p>\n

\u00d6sszefoglalva, a Buyang Huanwu f\u0151zet, amely a \"sz\u00edv j\u00f3t\u00e9kony, v\u00e9rstasis elt\u00e1vol\u00edt\u00f3 \u00e9s flegma felold\u00f3 m\u00f3dszer\u00e9n\" alapul, antioxidat\u00edv stressz hat\u00e1s\u00fa, jelent\u0151sen jav\u00edthatja az aorta patomorfol\u00f3giai v\u00e1ltoz\u00e1sait, cs\u00f6kkentheti a lipid lerak\u00f3d\u00e1st az aort\u00e1ban, \u00e9s az ateroszkler\u00f3zis elleni mechanizmusa az Nrf2 \/ ARE jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1s\u00e1hoz kapcsol\u00f3dhat.<\/p>","protected":false},"excerpt":{"rendered":"

A Buyang Huanwu f\u0151zet mechanizmus\u00e1nak vizsg\u00e1lata az ateroszkler\u00f3zis megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben az Nrf2\/ARE jel\u00fatvonalon kereszt\u00fcl Az ateroszkler\u00f3zis (AS) kr\u00f3nikus gyullad\u00e1sos betegs\u00e9g. Az AS betegek korai kezdete alattomos, \u00e9s nincsenek nyilv\u00e1nval\u00f3 klinikai megnyilv\u00e1nul\u00e1sok, de a betegs\u00e9g el\u0151rehaladt\u00e1val a c\u00e9lszervek, p\u00e9ld\u00e1ul a sz\u00edv \u00e9s az agy [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Mechanism of Buyang Huanwu Decoction in Preventing and Treating Atherosclerosis through Nrf2\/ARE Signal Pathway - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/prevention-and-treatment-of-atherosclerosis\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Mechanism of Buyang Huanwu Decoction in Preventing and Treating Atherosclerosis through Nrf2\/ARE Signal Pathway - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Mechanism of Buyang Huanwu Decoction in Preventing and Treating Atherosclerosis through Nrf2\/ARE Signal Pathway Atherosclerosis (AS) is a chronic inflammatory disease. Early onset of AS patients is insidious and there are no obvious clinical manifestations, but as the disease progresses, target organs such as the heart and brain may be affected in […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/hu\/prevention-and-treatment-of-atherosclerosis\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-03T08:34:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-19.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Szerz\u0151:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Becs\u00fclt olvas\u00e1si id\u0151\" \/>\n\t<meta name=\"twitter:data2\" content=\"11 perc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/prevention-and-treatment-of-atherosclerosis\/\",\"url\":\"https:\/\/longchangextracts.com\/prevention-and-treatment-of-atherosclerosis\/\",\"name\":\"Study on the Mechanism of Buyang Huanwu Decoction in Preventing and Treating Atherosclerosis through Nrf2\/ARE Signal Pathway - 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