{"id":3831,"date":"2024-08-03T08:17:48","date_gmt":"2024-08-03T08:17:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3831"},"modified":"2024-08-03T08:17:48","modified_gmt":"2024-08-03T08:17:48","slug":"total-caffeoylquinic-acid-of-lamplighter-xixin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/total-caffeoylquinic-acid-of-lamplighter-xixin\/","title":{"rendered":"A PI3K \/ Akt \/ FoxO3a \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1t \u00e9s az \u00f6reged\u00e9s k\u00e9sleltet\u00e9s\u00e9t szab\u00e1lyoz\u00f3 teljes koffeokininsav mechanizmus\u00e1nak vizsg\u00e1lata Scutellaria baicalensisben"},"content":{"rendered":"

A PI3K \/ Akt \/ FoxO3a \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1t \u00e9s az \u00f6reged\u00e9s k\u00e9sleltet\u00e9s\u00e9t szab\u00e1lyoz\u00f3 teljes koffeokininsav mechanizmus\u00e1nak vizsg\u00e1lata Scutellaria baicalensisben
\nAz \u00f6reged\u00e9s az \u00e9letkorral \u00f6sszef\u00fcgg\u0151 fokozatos fiziol\u00f3giai hanyatl\u00e1s, amely a t\u00fal\u00e9l\u00e9si k\u00e9pess\u00e9g elveszt\u00e9s\u00e9hez \u00e9s fokozott sebezhet\u0151s\u00e9ghez vezet. Az \u00f6reged\u00e9st k\u00f6rnyezeti \u00e9s genetikai t\u00e9nyez\u0151k befoly\u00e1solj\u00e1k, \u00e9s tizenk\u00e9t f\u0151 jellemz\u0151je van: genomi instabilit\u00e1s, epigenetikai v\u00e1ltoz\u00e1sok, telomerek kimer\u00fcl\u00e9se, t\u00e1pl\u00e1lkoz\u00e1si \u00e9rz\u00e9kel\u00e9si zavarok, feh\u00e9rje homeoszt\u00e1zis egyens\u00falyhi\u00e1ny, mitokondri\u00e1lis diszfunkci\u00f3, sejtek \u00f6reged\u00e9se, abnorm\u00e1lis intercellul\u00e1ris kommunik\u00e1ci\u00f3, \u0151ssejtek kimer\u00fcl\u00e9se, makroautof\u00e1gia inaktiv\u00e1l\u00f3d\u00e1sa, kr\u00f3nikus gyullad\u00e1s \u00e9s b\u00e9l mikrobi\u00f3ta diszbi\u00f3zis. E jellemz\u0151k k\u00f6z\u00fcl a \"t\u00e1pl\u00e1lkoz\u00e1si diszregul\u00e1ci\u00f3\" az els\u0151, amelyet molekul\u00e1ris szinten igazoltak, \u00e9s amely az inzulin \u00e9s az inzulinszer\u0171 n\u00f6veked\u00e9si faktor-1 (IGF-1) inzulinreceptorokhoz val\u00f3 k\u00f6t\u0151d\u00e9s\u00e9n kereszt\u00fcl a downstream jel\u00e1tviteli \u00fatvonalak szab\u00e1lyoz\u00e1s\u00e1val befoly\u00e1solja az \u00e9lettartamot. Az inzulin\/IGF-1 az inzulinreceptorokhoz k\u00f6t\u0151dve aktiv\u00e1lja a foszfatidil-inozitol-3-kin\u00e1zt (PI3K), amely kataliz\u00e1lja a 3,4,5-trifoszf\u00e1t foszfatidil-inozitol (PIP3) termel\u00e9s\u00e9t a 4,5-difoszf\u00e1t foszfatidil-inozitolb\u00f3l (PIP2). Ezt k\u00f6vet\u0151en a protein kin\u00e1z B (Akt\/protein kin\u00e1z B, Akt\/PKB) a plazmamembr\u00e1nba rekrut\u00e1l\u00f3dik, \u00e9s az Akt-ban l\u00e9v\u0151 treonin a PIP3-f\u00fcgg\u0151 kin\u00e1z-1 \u00e9s -2 (PDK-1 \u00e9s PDK-2) r\u00e9v\u00e9n fejez\u0151dik ki. A foszforil\u00e1ci\u00f3 a szerin 308 (Thr308) \u00e9s 473 (Ser473) poz\u00edci\u00f3j\u00e1ban t\u00f6rt\u00e9nik, foszforil\u00e1lt Ak (t phosphop Akt, p-Akt) k\u00e9pz\u0151dik, \u00e9s aktiv\u00e1lja az Aktot. A villafej\u0171 doboz O3a oszt\u00e1ly\u00fa (FOXO3a) a villafej\u0171 doboz transzkripci\u00f3s faktor O alcsal\u00e1d n\u00e9gy tagj\u00e1nak egyike. Az aktiv\u00e1lt Akt foszforil\u00e1lja a FoxO3a treonin 32-es hely\u00e9t (Thr32) \u00e9s szerin 253-as hely\u00e9t (Ser253), foszforil\u00e1lt FOXO3-at k\u00e9pezve (a phosphop-FOXO3a, p-FOXO3a), amely el\u0151seg\u00edti a FoxO3a k\u00f6t\u0151d\u00e9s\u00e9t a 14-3-3 feh\u00e9rj\u00e9hez, ez\u00e1ltal megakad\u00e1lyozza a FoxO3a magba jut\u00e1s\u00e1t \u00e9s a transzkripci\u00f3s aktivit\u00e1s elveszt\u00e9s\u00e9t. A FoxO3a az \u00f6reged\u00e9st szab\u00e1lyoz\u00f3 kulcsfontoss\u00e1g\u00fa transzkripci\u00f3s faktor, amely az autof\u00e1gia el\u0151seg\u00edt\u00e9s\u00e9vel, az oxidat\u00edv rezisztencia fokoz\u00e1s\u00e1val \u00e9s az \u0151ssejtek pluripotenci\u00e1j\u00e1nak fenntart\u00e1s\u00e1val szerepet j\u00e1tszhat a hossz\u00fa \u00e9let el\u0151seg\u00edt\u00e9s\u00e9ben. Az oxidat\u00edv rezisztencia tekintet\u00e9ben a FoxO3a transzkripci\u00f3s aktiv\u00e1ci\u00f3ja fokozza az olyan g\u00e9nek expresszi\u00f3j\u00e1t, mint a szuperoxid-dizmut\u00e1z (SOD), a glutation-peroxid\u00e1z (GSH Px) \u00e9s a katal\u00e1z (CAT), tiszt\u00edtja a reakt\u00edv oxig\u00e9nfajokat (ROS), \u00e9s cs\u00f6kkenti a lipidperoxid\u00e1ci\u00f3s term\u00e9k, a malondialdehid (MDA) szintj\u00e9t, ez\u00e1ltal k\u00e9slelteti a szervezet \u00f6reged\u00e9s\u00e9t \u00e9s meghosszabb\u00edtja az \u00e9lettartamot. Gerinctelen \u00e9s gerinces modelleken v\u00e9gzett vizsg\u00e1latok kimutatt\u00e1k, hogy az inzulin\/IGF-1 szintj\u00e9nek cs\u00f6kkent\u00e9se \u00e9s az inzulinreceptorok, a PI3K \u00e9s az Akt mut\u00e1ci\u00f3ja el\u0151seg\u00edti a FoxO3a nukle\u00e1ris transzlok\u00e1ci\u00f3j\u00e1t, fokozza transzkripci\u00f3s aktivit\u00e1s\u00e1t \u00e9s k\u00e9slelteti az \u00f6reged\u00e9st.
\nErigeron breviscapus (Vant.) Hand- Mazz.)\uff0c Dengzhan Hua n\u00e9ven is ismert, el\u0151sz\u00f6r a \"Dian Nan Ben Cao\"-ban jegyezt\u00e9k fel, hat\u00e1sa a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9se, a meridi\u00e1nok felold\u00e1sa, a f\u00e1jdalom enyh\u00edt\u00e9se, a sz\u00e9l \u00e9s a hideg el\u0171z\u00e9se. Els\u0151sorban a stroke hemiplegia, mellkasi f\u00e1jdalom, reum\u00e1s f\u00e1jdalom, fejf\u00e1j\u00e1s \u00e9s fogf\u00e1j\u00e1s kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k. A Scutellaria baicalensis f\u0151 akt\u00edv \u00f6sszetev\u0151i a flavonoidok \u00e9s a koffeoilkininsav (CQA). A h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t \u00e9s molekul\u00e1ris dokkol\u00e1st alkalmaz\u00f3 kor\u00e1bbi tanulm\u00e1nyok meg\u00e1llap\u00edtott\u00e1k, hogy a flavonoidok \u00e9s a CQA vegy\u00fcletek a Scutellaria baicalensis \u00f6reged\u00e9sg\u00e1tl\u00f3 tulajdons\u00e1gainak potenci\u00e1lis hat\u00f3anyagai, amelyek n\u00e9gy kulcsfontoss\u00e1g\u00fa c\u00e9lpont: a p53, AKT, HDAC1 \u00e9s SIRT1 szab\u00e1lyoz\u00e1s\u00e1val fejthetnek ki \u00f6reged\u00e9sg\u00e1tl\u00f3 hat\u00e1st. A molekul\u00e1ris dokkol\u00e1s sor\u00e1n a koffeoilvegy\u00fcletek, bele\u00e9rtve a 4-CQA, 5-CQA, klorog\u00e9nsav \u00e9s a dikafeoilkininsav (DCQA) 4,5-DCQA, 3,4-DCQA, 3,5-DCQA, 1,3-DCQA \u00e9s 1,5-DCQA komponenseket, magasabb dokkol\u00e1si pontsz\u00e1mot \u00e9rtek el az AKT-vel, mint a g\u00e1tl\u00f3 ligandumok. Az \u00e9lettartam-k\u00eds\u00e9rlet meg\u00e1llap\u00edtotta, hogy ezek a komponensek mindegyike meghosszabb\u00edtja a fon\u00e1lf\u00e9rgek \u00e9lettartam\u00e1t. K\u00f6z\u00fcl\u00fck mut\u00e1ns t\u00f6rzsek \u00e9s transzgenikus fon\u00e1lf\u00e9rgek seg\u00edts\u00e9g\u00e9vel igazolt\u00e1k, hogy a 3,5-DCQA g\u00e1tolja a PI3K \u00e9s az AGE-1 \u00e9s AKT-1 homol\u00f3gok AGE-1 \u00e9s AKT-1 aktivit\u00e1s\u00e1t fon\u00e1lf\u00e9rgekben, el\u0151seg\u00edti a FoxO3a homol\u00f3g DAF-16 bejut\u00e1s\u00e1t a sejtmagba, \u00e9s \u00edgy \u00e9lettartam-n\u00f6vel\u0151 hat\u00e1st fejt ki. A fenti eredm\u00e9nyek arra utalnak, hogy a Scutellaria baicalensis CQA komponensei k\u00e9sleltethetik az \u00f6reged\u00e9st az AKT aktivit\u00e1s g\u00e1tl\u00e1s\u00e1val \u00e9s a PI3K\/Akt\/FoxO3a \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1val. E tanulm\u00e1ny c\u00e9lja az Erigeron breviscapusb\u00f3l sz\u00e1rmaz\u00f3 teljes koffeoilkininsav (EBCQA) \u00f6reged\u00e9sg\u00e1tl\u00f3 hat\u00e1s\u00e1nak megfigyel\u00e9se a kor\u00e1bbi kutat\u00e1sok alapj\u00e1n, valamint az EBCQA \u00f6reged\u00e9sg\u00e1tl\u00f3 mechanizmus\u00e1nak felt\u00e1r\u00e1sa a PI3K\/Akt\/FoxO3a \u00fatvonal alapj\u00e1n.<\/p>\n

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\nAz \u00f6reged\u00e9s az \u00e9let term\u00e9szetes folyamata, \u00e9s b\u00e1r elker\u00fclhetetlen, a t\u00e1pl\u00e1lkoz\u00e1s szab\u00e1lyoz\u00e1s\u00e1val, genetikai manipul\u00e1ci\u00f3val, gy\u00f3gyszeres beavatkoz\u00e1ssal \u00e9s m\u00e1s eszk\u00f6z\u00f6kkel k\u00e9sleltethet\u0151. Ami m\u00e9g fontosabb, hogy ezek az \u00f6reged\u00e9sg\u00e1tl\u00f3 beavatkoz\u00e1sok nemcsak az \u00e9lettartamot hosszabb\u00edtj\u00e1k meg, hanem a szervezet \u00e1ltal\u00e1nos eg\u00e9szs\u00e9gi \u00e1llapot\u00e1t is jelent\u0151sen jav\u00edtj\u00e1k. Kor\u00e1bbi tanulm\u00e1nyainkban meg\u00e1llap\u00edtottuk, hogy az EBCQA potenci\u00e1lis \u00f6reged\u00e9sg\u00e1tl\u00f3 hat\u00e1ssal rendelkezik, \u00e9s \u00f6sszef\u00fcgg\u00e9sben \u00e1llhat az AKT-aktivit\u00e1s szab\u00e1lyoz\u00e1s\u00e1val. Ebben a vizsg\u00e1latban meger\u0151s\u00edtett\u00fck, hogy az EBCQA meghosszabb\u00edtja a fon\u00e1lf\u00e9rgek \u00e9lettartam\u00e1t, fokozza az oxidat\u00edv \u00e9s h\u0151\u00e1ll\u00f3s\u00e1got, valamint jav\u00edtja a motilit\u00e1st. A fon\u00e1lf\u00e9rgek mut\u00e1ns t\u00f6rzsein kereszt\u00fcl meger\u0151s\u00edtett\u00fck, hogy az EBCQA \u00f6reged\u00e9sg\u00e1tl\u00f3 hat\u00e1sa a PI3K\/Akt\/FoxO3a \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1hoz, az antioxid\u00e1ns enzimaktivit\u00e1s fokoz\u00e1s\u00e1hoz \u00e9s az MDA-szint cs\u00f6kkent\u00e9s\u00e9hez kapcsol\u00f3dik; D-galakt\u00f3zzal induk\u00e1lt \u00f6reged\u0151 patk\u00e1nyokban az EBCQA jav\u00edtja a tanul\u00e1si \u00e9s mem\u00f3ria k\u00e9pess\u00e9geket, a t\u00edmusz \u00e9s a l\u00e9p koefficiens\u00e9t, g\u00e1tolja a PI3K \u00e9s Akt aktiv\u00e1ci\u00f3t, valamint a FoxO3a foszforil\u00e1ci\u00f3t, fokozza az antioxid\u00e1ns enzimaktivit\u00e1st \u00e9s cs\u00f6kkenti az MDA-szintet.
\nA CQA oszt\u00e1ly\u00fa komponensek a Scutellaria baicalensis fenolos hat\u00f3anyagainak fontos oszt\u00e1ly\u00e1t alkotj\u00e1k, \u00e9s sz\u00e1mos \u00e9lelmiszerben (p\u00e9ld\u00e1ul a lila \u00e9desburgony\u00e1ban, a z\u00f6ld k\u00e1v\u00e9ban) \u00e9s gy\u00f3gyn\u00f6v\u00e9nyekben is jelen vannak. A CQA vegy\u00fcletek neuroprotekt\u00edv, sz\u00edv- \u00e9s \u00e9rrendszeri v\u00e9d\u0151, antioxid\u00e1ns, gyullad\u00e1scs\u00f6kkent\u0151, cukorbetegs\u00e9g elleni \u00e9s egy\u00e9b hat\u00e1sokkal rendelkeznek. Az \u00f6reged\u00e9sg\u00e1tl\u00e1s tekintet\u00e9ben a CQA-komponensekben gazdag z\u00f6ld k\u00e1v\u00e9 kivonat \u00e9s a lonc kivonat meghosszabb\u00edtotta a fon\u00e1lf\u00e9reg \u00e9lettartam\u00e1t, de m\u00e9g nem vil\u00e1gos, hogy az \u00f6reged\u00e9sg\u00e1tl\u00f3 mechanizmusaik a PI3K\/Akt\/FoxO3a \u00fatvonalat \u00e9rintik-e. A CQA-komponensek \u00f6reged\u00e9sg\u00e1tl\u00f3 hat\u00e1sair\u00f3l eml\u0151s\u00f6kben ritk\u00e1n sz\u00e1moltak be. \u00d6sszhangban a kor\u00e1bbi jelent\u00e9sekkel, amelyek szerint a CQA komponensek k\u00e9pesek meghosszabb\u00edtani a fon\u00e1lf\u00e9rgek \u00e9lettartam\u00e1t, azt tal\u00e1ltuk, hogy az EBCQA meghosszabb\u00edtja a fon\u00e1lf\u00e9rgek \u00e9lettartam\u00e1t 17,7% maxim\u00e1lis megny\u00fal\u00e1si sebess\u00e9ggel, \u00e9s fokozza az oxidat\u00edv rezisztenci\u00e1t, a h\u0151\u00e1ll\u00f3s\u00e1got \u00e9s a motilit\u00e1st. A D-galakt\u00f3zzal induk\u00e1lt \u00f6reged\u00e9si patk\u00e1nymodell bizony\u00edtottan hat\u00e9konyan szimul\u00e1lja a term\u00e9szetes \u00f6reged\u00e9st, ez\u00e9rt sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k az \u00f6reged\u00e9si mechanizmusok tanulm\u00e1nyoz\u00e1s\u00e1ra \u00e9s az \u00f6reged\u00e9st k\u00e9sleltet\u0151 gy\u00f3gyszerek sz\u0171r\u00e9s\u00e9re. A cs\u00f6kkent tanul\u00e1si \u00e9s mem\u00f3riak\u00e9pess\u00e9gek az \u00f6reged\u00e9ssel j\u00e1r\u00f3 gyakori \u00e9lettani jelens\u00e9gek, \u00e9s n\u00e9melyik\u00fckb\u0151l neurodegenerat\u00edv betegs\u00e9gek, p\u00e9ld\u00e1ul az Alzheimer-k\u00f3r alakulhatnak ki. Az \u00e9letkor n\u00f6veked\u00e9s\u00e9vel vagy a betegs\u00e9gek megjelen\u00e9s\u00e9vel a szervezet immunrendszer\u00e9nek kapacit\u00e1sa \u00e1ltal\u00e1ban fokozatosan cs\u00f6kken. A t\u00edmusz \u00e9s a l\u00e9p fontos immunszervek, \u00e9s szervi indexeik bizonyos m\u00e9rt\u00e9kig t\u00fckr\u00f6zhetik a szervezet immunkapacit\u00e1s\u00e1nak nagys\u00e1g\u00e1t. Ez\u00e9rt a tanul\u00e1si \u00e9s mem\u00f3ria k\u00e9pess\u00e9g, valamint a thymus\/l\u00e9p szervi index \u00e1ltal\u00e1nosan haszn\u00e1lt mutat\u00f3k az \u00f6reged\u00e9s \u00e9s az \u00f6reged\u00e9sg\u00e1tl\u00e1s \u00e9rt\u00e9kel\u00e9s\u00e9re. A D-galakt\u00f3zzal induk\u00e1lt \u00f6reged\u0151 patk\u00e1nyok cs\u00f6kkent tanul\u00e1si \u00e9s mem\u00f3ria k\u00e9pess\u00e9geket, valamint cs\u00f6kkent t\u00edmusz- \u00e9s l\u00e9p-koefficienseket mutattak. Az EBCQA bead\u00e1sa hat\u00e9konyan jav\u00edtotta a tanul\u00e1si \u00e9s mem\u00f3ria k\u00e9pess\u00e9geket, \u00e9s n\u00f6velte a thymus \u00e9s a l\u00e9p egy\u00fctthat\u00f3kat. Ezek az eredm\u00e9nyek azt mutatj\u00e1k, hogy az EBCQA \u00f6reged\u00e9sg\u00e1tl\u00f3 hat\u00e1ssal rendelkezik mind a gerinctelen fon\u00e1lf\u00e9rgekben, mind a gerinces D-galakt\u00f3z \u00e1ltal kiv\u00e1ltott \u00f6reged\u0151 patk\u00e1nyokban.
\nA PI3K\/Akt\/FoxO3a \u00fatvonal egy evol\u00faci\u00f3san konzerv\u00e1lt jel\u00e1tviteli \u00fatvonal, amelyet az inzulin, az IGF-1 \u00e9s m\u00e1s t\u00e9nyez\u0151k szab\u00e1lyoznak. Az \u00f6reged\u00e9s szab\u00e1lyoz\u00e1s\u00e1ban a PI3K \u00e9s az Akt pro-aging, m\u00edg a FOXO3a anti-aging szerepet j\u00e1tszik. A fon\u00e1lf\u00e9rgekben az AGE-1, az AKT-1 \u00e9s a DAF-16 az eml\u0151s PI3K, Akt, illetve a FoxO3a homol\u00f3gjai. Az AGE-1 mut\u00e1ci\u00f3val rendelkez\u0151 fon\u00e1lf\u00e9rgek \u00e9lettartama \u00e1tlagosan 40%-r\u0151l 65%-re hosszabbodik, az AKT-1 mut\u00e1ci\u00f3val rendelkez\u0151k szint\u00e9n jelent\u0151sen hosszabb \u00e9lettartammal rendelkeznek, a DAF-16 mut\u00e1ci\u00f3 pedig jelent\u0151sen ler\u00f6vid\u00edti az \u00e9lettartamot. Eml\u0151s\u00f6kben az AKT-1 t\u00falexpresszi\u00f3ja induk\u00e1lja a sejtek \u00f6reged\u00e9s\u00e9t. Az AKT-1 mut\u00e1ci\u00f3val rendelkez\u0151 (Akt1+\/-) egerekn\u00e9l a h\u00edmek \u00e9lettartama 8%-vel, a n\u0151st\u00e9nyek\u00e9 pedig 15%-vel n\u0151. A hossz\u00fa \u00e9let\u0171 popul\u00e1ci\u00f3kon v\u00e9gzett kutat\u00e1sok azt is meg\u00e1llap\u00edtott\u00e1k, hogy az IGF-1 receptorok, az inzulinreceptorok vagy ezek downstream faktorainak (pl. PI3K, AKT) funkci\u00f3veszt\u00e9s\u00e9hez vezet\u0151 genetikai polimorfizmusok\/mut\u00e1ci\u00f3k az emberi \u00e9lettartam meghosszabbod\u00e1s\u00e1val j\u00e1rnak. A jap\u00e1n-amerikaiak, han-k\u00ednaiak, kaliforniaiak, \u00faj-angliaiak, asken\u00e1zi zsid\u00f3k, d\u00e1nok, n\u00e9metek \u00e9s olaszok hossz\u00fa \u00e9let\u0171 popul\u00e1ci\u00f3inak vizsg\u00e1lata azt mutatja, hogy a FOXO3a rs2764264, rs2802292 stb. genetikai polimorfizmusai kapcsolatban \u00e1llnak a hossz\u00fa \u00e9letkorral \u00e9s az eg\u00e9szs\u00e9ges \u00f6reged\u00e9ssel. A PI3K\/Akt\/FoxO3a \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1ban az Akt a Thr308 \u00e9s Ser473 foszforil\u00e1ci\u00f3j\u00e1ra aktiv\u00e1l\u00f3dik, m\u00edg a FoxO3a a Thr32 \u00e9s Ser253 foszforil\u00e1ci\u00f3j\u00e1ra g\u00e1tol\u00f3dik. Ebben a vizsg\u00e1latban az EBCQA meghosszabb\u00edtotta a vad t\u00edpus\u00fa N2 fon\u00e1lf\u00e9reg \u00e9lettartam\u00e1t \u00e9s el\u0151seg\u00edtette a DAF-16 nukle\u00e1ris transzlok\u00e1ci\u00f3j\u00e1t, de nem volt hat\u00e1ssal az AGE-1, AKT-1 \u00e9s DAF-16 mut\u00e1nsok \u00e9lettartam\u00e1ra, ami azt jelzi, hogy az EBCQA \u00e9lettartamot meghosszabb\u00edt\u00f3 szerepe a PI3K\/Akt\/FoxO3a \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1t\u00f3l f\u00fcgg. A D-galakt\u00f3zzal kezelt patk\u00e1nyokn\u00e1l a PI3K, Akt, p-Akt \u00e9s p-FOXO3a expresszi\u00f3j\u00e1nak felfel\u00e9 t\u00f6rt\u00e9n\u0151 szab\u00e1lyoz\u00e1s\u00e1t mutatt\u00e1k, m\u00edg a FOXO3a expresszi\u00f3ja lecs\u00f6kkent. Ez \u00f6sszhangban van a D-galakt\u00f3zzal induk\u00e1lt \u00f6reged\u0151 patk\u00e1nyok \u00e9s a term\u00e9szetesen \u00f6reged\u0151 kis\/nagy patk\u00e1nyok v\u00e1ltoz\u00e1s\u00e1r\u00f3l sz\u00f3l\u00f3 kor\u00e1bbi jelent\u00e9sekkel. Ezek a feh\u00e9rjeexpresszi\u00f3ban bek\u00f6vetkez\u0151 v\u00e1ltoz\u00e1sok cs\u00f6kkent tanul\u00e1si \u00e9s mem\u00f3ria k\u00e9pess\u00e9gekhez, valamint cs\u00f6kkent t\u00edmusz- \u00e9s l\u00e9pkoefficienshez vezethetnek, ez\u00e1ltal \u00f6reged\u00e9st induk\u00e1lva. Az EBCQA bead\u00e1sa ut\u00e1n ezek a v\u00e1ltoz\u00e1sok g\u00e1tolt\u00e1k, ami \u00f6reged\u00e9sg\u00e1tl\u00f3 hat\u00e1ssal b\u00edrhat.
\nHarmna brit tud\u00f3s 1956-ban vetette fel el\u0151sz\u00f6r a szabadgy\u00f6k\u00f6s \u00f6reged\u00e9s elm\u00e9let\u00e9t, mivel \u00fagy v\u00e9lte, hogy a biomolekul\u00e1k szabadgy\u00f6k\u00f6s t\u00e1mad\u00e1sai \u00e1ltal okozott sejtm\u0171k\u00f6d\u00e9si zavarok a szervezet \u00f6reged\u00e9s\u00e9nek egyik alapvet\u0151 oka. Ebben a vizsg\u00e1latban az EBCQA n\u00f6velte a SOD, a GSH Px \u00e9s a CAT aktivit\u00e1s\u00e1t paraquattal kezelt fon\u00e1lf\u00e9rgekben \u00e9s D-galakt\u00f3zzal kezelt patk\u00e1nyokban, mik\u00f6zben cs\u00f6kkentette az MDA-szintet. Ezen antioxid\u00e1ns enzimek aktivit\u00e1s\u00e1nak n\u00f6veked\u00e9se a ROS \u00e9s az oxidat\u00edv k\u00e1rosod\u00e1s cs\u00f6kken\u00e9s\u00e9hez vezethet, ez\u00e1ltal seg\u00edtve az \u00f6reged\u00e9s k\u00e9sleltet\u00e9s\u00e9t. Az egyik downstream mechanizmus, amellyel a PI3K\/Akt\/FoxO3a \u00fatvonal befoly\u00e1solja az \u00e9lettartamot, az oxidat\u00edv rezisztencia szab\u00e1lyoz\u00e1sa. A fon\u00e1lf\u00e9rgekben egyes hossz\u00fa \u00e9let\u0171 mut\u00e1ns t\u00f6rzsek, p\u00e9ld\u00e1ul a daf-2 (e1368) \u00e9s az age-1 (hx546), a DAF-16-t\u00f3l f\u00fcgg\u0151 SOD, GSH Px \u00e9s CAT antioxid\u00e1ns enzimek fokozott aktivit\u00e1s\u00e1t mutatj\u00e1k. A DAF-16 mut\u00e1ci\u00f3 ut\u00e1n ezeknek a mut\u00e1ns t\u00f6rzseknek az antioxid\u00e1ns enzimaktivit\u00e1sa csaknem hasonl\u00f3 a vad t\u00edpus\u00fa N2 fon\u00e1lf\u00e9reg\u00e9hez. Eml\u0151s\u00f6kben a FoxO3a szab\u00e1lyozza az antioxid\u00e1ns enzimek, mint a SOD, GSH Px, CAT expresszi\u00f3j\u00e1t, \u00e9s g\u00e1tolja a FoxO3a aktivit\u00e1s\u00e1t, ami a ROS felhalmoz\u00f3d\u00e1s\u00e1hoz vezet a sejtekben, felgyors\u00edtja az \u00e9relmeszesed\u00e9st \u00e9s n\u00f6veli a r\u00e1k kock\u00e1zat\u00e1t. Az EBCQA el\u0151seg\u00edti a nemat\u00f3da DAF-16 nukle\u00e1ris bel\u00e9p\u00e9s\u00e9t \u00e9s g\u00e1tolja a patk\u00e1ny FoxO3a foszforil\u00e1ci\u00f3j\u00e1t, ami arra utal, hogy az EBCQA \u00f6reged\u00e9sg\u00e1tl\u00f3 szerepet j\u00e1tszhat a FoxO3a transzkripci\u00f3s aktivit\u00e1s\u00e1nak \u00e9s antioxid\u00e1ns enzimaktivit\u00e1s\u00e1nak fokoz\u00e1s\u00e1val.
\n\u00d6sszefoglalva, az EBCQA hat\u00e9konyan meghosszabb\u00edthatja a fon\u00e1lf\u00e9rgek \u00e9lettartam\u00e1t \u00e9s ellens\u00falyozhatja a D-galakt\u00f3z okozta \u00f6reged\u00e9st patk\u00e1nyokban. Hat\u00e1smechanizmusa a PI3K \u00e9s Akt aktiv\u00e1ci\u00f3 g\u00e1tl\u00e1s\u00e1n, a FOXO3a foszforil\u00e1ci\u00f3j\u00e1nak cs\u00f6kkent\u00e9s\u00e9n, a FOXO3a nukle\u00e1ris \u00e9s transzkripci\u00f3s aktivit\u00e1s\u00e1nak el\u0151seg\u00edt\u00e9s\u00e9n, az antioxid\u00e1ns enzimaktivit\u00e1s fokoz\u00e1s\u00e1n, az oxidat\u00edv stressz g\u00e1tl\u00e1s\u00e1n \u00e9s \u00edgy az \u00f6reged\u00e9s k\u00e9sleltet\u00e9s\u00e9n kereszt\u00fcl val\u00f3sulhat meg.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Mechanism of Total Caffeoylquinic Acid Regulating PI3K\/Akt\/FoxO3a Pathway and Delaying Aging in Scutellaria baicalensis Aging is a gradual physiological decline related to age, leading to loss of survival ability and increased vulnerability. Aging is influenced by environmental and genetic factors, and has twelve major characteristics: genomic instability, epigenetic changes, telomere depletion, nutritional […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Mechanism of Total Caffeoylquinic Acid Regulating PI3K\/Akt\/FoxO3a Pathway and Delaying Aging in Scutellaria baicalensis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/total-caffeoylquinic-acid-of-lamplighter-xixin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Mechanism of Total Caffeoylquinic Acid Regulating PI3K\/Akt\/FoxO3a Pathway and Delaying Aging in Scutellaria baicalensis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Mechanism of Total Caffeoylquinic Acid Regulating PI3K\/Akt\/FoxO3a Pathway and Delaying Aging in Scutellaria baicalensis Aging is a gradual physiological decline related to age, leading to loss of survival ability and increased vulnerability. 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