{"id":3822,"date":"2024-08-03T08:10:56","date_gmt":"2024-08-03T08:10:56","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3822"},"modified":"2024-08-03T08:10:56","modified_gmt":"2024-08-03T08:10:56","slug":"salvianolic-acid-b-liver-injury","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/salvianolic-acid-b-liver-injury\/","title":{"rendered":"A B szalvianolsav hat\u00e1sa a b\u00e9l mikrobi\u00f3t\u00e1ra \u00e9s a r\u00f6vid sz\u00e9nl\u00e1nc\u00fa zs\u00edrsavak metabolizmus\u00e1ra m\u00e1jk\u00e1rosodott egerekben"},"content":{"rendered":"<p>A B szalvianolsav hat\u00e1sa a b\u00e9l mikrobi\u00f3t\u00e1ra \u00e9s a r\u00f6vid sz\u00e9nl\u00e1nc\u00fa zs\u00edrsavak metabolizmus\u00e1ra m\u00e1jk\u00e1rosodott egerekben<br \/>\nA m\u00e1jk\u00e1rosod\u00e1s a m\u00e1jsejtek k\u00e1rosod\u00e1s\u00e1t \u00e9s a m\u00e1j rendellenes m\u0171k\u00f6d\u00e9s\u00e9t jelenti, amelyet k\u00fcl\u00f6nb\u00f6z\u0151 t\u00e9nyez\u0151k okoznak. A klinikai gyakorlatban gyakori patog\u00e9n t\u00e9nyez\u0151k k\u00f6z\u00e9 tartozik a gy\u00f3gyszeres stimul\u00e1ci\u00f3, a v\u00edrusfert\u0151z\u00e9s, az alkohol vagy a k\u00e9miai toxinok. A kutat\u00e1sok kimutatt\u00e1k, hogy a s\u00falyos vagy tart\u00f3s m\u00e1jk\u00e1rosod\u00e1s v\u00e9g\u00fcl cirr\u00f3zishoz \u00e9s m\u00e1jsejtes karcin\u00f3m\u00e1hoz vezethet.<br \/>\nA Danshen enyh\u00e9n hideg term\u00e9szet\u0171, keser\u0171 \u00edz\u0171, \u00e9s a sz\u00edv- \u00e9s m\u00e1jmeridi\u00e1nokba hatol. A klinikai gyakorlatban \u00e1ltal\u00e1nosan haszn\u00e1lt v\u00e9raktiv\u00e1l\u00f3 \u00e9s pang\u00e1s megsz\u00fcntet\u0151 gy\u00f3gyszer, \u00e9s a t\u00f6rt\u00e9nelem sor\u00e1n az orvosok sz\u00e9les k\u00f6rben alkalmazt\u00e1k a m\u00e1jbetegs\u00e9gek kezel\u00e9s\u00e9ben. A szalvianolsav B (Sal B) a Danshen v\u00edzben old\u00f3d\u00f3 kivonat\u00e1nak egyik f\u0151 hat\u00f3anyaga. A kutat\u00e1sok kimutatt\u00e1k, hogy a Sal B az oxidat\u00edv stressz, a TGF - \u03b2 jel\u00e1tviteli \u00fatvonal \u00e9s m\u00e1s mechanizmusok g\u00e1tl\u00e1s\u00e1val enyh\u00edtheti a m\u00e1jk\u00e1rosod\u00e1st. Vizsg\u00e1latok kimutatt\u00e1k, hogy a sz\u00e1jon \u00e1t szedhet\u0151 Sal B biohasznosul\u00e1sa alacsony, ami arra utal, hogy a b\u00e9l mikrobi\u00f3ta szab\u00e1lyoz\u00e1sa fontos c\u00e9lpontja lehet biol\u00f3giai aktivit\u00e1s\u00e1nak.<br \/>\nA b\u00e9l-m\u00e1j ciklus l\u00e9tez\u00e9se \u00f6sszek\u00f6ti a b\u00e9lrendszert a m\u00e1jjal, \u00e9s a b\u00e9l \u00e9s a m\u00e1j nemcsak \u00e9lettani szempontb\u00f3l kapcsol\u00f3dik egym\u00e1shoz, hanem \u00e9lettani m\u0171k\u00f6d\u00e9s szempontj\u00e1b\u00f3l is szoros kapcsolatban \u00e1ll egym\u00e1ssal. A b\u00e9l-m\u00e1j tengely rendelleness\u00e9ge, bele\u00e9rtve a b\u00e9lmikrobi\u00f3ta \u00f6sszet\u00e9tel\u00e9nek \u00e9s ar\u00e1ny\u00e1nak egyens\u00falyhi\u00e1ny\u00e1t, valamint a mikrobi\u00e1lis metabolitok, p\u00e9ld\u00e1ul a r\u00f6vidl\u00e1nc\u00fa zs\u00edrsavak (SCFA-k) \u00e9s az epesavak v\u00e1ltoz\u00e1s\u00e1t, szorosan \u00f6sszef\u00fcgg a k\u00fcl\u00f6nb\u00f6z\u0151 okokb\u00f3l bek\u00f6vetkez\u0151 m\u00e1jk\u00e1rosod\u00e1ssal. Az ut\u00f3bbi \u00e9vekben az irodalom sz\u00e1mos olyan term\u00e9szetes term\u00e9kr\u0151l sz\u00e1molt be, amelyek a b\u00e9lmikrobi\u00f3t\u00e1t c\u00e9lozz\u00e1k \u00e9s az SCFA-k szintj\u00e9t szab\u00e1lyozz\u00e1k a m\u00e1jk\u00e1rosod\u00e1s enyh\u00edt\u00e9se \u00e9rdek\u00e9ben. Ez a tanulm\u00e1ny felt\u00e1rja, hogy a SalB a b\u00e9l mikrobi\u00f3ta \u00e9s az SCFA-k rendelleness\u00e9geinek szab\u00e1lyoz\u00e1s\u00e1val m\u00e1jk\u00e1rosod\u00e1s elleni hat\u00e1st fejt ki, \u00faj tudom\u00e1nyos bizony\u00edt\u00e9kot szolg\u00e1ltatva a SalB m\u00e1jk\u00e1rosod\u00e1s elleni kutat\u00e1s mechanizmus\u00e1ra.<\/p>\n<p>A m\u00e1jk\u00e1rosod\u00e1s a k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e1jbetegs\u00e9gek gyakori patol\u00f3giai alapja, \u00e9s az akut \u00e9s kr\u00f3nikus m\u00e1jk\u00e1rosod\u00e1s elleni gy\u00f3gyszerek lehets\u00e9ges mechanizmusainak meg\u00e9rt\u00e9se hozz\u00e1j\u00e1rulhat a m\u00e1jk\u00e1rosod\u00e1s klinikai kezel\u00e9s\u00e9hez. Az elm\u00falt \u00e9vekben \u00fagy v\u00e9lt\u00e9k, hogy a b\u00e9lmikrobi\u00f3ta v\u00e1ltoz\u00e1sai fontos szerepet j\u00e1tszanak a m\u00e1jfunkci\u00f3k k\u00e1rosod\u00e1s\u00e1nak kiv\u00e1lt\u00e1s\u00e1ban \u00e9s el\u0151seg\u00edt\u00e9s\u00e9ben. A b\u00e9lmikrobi\u00f3ta egyens\u00falyhi\u00e1nya, a b\u00e9lfal g\u00e1tj\u00e1nak k\u00e1rosod\u00e1sa \u00e9s a fokozott b\u00e9lpermeabilit\u00e1s okozta b\u00e9l endotox\u00e9mia felbor\u00edthatja a b\u00e9l \u00e9s a m\u00e1j k\u00f6z\u00f6tti egyens\u00falyt, ez\u00e1ltal a b\u00e9l-m\u00e1j tengelyen kereszt\u00fcl k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e1jbetegs\u00e9gekre hat.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3823\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-12.png\" alt=\"\" width=\"578\" height=\"448\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3824\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-11.png\" alt=\"\" width=\"1084\" height=\"462\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-11.png 1084w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-11-768x327.png 768w\" sizes=\"(max-width: 1084px) 100vw, 1084px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3825\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-10.png\" alt=\"\" width=\"1102\" height=\"844\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-10.png 1102w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-10-768x588.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-10-940x720.png 940w\" sizes=\"(max-width: 1102px) 100vw, 1102px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3826\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-11.png\" alt=\"\" width=\"1074\" height=\"792\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-11.png 1074w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-11-768x566.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-11-976x720.png 976w\" sizes=\"(max-width: 1074px) 100vw, 1074px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3827\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-9.png\" alt=\"\" width=\"1092\" height=\"770\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-9.png 1092w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-9-768x542.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-9-1021x720.png 1021w\" sizes=\"(max-width: 1092px) 100vw, 1092px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3828\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-8.png\" alt=\"\" width=\"1070\" height=\"512\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-8.png 1070w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-8-768x367.png 768w\" sizes=\"(max-width: 1070px) 100vw, 1070px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3829\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-7.png\" alt=\"\" width=\"1138\" height=\"452\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-7.png 1138w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-7-768x305.png 768w\" sizes=\"(max-width: 1138px) 100vw, 1138px\" \/>A Sal B a Danshen egyik f\u0151 hat\u00f3anyaga, egy hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer, amelyet a klinikai gyakorlatban gyakran alkalmaznak m\u00e1jk\u00e1rosod\u00e1s kezel\u00e9s\u00e9re. Jelenleg a kutat\u00e1sok arr\u00f3l sz\u00e1moltak be, hogy a Sal B jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal van a CCl4, a magas zs\u00edrtartalm\u00fa \u00e9trend, a tioacetamid stb. \u00e1ltal kiv\u00e1ltott m\u00e1jk\u00e1rosod\u00e1sra. A kapcsol\u00f3d\u00f3 mechanizmuskutat\u00e1s t\u00f6bbnyire a m\u00e1j csillagsejtek aktiv\u00e1l\u00f3d\u00e1s\u00e1nak \u00e9s prolifer\u00e1ci\u00f3j\u00e1nak, a m\u00e1jgyullad\u00e1snak, az oxidat\u00edv stressznek stb. a g\u00e1tl\u00e1s\u00e1ra \u00f6sszpontos\u00edt. Ez a tanulm\u00e1ny in vivo k\u00eds\u00e9rleteken kereszt\u00fcl tov\u00e1bb tiszt\u00e1zta a Sal B beavatkoz\u00f3 hat\u00e1s\u00e1t a sz\u00e9n-tetraklorid \u00e1ltal kiv\u00e1ltott m\u00e1jk\u00e1rosod\u00e1sra, \u00e9s meg\u00e1llap\u00edtotta, hogy a Sal B aktivit\u00e1sa a b\u00e9l mikrobi\u00f3ta \u00e9s az SCFA-k Sal B \u00e1ltali szab\u00e1lyoz\u00e1s\u00e1hoz kapcsol\u00f3dik. A 16S rRNS szekven\u00e1l\u00e1si eredm\u00e9nyek e tanulm\u00e1nyban azt mutatt\u00e1k, hogy a Sal B b\u00e9l mikrobi\u00f3ta eloszl\u00e1sa a Con csoport \u00e9s a Mod csoport k\u00f6z\u00f6tt volt. A m\u00e1jk\u00e1rosod\u00e1s sor\u00e1n a Firmicutes \u00e9s a Bacteroidetes ar\u00e1nya \u00e1ltal\u00e1ban megv\u00e1ltozik, az el\u0151bbi cs\u00f6kken, az ut\u00f3bbi pedig n\u0151. Ebben a vizsg\u00e1latban a Mod csoportban ez a diszbi\u00f3zis jelentkezett, \u00e9s a Sal B beavatkoz\u00e1s ut\u00e1n ez a diszbi\u00f3zis jelent\u0151sen helyre\u00e1llt. A nemzets\u00e9gek szintj\u00e9n a Sal B beavatkoz\u00e1s szignifik\u00e1nsan n\u00f6velte a Lactobacillus relat\u00edv abundanci\u00e1j\u00e1t, \u00e9s cs\u00f6kkentette a Fecal \u00e9s a Bifidobacterium relat\u00edv abundanci\u00e1j\u00e1t. K\u00f6z\u00fcl\u00fck a Lactobacillus nemzets\u00e9gnek a jelent\u00e9sek szerint m\u00e1jv\u00e9d\u0151 k\u00e9pess\u00e9ge van, ami enyh\u00edtheti a k\u00e1rosodott m\u00e1j gyullad\u00e1s\u00e1t \u00e9s fibr\u00f3zis\u00e1t. Ezek az eredm\u00e9nyek mind azt bizony\u00edtj\u00e1k, hogy a SalB a b\u00e9l mikrobi\u00f3ta szab\u00e1lyoz\u00e1s\u00e1val enyh\u00edtheti a m\u00e1jk\u00e1rosod\u00e1st.<br \/>\nAz SCFA-k a vastagb\u00e9lsejtek f\u0151 energiaforr\u00e1sa, cs\u00f6kkentik a helyi gyullad\u00e1st \u00e9s el\u0151seg\u00edtik az antimikrobi\u00e1lis peptidek termel\u00e9s\u00e9t, ami seg\u00edt fenntartani a b\u00e9lg\u00e1tat \u00e9s cs\u00f6kkenti a b\u00e9l \u00e1tereszt\u0151k\u00e9pess\u00e9g\u00e9t. Az SCFA-kkal val\u00f3 kieg\u00e9sz\u00edt\u00e9s k\u00e9sleltetheti a m\u00e1jk\u00e1rosod\u00e1s progresszi\u00f3j\u00e1t az\u00e1ltal, hogy cs\u00f6kkenti a patog\u00e9n molekul\u00e1ris mint\u00e1k, k\u00f6zt\u00fck a bakteri\u00e1lis endotoxinok port\u00e1lis v\u00e9n\u00e1s tov\u00e1bb\u00edt\u00e1s\u00e1t. Az egerek b\u00e9lrendszer\u00e9ben l\u00e9v\u0151 SCFA-k mennyis\u00e9gi elemz\u00e9se ut\u00e1n ez a vizsg\u00e1lat meg\u00e1llap\u00edtotta, hogy az ecetsav, hex\u00e1nsav, izobajonsav, izovaleri\u00e1nsav, propionsav \u00e9s valeri\u00e1nsav szintje jelent\u0151sen cs\u00f6kkent a Mod csoportban, m\u00edg a Sal B beavatkoz\u00e1s helyre\u00e1ll\u00edtotta az izobajonsav, izovaleri\u00e1nsav, propionsav \u00e9s valeri\u00e1nsav szintj\u00e9t. Ez \u00f6sszef\u00fcgghet a Firmicutes megn\u00f6vekedett abundanci\u00e1j\u00e1val a Sal B csoport b\u00e9lmikrobi\u00f3t\u00e1j\u00e1ban, amelyet kor\u00e1bban azonos\u00edtottunk. Kutat\u00e1si jelent\u00e9sek szerint a Firmicutes a b\u00e9lbakt\u00e9riumok mintegy 60%-j\u00e9t teszik ki, \u00e9s szorosan kapcsol\u00f3dnak az SCFA-k termel\u00e9s\u00e9hez. Az ecetsavszint cs\u00f6kken\u00e9se mind a Mod csoportban, mind a Sal B csoportban felt\u00e9telezhet\u0151en az ecetsavat kiv\u00e1laszt\u00f3 bakt\u00e9riumk\u00f6z\u00f6ss\u00e9gek, p\u00e9ld\u00e1ul a Parabacterioides nemzets\u00e9g relat\u00edv abundanci\u00e1j\u00e1nak cs\u00f6kken\u00e9s\u00e9vel f\u00fcgg \u00f6ssze. Amellett, hogy a b\u00e9lg\u00e1t jav\u00edt\u00e1s\u00e1val enyh\u00edtik a m\u00e1jk\u00e1rosod\u00e1st, a leg\u00fajabb szakirodalom azt is kimutatta, hogy az SCFA-k jav\u00edthatj\u00e1k a m\u00e1jbetegs\u00e9geket, p\u00e9ld\u00e1ul a NASH-t az\u00e1ltal, hogy g\u00e1tolj\u00e1k a makrof\u00e1gok pro-inflammatorikus aktiv\u00e1ci\u00f3j\u00e1t a m\u00e1jsz\u00f6vetben, cs\u00f6kkentve a gyullad\u00e1sos v\u00e1laszokat. Kor\u00e1bbi kutat\u00e1sainkban nem figyelt\u00fck meg a Sal B hat\u00e1s\u00e1t a m\u00e1jk\u00e1rosodott egerek b\u00e9lbarrierj\u00e9re. Ez\u00e9rt felt\u00e9telezz\u00fck, hogy a m\u00e1jk\u00e1rosod\u00e1s SCFA-k \u00e1ltali javul\u00e1sa a m\u00e1jsz\u00f6vetben l\u00e9v\u0151 sejtekre gyakorolt k\u00f6zvetlen hat\u00e1sukkal f\u00fcgghet \u00f6ssze, miut\u00e1n a port\u00e1lis v\u00e9n\u00e1n kereszt\u00fcl bejutottak a m\u00e1jba.<br \/>\n\u00d6sszefoglalva, a Sal B k\u00e9pes g\u00e1tolni a CCl4 \u00e1ltal kiv\u00e1ltott m\u00e1jk\u00e1rosod\u00e1st egerekben a b\u00e9l mikrobi\u00f3ta egyens\u00faly\u00e1nak helyre\u00e1ll\u00edt\u00e1s\u00e1val. Ek\u00f6zben a Sal B r\u00e9szben helyre tudja \u00e1ll\u00edtani a b\u00e9lrendszeri SCFA-k tartalm\u00e1t a m\u00e1jk\u00e1rosod\u00e1sban szenved\u0151 egerekben, de tov\u00e1bbi kutat\u00e1sokra van sz\u00fcks\u00e9g azzal kapcsolatban, hogy ezek a helyre\u00e1ll\u00edtott SCFA-k hogyan vesznek r\u00e9szt a Sal B m\u00e1jk\u00e1rosod\u00e1s elleni folyamat\u00e1ban.<\/p>","protected":false},"excerpt":{"rendered":"<p>The effect of salvianolic acid B on gut microbiota and short chain fatty acid metabolism in mice with liver injury Liver injury refers to liver cell damage and abnormal liver function caused by various factors. Common pathogenic factors in clinical practice include drug stimulation, viral infection, alcohol or chemical toxins. Research has shown that severe [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The effect of salvianolic acid B on gut microbiota and short chain fatty acid metabolism in mice with liver injury - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/salvianolic-acid-b-liver-injury\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effect of salvianolic acid B on gut microbiota and short chain fatty acid metabolism in mice with liver injury - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The effect of salvianolic acid B on gut microbiota and short chain fatty acid metabolism in mice with liver injury Liver injury refers to liver cell damage and abnormal liver function caused by various factors. Common pathogenic factors in clinical practice include drug stimulation, viral infection, alcohol or chemical toxins. 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