{"id":3806,"date":"2024-08-03T08:05:12","date_gmt":"2024-08-03T08:05:12","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3806"},"modified":"2024-08-03T08:05:12","modified_gmt":"2024-08-03T08:05:12","slug":"danpi-ethanol-extract-antioxidant-and-anti-diabetes","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/danpi-etanolos-kivonat-antioxidans-es-cukorbetegseg-elleni-antioxidans\/","title":{"rendered":"A Cortex Moutanb\u00f3l sz\u00e1rmaz\u00f3 etanolos kivonatok antioxid\u00e1ns \u00e9s diab\u00e9teszellenes aktivit\u00e1s\u00e1nak vizsg\u00e1lata"},"content":{"rendered":"

A Cortex Moutanb\u00f3l sz\u00e1rmaz\u00f3 etanolos kivonatok antioxid\u00e1ns \u00e9s diab\u00e9teszellenes aktivit\u00e1s\u00e1nak vizsg\u00e1lata
\nA cukorbetegs\u00e9g kr\u00f3nikus anyagcsere-betegs\u00e9g, amelyet magas v\u00e9rcukorszint jellemez. A modern \u00e9letsz\u00ednvonal javul\u00e1s\u00e1val \u00e9s az \u00e9letm\u00f3dv\u00e1lt\u00e1ssal a cukorbetegs\u00e9g az emberi eg\u00e9szs\u00e9get befoly\u00e1sol\u00f3 harmadik legfontosabb t\u00e9nyez\u0151v\u00e9 v\u00e1lt, a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek \u00e9s a daganatok ut\u00e1n a m\u00e1sodik helyen \u00e1ll. 2021-re K\u00edn\u00e1ban 140 milli\u00f3 cukorbeteg lesz, \u00e9s a vil\u00e1gon a cukorbetegek sz\u00e1ma el\u00e9ri az 537 milli\u00f3t, ami a vil\u00e1g n\u00e9pess\u00e9g\u00e9nek 10,5%-\u00e9t teszi ki. A cukorbetegs\u00e9g k\u00e1ros hat\u00e1sa az emberi eg\u00e9szs\u00e9gre nemcsak \u00f6nmag\u00e1ban, hanem sz\u00e1mos sz\u00f6v\u0151dm\u00e9nyt is okoz, mint p\u00e9ld\u00e1ul art\u00e9ri\u00e1s \u00e9relmeszesed\u00e9s, cukorbeteg l\u00e1bbetegs\u00e9g, l\u00e1t\u00e1sveszt\u00e9s, s\u0151t a l\u00e1t\u00f3ideg s\u00e9r\u00fcl\u00e9se okozta vaks\u00e1g. Tanulm\u00e1nyok kimutatt\u00e1k, hogy az oxidat\u00edv stressz abnorm\u00e1lis n\u00f6veked\u00e9se el\u0151seg\u00edti a cukorbetegs\u00e9g \u00e9s sz\u00f6v\u0151dm\u00e9nyeinek kialakul\u00e1s\u00e1t. Ugyanakkor a cukorbetegek magas v\u00e9rcukor-koncentr\u00e1ci\u00f3ja miatt a sejtek \u00e1ltal felsz\u00edvott gl\u00fck\u00f3z messze meghaladja a norm\u00e1lis sz\u00fcks\u00e9gleteiket, ami a gl\u00fck\u00f3z t\u00falzott felhalmoz\u00f3d\u00e1s\u00e1hoz vezet a sejtekben, jelent\u0151sen n\u00f6veli a sejtek mitokondri\u00e1lis membr\u00e1npotenci\u00e1l-k\u00fcl\u00f6nbs\u00e9g\u00e9t, ami a koenzim Q-t az oxig\u00e9nmolekul\u00e1k redukci\u00f3j\u00e1nak felgyors\u00edt\u00e1s\u00e1ra k\u00e9szteti, ez\u00e1ltal nagysz\u00e1m\u00fa reakt\u00edv oxig\u00e9n species keletkezik a sejtekben, ami t\u00f6nkreteszi a B-szigetsejtek \u00e9s a mitokondriumok norm\u00e1lis m\u0171k\u00f6d\u00e9s\u00e9t, el\u0151seg\u00edti a fejlett glik\u00e1ci\u00f3s v\u00e9gterm\u00e9kek (AGE-k) kialakul\u00e1s\u00e1t, n\u00f6veli az oxidat\u00edv stressz \u00e1llapot\u00e1t, felgyors\u00edtja a cukorbetegs\u00e9g folyamat\u00e1t \u00e9s a sz\u00f6v\u0151dm\u00e9nyek kialakul\u00e1s\u00e1t. Az antioxid\u00e1nsok enyh\u00edthetik az oxidat\u00edv stresszt a t\u00falzott szabadgy\u00f6k\u00f6k elt\u00e1vol\u00edt\u00e1s\u00e1val vagy az endog\u00e9n antioxid\u00e1ns v\u00e9delmi rendszer aktiv\u00e1l\u00e1s\u00e1val, \u00edgy enyh\u00edtve a cukorbetegs\u00e9g \u00e9s a vele j\u00e1r\u00f3 sz\u00f6v\u0151dm\u00e9nyek el\u0151rehalad\u00e1s\u00e1t. Ez\u00e9rt az oxidat\u00edv stressz enyh\u00edt\u00e9se nagy jelent\u0151s\u00e9ggel b\u00edr a cukorbetegs\u00e9g \u00e9s sz\u00f6v\u0151dm\u00e9nyei megel\u0151z\u00e9se \u00e9s ellen\u0151rz\u00e9se szempontj\u00e1b\u00f3l.
\nA Moutan Cortex (MC), a Ranunculaceae csal\u00e1dba tartoz\u00f3 bazsar\u00f3zsaf\u00e9l\u00e9k sz\u00e1r\u00edtott gy\u00f6k\u00e9rk\u00e9rge keser\u0171 \u00e9s enyh\u00e9n cs\u00edp\u0151s \u00edz\u0171. Ez egy hagyom\u00e1nyos k\u00ednai gy\u00f3gyn\u00f6v\u00e9ny, amelynek h\u0151elvezet\u0151 \u00e9s v\u00e9rkering\u00e9st el\u0151seg\u00edt\u0151 hat\u00e1sa van, \u00e9s \u00e9vezredek \u00f3ta haszn\u00e1lj\u00e1k. A tanulm\u00e1ny meg\u00e1llap\u00edtotta, hogy a paeonia kivonata sz\u00e1mos farmakol\u00f3giai hat\u00e1ssal rendelkezik, p\u00e9ld\u00e1ul daganatellenes, antibakteri\u00e1lis, antioxid\u00e1ns, cukorbetegs\u00e9g elleni \u00e9s egy\u00e9b tulajdons\u00e1gokkal, amelyek k\u00f6z\u00fcl a paeonol, a fitoszterolok, a cukrok \u00e9s a flavonoidok a f\u0151 hat\u00f3anyagok. Zhang \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a paeonol jelent\u0151s in vitro antioxid\u00e1ns kapacit\u00e1ssal rendelkezik, \u00e9s k\u00e9pes oxidat\u00edv stresszt kiv\u00e1ltani a nukle\u00e1ris faktor E2-hez kapcsol\u00f3d\u00f3 2-es faktor (Nrf2)\/Kelch like ECH associated protein 1 (Keap1) - antioxid\u00e1ns v\u00e1laszelem (ARE) jel\u00e1tviteli \u00fatvonal (Nrf2\/Keap1-ARE) aktiv\u00e1l\u00e1s\u00e1val. Lian \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a cortex moutanban l\u00e9v\u0151 akt\u00edv poliszacharid komponens jav\u00edthatja a cukorbetegs\u00e9g sz\u00f6v\u0151dm\u00e9nyeinek nefrop\u00e1ti\u00e1j\u00e1t. Wu et al. r\u00e1mutatott, hogy a Danpi hat\u00f3anyagai jelent\u0151s hipoglik\u00e9mi\u00e1s hat\u00e1ssal rendelkeznek, \u00e9s mechanizmusa a gl\u00fckoneogenezis g\u00e1tl\u00e1s\u00e1val, a glikog\u00e9nszint\u00e9zis el\u0151seg\u00edt\u00e9s\u00e9vel \u00e9s antioxid\u00e1ns aktivit\u00e1s\u00e1val f\u00fcgg \u00f6ssze. Azonban nincs jelent\u00e9s a cortex moutan k\u00fcl\u00f6nb\u00f6z\u0151 pol\u00e1ris old\u00f3szeres kivonatainak in vitro \u00e9s in vivo antioxid\u00e1ns \u00e9s hipoglik\u00e9mi\u00e1s hat\u00e1s\u00e1r\u00f3l, valamint az idegekre gyakorolt v\u00e9d\u0151 hat\u00e1s\u00e1r\u00f3l a cukorbetegs\u00e9g sz\u00f6v\u0151dm\u00e9nyeiben.
\nEz a cikk 40%, 70% \u00e9s 95% etanolt haszn\u00e1l a Danpi ultrahangos extrakci\u00f3j\u00e1hoz, \u00f6sszehasonl\u00edtja a Danpi k\u00fcl\u00f6nb\u00f6z\u0151 koncentr\u00e1ci\u00f3j\u00fa etanol-kivonatainak teljes fenol- \u00e9s teljes flavonoidtartalm\u00e1t, meghat\u00e1rozza a mint\u00e1k antioxid\u00e1ns kapacit\u00e1s\u00e1t DPPH szabadgy\u00f6k- \u00e9s ABTS szabadgy\u00f6k-felsz\u00edv\u00f3 k\u00e9pess\u00e9ggel v\u00e9gzett k\u00eds\u00e9rletek seg\u00edts\u00e9g\u00e9vel, fluoreszcens spektroszk\u00f3pia seg\u00edts\u00e9g\u00e9vel vizsg\u00e1lja a kivonatok glikozil\u00e1ci\u00f3ellenes k\u00e9pess\u00e9g\u00e9t, acarb\u00f3zzal \u00f6sszehasonl\u00edtva \u00e9rt\u00e9keli a mint\u00e1k \u03b1 - gl\u00fckozid\u00e1z termel\u0151 k\u00e9pess\u00e9g\u00e9t, v\u00e9g\u00fcl pedig egy hiperglik\u00e9mi\u00e1s \u00e1llatmodell seg\u00edts\u00e9g\u00e9vel \u00e9rt\u00e9keli a mint\u00e1k hipoglik\u00e9mi\u00e1s k\u00e9pess\u00e9g\u00e9t \u00e1llatokban \u00e9s a perif\u00e9ri\u00e1s motoros idegekre gyakorolt v\u00e9d\u0151hat\u00e1s\u00e1t. V\u00e1rhat\u00f3an elm\u00e9leti alapot ny\u00fajt a paeonia-kivonat \u00e1tfog\u00f3 alkalmaz\u00e1s\u00e1hoz a cukorbetegs\u00e9g \u00e9s az oxid\u00e1ci\u00f3 elleni k\u00fczdelemben.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"A vonatkoz\u00f3 jelent\u00e9sek szerint a cukorbetegek sz\u00e1ma K\u00edn\u00e1ban nagy \u00e9s fiatal, ami s\u00falyosan vesz\u00e9lyezteti polg\u00e1raink \u00e9let\u00e9t \u00e9s eg\u00e9szs\u00e9g\u00e9t. Napjainkban a piacon l\u00e9v\u0151 cukorbetegs\u00e9g elleni gy\u00f3gyszerek t\u00f6bbs\u00e9ge k\u00e9miai szint\u00e9zis, amely bizonyos mell\u00e9khat\u00e1sokkal j\u00e1r, m\u00edg a n\u00f6v\u00e9nyi kivonatok term\u00e9szetes, hat\u00e9kony \u00e9s alacsony mell\u00e9khat\u00e1sokkal rendelkez\u0151 tulajdons\u00e1gokkal rendelkeznek. Ebben a tanulm\u00e1nyban a Cortex Moutan k\u00fcl\u00f6nb\u00f6z\u0151 koncentr\u00e1ci\u00f3j\u00fa etanolos oldat\u00e1b\u00f3l k\u00e9sz\u00fclt ultrahangos kivonatok cukorbetegs\u00e9g elleni \u00e9s antioxid\u00e1ns aktivit\u00e1s\u00e1t hasonl\u00edtott\u00e1k \u00f6ssze, \u00e9s elemezt\u00e9k a Cortex Moutan cukorbetegs\u00e9g elleni alkalmaz\u00e1si lehet\u0151s\u00e9geit. A kutat\u00e1s kimutatta, hogy amikor 70% etanolt haszn\u00e1lnak old\u00f3szerk\u00e9nt, a hozam 4,98%. A Danpi kivonatnak van a legmagasabb \u00f6sszes fenol- \u00e9s flavonoidtartalma, 59,17mg GAE\/g, illetve 82,59mg QUE\/g \u00e9rt\u00e9kkel. J\u00f3 in vitro antioxid\u00e1ns \u00e9s hipoglik\u00e9mi\u00e1s aktivit\u00e1ssal rendelkezik. A DPPH szabad gy\u00f6k, az ABTS szabad gy\u00f6kfog\u00f3 k\u00e9pess\u00e9g \u00e9s az \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 k\u00e9pess\u00e9g IC50 \u00e9rt\u00e9kei 16,30, 34,20, illetve 2,10 \u03bc g\/ml, a glikozil\u00e1ci\u00f3s g\u00e1tl\u00e1si ar\u00e1ny pedig 81,44%. A hiperglik\u00e9mi\u00e1s \u00e1llatmodellen v\u00e9gzett k\u00eds\u00e9rletek r\u00e9v\u00e9n tov\u00e1bb bizony\u00edtott\u00e1k, hogy az MC70-nek v\u00e9rcukorszint-cs\u00f6kkent\u0151 hat\u00e1sa van; Amikor a Danpi kivonat koncentr\u00e1ci\u00f3ja 2 mg \/ ml, a kieg\u00e9sz\u00edt\u0151 hipoglik\u00e9mi\u00e1s hat\u00e1s 52%, \u00e9s az MC70 perif\u00e9ri\u00e1s motoros neuroprotekt\u00edv hat\u00e1sa 56% ebben a koncentr\u00e1ci\u00f3ban. Az ultrahanggal extrah\u00e1lt k\u00e9reg moutan kivonat\u00e1nak 70% etanolos oldattal j\u00f3 antioxid\u00e1ns, cukorbetegs\u00e9g-ellenes k\u00e9pess\u00e9ggel \u00e9s seg\u00e9dhipoglik\u00e9mi\u00e1s hat\u00e1ssal rendelkezik. Kutat\u00e1si potenci\u00e1llal \u00e9s alkalmaz\u00e1si \u00e9rt\u00e9kkel rendelkezik a cukorbetegs\u00e9g elleni k\u00fczdelemben.<\/p>","protected":false},"excerpt":{"rendered":"

A Cortex Moutanb\u00f3l sz\u00e1rmaz\u00f3 etanolos kivonatok antioxid\u00e1ns \u00e9s cukorbetegs\u00e9g-ellenes hat\u00e1sainak vizsg\u00e1lata A cukorbetegs\u00e9g egy kr\u00f3nikus anyagcsere-betegs\u00e9g, amelyet magas v\u00e9rcukorszint jellemez. A modern \u00e9letsz\u00ednvonal javul\u00e1s\u00e1val \u00e9s az \u00e9letm\u00f3dv\u00e1lt\u00e1ssal a cukorbetegs\u00e9g az emberi eg\u00e9szs\u00e9get befoly\u00e1sol\u00f3 harmadik legfontosabb t\u00e9nyez\u0151v\u00e9 v\u00e1lt, a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek \u00e9s a daganatok ut\u00e1n a m\u00e1sodik helyen \u00e1ll. 2021-re [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on Antioxidant and Anti diabetes Activities of Ethanol Extracts from Cortex Moutan - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/danpi-etanolos-kivonat-antioxidans-es-cukorbetegseg-elleni-antioxidans\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on Antioxidant and Anti diabetes Activities of Ethanol Extracts from Cortex Moutan - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on Antioxidant and Anti diabetes Activities of Ethanol Extracts from Cortex Moutan Diabetes is a chronic metabolic disease characterized by high blood sugar. 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With the improvement of modern living standards and the change of lifestyle, diabetes has become the third major factor affecting human health, second only to cardiovascular diseases and tumors. 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