{"id":3768,"date":"2024-08-03T07:54:10","date_gmt":"2024-08-03T07:54:10","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3768"},"modified":"2024-08-03T07:54:10","modified_gmt":"2024-08-03T07:54:10","slug":"curcuma-zedoaria-and-turtle-shell-medicine","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/curcuma-zedoaria-es-teknospancel-gyogyszer\/","title":{"rendered":"A Curcuma zedoaria \u00e9s a Biejia gy\u00f3gyszer hat\u00e1smechanizmus\u00e1nak felt\u00e1r\u00e1sa a m\u00e1jfibr\u00f3zis elleni k\u00fczdelemben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1s \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n"},"content":{"rendered":"

A Curcuma zedoaria \u00e9s a Biejia gy\u00f3gyszer hat\u00e1smechanizmus\u00e1nak felt\u00e1r\u00e1sa a m\u00e1jfibr\u00f3zis elleni k\u00fczdelemben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1s \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n
\nA m\u00e1jfibr\u00f3zis a m\u00e1jsejtek kr\u00f3nikus gyullad\u00e1s\u00e1t \u00e9s elhal\u00e1s\u00e1t jelenti, amelyet k\u00fcl\u00f6nb\u00f6z\u0151 patog\u00e9n t\u00e9nyez\u0151k folyamatos hat\u00e1sa okoz. A m\u00e1jban egyes nem parenchim\u00e1lis sejtek aktiv\u00e1l\u00f3dnak, ami diff\u00faz extracellul\u00e1ris m\u00e1trix prolifer\u00e1ci\u00f3hoz, rostos prolifer\u00e1ci\u00f3hoz \u00e9s kiegyens\u00falyozatlan rostleboml\u00e1shoz vezet a m\u00e1jban, ami a m\u00e1jban rostos k\u00f6t\u0151sz\u00f6veti prolifer\u00e1ci\u00f3hoz vezet, \u00e9s elind\u00edtja a m\u00e1jfibr\u00f3zis folyamat\u00e1t. A k\u00e9s\u0151bbi szakaszban a m\u00e1j lebeny\u00e9nek \u00e1talakul\u00e1sa \u00e9s pszeudolobul\u00e1k k\u00e9pz\u0151d\u00e9se k\u00f6vetkezik be, \u00e9s a m\u00e1j text\u00far\u00e1ja megkem\u00e9nyedik, ami a m\u00e1j m\u0171k\u00f6d\u00e9si zavar\u00e1hoz vezet, amelyet cirr\u00f3zisnak nevez\u00fcnk; A m\u00e1jfibr\u00f3zis nem \u00f6n\u00e1ll\u00f3 betegs\u00e9g, hanem sz\u00e1mos kr\u00f3nikus m\u00e1jbetegs\u00e9g k\u00f6z\u00f6s patol\u00f3giai folyamata. Egy felm\u00e9r\u00e9s szerint vil\u00e1gszerte t\u00f6bb mint 50 milli\u00f3 feln\u0151tt szenved kr\u00f3nikus m\u00e1jbetegs\u00e9gben; K\u00edn\u00e1ban mintegy 300 milli\u00f3 embert \u00e9rint a m\u00e1jbetegs\u00e9g, ami a cirr\u00f3zis okozta glob\u00e1lis hal\u00e1loz\u00e1sok 11%-j\u00e9t teszi ki. Ez\u00e9rt a m\u00e1jfibr\u00f3zis megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re szolg\u00e1l\u00f3 gy\u00f3gyszerek megtal\u00e1l\u00e1sa nagy jelent\u0151s\u00e9ggel b\u00edr a m\u00e1jbetegs\u00e9gekben, p\u00e9ld\u00e1ul a m\u00e1jfibr\u00f3zisban szenved\u0151 betegek sz\u00e1m\u00e1ra. A kutat\u00e1sok szerint a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u00e9s a vegy\u00fcletk\u00e9sz\u00edtm\u00e9nyek (mint p\u00e9ld\u00e1ul a Compound Biejia Ruangan tabletta\/kapszula, Fuzheng Huayu tabletta\/kapszula, Dahuang Zhechong tabletta stb.) j\u00f3 ter\u00e1pi\u00e1s hat\u00e1ssal rendelkeznek a m\u00e1jfibr\u00f3zis megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben, \u00e9s el\u0151ny\u00fck a t\u00f6bb \u00f6sszetev\u0151 \u00e9s c\u00e9lpont.
\nA m\u00e1jfibr\u00f3zis a hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban a \"f\u00e1jdalomcsillap\u00edt\u00e1s\", a \"m\u00e1j elz\u00e1r\u00f3d\u00e1sa\", a \"m\u00e1j felhalmoz\u00f3d\u00e1sa\" \u00e9s a \"felhalmoz\u00f3d\u00e1s\" kateg\u00f3ri\u00e1j\u00e1ba tartozik. A Curcumae Rhizoma (CR) \u00e9s a Trionycis Carapax (TC) gyakran haszn\u00e1lt gy\u00f3gyszerek a m\u00e1jfibr\u00f3zis klinikai kezel\u00e9s\u00e9ben a hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban. A TC bejut a m\u00e1jba, felpuh\u00edtja a kem\u00e9ny \u00e9s sz\u00e9toszlatja a csom\u00f3kat, elt\u00e1vol\u00edtja a v\u00e9r pang\u00e1s\u00e1t \u00e9s megsz\u00fcnteti a t\u00fcneteket. A CR el\u0151seg\u00edti a v\u00e9rkering\u00e9st \u00e9s elt\u00e1vol\u00edtja a v\u00e9r pang\u00e1s\u00e1t, felpuh\u00edtja a kem\u00e9nyet \u00e9s el\u0151seg\u00edti a pang\u00e1st, valamint megsz\u00fcnteti a t\u00fcneteket \u00e9s a csom\u00f3kat. A kett\u0151t kombin\u00e1ci\u00f3ban haszn\u00e1ljuk, hogy fokozzuk a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9nek, a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9nek, valamint a kem\u00e9ny felpuh\u00edt\u00e1s\u00e1nak \u00e9s a csom\u00f3k eloszlat\u00e1s\u00e1nak hat\u00e1s\u00e1t. A modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy a CR t\u00f6bbf\u00e9le hat\u00e1smechanizmuson kereszt\u00fcl k\u00e9pes kifejteni m\u00e1jfibr\u00f3zis elleni hat\u00e1s\u00e1t. Ezen t\u00falmen\u0151en a TC-t tartalmaz\u00f3 k\u00fcl\u00f6nb\u00f6z\u0151 hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9nyek jav\u00edthatj\u00e1k a betegek m\u00e1jfunkci\u00f3j\u00e1t \u00e9s enyh\u00edthetik a fibr\u00f3zisfolyamatot. Klinikai \u00e9s k\u00eds\u00e9rletes vizsg\u00e1latok arra utalnak, hogy mind a CR, mind a TC egy\u00e9rtelm\u0171 m\u00e1jfibr\u00f3zis-ellenes hat\u00e1ssal rendelkezik, de a szinergista m\u00e1jfibr\u00f3zis-ellenes hat\u00e1suk szinergikus mechanizmus\u00e1t, amikor egy hat\u00f3anyagk\u00e9nt kombin\u00e1lj\u00e1k \u0151ket, m\u00e9g nem tiszt\u00e1zt\u00e1k. Ez a tanulm\u00e1ny k\u00fcl\u00f6nb\u00f6z\u0151 kutat\u00e1si m\u00f3dszereket alkalmaz, mint p\u00e9ld\u00e1ul a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1si technol\u00f3gia \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s, hogy felt\u00e1rja a hagyom\u00e1nyos gy\u00f3gyszerek szerep\u00e9t \u00e9s lehets\u00e9ges mechanizmusait a CRTC m\u00e1jfibr\u00f3zis elleni anti-m\u00e1jfibr\u00f3zis\u00e1ban az \u00f6sszetev\u0151k, a c\u00e9lpontok, a biol\u00f3giai funkci\u00f3k, a jel\u00e1tviteli utak stb. szempontj\u00e1b\u00f3l, rem\u00e9lve, hogy bizonyos alapot \u00e9s hivatkoz\u00e1si alapot biztos\u00edt a CRTC m\u00e1jfibr\u00f3zis elleni modern kutat\u00e1s\u00e1hoz.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s modern jellemz\u0151inek \u00e9s mechanizmusainak tanulm\u00e1nyoz\u00e1sa mindig is a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s modern kutat\u00e1s\u00e1nak egyik f\u0151 f\u00f3kusz\u00e1ban \u00e1llt. A Biejia \u00e9s a Curcuma zedoaria a hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban a m\u00e1jfibr\u00f3zis klinikai kezel\u00e9s\u00e9ben gyakran haszn\u00e1lt gy\u00f3gyszerek. A klinikai gyakorlatban a kett\u0151t gyakran felv\u00e1ltva haszn\u00e1lj\u00e1k, a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9se, a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9se, a csom\u00f3k l\u00e1gy\u00edt\u00e1sa \u00e9s sz\u00e9toszlat\u00e1sa, valamint a m\u00e1jfibr\u00f3zis elleni egy\u00e9rtelm\u0171 hat\u00e1suk r\u00e9v\u00e9n. A k\u00e9t gy\u00f3gyszer m\u00e1jfibr\u00f3zis elleni szinergista hat\u00e1s\u00e1nak konkr\u00e9t mechanizmusa azonban sok\u00e1ig nem volt vil\u00e1gos.
\nEz a cikk a modern h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t haszn\u00e1lja el\u0151sz\u00f6r a CRTC \u00e9s a m\u00e1jfibr\u00f3zis metsz\u00e9spontjainak sz\u0171r\u00e9s\u00e9re, majd egy PPI-h\u00e1l\u00f3zatot hoz l\u00e9tre az olyan alapvet\u0151 c\u00e9lpontok sz\u0171r\u00e9s\u00e9re, mint az IL-6, AKT1, STAT3, PPARG stb. K\u00f6z\u00fcl\u00fck az IL-6 a legmagasabb fok\u00fa rangsorol\u00e1ssal rendelkez\u0151 kulcsfontoss\u00e1g\u00fa c\u00e9lpont. Az IL-6 a pro-inflammatorikus citokin csal\u00e1d tagja, \u00e9s hat\u00e1ssal lehet k\u00fcl\u00f6nb\u00f6z\u0151 immunrendszeri \u00e9s fiziol\u00f3giai folyamatokra, p\u00e9ld\u00e1ul az akut f\u00e1zis\u00fa feh\u00e9rje termel\u00e9s\u00e9re (p\u00e9ld\u00e1ul C-reakt\u00edv feh\u00e9rje, ferritin stb.), gyullad\u00e1sra, antig\u00e9n-specifikus immunv\u00e1laszra, hematopo\u00e9zisre, sejt apopt\u00f3zisra, differenci\u00e1l\u00f3d\u00e1sra \u00e9s sejtanyagcser\u00e9re. Ezenk\u00edv\u00fcl a vizsg\u00e1latok azt tal\u00e1lt\u00e1k, hogy a STAT3 jel\u00e1tvitel aktiv\u00e1l\u00e1sa a m\u00e1jsejtekben \u00e1ltal\u00e1ban jav\u00edtja a m\u00e1jgyullad\u00e1st \u00e9s szab\u00e1lyozza a m\u00e1jfibr\u00f3zis folyamat\u00e1t a m\u00e1jsejtek k\u00e1rosod\u00e1s\u00e1nak megel\u0151z\u00e9s\u00e9vel \u00e9s a STAT1 jel\u00e1tvitel g\u00e1tl\u00e1s\u00e1val; a STAT3 szab\u00e1lyozhatja a fibroblasztokb\u00f3l a myofibroblasztokba val\u00f3 \u00e1tmenetet \u00e9s a m\u00e1trix metalloprotein\u00e1zok \u00e9s homol\u00f3g g\u00e1tl\u00f3 feh\u00e9rj\u00e9k \u00e1t\u00edr\u00e1s\u00e1t is, ez\u00e1ltal jav\u00edtja a m\u00e1jfibr\u00f3zist az extracellul\u00e1ris m\u00e1trix degrad\u00e1ci\u00f3j\u00e1nak szintj\u00e9n. Az elemz\u00e9s azt mutatja, hogy az IL-6 \u00e9s a STAT3 nagy jelent\u0151s\u00e9ggel b\u00edr a CRTC sz\u00e1m\u00e1ra a m\u00e1jfibr\u00f3zis elleni k\u00fczdelemben. \u200d
\nA h\u00e1l\u00f3zati modell topol\u00f3giai elemz\u00e9ssel t\u00f6rt\u00e9n\u0151 tov\u00e1bbi elemz\u00e9se felt\u00e1rta, hogy a CRTC t\u00f6bbkomponens\u0171, t\u00f6bbc\u00e9l\u00fa farmakol\u00f3giai hat\u00e1sai \u00f6sszetett h\u00e1l\u00f3zatot alkotnak. \u00d6t kulcsfontoss\u00e1g\u00fa funkcion\u00e1lis komponenst azonos\u00edtottak, nevezetesen a 9,12-oktadekadiensavat, a hederagenint, a 8-oktadekadiensavat, a 9-oktadekadiensavat \u00e9s a 11-oktadekadiensavat. A m\u00e1jfibr\u00f3zis elleni hat\u00e1s\u00e1ban r\u00e9szt vev\u0151 f\u0151 biol\u00f3giai folyamatok k\u00f6z\u00e9 tartozik a hormonv\u00e1lasz, a foszf\u00e1tanyagcsere pozit\u00edv szab\u00e1lyoz\u00e1sa \u00e9s a foszf\u00e1tanyagcsere pozit\u00edv szab\u00e1lyoz\u00e1sa. A sejtkomponensek receptorkomplexeket, membr\u00e1ntraf\u00e1kat, membr\u00e1n mikror\u00e9gi\u00f3kat stb. foglalnak magukban. A molekul\u00e1ris funkci\u00f3k f\u0151k\u00e9nt transzkripci\u00f3s faktor k\u00f6t\u0151d\u00e9st, kin\u00e1z k\u00f6t\u0151d\u00e9st, kin\u00e1z aktivit\u00e1st stb. tartalmaznak; A f\u0151 jel\u00e1tviteli \u00fatvonalak k\u00f6z\u00e9 tartozik az EGFR tirozinkin\u00e1z inhibitor rezisztencia, PI3K Akt jel\u00e1tviteli \u00fatvonal stb. Meg\u00e1llap\u00edtottuk, hogy a KEGG \u00fatvonalak gazdagod\u00e1si elemz\u00e9s\u00e9ben az EGFR tirozinkin\u00e1z inhibitor rezisztencia P-\u00e9rt\u00e9ke viszonylag kicsi volt, \u00e9s t\u00f6bb g\u00e9n volt ebben az \u00fatvonalban gazdagodva. Az alapvet\u0151 c\u00e9lpontok IL-6, AKT1, STAT3 stb. mind feld\u00fasultak az EGFR tirozinkin\u00e1z inhibitor rezisztencia \u00fatvonalban. Az EGFR tirozinkin\u00e1z g\u00e1tl\u00f3 rezisztencia \u00fatvonal nagy jelent\u0151s\u00e9ggel b\u00edr a CRTC m\u00e1jfibr\u00f3zis elleni hat\u00e1sa szempontj\u00e1b\u00f3l, \u00e9s a JAK-STAT, PI3K Akt \u00e9s m\u00e1s \u00fatvonalakkal val\u00f3 k\u00f6lcs\u00f6nhat\u00e1s\u00e1b\u00f3l kialakul\u00f3 jelh\u00e1l\u00f3zat nem hagyhat\u00f3 figyelmen k\u00edv\u00fcl a hat\u00e1smechanizmus\u00e1ban. Sz\u00e1mos tanulm\u00e1ny kimutatta, hogy az IL-6\/EGFR\/STAT jel\u00e1tviteli tengely sz\u00e1mos fontos biol\u00f3giai folyamatban, p\u00e9ld\u00e1ul a sejtn\u00f6veked\u00e9sben, a prolifer\u00e1ci\u00f3ban, a differenci\u00e1l\u00f3d\u00e1sban, az apopt\u00f3zisban \u00e9s az immunszab\u00e1lyoz\u00e1sban vesz r\u00e9szt. Az IL-6, mint a szervezet immunv\u00e1lasz\u00e1ban fontos gyullad\u00e1sos medi\u00e1tor, el\u0151seg\u00edtheti a JAK\/STAT jel\u00e1tvitel aktiv\u00e1l\u00f3d\u00e1s\u00e1t. Amikor receptorokhoz k\u00f6t\u0151dik, el\u0151seg\u00edtheti a JAK1 aktiv\u00e1l\u00f3d\u00e1s\u00e1t \u00e9s a STAT3 foszforil\u00e1ci\u00f3j\u00e1t \u00e9s transzkripci\u00f3j\u00e1t. A legt\u00f6bb vizsg\u00e1lat kimutatta, hogy a STAT3 gyakran aktiv\u00e1l\u00f3dik szinte minden fibrotikus rendszerben; A m\u00e1jban a STAT3 jel\u00e1tvitel kulcsfontoss\u00e1g\u00fa gyullad\u00e1scs\u00f6kkent\u0151 jel, amely szab\u00e1lyozza a m\u00e1jgyullad\u00e1st, \u00e9s aktiv\u00e1l\u00e1sa gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s immunszab\u00e1lyoz\u00f3 szerepet j\u00e1tszhat a m\u00e1jfibr\u00f3zis folyamat\u00e1ban. Ezenk\u00edv\u00fcl a STAT3-g\u00e1tl\u00f3k alkalmaz\u00e1sa preklinikai \u00e1llatmodellekben j\u00f3 anti-fibr\u00f3zisos aktivit\u00e1st mutatott, ami azt jelzi, hogy a STAT3 a val\u00f3di c\u00e9lpont a fibrotikus betegs\u00e9gek kezel\u00e9s\u00e9ben a betegekn\u00e9l. Az EGFR a m\u00e1jregener\u00e1ci\u00f3 kezdeti szakasz\u00e1ban a m\u00e1jsejtek prolifer\u00e1ci\u00f3j\u00e1nak kulcsfontoss\u00e1g\u00fa szab\u00e1lyoz\u00f3 t\u00e9nyez\u0151jek\u00e9nt ismert; az \u00f6sszes sz\u00f6vet k\u00f6z\u00fcl az EGFR a feln\u0151tt m\u00e1jsejtekben fejez\u0151dik ki a legnagyobb m\u00e9rt\u00e9kben, ami a m\u00e1jfunkci\u00f3 fenntart\u00e1s\u00e1ban bet\u00f6lt\u00f6tt fontos szerep\u00e9re utal. El\u0151sz\u00f6r is, az EGF ismert oldhat\u00f3 medi\u00e1tor, amely r\u00e9szt vesz a HSC aktiv\u00e1ci\u00f3ban, \u00e9s az EGFR k\u00f6zvet\u00edtheti a HSC aktiv\u00e1ci\u00f3t \u00e9s el\u0151seg\u00edtheti a pro-fibrotikus fenot\u00edpust. Pontos mechanizmusa a m\u00e1jsz\u00f6vetben a reakt\u00edv oxig\u00e9nfajok termel\u0151d\u00e9s\u00e9t foglalhatja mag\u00e1ban. M\u00e1sodszor, Fuchs \u00e9s munkat\u00e1rsai tanulm\u00e1nyukban meg\u00e1llap\u00edtott\u00e1k, hogy az EGFR-g\u00e1tl\u00f3k t\u00f6bb ismert profibrotikus g\u00e9n expresszi\u00f3j\u00e1t k\u00e9pesek g\u00e1tolni t\u00f6bb m\u00e1jfibr\u00f3zis-modellben, ami az els\u0151 bizony\u00edt\u00e9k arra, hogy az EGFR g\u00e1tl\u00e1sa visszaford\u00edthatja a m\u00e1jfibr\u00f3zist. V\u00e9g\u00fcl, az EGFR k\u00e9pes specifikus ligandumaihoz k\u00f6t\u0151dve dimereket k\u00e9pezni, amelyek k\u00fcl\u00f6nb\u00f6z\u0151 effektorfeh\u00e9rj\u00e9k foszforil\u00e1ci\u00f3j\u00e1t v\u00e1ltj\u00e1k ki, \u00e9s sz\u00e1mos klasszikus downstream jel\u00e1tviteli \u00fatvonalat aktiv\u00e1lnak, p\u00e9ld\u00e1ul a jel\u00e1tviv\u0151 \u00e9s transzkripci\u00f3s aktiv\u00e1tor (STAT) \u00fatvonalakat; az EGFR, mint a m\u00e1j s\u00e9r\u00fcl\u00e9sre adott v\u00e1lasz\u00e1nak minden szakasz\u00e1ban kulcsfontoss\u00e1g\u00fa r\u00e9sztvev\u0151, k\u00e9pes a klasszikus STAT3 Tyr705 foszforil\u00e1ci\u00f3t induk\u00e1lni, ez\u00e1ltal szab\u00e1lyozva a citokin prolifer\u00e1ci\u00f3t \u00e9s differenci\u00e1l\u00f3d\u00e1st, \u00e9s g\u00e1tolva a fibr\u00f3zis kialakul\u00e1s\u00e1t. Ez\u00e9rt az alapvet\u0151 c\u00e9lpontok \u00e9s \u00fatvonalak el\u0151rejelz\u00e9se a h\u00e1l\u00f3zati farmakol\u00f3gia seg\u00edts\u00e9g\u00e9vel, valamint az el\u0151re jelzett IL-6\/EGFR\/STAT3 jel\u00e1tviteli tengely m\u00e1jfibr\u00f3zisra gyakorolt szab\u00e1lyoz\u00f3 hat\u00e1s\u00e1nak tov\u00e1bbi ellen\u0151rz\u00e9se k\u00eds\u00e9rletek r\u00e9v\u00e9n seg\u00edt meg\u00e9rteni a CRTC m\u00e1jfibr\u00f3zis-ellenes hat\u00e1s\u00e1nak mechanizmus\u00e1t.
\n\u00c1llatk\u00eds\u00e9rletekben a HE-fest\u00e9s eredm\u00e9nyei a patol\u00f3giai morfol\u00f3gia, p\u00e9ld\u00e1ul a gyullad\u00e1s \u00e9s az infiltr\u00e1ci\u00f3 javul\u00e1s\u00e1t mutatt\u00e1k a bead\u00e1st k\u00f6vet\u0151en, ami azt jelzi, hogy a CRTC k\u00e9pes enyh\u00edteni a sert\u00e9ssz\u00e9rum \u00e1ltal okozott m\u00e1jfibr\u00f3zist. Tov\u00e1bbi ELISA eredm\u00e9nyek azt mutatt\u00e1k, hogy az IL-6, az EGFR \u00e9s a STAT3 szintje a modellcsoportba tartoz\u00f3 patk\u00e1nyok sz\u00e9rum\u00e1ban jelent\u0151sen megemelkedett, \u00e9s mindegyik jelent\u0151sen lecs\u00f6kkent a bead\u00e1st k\u00f6vet\u0151en, ami d\u00f3zisf\u00fcgg\u0151 \u00f6sszef\u00fcgg\u00e9st mutat. Ez a tanulm\u00e1ny azt sugallja, hogy a CRTC hat\u00e1smechanizmusa a m\u00e1jfibr\u00f3zis kezel\u00e9s\u00e9ben az IL-6\/EGFR\/STAT3 jel\u00e1tviteli tengelyhez kapcsol\u00f3dhat, ami bizonyos alapot ny\u00fajt a m\u00e1jfibr\u00f3zis hagyom\u00e1nyos CRTC kezel\u00e9s\u00e9nek modern mechanizmus\u00e1nak felt\u00e1r\u00e1s\u00e1hoz, \u00e9s hasznos hivatkoz\u00e1sokat ny\u00fajt a h\u00e1l\u00f3zati farmakol\u00f3gia molekul\u00e1ris mechanizmus\u00e1nak kutat\u00e1s\u00e1hoz \u00e9s a hagyom\u00e1nyos gy\u00f3gyszerek molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1j\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"

A Curcuma zedoaria \u00e9s a Biejia gy\u00f3gyszer hat\u00e1smechanizmus\u00e1nak felt\u00e1r\u00e1sa a m\u00e1jfibr\u00f3zis elleni k\u00fczdelemben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1s \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n A m\u00e1jfibr\u00f3zis a m\u00e1jsejtek kr\u00f3nikus gyullad\u00e1s\u00e1t \u00e9s elhal\u00e1s\u00e1t jelenti, amelyet k\u00fcl\u00f6nb\u00f6z\u0151 patog\u00e9n t\u00e9nyez\u0151k folyamatos hat\u00e1sa okoz. A m\u00e1jban egyes nem parenchim\u00e1lis sejtek aktiv\u00e1l\u00f3dnak, ami [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of action of Curcuma zedoaria and Biejia medicine in combating liver fibrosis based on network pharmacology, molecular docking, and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/curcuma-zedoaria-es-teknospancel-gyogyszer\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of action of Curcuma zedoaria and Biejia medicine in combating liver fibrosis based on network pharmacology, molecular docking, and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of action of Curcuma zedoaria and Biejia medicine in combating liver fibrosis based on network pharmacology, molecular docking, and experimental verification Liver fibrosis refers to the chronic inflammation and necrosis of liver cells caused by the continuous action of various pathogenic factors. 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