{"id":3754,"date":"2024-08-03T07:47:30","date_gmt":"2024-08-03T07:47:30","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3754"},"modified":"2024-08-03T07:47:30","modified_gmt":"2024-08-03T07:47:30","slug":"inflammation-ma-qian-zi-processed-to-reduce-toxicity","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/","title":{"rendered":"A feldolgozott Ma Qian Zi toxicit\u00e1s cs\u00f6kkent\u00e9s\u00e9nek \u00e9s meg\u0151rz\u00e9s\u00e9nek mechanizmus\u00e1nak vizsg\u00e1lata gyullad\u00e1sos patk\u00e1nyok metabolizmusa alapj\u00e1n"},"content":{"rendered":"

A feldolgozott Ma Qian Zi toxicit\u00e1s cs\u00f6kkent\u00e9s\u00e9nek \u00e9s meg\u0151rz\u00e9s\u00e9nek mechanizmus\u00e1nak vizsg\u00e1lata gyullad\u00e1sos patk\u00e1nyok metabolizmusa alapj\u00e1n
\nA Ma Qian Zi egy fontos \u00e9s gyakran haszn\u00e1lt hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer K\u00edn\u00e1ban, amelyet el\u0151sz\u00f6r a Compendium of Materia Medica-ban jegyeztek fel. Hat\u00e1sai k\u00f6z\u00e9 tartozik a kollater\u00e1lisok felold\u00e1sa, a f\u00e1jdalom enyh\u00edt\u00e9se, a csom\u00f3k eloszlat\u00e1sa \u00e9s a duzzanat cs\u00f6kkent\u00e9se; els\u0151sorban olyan betegs\u00e9gek kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k, mint a duzzanat, a mell t\u00e1lyogja \u00e9s a scrofula. A nyers l\u00f3sz\u0151r s\u00falyos toxicit\u00e1sa nagym\u00e9rt\u00e9kben korl\u00e1tozza klinikai alkalmaz\u00e1s\u00e1t. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s \u00fagy v\u00e9li, hogy a feldolgoz\u00e1ssal el\u00e9rhet\u0151 a toxicit\u00e1s cs\u00f6kkent\u00e9se \u00e9s a hat\u00e9konys\u00e1g meg\u0151rz\u00e9se. A torma feldolgoz\u00e1s\u00e1ra sz\u00e1mos m\u00f3dszer l\u00e9tezik, t\u00f6bbek k\u00f6z\u00f6tt a homokblan\u00edroz\u00e1s, a m\u00e9lys\u00fct\u00e9s, a kevert s\u00fct\u00e9s, a tofuk\u00e9sz\u00edt\u00e9s stb. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a magas h\u0151m\u00e9rs\u00e9klet\u0171 s\u00fct\u00e9si folyamat sor\u00e1n a sztrichnin \u00e9s a sztrichnin f\u0151 toxikus \u00f6sszetev\u0151i hat\u00e9konyan cs\u00f6kkennek a nitrog\u00e9n-oxidok el\u0151\u00e1ll\u00edt\u00e1sa sor\u00e1n, amelyek alacsonyabb toxicit\u00e1ssal \u00e9s jobb ter\u00e1pi\u00e1s hat\u00e1ssal rendelkeznek. Jelenleg a kutat\u00e1s m\u00e9g mindig a jellemz\u0151 komponensek elemz\u00e9s\u00e9nek szintj\u00e9n \u00e1ll. B\u00e1r a Fructus Strychni feldolgoz\u00e1sa sor\u00e1n a toxicit\u00e1s cs\u00f6kkent\u00e9s\u00e9nek mechanizmus\u00e1t el\u0151zetesen megmagyar\u00e1zt\u00e1k, a Fructus Strychni \u00f6sszetett k\u00e9miai \u00f6sszet\u00e9tele \u00e9s a felsz\u00edv\u00f3d\u00e1s, \u00e1talakul\u00e1s, metabolizmus \u00e9s szab\u00e1lyoz\u00e1s tiszt\u00e1zatlan mechanizmusai az emberi szervezetbe val\u00f3 bejut\u00e1s ut\u00e1n akad\u00e1lyozz\u00e1k a farmakol\u00f3giai hat\u00e1sok \u00e9s hat\u00f3anyagok m\u00e9lyrehat\u00f3 \u00e9rtelmez\u00e9s\u00e9t.<\/p>\n

Az elm\u00falt \u00e9vekben a metabolizmus a nagy \u00e1tereszt\u0151k\u00e9pess\u00e9g\u0171 \u00e9s nagy felbont\u00e1s\u00fa eszk\u00f6z\u00f6k seg\u00edts\u00e9g\u00e9vel gyorsan fejl\u0151d\u00f6tt, k\u00fcl\u00f6n\u00f6sen a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s ter\u00fclet\u00e9n, ahol sz\u00e9les k\u00f6rben alkalmazz\u00e1k. Az endog\u00e9n kis molekul\u00e1k min\u0151s\u00e9gi \u00e9s mennyis\u00e9gi v\u00e1ltoz\u00e1sainak nyomon k\u00f6vet\u00e9s\u00e9vel, a szervezet funkcion\u00e1lis \u00e1llapot\u00e1ban bek\u00f6vetkez\u0151 v\u00e1ltoz\u00e1sokkal kombin\u00e1lva, a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s hat\u00e9konys\u00e1g\u00e1nak molekul\u00e1ris mechanizmusai tiszt\u00e1zhat\u00f3k. Ez a tanulm\u00e1ny el\u0151zetesen \u00e9rt\u00e9kelte a feldolgozott Semen Strychni toxicit\u00e1si v\u00e1ltoz\u00e1sait a feldolgoz\u00e1s el\u0151tt \u00e9s ut\u00e1n a hal\u00e1loz\u00e1si ar\u00e1ny alapj\u00e1n; \u00c9rt\u00e9kelje a gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st a feldolgoz\u00e1s el\u0151tt \u00e9s ut\u00e1n a duzzad\u00e1si ar\u00e1ny \u00e9s a gyullad\u00e1sos faktorok szintje alapj\u00e1n; Ezt k\u00f6vet\u0151en a v\u00e9r\u00e1ramba jut\u00e1s ut\u00e1n a hat\u00e9kony anyagokat a plazma gy\u00f3gyszerk\u00e9mi\u00e1j\u00e1val elemezt\u00e9k. V\u00e9g\u00fcl a plazm\u00e1ban l\u00e9v\u0151 endog\u00e9n metabolitokat elemezt\u00e9k \u00e9s azonos\u00edtott\u00e1k a Ma Qian Zi gyullad\u00e1sos beavatkoz\u00e1si modell seg\u00edts\u00e9g\u00e9vel. A Ma Qian Zi m\u00e9regtelen\u00edt\u00e9s\u00e9nek \u00e9s hat\u00e9konys\u00e1g\u00e1nak mechanizmus\u00e1t a feldolgoz\u00e1s el\u0151tt \u00e9s ut\u00e1n k\u00e9miai, molekul\u00e1ris \u00e9s metabolikus szinten vizsg\u00e1lt\u00e1k.<\/p>\n

Az el\u0151zetes toxicit\u00e1si k\u00eds\u00e9rletek azt mutatt\u00e1k, hogy a homokforr\u00e1z\u00e1ssal kezelt csoport mortalit\u00e1si ar\u00e1nya nagy d\u00f3zisok eset\u00e9n jelent\u0151sen alacsonyabb, mint a nyers csoport\u00e9, ami azt jelzi, hogy a sz\u00e1r\u00edtott l\u00f3magok toxicit\u00e1sa val\u00f3ban jelent\u0151sen cs\u00f6kken a magas h\u0151m\u00e9rs\u00e9klet\u0171 feldolgoz\u00e1s ut\u00e1n. A talpduzzad\u00e1s m\u00e9rt\u00e9k\u00e9re vonatkoz\u00f3 k\u00eds\u00e9rlet azt mutatta, hogy magas d\u00f3zisok eset\u00e9n mind a nyers term\u00e9kcsoport, mind a homokforr\u00e1zott term\u00e9kcsoport duzzad\u00e1si ar\u00e1nya jelent\u0151sen cs\u00f6kkent, ami azt bizony\u00edtja, hogy a nyers term\u00e9k \u00e9s a homokforr\u00e1zott term\u00e9k val\u00f3ban rendelkezik bizonyos gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1ssal. Nem volt statisztikailag szignifik\u00e1ns k\u00fcl\u00f6nbs\u00e9g a duzzad\u00e1si ar\u00e1nyban a homokforr\u00e1z\u00f3 csoport \u00e9s a nyers term\u00e9kcsoport k\u00f6z\u00f6tt, ami azt jelzi, hogy a feldolgoz\u00e1s el\u0151tt \u00e9s ut\u00e1n nem volt jelent\u0151s v\u00e1ltoz\u00e1s a gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sban. A gyullad\u00e1scs\u00f6kkent\u0151 t\u00e9nyez\u0151k kimutat\u00e1si eredm\u00e9nyei nagyj\u00e1b\u00f3l \u00f6sszhangban vannak a duzzad\u00e1si sebess\u00e9ggel v\u00e9gzett k\u00eds\u00e9rlettel. A torma el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra k\u00fcl\u00f6nb\u00f6z\u0151 feldolgoz\u00e1si m\u00f3dszerek l\u00e9teznek, t\u00f6bbek k\u00f6z\u00f6tt a homokleves\u00edt\u00e9s, a m\u00e9lys\u00fct\u00e9s, a kevert s\u00fct\u00e9s, a robban\u00e1sszer\u0171 pr\u00e9sel\u00e9s, a s\u00fct\u00e9s, a mikrohull\u00e1m\u00fa s\u00fct\u00e9s, a f\u0151z\u00e9s stb. A feldolgoz\u00e1si l\u00e9p\u00e9sek t\u00f6bbs\u00e9ge hev\u00edt\u00e9ssel j\u00e1r, \u00e9s \u00e1ltal\u00e1ban \u00fagy v\u00e9lik, hogy a hev\u00edt\u00e9s cs\u00f6kkenti a f\u0151 m\u00e9rgez\u0151 \u00f6sszetev\u0151k, a brucin \u00e9s a sztrichnin tartalm\u00e1t. Azonban a hat\u00e9konyabb kezel\u00e9sek, mint p\u00e9ld\u00e1ul az izobrucin, izobrucin, sztrichnin nitrog\u00e9n-oxidok \u00e9s brucin nitrog\u00e9n-oxidok tartalma n\u00f6vekedni fog. Liu Jun et al. \u00fagy v\u00e9lte, hogy a meleg\u00edt\u00e9ses feldolgoz\u00e1s az alkaloidok boml\u00e1si \u00e9s oxid\u00e1ci\u00f3s reakci\u00f3inak eredm\u00e9nye, \u00e9s H2O2 haszn\u00e1lat\u00e1val igazolta. Ez a tanulm\u00e1ny tov\u00e1bb\u00e1 el\u0151zetes toxicit\u00e1si k\u00eds\u00e9rletekkel \u00e9s farmakol\u00f3giai k\u00eds\u00e9rletekkel meger\u0151s\u00edtette, hogy a homokblans\u00edroz\u00f3 feldolgoz\u00e1s val\u00f3ban cs\u00f6kkentheti a Semen Strychni toxicit\u00e1s\u00e1t, \u00e9s megtarthatja bizonyos gyullad\u00e1scs\u00f6kkent\u0151 ter\u00e1pi\u00e1s hat\u00e1s\u00e1t.<\/p>\n

\"\"\"\"\"\"\"\"
\nA plazma metabolitok vizsg\u00e1lat\u00e1val meg\u00e1llap\u00edtott\u00e1k, hogy a gy\u00f3gyszert tartalmaz\u00f3 plazm\u00e1ban azonos\u00edtott alkaloidok az \u00e1tmeneti komponensek 77%-j\u00e9t tett\u00e9k ki, ami azt jelzi, hogy az alkaloidok els\u0151sorban a gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sok\u00e9rt felel\u0151sek; A jobb ter\u00e1pi\u00e1s hat\u00e1s\u00fa \u00e9s alacsonyabb toxicit\u00e1s\u00fa nitrog\u00e9n-oxidok azonos\u00edt\u00e1sa a mobil komponensekben \u00f6sszhangban van a Semen Strychni feldolgoz\u00e1si mechanizmus\u00e1r\u00f3l sz\u00f3l\u00f3 kor\u00e1bbi tanulm\u00e1nyokkal. A 60 azonos\u00edtott metabolitb\u00f3l csak 7 ment \u00e1t II. f\u00e1zis\u00fa reakci\u00f3kon, ami azt jelzi, hogy ezek a v\u00e1ndorl\u00f3 komponensek az I. f\u00e1zis\u00fa reakci\u00f3kat k\u00f6vet\u0151en k\u00f6nnyen ki\u00fcr\u00fclnek a szervezetb\u0151l. A drogot tartalmaz\u00f3 plazma differenci\u00e1lanal\u00edzise r\u00e9v\u00e9n meg\u00e1llap\u00edtott\u00e1k, hogy az alkaloidok tett\u00e9k ki az azonos\u00edt\u00e1si eredm\u00e9nyek t\u00f6bbs\u00e9g\u00e9t, \u00e9s a homoki leforr\u00e1zott csoport anyagmin\u0151s\u00e9ge jelent\u0151sen magasabb volt, mint a nyers term\u00e9kcsoport\u00e9; a homoki leforr\u00e1zott csoportban a brucin \u00e9s a sztrichnin nitrog\u00e9n-oxidjait is azonos\u00edtott\u00e1k; A differenci\u00e1lanal\u00edzis sor\u00e1n csak a shidianingot azonos\u00edtott\u00e1k, \u00e9s a szakirodalmi jelent\u00e9sek szerint a shidianing farmakol\u00f3giai ereje 40-szerese a sztrichninnek; A fenti eredm\u00e9nyek meger\u0151s\u00edtik, hogy a feldolgozott term\u00e9kek gyullad\u00e1scs\u00f6kkent\u0151 ter\u00e1pi\u00e1s hat\u00e1sa nem lehet alacsonyabb, mint a nyers term\u00e9kek\u00e9. A differenci\u00e1lanal\u00edzis sor\u00e1n h\u00e1rom szerves savat is azonos\u00edtottak, \u00e9s a homokforr\u00e1z\u00f3 csoport t\u00f6mege alacsonyabb volt, mint a nyers csoport\u00e9, ami \u00f6sszef\u00fcgghet a szerves savkomponensek magas h\u0151m\u00e9rs\u00e9kleten t\u00f6rt\u00e9n\u0151 k\u00f6nny\u0171 boml\u00e1s\u00e1val. A fenti plazma gy\u00f3gyszerk\u00e9miai kutat\u00e1sok adathivatkoz\u00e1st ny\u00fajtanak a Fructus Strychni feldolgozott term\u00e9keinek in vivo funkcion\u00e1lis anyagalapj\u00e1nak tiszt\u00e1z\u00e1s\u00e1hoz.
\nA metabolizmus-kutat\u00e1s sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy a dexametazon csoport kiv\u00e9tel\u00e9vel a Ma Qian Zi homok leforr\u00e1z\u00e1s\u00e1val kezelt csoport anyagcsere-profilja a legk\u00f6zelebb \u00e1llt a norm\u00e1l csoport\u00e9hoz, ami azt jelzi, hogy a feldolgozott term\u00e9k j\u00f3 szab\u00e1lyoz\u00f3 hat\u00e1ssal van a szervezetben l\u00e9v\u0151 gyullad\u00e1s okozta anyagcserezavarokra. A biomarkerek elemz\u00e9se bizony\u00edtja, hogy a feldolgozott Ma Qian Zi term\u00e9kek gyullad\u00e1scs\u00f6kkent\u0151 mechanizmusa els\u0151sorban az aminosav- \u00e9s a lipidanyagcser\u00e9hez kapcsol\u00f3dik. A m\u00e1j az \u00e1llatokban az aminosav-anyagcsere f\u0151 szerve, \u00e9s a m\u00e1jk\u00e1rosod\u00e1s anyagcserezavarokat \u00e9s funkcion\u00e1lis k\u00e1rosod\u00e1sokat okozhat. Az aminosav-anyagcsere cs\u00f6kken\u00e9se a m\u00e1jsejtekben az aminosavak koncentr\u00e1ci\u00f3j\u00e1nak n\u00f6veked\u00e9s\u00e9hez vezethet a v\u00e9rben, ez\u00e1ltal befoly\u00e1solva a v\u00e9r, a vizelet \u00e9s az epe aminosavszintj\u00e9nek v\u00e1ltoz\u00e1s\u00e1t. A glutam\u00e1t fontos izgalmi neurotranszmitter. Ha a glutam\u00e1t-anyagcsere zavart szenved, a \"glutam\u00e1t-glutamin-ciklus\" megszakad. A glutam\u00e1t t\u00falzott koncentr\u00e1ci\u00f3ja az extracellul\u00e1ris folyad\u00e9kban t\u00fal sok gerjeszt\u0151 aminosavat aktiv\u00e1lhat, ami toxikus reakci\u00f3khoz vezet. A glutamin fontos alapanyag az \u03b1 - ketoglutar\u00e1t szint\u00e9zis\u00e9hez. \u03b1 - ketoglutar\u00e1t bizonyos m\u00e9rt\u00e9kig cs\u00f6kkentheti a gyullad\u00e1sos faktorok szintj\u00e9t a stresszben, \u00e9s a gyullad\u00e1s modellez\u00e9se ut\u00e1n a sz\u00f6vetekben glutam\u00e1t anyagcserezavarokat okozhat, ami toxikus hat\u00e1sokat eredm\u00e9nyez. A k\u00eds\u00e9rleti eredm\u00e9nyek azt mutatt\u00e1k, hogy a homokkal leforr\u00e1zott csoport plazm\u00e1j\u00e1nak glutam\u00e1t-tartalma jelent\u0151sen cs\u00f6kkent, ez\u00e1ltal cs\u00f6kkentve az agyidegek ingerl\u00e9kenys\u00e9g\u00e9t \u00e9s nyugtat\u00f3 hat\u00e1st kifejtve. Ugyanakkor a glutamintartalom felszab\u00e1lyoz\u00f3dott a gyullad\u00e1scs\u00f6kkent\u0151 ter\u00e1pi\u00e1s hat\u00e1sok el\u00e9r\u00e9se \u00e9rdek\u00e9ben. A fenilalanin els\u0151sorban tirozinn\u00e1 metaboliz\u00e1l\u00f3dik a sz\u00f6vetekben, p\u00e9ld\u00e1ul a m\u00e1jban, majd az idegrendszerben \u00e9s a mell\u00e9kvesek\u00e9regben szintetiz\u00e1l\u00f3dik, p\u00e9ld\u00e1ul dopamin, noradrenalin, adrenalin stb. form\u00e1j\u00e1ban. A fenilalanin metabolikus \u00e1llapota k\u00f6zvetlen\u00fcl befoly\u00e1solja a szervezet n\u00f6veked\u00e9s\u00e9t, fejl\u0151d\u00e9s\u00e9t \u00e9s norm\u00e1lis \u00e9lettani funkci\u00f3it. A vizsg\u00e1lat eredm\u00e9nyei azt mutatj\u00e1k, hogy a fenilalanin a norm\u00e1l csoportban jelent\u0151sen felfel\u00e9 szab\u00e1lyozott, m\u00edg a nyers term\u00e9kcsoportban \u00e9s a homokleves csoportban kiss\u00e9 lefel\u00e9 szab\u00e1lyozott. A homokperzsel\u00e9s csoport k\u00f6zelebb \u00e1ll a norm\u00e1l csoporthoz, ami azt jelzi, hogy a homokperzsel\u00e9s csoport jobban tudja szab\u00e1lyozni a gyullad\u00e1s okozta fenilalanin anyagcserezavart. A citrullin az arginin \u00e9s a prolin metabolikus \u00fatjain keletkezik, \u00e9s a megfelel\u0151 enzimek hat\u00e1s\u00e1ra arginint, ornitint stb. hoz l\u00e9tre. Hat\u00e9konyan cs\u00f6kkentheti a v\u00e9r amm\u00f3niaszintj\u00e9t, elker\u00fclheti a szervi k\u00e1rosod\u00e1st \u00e9s enyh\u00edtheti a szervezetben fell\u00e9p\u0151 f\u00e1jdalomreakci\u00f3kat. A citrullin tartalma a modellcsoportban jelent\u0151sen lecs\u00f6kkent a norm\u00e1l csoporthoz k\u00e9pest, m\u00edg a nyers term\u00e9kcsoportban \u00e9s a homokleves csoportban egyar\u00e1nt felfel\u00e9 szab\u00e1lyoz\u00f3dott, ami azt jelzi, hogy a homokleves hat\u00e9konyan szab\u00e1lyozza az arginin anyagcser\u00e9t, t\u00e1g\u00edtja az ereket \u00e9s enyh\u00edti a gyullad\u00e1s okozta f\u00e1jdalmat. A tirozint f\u0151k\u00e9nt a tirozin-hidrogen\u00e1z metaboliz\u00e1lja dihidroxifenilalanin el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra, amely azt\u00e1n a tirozin-hidroxil\u00e1z hat\u00e1s\u00e1ra dop\u00e1v\u00e1 \u00e9s m\u00e1s szimpatikus neurotranszmitterekk\u00e9 alakul \u00e1t. A patk\u00e1ny toj\u00e1sfeh\u00e9rje \u00e1ltal kiv\u00e1ltott talpi duzzanat gyullad\u00e1sos modellje a helyi v\u00e9r\u00e1raml\u00e1s gyors cs\u00f6kken\u00e9s\u00e9t okozhatja, amelyet gyullad\u00e1sos reakci\u00f3k \u00e9s f\u00e1jdalom k\u00eds\u00e9r, \u00e9s a f\u00e1jdalom\u00e9rz\u00e9kenys\u00e9gi v\u00e1lasz fokozatosan n\u00f6vekszik. A dopamin tartalma a modellcsoportban felszab\u00e1lyoz\u00f3dott, m\u00edg a homokf\u0171 csoportban jelent\u0151sen lecs\u00f6kkent, ami azt jelzi, hogy a homokf\u0171 term\u00e9kek a dopamin anyagcsere szab\u00e1lyoz\u00e1s\u00e1val cs\u00f6kkenthetik a f\u00e1jdalom\u00e9rz\u00e9kenys\u00e9get. A glicerofoszfolipidek metabolizmusa a szendvics sztyeppei hepatotoxicit\u00e1s \u00e9s a feldolgoz\u00e1s csillap\u00edt\u00e1s\u00e1nak kulcsfontoss\u00e1g\u00fa metabolikus \u00fatvonala. A glicerofoszfolipidek anyagcser\u00e9j\u00e9ben k\u00e9t kulcsfontoss\u00e1g\u00fa c\u00e9lpont vesz r\u00e9szt, nevezetesen a foszfatidil-kolin \u00e9s a foszfatidil-etanolamin, amelyek f\u0151k\u00e9nt a m\u00e1jsz\u00f6vetben alakulhatnak \u00e1t egym\u00e1sba. Kor\u00e1bbi tanulm\u00e1nyok kimutatt\u00e1k, hogy a l\u00f3sz\u0151r \u00e1ltal okozott m\u00e1jk\u00e1rosod\u00e1s lipidanyagcsere-zavarokhoz vezethet, ami olyan anyagok v\u00e1ltoz\u00e1s\u00e1val j\u00e1r, mint a gliceridek, acilglicerin, foszfatidil-etanolaminok, foszfatidil-kolin, valamint a kapcsol\u00f3d\u00f3 gyullad\u00e1sos faktorok szintje. A foszfatidil-kolin gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s immuner\u0151s\u00edt\u0151 hat\u00e1s\u00fa, \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s potenci\u00e1lis ter\u00e1pi\u00e1s hat\u00e1sai a neutrofilek \u00e1ltal kiv\u00e1ltott mikrocirkul\u00e1ci\u00f3s gyullad\u00e1sos v\u00e1lasz cs\u00f6kkent\u00e9s\u00e9vel f\u00fcgghetnek \u00f6ssze; a lizofoszfatidil-kolin a foszfatidil-kolin term\u00e9ke vagy metabolitja, amely az extrahepatikus sz\u00f6vetek plazmapoolj\u00e1ban oszlik el, \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 pro-inflammatorikus reakci\u00f3kat induk\u00e1lhat. A k\u00eds\u00e9rleti eredm\u00e9nyek szerint a foszfatidil-kolin \u00e9s a lizofoszfatidil-kolin szintje a modellcsoportban felfel\u00e9 szab\u00e1lyozott volt, m\u00edg a nyers term\u00e9kcsoportban \u00e9s a homokforr\u00e1z\u00f3 csoportban cs\u00f6kkent, \u00e9s k\u00f6zel \u00e1llt a norm\u00e1l csoporthoz. Ez azt jelzi, hogy a Malvaceae kivonata hat\u00e9konyan szab\u00e1lyozza a foszfatidil-kolin \u00e9s a lizofoszfatidil-kolin szintj\u00e9t az egyens\u00faly helyre\u00e1ll\u00edt\u00e1sa \u00e9rdek\u00e9ben. A m\u00e1j a szervezetben a glicerofoszfolipidek szint\u00e9zis\u00e9nek legakt\u00edvabb helye, ami bizonyos m\u00e9rt\u00e9kig meger\u0151s\u00edti a Malvaceae m\u00e1jtoxicit\u00e1s\u00e1nak objekt\u00edv l\u00e9tez\u00e9s\u00e9t; Ugyanakkor azt is meger\u0151s\u00edti, hogy a Ma Qian Zi Sha Hot Pot j\u00f3 gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s m\u00e9regtelen\u00edt\u0151 hat\u00e1ssal rendelkezik.
\n\u00d6sszefoglalva, ez a tanulm\u00e1ny a metabolizmus seg\u00edts\u00e9g\u00e9vel meger\u0151s\u00edtette, hogy a feldolgozott Ma Qian Zi toxicit\u00e1sa cs\u00f6kkent, mik\u00f6zben tov\u00e1bbra is j\u00f3 gyullad\u00e1scs\u00f6kkent\u0151 ter\u00e1pi\u00e1s hat\u00e1st fejtett ki. A szervezet\u00e9ben l\u00e9v\u0151 hat\u00f3anyagok f\u0151leg alkaloidok lehetnek; A Ma Qian Zi gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1sai, valamint a m\u00e1j- \u00e9s vesetoxicit\u00e1sa szorosan \u00f6sszef\u00fcgg az olyan \u00fatvonalak megzavar\u00e1s\u00e1val, mint a glutamin-glutam\u00e1t anyagcsere, fenilalanin anyagcsere, tiometabolizmus, glicerofoszfolipid anyagcsere, arginin \u00e9s prolin anyagcsere. A kutat\u00e1si eredm\u00e9nyek hasznos tudom\u00e1nyos hivatkoz\u00e1sokkal szolg\u00e1lnak a toxicit\u00e1s cs\u00f6kkent\u00e9s\u00e9nek, a hat\u00e9konys\u00e1g fokoz\u00e1s\u00e1nak vagy a hat\u00e9konys\u00e1g meg\u0151rz\u00e9s\u00e9nek mechanizmusainak felt\u00e1r\u00e1s\u00e1hoz a toxikus, alkaloid\u00e1kat tartalmaz\u00f3 hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szati anyagok feldolgoz\u00e1sa sor\u00e1n.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats Ma Qian Zi is an important and commonly used traditional Chinese medicine in China, first recorded in the Compendium of Materia Medica. It has the effects of unblocking collaterals, relieving pain, dispersing nodules, and reducing […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats Ma Qian Zi is an important and commonly used traditional Chinese medicine in China, first recorded in the Compendium of Materia Medica. It has the effects of unblocking collaterals, relieving pain, dispersing nodules, and reducing […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/hu\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-03T07:47:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-5.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Szerz\u0151:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Becs\u00fclt olvas\u00e1si id\u0151\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 perc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/\",\"url\":\"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/\",\"name\":\"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-5.png\",\"datePublished\":\"2024-08-03T07:47:30+00:00\",\"dateModified\":\"2024-08-03T07:47:30+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#breadcrumb\"},\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-5.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-5.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"hu\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tanulm\u00e1ny a mechanizmus a toxicit\u00e1s cs\u00f6kkent\u00e9se \u00e9s meg\u0151rz\u00e9se feldolgozott Ma Qian Zi alapj\u00e1n metabolizmus gyullad\u00e1sos patk\u00e1nyok - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/hu\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/","og_locale":"hu_HU","og_type":"article","og_title":"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats - China Chemical Manufacturer","og_description":"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats Ma Qian Zi is an important and commonly used traditional Chinese medicine in China, first recorded in the Compendium of Materia Medica. It has the effects of unblocking collaterals, relieving pain, dispersing nodules, and reducing […]","og_url":"https:\/\/longchangextracts.com\/hu\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-03T07:47:30+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-5.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Szerz\u0151:":"longcha9","Becs\u00fclt olvas\u00e1si id\u0151":"9 perc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/","url":"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/","name":"Tanulm\u00e1ny a mechanizmus a toxicit\u00e1s cs\u00f6kkent\u00e9se \u00e9s meg\u0151rz\u00e9se feldolgozott Ma Qian Zi alapj\u00e1n metabolizmus gyullad\u00e1sos patk\u00e1nyok - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-5.png","datePublished":"2024-08-03T07:47:30+00:00","dateModified":"2024-08-03T07:47:30+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#breadcrumb"},"inLanguage":"hu","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/"]}]},{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-5.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-5.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"K\u00edna Vegyi Gy\u00e1rt\u00f3","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/3754"}],"collection":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/comments?post=3754"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/3754\/revisions"}],"predecessor-version":[{"id":3759,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/3754\/revisions\/3759"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/media?parent=3754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/categories?post=3754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/tags?post=3754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}