{"id":3748,"date":"2024-08-03T07:42:11","date_gmt":"2024-08-03T07:42:11","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3748"},"modified":"2024-08-03T07:42:11","modified_gmt":"2024-08-03T07:42:11","slug":"trichothecium-roseum-diterpene","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/trichothecium-roseum-diterpene\/","title":{"rendered":"Citotoxikus hat\u00e1s\u00fa diterp\u00e9nek a r\u00f3zsasz\u00edn trichoderma ferment\u00e1ci\u00f3s term\u00e9keiben"},"content":{"rendered":"

Citotoxikus hat\u00e1s\u00fa diterp\u00e9nek a r\u00f3zsasz\u00edn trichoderma ferment\u00e1ci\u00f3s term\u00e9keiben
\nA r\u00f3zsasz\u00edn trichothecium roseumot, amely a Deuteromycotina alt\u00f6rzs Hyphomyceales rendj\u00e9be tartozik, 2008-ban fedezt\u00e9k fel \u00e9s nevezt\u00e9k el. Ez a gomba k\u00f6nnyen izol\u00e1lhat\u00f3 rothad\u00f3 n\u00f6v\u00e9nyi testekb\u0151l, talajb\u00f3l \u00e9s leveg\u0151b\u0151l, \u00e9s vil\u00e1gszerte sz\u00e9les k\u00f6rben elterjedt n\u00f6v\u00e9ny- \u00e9s z\u00f6lds\u00e9gpatog\u00e9n gomba. A r\u00f3zsasz\u00edn trichoderma metabolitjait laborat\u00f3riumi teny\u00e9szt\u00e9si k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt sz\u00e1mos tanulm\u00e1ny vizsg\u00e1lta, a reprezentat\u00edv szerkezetek k\u00f6z\u00f6tt szeszkviterp\u00e9nek, szeszkviterp\u00e9nek, diterp\u00e9nek \u00e9s ciklikus peptidek is szerepelnek. K\u00f6z\u00fcl\u00fck a legsz\u00e9lesebb k\u00f6rben vizsg\u00e1lt a trichothec\u00e9n. Tang \u00e9s munkat\u00e1rsai arr\u00f3l sz\u00e1moltak be, hogy a monotrichothec\u00e9n vegy\u00fcletek rothad\u00e1st okozhatnak az almamagokban, m\u00edg a monotrichothec\u00e9n toxinok g\u00e1tolj\u00e1k \u00e9s zavarj\u00e1k a feh\u00e9rje- \u00e9s nukleinsavszint\u00e9zist emberekben \u00e9s \u00e1llatokban egyar\u00e1nt, ami az emberi \u00e9s \u00e1llati eg\u00e9szs\u00e9g immunszuppresszi\u00f3j\u00e1hoz vezet. Az ilyen toxinokkal szennyezett \u00e9lelmiszerek \u00e9s term\u00e9kek fogyaszt\u00e1sa sz\u00e9les k\u00f6r\u0171 m\u00e9rgez\u0151 hat\u00e1sokat okozhat emberekben \u00e9s \u00e1llatokban.<\/p>\n

\"\"\"\"\"\"\"\"
\nA toxin vegy\u00fcletek mellett citotoxikus hat\u00e1s\u00fa vegy\u00fcleteket is tal\u00e1ltak ebben a ferment\u00e1ci\u00f3s levesben, mint p\u00e9ld\u00e1ul az ebben a nemzets\u00e9gben tal\u00e1lhat\u00f3 szeszkviterp\u00e9n vegy\u00fclet, a cuspidatol, amely er\u0151s immunszuppressz\u00edv hat\u00e1st mutatott MLR vizsg\u00e1latokban 11 \u03bc g\/mL IC50 \u00e9rt\u00e9kkel; a Monotrichothecin A er\u0151s g\u00e1tl\u00f3 hat\u00e1ssal van a HL-60, SMMC-7721, A549, MCF-7 \u00e9s SW480 sejtek n\u00f6veked\u00e9s\u00e9re, az IC50 \u00e9rt\u00e9kek 0 \u03bc g\/mL.022, 0,020, 0,015, 0,006, \u00e9s 0,015, 0,006 \u00e9s 0,006.011 \u03bc mol\/L, amelyek \u00f6sszehasonl\u00edthat\u00f3ak a pozit\u00edv kontroll paclitaxelhez; A diterp\u00e9n vegy\u00fclet, a rosonolakton er\u0151s antiproliferat\u00edv \u00e9s proapoptotikus hat\u00e1ssal rendelkezik a hum\u00e1n m\u00e9hnyakr\u00e1kos HeLa sejtekre; A r\u00f3zsakardin, egy ciklikus \u00e9szter peptidvegy\u00fclet pozit\u00edv inotr\u00f3p hat\u00e1ssal van a patk\u00e1nyok sz\u00edvizomzat\u00e1ra; A ciklikus peptidvegy\u00fclet trikomid D jelent\u0151s citotoxicit\u00e1st mutatott h\u00e1rom emberi r\u00e1kos sejtvonallal (MCF-7, SW480, HL-6) szemben, az IC50 \u00e9rt\u00e9kek 0.079, 0,107 \u00e9s 0,149 \u03bc mol\/l \u00e9rt\u00e9keket \u00e9rtek el. Ez az els\u0151 jelent\u00e9s a ciklikus peptidek citotoxikus aktivit\u00e1s\u00e1r\u00f3l. A citotoxikus aktivit\u00e1s\u00fa \u00faj vegy\u00fcletek tov\u00e1bbi keres\u00e9se \u00e9rdek\u00e9ben kutat\u00f3csoportunk izol\u00e1lt \u00e9s azonos\u00edtott egy r\u00f3zsasz\u00edn trichothecus t\u00f6rzset abb\u00f3l a talajb\u00f3l, ahol a vad Ganoderma lucidum Baise-ban (a Ganoderma lucidum sz\u00fcl\u0151v\u00e1ros\u00e1ban) n\u0151. A ferment\u00e1ci\u00f3s folyamat kiterjeszt\u00e9s\u00e9hez rizskult\u00far\u00e1s t\u00e1ptalajt haszn\u00e1ltunk, hogy \u00faj szerkezet\u0171 \u00e9s j\u00f3 biol\u00f3giai aktivit\u00e1s\u00fa vegy\u00fcleteket fedezz\u00fcnk fel, \u00e9s gy\u00f3gyszer-el\u0151rejelz\u0151 szerkezeteket biztos\u00edtsunk.<\/p>\n

Ebben a tanulm\u00e1nyban \u00f6t vegy\u00fcletet izol\u00e1ltak \u00e9s azonos\u00edtottak a T. roseum ferment\u00e1ci\u00f3s term\u00e9keib\u0151l, amelyek mindegyike diterp\u00e9n. K\u00f6z\u00fcl\u00fck az 1. vegy\u00fclet egy \u00faj diterpenoid vegy\u00fclet. Ez az eredm\u00e9ny gazdag\u00edtja a r\u00f3zsasz\u00edn trichoderma \u00e1ltal termelt metabolitok sokf\u00e9les\u00e9g\u00e9t. \u00d6t vegy\u00fclet mutatott k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e9rt\u00e9k\u0171 g\u00e1tl\u00f3 hat\u00e1st az MCF-7 sejtekre, az 1. \u00e9s az 5. vegy\u00fclet mutatta a legjobb aktivit\u00e1st. Felt\u00e9telezhet\u0151, hogy ez az 1. \u00e9s 5. vegy\u00fclet hasonl\u00f3 A \u00e9s B gy\u0171r\u0171szerkezet\u00e9nek k\u00f6sz\u00f6nhet\u0151, m\u00edg az 5. vegy\u00fclet, b\u00e1r l\u00e1ncszer\u0171, az 1. vegy\u00fclethez hasonl\u00f3 t\u00e9rbeli kiterjed\u00e9s\u0171 domin\u00e1ns konform\u00e1ci\u00f3val rendelkezik. Az ezzel a szerkezeti jellemz\u0151vel rendelkez\u0151 vegy\u00fcletek jobb aktivit\u00e1st mutattak az ebben a cikkben kiv\u00e1lasztott aktivit\u00e1skutat\u00e1si modellben. Ez a tanulm\u00e1ny gazdag\u00edtja a Trichothecaum gomb\u00e1k m\u00e1sodlagos metabolitszerkezet\u00e9nek sokf\u00e9les\u00e9g\u00e9t, \u00e9s referenci\u00e1t ny\u00fajt a daganatellenes akt\u00edv vegy\u00fcletek sz\u0171r\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. This fungus is easily isolated from decaying plant bodies, soil, and air, and is a widely distributed plant and vegetable pathogenic fungus worldwide. There have […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nDiterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/trichothecium-roseum-diterpene\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. 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