{"id":3648,"date":"2024-08-02T15:59:52","date_gmt":"2024-08-02T15:59:52","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3648"},"modified":"2024-08-02T15:59:52","modified_gmt":"2024-08-02T15:59:52","slug":"seabuckthorn-flavone","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/seabuckthorn-flavone\/","title":{"rendered":"Mechanizmus vizsg\u00e1lat a homokt\u00f6vis flavonoidok kardioprotekt\u00edv hat\u00e1s\u00e1r\u00f3l a hossz\u00fa t\u00e1v\u00fa kimer\u00fclts\u00e9gi testmozg\u00e1s patk\u00e1nyain\u00e1l"},"content":{"rendered":"

Mechanizmus vizsg\u00e1lat a homokt\u00f6vis flavonoidok kardioprotekt\u00edv hat\u00e1s\u00e1r\u00f3l a hossz\u00fa t\u00e1v\u00fa kimer\u00fclts\u00e9gi testmozg\u00e1s patk\u00e1nyain\u00e1l
\nA kutat\u00e1sok meger\u0151s\u00edtett\u00e9k, hogy a m\u00e9rs\u00e9kelt testmozg\u00e1s j\u00f3indulat\u00fa v\u00e1ltoz\u00e1sokat id\u00e9zhet el\u0151 a sz\u00edv alakj\u00e1ban, szerkezet\u00e9ben \u00e9s m\u0171k\u00f6d\u00e9s\u00e9ben, de a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 testmozg\u00e1s negat\u00edv hat\u00e1ssal lehet a sz\u00edv- \u00e9s \u00e9rrendszerre, \u00e9s ak\u00e1r a sz\u00edvizomzat edz\u00e9s okozta k\u00e1rosod\u00e1s\u00e1hoz is vezethet. A folyamatos kimer\u00edt\u0151 edz\u00e9s sor\u00e1n megn\u0151 az endog\u00e9n reakt\u00edv oxig\u00e9nfajok (ROS) keletkez\u00e9se, ami korl\u00e1tozza a ROS ki\u00fcr\u00edt\u00e9s\u00e9nek k\u00e9pess\u00e9g\u00e9t. A t\u00falzott ROS a sz\u00edvizomsejtek diszfunkci\u00f3j\u00e1t, feh\u00e9rje- \u00e9s lipidperoxid\u00e1ci\u00f3t, valamint DNS-k\u00e1rosod\u00e1st id\u00e9z el\u0151. Ezenk\u00edv\u00fcl a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 testmozg\u00e1s sz\u00e9les k\u00f6r\u0171 gyullad\u00e1sos v\u00e1laszt induk\u00e1lhat a szervezetben, \u00e9s a gyullad\u00e1sos sejtek besziv\u00e1rg\u00e1sa a sz\u00edvizomsejtek struktur\u00e1lis \u00e9s funkcion\u00e1lis k\u00e1rosod\u00e1s\u00e1t okozhatja. A kimer\u00edt\u0151 testmozg\u00e1s \u00e1ltal kiv\u00e1ltott oxidat\u00edv stressz \u00e9s gyullad\u00e1sos v\u00e1lasz aktiv\u00e1lja a k\u00fcl\u00f6nb\u00f6z\u0151 sz\u00edvizom hipertr\u00f3fi\u00e1t jelz\u0151 kin\u00e1zokat \u00e9s transzkripci\u00f3s faktorokat, \u00e9s a DNS \u00e9s a mitokondriumok k\u00e1rosod\u00e1s\u00e1n, valamint a proapoptotikus jelek aktiv\u00e1l\u00e1s\u00e1n kereszt\u00fcl sejt apopt\u00f3zist induk\u00e1l. Egy tanulm\u00e1ny meg\u00e1llap\u00edtotta, hogy a 6 hetes kimer\u00edt\u0151 edz\u00e9s aktiv\u00e1lhatja a sz\u00edvizomsejtek apopt\u00f3zis programj\u00e1t \u00e9s felgyors\u00edthatja a sz\u00edvszerkezet funkcion\u00e1lis \"remodelling\" folyamat\u00e1t az\u00e1ltal, hogy felszab\u00e1lyozza a Bcl-2 asszoci\u00e1lt X feh\u00e9rje (Bax)\/B sejt iymphoma-2 g\u00e9n (Bcl-2) expresszi\u00f3s ar\u00e1ny\u00e1t patk\u00e1ny sz\u00edvizomsejtekben. Emellett vizsg\u00e1latok meger\u0151s\u00edtett\u00e9k, hogy a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 testmozg\u00e1s \u00e1ltal kiv\u00e1ltott extracellul\u00e1ris m\u00e1trix komponensek lerak\u00f3d\u00e1sa \u00e9s fibr\u00f3zisa szorosan \u00f6sszef\u00fcgghet a sejtek apopt\u00f3zis\u00e1val.<\/p>\n

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\nA homokt\u00f6vis az Elapidae csal\u00e1dba tartozik, \u00e9s K\u00edn\u00e1ban hagyom\u00e1nyos gy\u00f3gy- \u00e9s ehet\u0151 n\u00f6v\u00e9ny. Antioxid\u00e1ns, daganatellenes \u00e9s apopt\u00f3zisellenes hat\u00e1s\u00e1t sz\u00e9les k\u00f6rben igazolt\u00e1k. A homokt\u00f6vis legfontosabb akt\u00edv \u00f6sszetev\u0151i a homokt\u00f6vis flavonoidjai (SF). 50-250 \u03bc g\/ml SF jav\u00edthatja az eg\u00e9rsejtek fagocit\u00e1l\u00f3 k\u00e9pess\u00e9g\u00e9t, \u00e9s hat\u00e9konyan g\u00e1tolja az oxidat\u00edv stressz \u00e9s a gyullad\u00e1sos markerek keletkez\u00e9s\u00e9t a Raw 264.7 sejtekben; 4 g\/kg SF bead\u00e1sa aerob testmozg\u00e1ssal kombin\u00e1lva g\u00e1tolja a patk\u00e1ny hippokampusz sz\u00f6vet apopt\u00f3zis v\u00e1lasz\u00e1t. Jelenleg azonban hi\u00e1nyoznak a kutat\u00e1sok az SF kardioprotekt\u00edv hat\u00e1sair\u00f3l a hossz\u00fa t\u00e1v\u00fa kimer\u00fclt testmozg\u00e1st v\u00e9gz\u0151 patk\u00e1nyok eset\u00e9ben. Ennek alapj\u00e1n e tanulm\u00e1ny c\u00e9lja, hogy l\u00e9trehozza a terhel\u00e9s \u00e1ltal kiv\u00e1ltott sz\u00edvizomk\u00e1rosod\u00e1s patk\u00e1nymodellj\u00e9t hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 testmozg\u00e1s r\u00e9v\u00e9n, \u00e9s megvizsg\u00e1lja az SF beavatkoz\u00f3 hat\u00e1s\u00e1t a sz\u00edvizomk\u00e1rosod\u00e1sra a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 testmozg\u00e1st v\u00e9gz\u0151 patk\u00e1nyokn\u00e1l, annak \u00e9rdek\u00e9ben, hogy k\u00eds\u00e9rleti bizony\u00edt\u00e9kot szolg\u00e1ltasson a terhel\u00e9s \u00e1ltal kiv\u00e1ltott sz\u00edvizomk\u00e1rosod\u00e1s megel\u0151z\u00e9s\u00e9re \u00e9s rehabilit\u00e1ci\u00f3j\u00e1ra.<\/p>\n

A szisztematikus \u00e9s tudom\u00e1nyos edz\u00e9s j\u00f3t\u00e9kony adapt\u00edv v\u00e1ltoz\u00e1sokat id\u00e9zhet el\u0151 a sz\u00edvben, de a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 edz\u00e9s gyullad\u00e1sos reakci\u00f3k, oxidat\u00edv stresszreakci\u00f3k, a sejtek apopt\u00f3zis\u00e1nak aktiv\u00e1l\u00e1sa \u00e9s fibr\u00f3zis r\u00e9v\u00e9n k\u00e1ros hat\u00e1ssal lehet a sz\u00edvizomsz\u00f6vetre. Vannak kutat\u00e1sok, amelyek meger\u0151s\u00edtik, hogy a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 edz\u00e9s aktiv\u00e1lhatja a sz\u00edvizomsejtek oxidat\u00edv stresszv\u00e1lasz\u00e1t \u00e9s k\u00f6zvet\u00edtheti az apopt\u00f3zisprogramot. A ROS \u00e9s a kaszp\u00e1z-3 \u00fatvonalak aktiv\u00e1l\u00f3d\u00e1si folyamata szorosan \u00f6sszef\u00fcgg, ami mitokondri\u00e1lis k\u00e1rosod\u00e1st id\u00e9zhet el\u0151, \u00e9s a sz\u00edvizom mechanikai diszfunkci\u00f3j\u00e1hoz vezethet. Ek\u00f6zben a citokin felszabadul\u00e1s \u00e9s a neutrofil infiltr\u00e1ci\u00f3 \u00e1ltal kiv\u00e1ltott gyullad\u00e1sos v\u00e1lasz a sejtek apopt\u00f3zis\u00e1nak ind\u00edt\u00f3 t\u00e9nyez\u0151i lehetnek, \u00e9s az apopt\u00f3zis el\u0151fordul\u00e1sa a sz\u00f6veti gyullad\u00e1sos v\u00e1lasz s\u00falyosbod\u00e1s\u00e1nak felt\u00e9teleit is biztos\u00edtja. A kutat\u00e1sok azt tal\u00e1lt\u00e1k, hogy a sz\u00edvizom apopt\u00f3zis g\u00e9njeinek expresszi\u00f3s profilja megv\u00e1ltozik kimer\u00edt\u0151 edz\u00e9s ut\u00e1n, a sz\u00edvizom pro apoptotikus g\u00e9nek expresszi\u00f3j\u00e1nak \u00e9s a Bax\/Bcl-2 ar\u00e1nynak a jelent\u0151s felszab\u00e1lyoz\u00e1s\u00e1val. Hasonl\u00f3 eredm\u00e9nyeket figyelt\u00fcnk meg ebben a k\u00eds\u00e9rletben, ahol a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 edz\u00e9s az MDA, IL-1 \u03b2, IL-6, TNF - \u03b1 szintek, a kaszp\u00e1z-3, a Bax feh\u00e9rje expresszi\u00f3 \u00e9s a Bcl-2\/Bax ar\u00e1ny jelent\u0151s n\u00f6veked\u00e9s\u00e9hez vezetett a patk\u00e1nyok sz\u00edvizomzat\u00e1ban. A SOD, a GSH Px szintek \u00e9s a Bcl-2 feh\u00e9rje expresszi\u00f3ja szignifik\u00e1nsan cs\u00f6kkent, ami azt jelzi, hogy a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 edz\u00e9s fokozta az oxidat\u00edv stresszt \u00e9s a gyullad\u00e1sos v\u00e1laszokat, \u00e9s induk\u00e1lta a patk\u00e1ny sz\u00edvizom sz\u00f6veti apopt\u00f3zis programj\u00e1nak aktiv\u00e1l\u00f3d\u00e1s\u00e1t.<\/p>\n

A kutat\u00e1sok azt tal\u00e1lt\u00e1k, hogy a t\u00falzott fizikai ingerl\u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 \u00fatvonalakon kereszt\u00fcl sz\u00edvizom sz\u00f6veti fibr\u00f3zist induk\u00e1lhat, \u00e9s a sz\u00edvizom sz\u00f6veti apopt\u00f3zis\u00e1nak aktiv\u00e1l\u00e1sa felgyors\u00edthatja a kollag\u00e9nszint\u00e9zist \u00e9s a sz\u00edvizom fibr\u00f3zis\u00e1nak folyamat\u00e1t. A hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 edz\u00e9s el\u0151seg\u00edti a sz\u00edvizominfarktust \u00e9s a fibr\u00f3zist az\u00e1ltal, hogy mikrok\u00f6rnyezeti k\u00e1rosod\u00e1st (gyullad\u00e1s, sejt apopt\u00f3zis stb.) induk\u00e1l a szervezetben. A hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 testmozg\u00e1s pro-inflammatorikus citokinek, mint p\u00e9ld\u00e1ul a TNF - \u03b1 \u00e9s az intercellul\u00e1ris adh\u00e9zi\u00f3s molekula-1 expresszi\u00f3ja r\u00e9v\u00e9n sz\u00edvizom sz\u00f6veti gyullad\u00e1st induk\u00e1lhat patk\u00e1nyokban, ami a testmozg\u00e1s \u00e1ltal kiv\u00e1ltott sz\u00edvizom sz\u00f6veti szerkezeti mikrok\u00e1rosod\u00e1shoz \u00e9s pitvari fibr\u00f3zishoz vezet. A kimer\u00edt\u0151 testmozg\u00e1s \u00e1ltal kiv\u00e1ltott myocardialis oxidat\u00edv stresszv\u00e1lasz tov\u00e1bb induk\u00e1lhatja a myocardialis fibr\u00f3zist, de k\u00f6zvetlen bizony\u00edt\u00e9k jelenleg hi\u00e1nyzik. Emellett vizsg\u00e1latok azt tal\u00e1lt\u00e1k, hogy a 6 hetes kimer\u00edt\u0151 testmozg\u00e1s sz\u00edvizomfibr\u00f3zist \u00e9s fibroblaszt prolifer\u00e1ci\u00f3t induk\u00e1lhat a Bax\/Bcl-2 ar\u00e1ny felszab\u00e1lyoz\u00e1s\u00e1val a patk\u00e1nyok sz\u00edvizomsz\u00f6vet\u00e9ben \u00e9s a p38 MAPK\/Smad2\/3 jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1s\u00e1val. Ez a k\u00eds\u00e9rlet \u00f6sszhangban van a kor\u00e1bbi vizsg\u00e1latokkal. Hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 fut\u00f3szalagos edz\u00e9st haszn\u00e1ltunk a terhel\u00e9s okozta sz\u00edvizomk\u00e1rosod\u00e1s \u00e1llatmodellj\u00e9nek l\u00e9trehoz\u00e1s\u00e1ra. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 fut\u00f3g\u00e9pes edz\u00e9snek kitett patk\u00e1nyokn\u00e1l a sz\u00edvizomk\u00e1rosod\u00e1s sz\u00e9rum markereinek upregul\u00e1ci\u00f3ja, fokozott oxidat\u00edv stressz, gyullad\u00e1sos v\u00e1lasz \u00e9s sejt apopt\u00f3zis a sz\u00edvizomsz\u00f6vetben, valamint a sz\u00f6veti morfol\u00f3gia \u00e9s a fibr\u00f3zis v\u00e1ltoz\u00e1sai mutatkoztak.<\/p>\n

Jelenleg hi\u00e1nyoznak a kutat\u00e1sok az SF beavatkoz\u00e1si hat\u00e1s\u00e1r\u00f3l a terhel\u00e9s okozta sz\u00edvizomk\u00e1rosod\u00e1sra. Azonban a n\u00f6v\u00e9nyi eredet\u0171 flavonoid kivonatok n\u00e9h\u00e1ny mell\u00e9kes beavatkoz\u00e1si bizony\u00edt\u00e9ka azt mutatja, hogy a k\u00fcl\u00f6nb\u00f6z\u0151 n\u00f6v\u00e9nyi eredet\u0171 flavonoid kivonatoknak megel\u0151z\u0151 \u00e9s ter\u00e1pi\u00e1s hat\u00e1suk van a terhel\u00e9s okozta sz\u00edvizoms\u00e9r\u00fcl\u00e9sre. Ebben a k\u00eds\u00e9rletben a modellcsoporttal \u00f6sszehasonl\u00edtva az SF k\u00f6zepes \u00e9s magas d\u00f3zisai (200, 400 mg\/kg) hat\u00e9konyan cs\u00f6kkentett\u00e9k a sz\u00e9rum sz\u00edvizomk\u00e1rosod\u00e1si markereket patk\u00e1nyokn\u00e1l. Ugyanakkor a sz\u00edvizom HE-fest\u00e9se azt mutatta, hogy a k\u00f6zepes \u00e9s nagy d\u00f3zis\u00fa SF (200, 400 mg\/kg) hat\u00e9konyan enyh\u00edtette a sz\u00edvizomsz\u00f6vet morfol\u00f3giai k\u00e1rosod\u00e1s\u00e1t, amelyet a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 edz\u00e9s okozott. Jelenleg az SF antioxid\u00e1ns \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sa sz\u00e9les k\u00f6rben elismert, \u00e9s ez a tanulm\u00e1ny is al\u00e1t\u00e1masztja a kor\u00e1bbi kutat\u00e1si k\u00f6vetkeztet\u00e9seket. Ebben a vizsg\u00e1latban is meger\u0151s\u00edt\u00e9st nyert, hogy a 200 \u00e9s 400 mg\/(kg - d) SF kieg\u00e9sz\u00edt\u00e9s hat\u00e9konyan g\u00e1tolja az oxidat\u00edv stresszt, a gyullad\u00e1sos v\u00e1laszt \u00e9s a sz\u00e9rum sz\u00edvizomk\u00e1rosod\u00e1s marker kifejez\u0151d\u00e9s\u00e9t a sz\u00edvizomsz\u00f6vetben. A modellcsoporttal \u00f6sszehasonl\u00edtva, 100 mg\/kg SF bead\u00e1sa szint\u00e9n cs\u00f6kkentheti a gyullad\u00e1sos faktorok \u00e9s az oxidat\u00edv stressz szintj\u00e9t a hossz\u00fa t\u00e1v\u00fa kimer\u00fclt edz\u00e9sben l\u00e9v\u0151 patk\u00e1nyok sz\u00edvizomsz\u00f6vet\u00e9ben, de hat\u00e1sa nem szignifik\u00e1ns. A kutat\u00e1sok kimutatt\u00e1k, hogy a homokt\u00f6vis vizes kivonat g\u00e1tolja az apopt\u00f3zist \u00e9s el\u0151seg\u00edti a hum\u00e1n immortaliz\u00e1lt keratinocit\u00e1k prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben r\u00e9szt vesz a t\u00f6bbc\u00e9l\u00fa downstream apopt\u00f3zis jel\u00e1tviteli \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1ban is. Ezenk\u00edv\u00fcl a homokt\u00f6vis poliszacharidok or\u00e1lis bead\u00e1sa (200mg\/kg) g\u00e1tolja a m\u00e1jsejtek apopt\u00f3zis\u00e1t szeptikus induk\u00e1lt m\u00e1jk\u00e1rosod\u00e1sban szenved\u0151 egerekben, felszab\u00e1lyozza a peroxisz\u00f3ma prolifer\u00e1tor aktiv\u00e1lt receptor gamma \u00e9s a Bcl-2 expresszi\u00f3j\u00e1t szeptikus eg\u00e9r m\u00e1j\u00e1ban, \u00e9s szab\u00e1lyozza az NF - \u03ba B, Bax \u00e9s Caspase-3 expresszi\u00f3j\u00e1t.
\nEz a vizsg\u00e1lat meg\u00e1llap\u00edtotta, hogy az SF beavatkoz\u00e1s ut\u00e1n a kimer\u00fclt edz\u00e9sen \u00e1tesett patk\u00e1nyok sz\u00edvizomzat\u00e1ban a Caspase-3 \u00e9s Bax feh\u00e9rj\u00e9k expresszi\u00f3ja \u00e9s a Bcl-2\/Bax ar\u00e1ny jelent\u0151sen megn\u0151tt, m\u00edg a Bcl-2 feh\u00e9rje expresszi\u00f3ja jelent\u0151sen cs\u00f6kkent. Ez azt bizony\u00edtja, hogy az SF (100, 200, 400 mg\/(kg - d)) k\u00e9pes g\u00e1tolni a hossz\u00fa t\u00e1v\u00fa kimer\u00fclt testmozg\u00e1s \u00e1ltal kiv\u00e1ltott kardiomiocita apopt\u00f3zis v\u00e1laszt. A kutat\u00e1sok kimutatt\u00e1k, hogy a homokt\u00f6visb\u0151l sz\u00e1rmaz\u00f3 \u00f6sszes flavonoidok cs\u00f6kkenthetik a fibr\u00f3zissal kapcsolatos feh\u00e9rj\u00e9k kifejez\u0151d\u00e9s\u00e9t az\u00e1ltal, hogy g\u00e1tolj\u00e1k a gyullad\u00e1sos \u00e9s oxidat\u00edv stresszv\u00e1laszokat a ny\u00fal f\u00fcl hipertr\u00f3fi\u00e1s hegsz\u00f6vet\u00e9ben, ez\u00e1ltal cs\u00f6kkentik a fibroblasztok \u00e1talakul\u00e1s\u00e1nak hat\u00e9konys\u00e1g\u00e1t a fibrotikus sz\u00f6vetben \u00e9s g\u00e1tolj\u00e1k a hipertr\u00f3fi\u00e1s hegek progresszi\u00f3j\u00e1t. A flavonoid hat\u00f3anyagok felszab\u00e1lyozz\u00e1k a fibroblaszt n\u00f6veked\u00e9si faktor 21 feh\u00e9rje expresszi\u00f3j\u00e1t, g\u00e1tolj\u00e1k a transzform\u00e1ci\u00f3s n\u00f6veked\u00e9si faktor - \u03b2 1 jel\u00e1tviteli \u00fatvonalat, a sz\u00edvizomfibr\u00f3zis markerek CTGF, kollag\u00e9n-I \u00e9s kollag\u00e9n-III expresszi\u00f3j\u00e1nak downregul\u00e1ci\u00f3j\u00e1t induk\u00e1lj\u00e1k, ez\u00e1ltal cs\u00f6kkentik a sz\u00edvizomfibr\u00f3zist, az oxidat\u00edv stresszt \u00e9s a sejt apopt\u00f3zist, \u00e9s v\u00e9g\u00fcl jav\u00edtj\u00e1k a sz\u00edvm\u0171k\u00f6d\u00e9st sz\u00edvizomfibr\u00f3zisban szenved\u0151 egerekben. Hasonl\u00f3 eredm\u00e9nyeket kaptunk ebben a k\u00eds\u00e9rletben, ahol a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 testmozg\u00e1s jelent\u0151sen felszab\u00e1lyozta a CTGF \u00e9s a Kollag\u00e9n-I feh\u00e9rj\u00e9k expresszi\u00f3j\u00e1t a patk\u00e1nyok sz\u00edvizomsz\u00f6vet\u00e9ben, valamint a sz\u00edvizom sz\u00f6veti CVF-j\u00e9t. Az SF (100, 200, 400 mg\/(kg - d)) hat\u00e9konyan tudta g\u00e1tolni a sz\u00edvizom sz\u00f6veti fibr\u00f3zist.
\n\u00d6sszefoglalva, ez a tanulm\u00e1ny azt jelzi, hogy a 6 hetes folyamatos kimer\u00edt\u0151 edz\u00e9s oxidat\u00edv stresszt \u00e9s fokozott gyullad\u00e1sos v\u00e1laszt v\u00e1lt ki a patk\u00e1nyok sz\u00edvizomsz\u00f6vet\u00e9ben, ami sz\u00edvizomsejt apopt\u00f3zishoz \u00e9s fibr\u00f3zishoz vezet, ami sz\u00edvizomsz\u00f6veti k\u00e1rosod\u00e1st eredm\u00e9nyez. Az SF hat\u00e9konyan enyh\u00edtheti az oxidat\u00edv stresszt \u00e9s a gyullad\u00e1sos v\u00e1laszt a hossz\u00fa t\u00e1v\u00fa kimer\u00edt\u0151 testmozg\u00e1st v\u00e9gz\u0151 patk\u00e1nyok sz\u00edvizomsz\u00f6vet\u00e9ben, g\u00e1tolhatja a sz\u00edvizomsejt apopt\u00f3zist \u00e9s a fibr\u00f3zist, \u00e9s \u00edgy sz\u00edvizomv\u00e9d\u0151 hat\u00e1st fejt ki.<\/p>","protected":false},"excerpt":{"rendered":"

Mechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats Research has confirmed that moderate physical exercise can induce benign changes in the shape, structure, and function of the heart, but long-term exhaustive exercise may have negative effects on the cardiovascular system and even lead to exercise-induced myocardial injury. During continuous […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nMechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/seabuckthorn-flavone\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Mechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats Research has confirmed that moderate physical exercise can induce benign changes in the shape, structure, and function of the heart, but long-term exhaustive exercise may have negative effects on the cardiovascular system and even lead to exercise-induced myocardial injury. 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During continuous […]","og_url":"https:\/\/longchangextracts.com\/hu\/seabuckthorn-flavone\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-02T15:59:52+00:00","author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Szerz\u0151:":"longcha9","Becs\u00fclt olvas\u00e1si id\u0151":"7 perc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/seabuckthorn-flavone\/","url":"https:\/\/longchangextracts.com\/seabuckthorn-flavone\/","name":"Mechanizmus tanulm\u00e1ny a kardioprotekt\u00edv hat\u00e1sa homokt\u00f6vis flavonoidok a hossz\u00fa t\u00e1v\u00fa kimer\u00fclts\u00e9g gyakorlat patk\u00e1nyok - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"datePublished":"2024-08-02T15:59:52+00:00","dateModified":"2024-08-02T15:59:52+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/seabuckthorn-flavone\/#breadcrumb"},"inLanguage":"hu","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/seabuckthorn-flavone\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/seabuckthorn-flavone\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Mechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"K\u00edna Vegyi Gy\u00e1rt\u00f3","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/3648"}],"collection":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/comments?post=3648"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/3648\/revisions"}],"predecessor-version":[{"id":3655,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/3648\/revisions\/3655"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/media?parent=3648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/categories?post=3648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/tags?post=3648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}