{"id":3437,"date":"2024-06-28T02:31:09","date_gmt":"2024-06-28T02:31:09","guid":{"rendered":"https:\/\/pharm.sinocurechem.com\/?p=3437"},"modified":"2024-06-28T02:31:09","modified_gmt":"2024-06-28T02:31:09","slug":"comprehensive-overview-of-4-hydroxyphenylacetic-acid-properties-synthesis-applications-and-biological-activity","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/atfogo-attekintes-a-4-hidroxifenil-ecetsav-tulajdonsagairol-szinteziserol-alkalmazasairol-es-biologiai-aktivitasarol\/","title":{"rendered":"A 4-hidroxifenil-ecetsav \u00e1tfog\u00f3 \u00e1ttekint\u00e9se: Hicil\u00e9nhidrog\u00e9n-fenil\u00e9nhidrog\u00e9n-piril\u00e9n: Tulajdons\u00e1gok, szint\u00e9zis, alkalmaz\u00e1sok \u00e9s biol\u00f3giai aktivit\u00e1s"},"content":{"rendered":"

4-hidroxi-fenilecetsav<\/span><\/b><\/b><\/p>\n

Meghat\u00e1roz\u00e1s<\/span><\/b><\/b><\/p>\n

A 4-hidroxi-fenilecetsav (k\u00e9miai k\u00e9plet: C8H8O3, CAS-sz\u00e1m: 156-38-7) egy szerves vegy\u00fclet, amely a fenilecetsav sz\u00e1rmaz\u00e9ka. Molekulat\u00f6mege 152,15, olvad\u00e1spontja 148-151 \u00b0C, forr\u00e1spontja k\u00f6r\u00fclbel\u00fcl 234,6 \u00b0C, \u00e9s dimetil-szulfoxidban \u00e9s metanolban old\u00f3dik. Ezt a vegy\u00fcletet a vegyiparban sokf\u00e9lek\u00e9ppen alkalmazz\u00e1k, pl. \u00e9szterek szint\u00e9zis\u00e9nek alapanyagak\u00e9nt.<\/span><\/p>\n

A 4-hidroxifenil-ecetsav egy monokarbonsav, olyan ecetsav, amelyben az egyik metilvegy\u00fcletet 4-hidroxifenil helyettes\u00edti. N\u00f6v\u00e9nyi metabolit, gomb\u00e1k metabolitja, emberi metabolit \u00e9s eg\u00e9r metabolit. Monokarbonsav \u00e9s a fenolos csoportba tartozik. Az ecetsavb\u00f3l sz\u00e1rmazik. A 4-hidroxifenil-ecetsav konjug\u00e1lt sava. 4-hidroxifenil-ecetsav (4-HPAA) olyan vegy\u00fclet, amely a term\u00e9szetben sz\u00e1mos szervezetben, t\u00f6bbek k\u00f6z\u00f6tt n\u00f6v\u00e9nyekben, \u00e1llatokban \u00e9s emberekben fordul el\u0151. dopamin \u00e9s noradrenalin el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra haszn\u00e1lj\u00e1k. A dopamin \u00e9s a noradrenalin, k\u00e9t neurotranszmitter, a katabolizmus sor\u00e1n termeli ezt az esszenci\u00e1lis metabolitot. Funkcion\u00e1lisan az ecetsavval \u00e1ll rokons\u00e1gban. A 4-hidroxifenil-ecetsav konjug\u00e1tja.<\/span><\/p>\n

A 4-hidroxifenil-ecetsav term\u00e9szetes term\u00e9k, amely megtal\u00e1lhat\u00f3 az Epichloe typhina, az Oenothera glazioviana \u00e9s m\u00e1s olyan szervezetekben, amelyekr\u0151l adatok \u00e1llnak rendelkez\u00e9sre.A 4-hidroxifenil-ecetsav a s\u00f6r\u00e9leszt\u0151ben tal\u00e1lhat\u00f3 vagy az \u00e1ltal termelt metabolit.<\/span><\/p>\n

A 4-hidroxi-fenilecetsav biol\u00f3giai tev\u00e9kenys\u00e9gek sz\u00e9les sk\u00e1l\u00e1j\u00e1val rendelkezik, \u00e9s potenci\u00e1lis gy\u00f3gy\u00e1szati \u00e9rt\u00e9kkel b\u00edr\u00f3 vegy\u00fcletnek tekintik. Az \u00e9lelmiszeriparban is felhaszn\u00e1lhat\u00f3, p\u00e9ld\u00e1ul \u00e9lelmiszer-adal\u00e9kanyagok prekurzorak\u00e9nt. Ezenk\u00edv\u00fcl analitikai standardk\u00e9nt haszn\u00e1lj\u00e1k a k\u00f6rnyezettudom\u00e1nyokban a k\u00f6rnyezetszennyez\u0151 anyagok viselked\u00e9s\u00e9nek \u00e9s hat\u00e1sainak kimutat\u00e1s\u00e1ra \u00e9s tanulm\u00e1nyoz\u00e1s\u00e1ra.<\/span><\/p>\n

A 4-hidroxifenil-ecetsav szint\u00e9n fontos szerepet j\u00e1tszik a gy\u00f3gyszerfejleszt\u00e9sben. A gy\u00f3gyszerszint\u00e9zisben k\u00f6ztes term\u00e9kk\u00e9nt haszn\u00e1lj\u00e1k sz\u00e1mos gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s antioxid\u00e1ns gy\u00f3gyszer el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz. A hidroxilcsoport jelenl\u00e9te a szerkezet\u00e9ben igen akt\u00edvv\u00e1 teszi a k\u00e9miai szint\u00e9zisben, \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 k\u00e9miai reakci\u00f3k r\u00e9v\u00e9n k\u00fcl\u00f6nb\u00f6z\u0151 vegy\u00fcletekk\u00e9 alak\u00edthat\u00f3.<\/span><\/p>\n

Szint\u00e9zis<\/span><\/b><\/b><\/p>\n

A 4-hidroxi-fenilecetsavat (4HPAA) a 4-hidroximandelinsav (4-hidroximandelinsav) elemi foszforral \u00e9s j\u00f3ddal t\u00f6rt\u00e9n\u0151 redukci\u00f3j\u00e1val nyerik.<\/span><\/p>\n

A 4HPAA jelenleg csak k\u00e9miai \u00faton \u00e1ll\u00edthat\u00f3 el\u0151, de ez a m\u00f3dszer hajlamos a k\u00f6rnyezetszennyez\u00e9sre \u00e9s a kem\u00e9ny reakci\u00f3k\u00f6r\u00fclm\u00e9nyekre.<\/span><\/p>\n

A mikrobi\u00e1lis sejtgy\u00e1rak haszn\u00e1lata \u00faj gondolkod\u00e1sm\u00f3dot jelentene a 4HPAA el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra, valamint k\u00edv\u00e1natosabb \u00e9s fenntarthat\u00f3bb m\u00f3dszer lenne. A \"Combining Directed Evolution of Pathway Enzymes and Dynamic Pathway Regulation Using Quorum Sensing Circuits to Enhance 4-Hydroxyphenylacetic Acid Production in Escherichia coli\" c\u00edm\u0171 tanulm\u00e1nyban a tud\u00f3sok egy mikrobi\u00e1lis bioszint\u00e9zis rendszert hoztak l\u00e9tre a 4HPAA el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra gl\u00fck\u00f3z felhaszn\u00e1l\u00e1s\u00e1val E. coli-ban.<\/span><\/p>\n

A 4- hidroximandelinsav a 4-hidroximandelinsav elemi foszforral \u00e9s j\u00f3ddal t\u00f6rt\u00e9n\u0151 redukci\u00f3j\u00e1val nyerhet\u0151.<\/span><\/p>\n

K\u00e9miai tulajdons\u00e1gok <\/span><\/b><\/b><\/p>\n

Megjelen\u00e9s \u00e9s tulajdons\u00e1gok Feh\u00e9r vagy enyh\u00e9n s\u00e1rga krist\u00e1lyos por.<\/span><\/p>\n

Szublim\u00e1l\u00f3dhat. Old\u00f3dik \u00e9terben, etanolban, etil-acet\u00e1tban.<\/span><\/p>\n

Olvad\u00e1spont 148-151 \u00b0C (lit.)<\/span><\/p>\n

forr\u00e1spont 234,6 \u00b0C (durva becsl\u00e9s)<\/span><\/p>\n

S\u0171r\u0171s\u00e9g 1,2143 (durva becsl\u00e9s)<\/span><\/p>\n

G\u0151znyom\u00e1s 0,007 Pa 25 \u00b0C-on<\/span><\/p>\n

T\u00f6r\u00e9smutat\u00f3 1,4945 (becsl\u00e9s)<\/span><\/p>\n

T\u00e1rol\u00e1si felt\u00e9tel Inert atmoszf\u00e9ra, szobah\u0151m\u00e9rs\u00e9klet<\/span><\/p>\n

Oldhat\u00f3s\u00e1g 50g\/liter<\/span><\/p>\n

Savass\u00e1gi egy\u00fctthat\u00f3 (pKa) 4,50\u00b10,10 (el\u0151rejelzett)<\/span><\/p>\n

Form\u00e1jaKrist\u00e1lyos por<\/span><\/p>\n

Sz\u00edn A feh\u00e9rt\u0151l a kr\u00e9msz\u00edn\u0171ig vagy vil\u00e1gosbarna sz\u00ednig<\/span><\/p>\n

PH \u00e9rt\u00e9k 2,0-2,4 (30g\/l, H2O, 20\u2103)<\/span><\/p>\n

Dimetil-szulfoxidban \u00e9s metanolban old\u00f3dik. V\u00edzben enyh\u00e9n old\u00f3dik.<\/span><\/p>\n

Fizikai-k\u00e9miai tulajdons\u00e1gok<\/span><\/b><\/b><\/p>\n

V\u00edzb\u0151l kicsapva feh\u00e9r, t\u0171szer\u0171 krist\u00e1lyok. Relat\u00edv molekulat\u00f6mege 152,15, olvad\u00e1spontja 149\uff5e<\/span>151\u2103. Szublim\u00e1l\u00f3dhat. Hideg v\u00edzben nehezen old\u00f3dik, forr\u00f3 v\u00edzben, \u00e9terben, etanolban \u00e9s etil-acet\u00e1tban old\u00f3dik. A P-hidroxi-fenilecetsav lil\u00e1s-z\u00f6ld csapad\u00e9kot k\u00e9pez, ha vas-kloriddal tal\u00e1lkozik. Gy\u00f3gyszeripari nyersanyagk\u00e9nt haszn\u00e1lj\u00e1k, cefalosporin antibiotikus gy\u00f3gyszerek, l\u00e1z- \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3k stb. el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz; n\u00f6v\u00e9nyv\u00e9d\u0151szer-nyersanyagk\u00e9nt, piretroid rovar\u00f6l\u0151 szerek el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz; fluoreszcens reagensk\u00e9nt haszn\u00e1lj\u00e1k oxidat\u00edv enzimek meghat\u00e1roz\u00e1s\u00e1ra; k\u00f6ztes term\u00e9kek a szerves szint\u00e9zisben. A 4-hidroxi-benzol-ecetsav feh\u00e9r vagy kr\u00e9mfeh\u00e9r vagy vil\u00e1gosbarna krist\u00e1lyos por. Hideg v\u00edzben nem old\u00f3dik, forr\u00f3 v\u00edzben, \u00e9terben, etanolban \u00e9s etil-acet\u00e1tban old\u00f3dik. Ha vas-klorid, akkor lil\u00e1s-z\u00f6ld csapad\u00e9k.<\/span><\/span><\/p>\n

Megjelen\u00e9s \u00e9s tulajdons\u00e1gok: A 4-hidroxi-fenilecetsav feh\u00e9r vagy enyh\u00e9n s\u00e1rg\u00e1s sz\u00edn\u0171 krist\u00e1lyos por, amely szublim\u00e1lhat\u00f3. \u00c9terben, etanolban \u00e9s etil-acet\u00e1tban old\u00f3dik.<\/span><\/p>\n

S\u0171r\u0171s\u00e9g \u00e9s g\u0151znyom\u00e1s: A s\u0171r\u0171s\u00e9g k\u00f6r\u00fclbel\u00fcl 1,2143, a g\u0151znyom\u00e1s pedig k\u00f6r\u00fclbel\u00fcl 0,007 Pa 25 \u00b0C-on.<\/span><\/p>\n

T\u00c1ROL\u00c1SI FELT\u00c9TELEK \u00c9S OLYAMOSS\u00c1G: A legjobb szobah\u0151m\u00e9rs\u00e9kleten, inert l\u00e9gk\u00f6rben t\u00e1rolni. Oldhat\u00f3s\u00e1ga k\u00f6r\u00fclbel\u00fcl 50 g\/liter.<\/span><\/p>\n

Biol\u00f3giai aktivit\u00e1s<\/span><\/b><\/b><\/p>\n

4-<\/span>A hidroxifenil-ecetsav (p-hidroxifenil-ecetsav, parahidroxifenil-acet\u00e1t) az ol\u00edvaolajban \u00e9s a s\u00f6rben tal\u00e1lhat\u00f3 vegy\u00fclet, amelyet az atenolol \u00e9s a 3,4-hidroxifenil-ecetsav szint\u00e9zis\u00e9ben k\u00e9miai intermedierk\u00e9nt haszn\u00e1lnak. dihidroxifenil-ecetsav.<\/span><\/p>\n

A 4-hidroxifenil-ecetsavr\u00f3l meg\u00e1llap\u00edtott\u00e1k, hogy gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s zs\u00edrm\u00e1j-ellenes hat\u00e1ssal rendelkezik, \u00e9s a b\u00e9lmikrob\u00e1k \u00e1ltal arom\u00e1s aminosavakk\u00e1 \u00e9s polifenolokk\u00e1 metaboliz\u00e1lhat\u00f3. Emellett a vizsg\u00e1latok kimutatt\u00e1k, hogy a 4-hidroxi-fenilecetsav a katecholamin neurotranszmitter rendszer modul\u00e1ci\u00f3j\u00e1n kereszt\u00fcl hat, de a specifikus hat\u00e1smechanizmusa m\u00e9g nem teljesen tiszt\u00e1zott.<\/span><\/p>\n

Gy\u00e1rt\u00e1si m\u00f3dszer<\/span><\/b><\/b><\/p>\n

A p-aminofenil-ecetsav diazot\u00e1l\u00e1s\u00e1val \u00e9s hidrol\u00edzis\u00e9vel nyerik. K\u00e9sz\u00edts\u00fcnk p-aminofenil-ecetsavat l\u00fagos oldattal n\u00e1triums\u00f3 k\u00e9pz\u0151d\u00e9s\u00e9hez, majd adjunk hozz\u00e1 k\u00e9nsavat. Hideg 0 \u2103-ra, szab\u00e1lyozza a h\u0151m\u00e9rs\u00e9kletet 0-5 \u2103 cseppenk\u00e9nt hozz\u00e1ad\u00e1s\u00e1val n\u00e1trium-nitr\u00e1t oldat, plusz diplom\u00e1s reakci\u00f3 0,5h. A kapott diazo oldatot cseppenk\u00e9nt adtuk hozz\u00e1 h\u00edg\u00edtott k\u00e9nsavhoz 90-95 \u2103-on, kb. 1h csepp, majd folytassuk a reakci\u00f3t 1h-ig. A reakci\u00f3oldatot elsz\u00edntelen\u00edtett\u00fck \u00e9s sz\u0171rt\u00fck, leh\u0171t\u00f6tt\u00fck \u00e9s etil-acet\u00e1ttal extrah\u00e1ltuk, \u00e9s a k\u00e9szterm\u00e9ket az etil-acet\u00e1tb\u00f3l kinyert kivonat ut\u00e1n kaptuk. A hozam kb. 85%.2.3-Fluoro-p-hidroxi-fenilecetsav.<\/span><\/p>\n

Felhaszn\u00e1l\u00e1sok<\/span><\/b><\/b><\/p>\n

Az iparban a 4-hidroxifenil-ecetsav k\u00f6ztes term\u00e9k az atenolol, a 3,4-dihidroxifenil-ecetsav \u00e9s a kokain szint\u00e9zis\u00e9ben.<\/span><\/p>\n

A hidroxifenil-ecetsav (4HPAA) fontos alapanyag gy\u00f3gyszerek, peszticidek \u00e9s biok\u00e9miai term\u00e9kek szint\u00e9zis\u00e9hez. Felhaszn\u00e1lhat\u00f3 v\u00e9rnyom\u00e1scs\u00f6kkent\u0151 gy\u00f3gyszerek (Atenolol), sz\u00edv- \u00e9s \u00e9rrendszeri gy\u00f3gyszerek (Metoprolol \u00e9s Betaxolol), valamint antidepressz\u00e1nsok, gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3 gy\u00f3gyszerek, antibiotikumok stb. szint\u00e9zis\u00e9ben. Az \u00faj gy\u00f3gyszer, a 4,7-dihidroxiizoflavonok szint\u00e9zis\u00e9nek k\u00f6ztes term\u00e9ke, \u00e9s peszticid intermedierk\u00e9nt is felhaszn\u00e1lhat\u00f3.<\/span><\/p>\n

A polimerek \u00e9s a folyad\u00e9kkrist\u00e1lyos anyagok eset\u00e9ben is relev\u00e1ns alkalmaz\u00e1sokat k\u00edn\u00e1l. A Rhodiola rosea glikozidok hat\u00f3anyaga is, gyullad\u00e1scs\u00f6kkent\u0151, daganatellenes, szorong\u00e1scs\u00f6kkent\u0151, v\u00e9rlemezke- \u00e9s m\u00e1jv\u00e9d\u0151 hat\u00e1s\u00fa. Ezenk\u00edv\u00fcl a 4-hidroxifenil-ecetsav fenol- \u00e9s amin-acil\u00e1l\u00e1shoz haszn\u00e1lt reagens.<\/span><\/p>\n

B\u00e1r a 4-hidroxifenil-ecetsav pontos hat\u00e1smechanizmusa m\u00e9g nem teljesen tiszt\u00e1zott, a jelenlegi kutat\u00e1sok szerint a katekolamin neurotranszmitter-rendszer modul\u00e1l\u00e1s\u00e1val hat.<\/span><\/p>\n

Alkalmaz\u00e1sok: <\/span><\/p>\n

1.\u00a0<\/span>Gy\u00f3gyszeripari nyersanyagk\u00e9nt felhaszn\u00e1lva Gy\u00f3gyszeripari nyersanyagk\u00e9nt felhaszn\u00e1lva, pl. az \"indometacin\" \u00e9s az \"indolpiperidin\" el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz.<\/span><\/p>\n

2.\u00a0<\/span>Gy\u00f3gyszeripari nyersanyagk\u00e9nt, p\u00e9ld\u00e1ul cefalosporin antibiotikus gy\u00f3gyszerek, l\u00e1zcsillap\u00edt\u00f3 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3 gy\u00f3gyszerek el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra haszn\u00e1lj\u00e1k.<\/span><\/p>\n

3.\u00a0<\/span>Peszticid-alapanyagok, amelyeket piretroid rovar\u00f6l\u0151 szerek el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz haszn\u00e1lnak.<\/span><\/p>\n

4.\u00a0<\/span>Az oxid\u00e1z fluoreszcens reagens meghat\u00e1roz\u00e1s\u00e1ra szolg\u00e1l.<\/span><\/p>\n

5.\u00a0<\/span>Szerves szint\u00e9zis intermedierek, amelyeket az atenolol \u00e9s a 3,4-dihidroxi-fenilecetsav szint\u00e9zis\u00e9ben haszn\u00e1lnak.<\/span><\/p>\n

6.\u00a0<\/span>Gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s zs\u00edrm\u00e1j-ellenes hat\u00e1ssal rendelkezik, \u00e9s a b\u00e9lben \u00e9l\u0151 mikroorganizmusok \u00e1ltal arom\u00e1s aminosavak \u00e9s polifenolos vegy\u00fcletekk\u00e9 metaboliz\u00e1lhat\u00f3.<\/span><\/p>\n

Alkalmaz\u00e1si ter\u00fcletek:<\/span><\/p>\n

Ez a k\u00f6ztes term\u00e9k az \u00faj gy\u00f3gyszer, a 4,7-dihidroxi-izoflavon szint\u00e9zis\u00e9hez, \u00e9s peszticid intermedierk\u00e9nt is haszn\u00e1lhat\u00f3.<\/span><\/p>\n

Szerves szint\u00e9zis intermedierek, amelyeket a \u03b2-blokkol\u00f3 atenolol \u00e9s a Pueraria Mirifica sz\u00f3ja glikozid yuan hat\u00f3anyag -4,7-dihidroxi-izoflavon szint\u00e9zis el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz haszn\u00e1lnak; peszticid intermedierk\u00e9nt is felhaszn\u00e1lhat\u00f3.<\/span><\/p>\n

Szerves szint\u00e9zis. Szerves szint\u00e9zis intermedierek, amelyeket a \u03b2-blokkol\u00f3 atenolol \u00e9s a Pueraria lobata glikozidok hat\u00f3anyag\u00e1nak el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz haszn\u00e1lnak...<\/span><\/p>\n

Az ol\u00edvaolajban tal\u00e1lhat\u00f3 vegy\u00fclet. Fontos finomk\u00e9miai k\u00f6ztes term\u00e9k, sz\u00e9lesk\u00f6r\u0171 alkalmaz\u00e1si fejleszt\u00e9si kil\u00e1t\u00e1sokkal.<\/span><\/p>\n

Fenolok \u00e9s aminok acilez\u00e9si reagensek\u00e9nt haszn\u00e1lj\u00e1k. Oxid\u00e1z fluoreszcenci\u00e1s meghat\u00e1roz\u00e1s\u00e1ra is haszn\u00e1lhat\u00f3.<\/span><\/p>\n

Gy\u00f3gyszeripari nyersanyagk\u00e9nt haszn\u00e1lj\u00e1k cefalosporin antibiotikumok, l\u00e1z- \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3k szint\u00e9zis\u00e9hez.<\/span><\/p>\n

A 4-hidroxifenil-ecetsav szint\u00e9n megmutatta jelent\u0151s\u00e9g\u00e9t a gy\u00f3gyszerfejleszt\u00e9sben. A gy\u00f3gyszerszint\u00e9zisben k\u00f6ztes term\u00e9kk\u00e9nt haszn\u00e1lhat\u00f3 sz\u00e1mos gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s antioxid\u00e1ns gy\u00f3gyszer el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz. A hidroxilcsoport jelenl\u00e9te a szerkezet\u00e9ben igen akt\u00edvv\u00e1 teszi a k\u00e9miai szint\u00e9zisben, \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 k\u00e9miai reakci\u00f3k r\u00e9v\u00e9n k\u00fcl\u00f6nb\u00f6z\u0151 vegy\u00fcletekk\u00e9 alak\u00edthat\u00f3.<\/span><\/p>\n

Alkalmaz\u00e1sok: Gy\u00f3gyszeripari nyersanyagk\u00e9nt haszn\u00e1lj\u00e1k Gy\u00f3gyszeripari nyersanyagk\u00e9nt haszn\u00e1lj\u00e1k, pl. az \"indometacin\" \u00e9s az \"indolpiperidin\" el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz.<\/span><\/p>\n

Gy\u00f3gyszeripari nyersanyagk\u00e9nt, p\u00e9ld\u00e1ul cefalosporin antibiotikus gy\u00f3gyszerek, l\u00e1zcsillap\u00edt\u00f3 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3 gy\u00f3gyszerek el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra haszn\u00e1lj\u00e1k.<\/span><\/p>\n

Peszticid-alapanyagok, amelyeket piretroid rovar\u00f6l\u0151 szerek el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz haszn\u00e1lnak.<\/span><\/p>\n

Az oxid\u00e1z fluoreszcens reagens meghat\u00e1roz\u00e1s\u00e1ra szolg\u00e1l.<\/span><\/p>\n

Szerves szint\u00e9zis intermedierek, amelyeket az atenolol \u00e9s a 3,4-dihidroxi-fenilecetsav szint\u00e9zis\u00e9ben haszn\u00e1lnak.<\/span><\/p>\n

Gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s zs\u00edrm\u00e1jv\u00e9d\u0151 hat\u00e1ssal rendelkezik, \u00e9s a b\u00e9lben \u00e9l\u0151 mikroorganizmusok \u00e1ltal arom\u00e1s aminosavak \u00e9s polifenolos vegy\u00fcletekk\u00e9 metaboliz\u00e1lhat\u00f3.<\/span><\/p>\n

A gy\u00f3gyszeripari alkalmaz\u00e1sokon k\u00edv\u00fcl a 4-hidroxi-fenilecetsav a polimerekben \u00e9s a folyad\u00e9kkrist\u00e1lyos anyagokban is fontos felhaszn\u00e1l\u00e1si ter\u00fclet. Ezenk\u00edv\u00fcl a Rhodiola rosea glikozidok hat\u00f3anyaga, amelyeket K\u00edn\u00e1ban sz\u00e9les k\u00f6rben alkalmaznak t\u00fcd\u0151betegs\u00e9gek, hepatitis B v\u00edrusfert\u0151z\u00e9sek \u00e9s r\u00e1k kezel\u00e9s\u00e9re. A 4-hidroxi-fenilecetsavat fenolok \u00e9s aminok acilez\u00e9s\u00e9re, valamint enzimek fluoreszcenci\u00e1s meghat\u00e1roz\u00e1s\u00e1ra szolg\u00e1l\u00f3 reagensk\u00e9nt is haszn\u00e1lj\u00e1k.<\/span><\/p>\n

A 4-hidroxifenil-ecetsav (4-hidroxifenil-ecetsav) egy ecetsavsz\u00e1rmaz\u00e9k, amelyet fenolok \u00e9s aminok acilez\u00e9s\u00e9re haszn\u00e1lnak. Ez az Aster tataricus k\u00ednai gy\u00f3gyn\u00f6v\u00e9ny hat\u00f3anyaga, amelyet K\u00edn\u00e1ban sz\u00e9les k\u00f6rben alkalmaznak t\u00fcd\u0151betegs\u00e9gek, HBV \u00e9s r\u00e1k kezel\u00e9s\u00e9re.<\/span><\/p>\n

Az aminosav-anyagcsere akt\u00edv metabolitja. Azt is kimutatt\u00e1k, hogy cs\u00f6kkenti a gyullad\u00e1st \u00e9s az \u00f6d\u00e9m\u00e1t az\u00e1ltal, hogy g\u00e1tolja a HIF-1\u03b1 hipert\u00f3nia \u00e9s hipoxia \u00e1ltal kiv\u00e1ltott indukci\u00f3j\u00e1t tengerv\u00edz-aspir\u00e1ci\u00f3 okozta t\u00fcd\u0151s\u00e9r\u00fcl\u00e9sben patk\u00e1nyokban.<\/span><\/p>\n

Elk\u00e9sz\u00edt\u00e9si m\u00f3d<\/span><\/b><\/b><\/p>\n

A 4-hidroxi-fenilecetsavat a 4-aminofenilecetsav diazot\u00e1l\u00e1s\u00e1val \u00e9s hidrol\u00edzis\u00e9vel szintetiz\u00e1lt\u00e1k.<\/span><\/p>\n

A n\u00e1triums\u00f3 el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz 4-aminofenil-ecetsavat \u00e9s b\u00e1zisoldatot k\u00e9sz\u00edtett\u00fcnk, majd k\u00e9nsavat adtunk hozz\u00e1. A reakci\u00f3t 0 \u00b0C-ra h\u0171t\u00f6tt\u00fck, 0-5 \u00b0C-on szab\u00e1lyoztuk, majd cseppenk\u00e9nt n\u00e1trium-nitr\u00e1toldatot adtunk hozz\u00e1, \u00e9s a reakci\u00f3 0,5 \u00f3ra alatt befejez\u0151d\u00f6tt.<\/span><\/p>\n

A kapott diaz\u00f3t 90-95 \u00b0C-on cseppenk\u00e9nt h\u00edg k\u00e9nsavhoz adtuk, \u00e9s kb. 1 \u00f3r\u00e1n \u00e1t reag\u00e1ltattuk. A reakci\u00f3t 1 \u00f3r\u00e1n \u00e1t folytattuk, a reakci\u00f3oldatot elsz\u00edntelen\u00edtett\u00fck \u00e9s sz\u0171rt\u00fck.<\/span><\/p>\n

A reakci\u00f3oldatot elsz\u00edntelen\u00edtett\u00fck \u00e9s lesz\u0171rt\u00fck, leh\u0171t\u00f6tt\u00fck \u00e9s etil-acet\u00e1ttal extrah\u00e1ltuk, majd a kivonatot etil-acet\u00e1ttal visszanyert\u00fck, \u00e9s 4-hidroxifenil-ecetsavat kaptunk. A hozam k\u00f6r\u00fclbel\u00fcl 85% volt.<\/span><\/p>\n

A k\u00e9miai szint\u00e9zis mellett a megl\u00e9v\u0151 kutat\u00e1sok azt sugallj\u00e1k, hogy a 4-hidroxifenil-ecetsav el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz a mikrobi\u00e1lis sejtgy\u00e1rak haszn\u00e1lata el\u0151ny\u00f6sebb \u00e9s fenntarthat\u00f3 megk\u00f6zel\u00edt\u00e9s. A \"A 4-hidroxi-fenilecetsav termel\u00e9s\u00e9nek fokoz\u00e1sa Escherichia coli-ban az \u00fatvonal enzimek ir\u00e1ny\u00edtott evol\u00faci\u00f3j\u00e1val \u00e9s dinamikus \u00fatvonal-szab\u00e1lyoz\u00e1ssal popul\u00e1ci\u00f3\u00e9rz\u00e9kel\u0151 \u00e1ramk\u00f6r\u00f6k seg\u00edts\u00e9g\u00e9vel\" c\u00edm\u0171 tanulm\u00e1nyban a tud\u00f3sok egy mikrobi\u00e1lis bioszintetikus rendszert hoztak l\u00e9tre a 4-hidroxi-fenilecetsav termel\u00e9s\u00e9re Escherichia coli-ban gl\u00fck\u00f3z felhaszn\u00e1l\u00e1s\u00e1val.<\/span><\/p>\n

Biztons\u00e1gi adatok.<\/span><\/b><\/b><\/p>\n

B\u0151rirrit\u00e1ci\u00f3t, s\u00falyos szemirrit\u00e1ci\u00f3t \u00e9s az OSHA HCS besorol\u00e1sa szerint egyszeri expoz\u00edci\u00f3val j\u00e1r\u00f3 specifikus c\u00e9lszervi toxicit\u00e1st (l\u00e9gz\u0151szervi) okozhat.<\/span><\/p>\n

K\u00f6rnyezeti hat\u00e1sok.<\/span><\/b><\/b><\/p>\n

4-<\/span>A hidroxifenil-ecetsav az antioxid\u00e1ns hat\u00e1sban r\u00e9szt vev\u0151 egyik f\u0151 mikrobi\u00e1lis metabolit.<\/span><\/p>\n

Az OSHA HCS besorol\u00e1sa szerint a 4-hidroxifenil-ecetsav b\u0151rirrit\u00e1ci\u00f3t, s\u00falyos szemirrit\u00e1ci\u00f3t \u00e9s egyszeri expoz\u00edci\u00f3val j\u00e1r\u00f3 specifikus c\u00e9lszervi toxicit\u00e1st (l\u00e9gz\u0151szervi) okozhat. Ezenk\u00edv\u00fcl fontos szerepet j\u00e1tszik a mikrobi\u00e1lis anyagcser\u00e9ben, r\u00e9szt vesz az antioxid\u00e1ns v\u00e1laszokban \u00e9s induk\u00e1lja az Nrf2.c expresszi\u00f3j\u00e1t.<\/span><\/p>","protected":false},"excerpt":{"rendered":"

4-hidroxi-fenilecetsav Meghat\u00e1roz\u00e1s A 4-hidroxi-fenilecetsav (k\u00e9miai k\u00e9plet: C8H8O3, CAS-sz\u00e1m: 156-38-7) egy szerves vegy\u00fclet, amely a fenilecetsav sz\u00e1rmaz\u00e9ka. Molekulat\u00f6mege 152,15, olvad\u00e1spontja 148-151 \u00b0C, forr\u00e1spontja k\u00f6r\u00fclbel\u00fcl 234,6 \u00b0C, \u00e9s dimetil-szulfoxidban \u00e9s metanolban old\u00f3dik. Ez a vegy\u00fclet sz\u00e9les [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nComprehensive Overview of 4-Hydroxyphenylacetic Acid: Properties, Synthesis, Applications, and Biological Activity - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/atfogo-attekintes-a-4-hidroxifenil-ecetsav-tulajdonsagairol-szinteziserol-alkalmazasairol-es-biologiai-aktivitasarol\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comprehensive Overview of 4-Hydroxyphenylacetic Acid: Properties, Synthesis, Applications, and Biological Activity - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"4-Hydroxyphenylacetic acid Definition 4-Hydroxyphenylacetic acid (chemical formula: C8H8O3, CAS No. 156-38-7) is an organic compound that is a derivative of phenylacetic acid. 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