{"id":3434,"date":"2024-06-27T01:15:30","date_gmt":"2024-06-27T01:15:30","guid":{"rendered":"https:\/\/pharm.sinocurechem.com\/?p=3434"},"modified":"2024-06-27T01:15:30","modified_gmt":"2024-06-27T01:15:30","slug":"benzylacetone-properties-applications-and-production-methods","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/benzylacetone-properties-applications-and-production-methods\/","title":{"rendered":"Benzilaceton: Benzolbenzol: Tulajdons\u00e1gok, alkalmaz\u00e1sok \u00e9s gy\u00e1rt\u00e1si m\u00f3dszerek"},"content":{"rendered":"

Benzilaceton: Benzolbenzol: Tulajdons\u00e1gok, alkalmaz\u00e1sok \u00e9s gy\u00e1rt\u00e1si m\u00f3dszerek<\/span><\/b><\/b><\/p>\n

Benzilaceton<\/span><\/b>\u00a0<\/span><\/b>2550-26-7<\/span><\/b><\/b><\/p>\n

A benzilaceton (IUPAC-n\u00e9v: 4-fenilbut\u00e1n-2-on) egy \u00e9des vir\u00e1gillat\u00fa folyad\u00e9k, amelyet a vir\u00e1gok (pl. a pr\u00e9rifarkasdoh\u00e1ny, Nicotiana attenuata) legnagyobb mennyis\u00e9gben el\u0151fordul\u00f3 vonz\u00f3 vegy\u00fclet\u00e9nek tartanak, \u00e9s a kaka\u00f3 egyik ill\u00e9kony \u00f6sszetev\u0151je. A dinnyel\u00e9gy (Bactrocera cucurbitae) csalogat\u00f3anyagak\u00e9nt, valamint illatanyagk\u00e9nt haszn\u00e1lj\u00e1k parf\u00fcm\u00f6kben \u00e9s szappanokban.<\/span>.<\/span><\/p>\n

A benzil-aceton k\u00e9miai tulajdons\u00e1gai<\/span><\/b><\/b><\/p>\n

Megjelen\u00e9s: sz\u00edntelen folyad\u00e9k. \u00c9des vir\u00e1gillat.<\/span><\/p>\n

V\u00edzben val\u00f3 oldhat\u00f3s\u00e1g: csek\u00e9ly<\/span><\/b><\/p>\n

Olvad\u00e1spont:-13\u00b0C<\/span><\/p>\n

Forr\u00e1spont: 235 \u00b0C (lit.)<\/span><\/p>\n

S\u0171r\u0171s\u00e9g:0,989 g\/ml 25 \u00b0C-on (lit.)<\/span><\/p>\n

G\u0151znyom\u00e1s:0,0386 hPa (20 \u00b0C)<\/span><\/p>\n

T\u00f6r\u00e9smutat\u00f3: n20\/D 1,512 (lit.)<\/span><\/p>\n

Lobban\u00e1spont:209 \u00b0F<\/span><\/p>\n

T\u00e1rol\u00e1si felt\u00e9tel: Sz\u00e1raz, szobah\u0151m\u00e9rs\u00e9kleten lez\u00e1rt \u00e1llapotban<\/span><\/p>\n

Oldhat\u00f3s\u00e1g: Kloroform, metanol<\/span><\/p>\n

Form\u00e1ja: Foly\u00e9kony<\/span><\/p>\n

Sz\u00edn: Tiszta sz\u00edntelen vagy halv\u00e1nys\u00e1rga<\/span><\/p>\n

Szag:100.00-n\u00e1l %. vir\u00e1gos balzsam<\/span><\/p>\n

Illat:Vir\u00e1gos<\/span><\/p>\n

V\u00edzoldhat\u00f3s\u00e1g: gyakorlatilag oldhatatlan<\/span><\/p>\n

BRN:1907123<\/span><\/p>\n

LogP:2 25\u2103-n\u00e1l<\/span><\/p>\n

K\u00e9miai tulajdons\u00e1gok <\/span><\/b><\/b><\/p>\n

Sz\u00edntelen folyad\u00e9k. Forr\u00e1spont 235\u2103, 115\u2103 (1,73kPa), relat\u00edv s\u0171r\u0171s\u00e9g 0,985 (22\/4\u2103), t\u00f6r\u00e9smutat\u00f3 1,511 (22\u2103), lobban\u00e1spont 98\u2103.<\/span><\/p>\n

Els\u0151dleges illat: vir\u00e1gos; M\u00e1sodlagos illat: z\u00f6ld.<\/span><\/p>\n

Illat Le\u00edr\u00e1s: Gyakran haszn\u00e1lj\u00e1k a szappank\u00e9sz\u00edt\u00e9sben, a benzilaceton vir\u00e1gos \u00e9s \u00e9des \u00edzzel rendelkezik, amely term\u00e9szetes m\u00f3don a kaka\u00f3ban \u00e9s a m\u00e1ln\u00e1ban fordul el\u0151.<\/span><\/p>\n

Term\u00e9szetes forr\u00e1sok: Marhah\u00fas, kaka\u00f3, toj\u00e1s, szeder, v\u00edz Yam.<\/span><\/p>\n

T\u00e1rol\u00e1si m\u00f3dszerek<\/span><\/b><\/b><\/p>\n

Tartsa a tart\u00e1lyt szorosan lez\u00e1rva, helyezze szorosan csomagolt adagol\u00f3ba, \u00e9s t\u00e1rolja h\u0171v\u00f6s, sz\u00e1raz helyen.<\/span><\/p>\n

Felhaszn\u00e1l\u00e1sok <\/span><\/b><\/b><\/p>\n

A benzil-acetont els\u0151sorban \u00edz- \u00e9s illatanyagok, valamint gy\u00f3gyszeripari k\u00f6ztes term\u00e9kek el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra haszn\u00e1lj\u00e1k. A benzil-aceton hagyom\u00e1nyos el\u0151\u00e1ll\u00edt\u00e1si m\u00f3dszerei a k\u00f6vetkez\u0151k: (1) A benzil-kloridot kondenz\u00e1ci\u00f3val, hidrol\u00edzissel \u00e9s dekarboniz\u00e1ci\u00f3val nyerik; (2) a benzil-acetont benzaldehidb\u0151l \u00e9s acetonb\u00f3l szintetiz\u00e1lj\u00e1k, majd a benzil-acetont hidrog\u00e9nez\u00e9si redukci\u00f3val nyerik. A hagyom\u00e1nyos benzil-aceton gy\u00e1rt\u00e1si m\u00f3dszer sok l\u00e9p\u00e9st, bonyolult folyamatot, nagy berendez\u00e9seket \u00e9s t\u0151kebefektet\u00e9st jelent, \u00e9s a gy\u00e1rt\u00e1si folyamat nagy mennyis\u00e9g\u0171 hullad\u00e9k s\u00f3sav keletkezik, amelyet neh\u00e9z kezelni, \u00e9s nagy k\u00f6rnyezetv\u00e9delmi nyom\u00e1st gyakorol a v\u00e1llalkoz\u00e1sra.<\/span><\/p>\n

A benzilaceton (benzilaceton) a f\u00fcst\u00f6l\u0151olaj \u00e9s a f\u00fcst\u00f6l\u0151kivonatok egyik leggyakrabban eml\u00edtett \u00f6sszetev\u0151je. A f\u00fcst\u00f6l\u0151olajban sok m\u00e1s fenol van kisebb mennyis\u00e9gben, de ez az egyik legfontosabb. \u00c9rdekes m\u00f3don a The Good Scents Company szerint ennek a vegy\u00fcletnek a balzsamos aroma ellen\u00e9re eper \u00edze van. Megfigyelt\u00e9k \u00e9s jelentett\u00e9k, hogy a f\u00fcst\u00f6l\u0151olajban 0,5% \u00e9s 8% k\u00f6z\u00f6tt v\u00e1ltozik, \u00e9s a f\u00fcst\u00f6l\u0151olaj egyik jellegzetes aromameghat\u00e1roz\u00f3 vegy\u00fcletek\u00e9nt tartj\u00e1k sz\u00e1mon.<\/span><\/p>\n

A benzilaceton feltehet\u0151en egy m\u00e1sik, a f\u00fcst\u00f6l\u0151ben zajl\u00f3, nagyon fontos anyagcsere-folyamat \"mell\u00e9kterm\u00e9ke\", amely a 2-feniletil-kromonok sorozat\u00e1nak el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz vezet. E nehezebb fenolos vegy\u00fcletek t\u00falnyom\u00f3 t\u00f6bbs\u00e9ge nem illan el az ill\u00f3olajba, de kis mennyis\u00e9g\u0171 megapanax-kromon (Flindersiachromon) gyakran megtal\u00e1lhat\u00f3 a kromatogram legv\u00e9g\u00e9n. A kromonok e csoportja nagyon jellemz\u0151 a f\u00fcst\u00f6l\u0151kre, \u00e9s n\u00e9h\u00e1ny \u00e9rdekes biol\u00f3giai tulajdons\u00e1ga miatt az \u00e9vek sor\u00e1n nagy kutat\u00e1si \u00e9rdekl\u0151d\u00e9st v\u00e1ltott ki.<\/span><\/p>\n

A benzilaceton a felmeleg\u00edtett sedum f\u00e1b\u00f3l szabadul fel, \u00e9s bel\u00e9legezve hat\u00e9konyan cs\u00f6kkenti a mozg\u00e1sszervi aktivit\u00e1st egerekben.<\/span><\/p>\n

A jelen tanulm\u00e1nyban a benzilaceton \u00e9s sz\u00e1rmaz\u00e9kai k\u00f6z\u00f6tti kapcsolatot vizsg\u00e1lt\u00e1k egerekben kifejtett nyugtat\u00f3 hat\u00e1suk \u00e9s e vegy\u00fcletek k\u00e9miai szerkezet\u00e9nek \u00f6sszehasonl\u00edt\u00e1s\u00e1val.<\/span><\/p>\n

Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a benzilacetonok nyugtat\u00f3 hat\u00e1s\u00faak, amelynek er\u0151ss\u00e9ge a sz\u00e9nl\u00e1nc funkci\u00f3s csoportjait\u00f3l, a benzolgy\u0171r\u0171n l\u00e9v\u0151 szubsztituensekt\u0151l \u00e9s ezek kombin\u00e1ci\u00f3it\u00f3l f\u00fcgg\u0151en v\u00e1ltozik.<\/span><\/p>\n

A kutat\u00f3k 17 benzilaceton-sz\u00e1rmaz\u00e9k sorozat\u00e1val kvantitat\u00edv szerkezet-hat\u00e1skapcsolati vizsg\u00e1latot v\u00e9geztek, hogy azonos\u00edts\u00e1k a nyugtat\u00f3 hat\u00e1s szempontj\u00e1b\u00f3l fontos szerkezeti jellemz\u0151ket.<\/span><\/p>\n

Haszn\u00e1lat <\/span><\/b><\/b><\/p>\n

Gy\u00f3gyszeripari szint\u00e9zisben k\u00f6ztes term\u00e9kk\u00e9nt haszn\u00e1latos<\/span><\/p>\n

Alkalmaz\u00e1si ter\u00fcletek<\/span><\/b><\/b><\/p>\n

1.\u00a0<\/span>A kaka\u00f3ban ill\u00e9kony komponensk\u00e9nt van jelen.Szappanarom\u00e1k k\u00e9sz\u00edt\u00e9s\u00e9n\u00e9l haszn\u00e1lj\u00e1k.Szappanarom\u00e1k k\u00e9sz\u00edt\u00e9s\u00e9n\u00e9l haszn\u00e1lj\u00e1k. A dinnyelegyek vonz\u00f3anyagak\u00e9nt haszn\u00e1lj\u00e1k.K\u00e9miai szint\u00e9zisben 4-oxociklohex\u00e1n-karboxaldehid-sz\u00e1rmaz\u00e9kok el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra haszn\u00e1lj\u00e1k.<\/span><\/p>\n

2.\u00a0<\/span>\u00cdzes\u00edt\u0151ipar<\/span>:<\/span>Az acetofenon fontos illatanyag-\u00f6sszetev\u0151, amelyet sz\u00e9les k\u00f6rben haszn\u00e1lnak parf\u00fcm\u00f6kben, arom\u00e1kban \u00e9s illatanyagokban. Hosszan tart\u00f3 illatot k\u00f6lcs\u00f6n\u00f6z a term\u00e9keknek, \u00e9s n\u00f6veli a term\u00e9kek r\u00e9tegezetts\u00e9g\u00e9t \u00e9s vonzerej\u00e9t.<\/span><\/p>\n

3.\u00a0<\/span>Kozmetikai ipar<\/span>:<\/span>A kozmetikumokban az acetofenont gyakran haszn\u00e1lj\u00e1k illatanyagok \u00e9s arom\u00e1k \u00f6sszetev\u0151jek\u00e9nt is. Kellemes illatot k\u00f6lcs\u00f6n\u00f6z a kozmetikumoknak, \u00e9s jav\u00edtja a term\u00e9kek min\u0151s\u00e9g\u00e9t \u00e9s piaci versenyk\u00e9pess\u00e9g\u00e9t.<\/span><\/p>\n

4.\u00a0<\/span>Gy\u00f3gyszer\u00e9szeti ter\u00fclet<\/span>:<\/span>Az acetofenont \u00e9s sz\u00e1rmaz\u00e9kait a gy\u00f3gyszeriparban is haszn\u00e1lj\u00e1k. A szerves szint\u00e9zisben k\u00f6ztiterm\u00e9kk\u00e9nt haszn\u00e1lj\u00e1k gy\u00f3gyszerek \u00e9s biol\u00f3giailag akt\u00edv vegy\u00fcletek sz\u00e9les k\u00f6r\u00e9nek el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz, mint p\u00e9ld\u00e1ul gy\u00f3gyszeripari nyersanyagok \u00e9s gy\u00f3gyszeripari k\u00f6ztiterm\u00e9kek.<\/span><\/p>\n

5.\u00a0<\/span>Szerves szint\u00e9zis<\/span>:<\/span>Az acetofenon fontos szerepet t\u00f6lt be a szerves szint\u00e9zis ter\u00fclet\u00e9n, \u00e9s sz\u00e1mos szerves vegy\u00fclet fontos szint\u00e9zis k\u00f6zbens\u0151 term\u00e9ke. Az acetofenon oxid\u00e1ci\u00f3j\u00e1val, redukci\u00f3j\u00e1val, hidroxil\u00e1l\u00e1s\u00e1val \u00e9s m\u00e1s reakci\u00f3kkal sz\u00e1mos szerves vegy\u00fclet, p\u00e9ld\u00e1ul ketonok, alkoholok \u00e9s \u00e9terek \u00e1ll\u00edthat\u00f3k el\u0151.<\/span><\/p>\n

El\u0151k\u00e9sz\u00edt\u00e9s<\/span><\/b><\/b><\/p>\n

1. m\u00f3dszer: A benzil-aceton szint\u00e9zis\u00e9nek m\u00f3dszere a k\u00f6vetkez\u0151 l\u00e9p\u00e9seket tartalmazza:<\/span><\/p>\n

(1) Adjunk alum\u00ednium-trikloridot (150 g, 1,1 mol), az els\u0151 r\u00e9sz benzolhoz (350 g) egy kever\u0151vel, visszafoly\u00e1si h\u0171t\u0151vel \u00e9s h\u0151m\u00e9r\u0151vel felszerelt n\u00e9gynyak\u00fa lombikba, \u00e9s 30-35 \u00b0C-os h\u0151m\u00e9rs\u00e9kleten j\u00f3l keverj\u00fck;<\/span><\/p>\n

(2) Az (1) l\u00e9p\u00e9sben a cseppent\u0151 t\u00f6lcs\u00e9rbe butenon (73 g, 1 mol) \u00e9s a benzol m\u00e1sodik r\u00e9sz\u00e9nek (150 g) kever\u00e9k\u00e9t adtuk, a reakci\u00f3 h\u0151m\u00e9rs\u00e9klet\u00e9t 30-35 \u00b0C-on szab\u00e1lyoztuk. 2,5-3 \u00f3r\u00e1val a benzol \u00e9s a butenon kever\u00e9k\u00e9nek m\u00e1sodik r\u00e9sz\u00e9nek cseppenk\u00e9nti hozz\u00e1ad\u00e1sa ut\u00e1n a reakci\u00f3t 0.5 \u00f3r\u00e1n \u00e1t, vizet adtunk a mos\u00e1shoz, \u00e9s a benzol visszanyer\u00e9se ut\u00e1n az olajf\u00fcrd\u0151ben t\u00f6rt\u00e9n\u0151 finom\u00edt\u00e1st v\u00e9gezt\u00fck, \u00e9s 80-85 \u00b0 C h\u0151m\u00e9rs\u00e9kleten (50pa) \u00f6sszegy\u0171jt\u00f6tt\u00fck, hogy 99,95 g-ot kapjunk; GC kimutat\u00e1sa benzil-aceton tartalom 98,97%, hozam 66,84%.<\/span><\/p>\n

2. m\u00f3dszer: A reakci\u00f3ed\u00e9nybe, amelybe kever\u0151, visszafoly\u00e1si h\u0171t\u0151, csepegtet\u0151 t\u00f6lcs\u00e9r, h\u0151m\u00e9r\u0151 van szerelve, adjunk hozz\u00e1 60% ciklohex\u00e1n 320 ml t\u00f6megfrakci\u00f3t, adjunk hozz\u00e1 1,3 mol \u00f3n-kloridot szakaszosan, adjunk hozz\u00e1 etil-acetoacet\u00e1tot (1) 2,3 mol, szab\u00e1lyozzuk a kever\u00e9si sebess\u00e9get 130 rpm, a reakci\u00f3t 60 percig, n\u00f6velj\u00fck az oldat h\u0151m\u00e9rs\u00e9klet\u00e9t 65 \u00b0 C-ra, 3 \u00f3r\u00e1n \u00e1t reflux, cseppenk\u00e9nt adjunk hozz\u00e1 benzil-amint (3) 2,6 mol. ) 2,6mol, cseppenk\u00e9nti hozz\u00e1ad\u00e1sa id\u0151szab\u00e1lyoz\u00e1s 3h, reflux reakci\u00f3 3h, a gener\u00e1ci\u00f3 a k\u00f6ztes term\u00e9kek (4), cs\u00f6kkenti az oldat h\u0151m\u00e9rs\u00e9klet\u00e9t 10 \u2103, hozz\u00e1adjuk 330ml t\u00f6megfrakci\u00f3 30% k\u00e1lium-biszulfit oldat, tartsa reflux 4h, a gener\u00e1ci\u00f3 olajos, adjunk hozz\u00e1 egy t\u00f6megfrakci\u00f3 20% ox\u00e1lsav, hogy \u00e1ll\u00edtsa be az oldat pH-j\u00e1t 4-re, tov\u00e1bbra is reflux 4h, 1.13kPa dekompresszi\u00f3s desztill\u00e1ci\u00f3, gy\u0171jt\u00e9se 95- 105 \u2103 frakci\u00f3, n\u00e1trium-nitr\u00e1t oldat mos\u00e1s, t\u00f6megfrakci\u00f3 70% acetonitril mos\u00e1s, a t\u00f6megfrakci\u00f3 90% nitromet\u00e1n az \u00e1tkrist\u00e1lyos\u00edt\u00e1s, kap krist\u00e1ly benzil-aceton 241,68g, hozam 71%.<\/span><\/p>\n

Gy\u00e1rt\u00e1si m\u00f3dszer <\/span><\/b><\/b><\/p>\n

Az acetofenon f\u0151 el\u0151\u00e1ll\u00edt\u00e1si m\u00f3dszerei k\u00f6z\u00e9 tartozik az arom\u00e1s sz\u00e9nhidrog\u00e9nek ketonokkal t\u00f6rt\u00e9n\u0151 \u00e9terez\u00e9se, az acil\u00e1ci\u00f3s redukci\u00f3 \u00e9s az alkohol-sav \u00e9szteres\u00edt\u00e9s. Ezek k\u00f6z\u00fcl az arom\u00e1s sz\u00e9nhidrog\u00e9nek ketonokkal t\u00f6rt\u00e9n\u0151 \u00e9teres\u00edt\u00e9si reakci\u00f3ja az egyik leggyakrabban alkalmazott ipari el\u0151\u00e1ll\u00edt\u00e1si m\u00f3dszer. A reakci\u00f3t \u00e1ltal\u00e1ban l\u00fagos k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt v\u00e9gzik, \u00e9s az acetofenon el\u0151\u00e1ll\u00edthat\u00f3 az acetofenon prekurzorok szelekt\u00edv oxid\u00e1ci\u00f3j\u00e1val, redukci\u00f3j\u00e1val vagy hidroxil\u00e1l\u00e1s\u00e1val.<\/span><\/p>\n

(1)\u00a0<\/span>Kondenz\u00e1ci\u00f3val, hidrol\u00edzissel \u00e9s dekarboniz\u00e1ci\u00f3val benzil-kloridb\u00f3l nyerik. (2) A benzilacetont benzaldehidb\u0151l \u00e9s acetonb\u00f3l szintetiz\u00e1lj\u00e1k, majd 4-fenilbut\u00e1non-2 hidrog\u00e9nez\u00e9ssel \u00e9s redukci\u00f3val nyerik. A 4-fenilbut\u00e1non-2-t \u00fagy \u00e1ll\u00edtjuk el\u0151, hogy etanolt (95% 1100 ml), benzilacetont (480 g), Raney Ni-t (48 g) \u00e9s ecetsavat tesz\u00fcnk a reakci\u00f3s lombikba, majd a h\u0151m\u00e9rs\u00e9kletet 48-50 \u00b0C-on szab\u00e1lyozzuk, keverj\u00fck \u00e9s a hidrog\u00e9nt atmoszf\u00e9rikus nyom\u00e1son elnyelj\u00fck, am\u00edg a mennyis\u00e9g elegend\u0151 nem lesz. Reakci\u00f3 4-5h. lesz\u0171rve Raney Ni. sz\u0171rlet elp\u00e1rologtatott etanol, desztill\u00e1ci\u00f3 cs\u00f6kkentett nyom\u00e1son, gy\u0171jt\u00e9se 123-125 \u2103 (2,67kPa) frakci\u00f3, kapott 4-fenilbutanon-2 465,8g. t\u00f6r\u00e9smutat\u00f3 1,513, hozam 95,7%.<\/span><\/p>\n

Szint\u00e9zis m\u00f3dszer<\/span><\/b><\/b><\/p>\n

Az acetofenon benzilid\u00e9n-aceton (benzaldehidb\u0151l \u00e9s acetonb\u00f3l el\u0151\u00e1ll\u00edtott) benzilid\u00e9n-aceton szelekt\u00edv hidrog\u00e9nez\u00e9s\u00e9vel \u00e1ll\u00edthat\u00f3 el\u0151.<\/span><\/b><\/p>\n

Kondenz\u00e1ci\u00f3val, hidrol\u00edzissel \u00e9s dekarboniz\u00e1ci\u00f3val benzil-kloridb\u00f3l nyerik. A benzilid\u00e9n-acetont benzaldehidb\u0151l \u00e9s acetonb\u00f3l szintetiz\u00e1lt\u00e1k, majd hidrog\u00e9nez\u00e9ssel \u00e9s redukci\u00f3val 4-fenilbut\u00e1non-2-t nyertek. A 4-fenilbut\u00e1non-2-t \u00fagy \u00e1ll\u00edtottuk el\u0151, hogy etanolt (95% 1100 ml), benzilid\u00e9n-acetont (480 g), Raney Ni-t (48 g) \u00e9s ecetsavat tett\u00fcnk a reakci\u00f3s lombikba, majd a h\u0151m\u00e9rs\u00e9kletet 48-50 \u2103-on szab\u00e1lyoztuk, kevertett\u00fck \u00e9s a hidrog\u00e9nt l\u00e9gk\u00f6ri nyom\u00e1son elnyelt\u00fck, am\u00edg a mennyis\u00e9g elegend\u0151 volt. Reakci\u00f3 4-5h. sz\u0171rt Raney Ni. sz\u0171rlet elp\u00e1rologtatott etanol, desztill\u00e1ci\u00f3 cs\u00f6kkentett nyom\u00e1son, gy\u0171jts\u00fck 123-125 \u2103 (2,67kPa) frakci\u00f3, kap 4-phenylbutanone-2 465,8g. t\u00f6r\u00e9smutat\u00f3 1,513, hozam 95,7%.<\/span><\/p>\n

(2) Elk\u00e9sz\u00edt\u00e9si m\u00f3dszer:<\/span><\/p>\n

A fenilaceton el\u0151\u00e1ll\u00edt\u00e1si m\u00f3dszer\u00e9re hivatkozva 100g (0,66mol) fenilprop\u00e1nsavat \u00e9s 160g (2,66mol) j\u00e9gecetet haszn\u00e1ltunk a reakci\u00f3hoz, amelyet \u00e9terrel extrah\u00e1ltunk, majd desztill\u00e1ltunk, \u00e9s a frakci\u00f3kat 230-235\u00b0C-on gy\u0171jt\u00f6tt\u00fck, \u00edgy 70g 4-fenil-2-but\u00e1non keletkezett 71% hozammal. Tiszta 4-fenil-2-but\u00e1non bp234\u00b0C.<\/span><\/p>\n

Els\u0151seg\u00e9ly<\/span><\/b><\/b><\/p>\n

Em\u00e9szt\u00e9si zavarok: Orvosi seg\u00edts\u00e9get k\u00e9rjen. \u00d6bl\u00edtse ki a sz\u00e1j\u00e1t v\u00edzzel.<\/span><\/p>\n

L\u00c9GZ\u00c9S: Azonnal friss leveg\u0151re kell vinni.<\/span><\/p>\n

B\u0151r: A b\u0151r: \u00f6bl\u00edtse le a b\u0151rt b\u0151 szappannal \u00e9s v\u00edzzel legal\u00e1bb 15 percig, \u00e9s vegye le a szennyezett ruh\u00e1zatot \u00e9s cip\u0151t.<\/span><\/p>\n

SZEM: Legal\u00e1bb 15 percig b\u0151 v\u00edzzel \u00f6bl\u00edtse a szem\u00e9t, id\u0151nk\u00e9nt felemelve a fels\u0151 \u00e9s als\u00f3 szemh\u00e9jat. Forduljon orvoshoz.<\/span><\/p>\n

Kezel\u00e9s \u00e9s t\u00e1rol\u00e1s<\/span><\/b><\/b><\/p>\n

T\u00c1ROL\u00c1S: T\u00e1rol\u00e1s: H\u0171v\u00f6s, sz\u00e1raz helyen t\u00e1roland\u00f3. L\u00e9gmentesen z\u00e1r\u00f3d\u00f3 ed\u00e9nyben t\u00e1rolja.<\/span><\/p>\n

KEZEL\u00c9S: Ker\u00fclje a por, g\u0151z\u00f6k, k\u00f6d\u00f6k vagy g\u00e1zok bel\u00e9gz\u00e9s\u00e9t. Ker\u00fclj\u00fck a b\u0151rrel \u00e9s a szemmel val\u00f3 \u00e9rintkez\u00e9st.<\/span><\/p>\n

Vesz\u00e9lyazonos\u00edt\u00e1s<\/span><\/b><\/b><\/p>\n

\u00c9RZ\u00c9S: Lenyel\u00e9s eset\u00e9n \u00e1rtalmas lehet.<\/span><\/p>\n

BEVEG\u00c9S: Irrit\u00e1lhatja a l\u00e9gutakat. Bel\u00e9legezve k\u00e1ros lehet.<\/span><\/p>\n

B\u0150R: S\u00falyos b\u0151rirrit\u00e1ci\u00f3t okoz. K\u00e1ros lehet, ha a b\u0151r\u00f6n kereszt\u00fcl felsz\u00edv\u00f3dik.<\/span><\/p>\n

Szem: irrit\u00e1lhatja a szemet.<\/span><\/p>\n

EK kock\u00e1zati szavak: R 36\/38<\/span><\/p>\n

EU biztons\u00e1gi kifejez\u00e9s: S 26 36<\/span><\/p>\n

Az expoz\u00edci\u00f3 ellen\u0151rz\u00e9se\/szem\u00e9lyes v\u00e9delem<\/span><\/b><\/b><\/p>\n

SZEM\u00c9LYV\u00c9DELMI V\u00c9DELEM: B\u0150R: A b\u0151rrel val\u00f3 \u00e9rintkez\u00e9s megakad\u00e1lyoz\u00e1sa \u00e9rdek\u00e9ben viseljen megfelel\u0151 v\u00e9d\u0151keszty\u0171t. Ruh\u00e1zat: Vegyi k\u00f6t\u00e9nyt viselni.<\/span><\/p>\n

L\u00c9LEGZ\u0150K: Megfelel az OSHA l\u00e9gz\u0151k\u00e9sz\u00fcl\u00e9kekre vonatkoz\u00f3 29CFR 1910.134 rendeletnek vagy az EN 149 eur\u00f3pai szabv\u00e1nynak. Sz\u00fcks\u00e9g eset\u00e9n mindig haszn\u00e1ljon NIOSH vagy EN 149 eur\u00f3pai szabv\u00e1ny szerint j\u00f3v\u00e1hagyott l\u00e9gz\u0151k\u00e9sz\u00fcl\u00e9ket.<\/span><\/p>\n

T\u0171zv\u00e9delmi int\u00e9zked\u00e9sek<\/span><\/b><\/b><\/p>\n

Gy\u00fajt\u00f3pont: >100<\/span><\/p>\n

T\u0170ZOLT\u00c1S: Viseljen MSHA\/NIOSH (j\u00f3v\u00e1hagyott vagy azzal egyen\u00e9rt\u00e9k\u0171), nyom\u00e1sf\u00fcgg\u0151, \u00f6n\u00e1ll\u00f3 l\u00e9gz\u0151k\u00e9sz\u00fcl\u00e9ket (SCBA) \u00e9s teljes v\u00e9d\u0151felszerel\u00e9st. A t\u00fczet v\u00edzpermettel, sz\u00e1raz vegyszerrel, sz\u00e9n-dioxiddal vagy k\u00e9miai habbal oltsa el.<\/span><\/p>\n

V\u00e9letlenszer\u0171 kibocs\u00e1t\u00e1s elleni int\u00e9zked\u00e9sek<\/span><\/b><\/b><\/p>\n

Kisebb ki\u00f6ml\u00e9sek\/sziv\u00e1rg\u00e1sok: a ki\u00f6ml\u00f6tt anyagot inert anyaggal (pl. sz\u00e1raz homokkal vagy f\u00f6lddel) fel kell sz\u00edvni, \u00e9s vegyszeres hullad\u00e9kgy\u0171jt\u0151 ed\u00e9nybe kell helyezni.<\/span><\/p>\n

Biztons\u00e1gi inform\u00e1ci\u00f3k<\/span><\/b><\/b><\/p>\n

Vesz\u00e9lyszimb\u00f3lum: Xi<\/span><\/p>\n

Vesz\u00e9lyess\u00e9gi oszt\u00e1ly k\u00f3d: 38<\/span><\/p>\n

Biztons\u00e1gi utas\u00edt\u00e1sok: 37-24\/25<\/span><\/p>\n

WGK N\u00e9metorsz\u00e1g: 1<\/span><\/p>\n

RTECS-sz\u00e1m: EL9600000<\/span><\/p>\n

TSCA: Igen<\/span><\/p>\n

V\u00e1mk\u00f3d: 29143900<\/span><\/p>\n

Toxicit\u00e1s: LD50 sz\u00e1jon \u00e1t ny\u00falban: 3200 mg\/kg<\/span><\/p>\n

Biztons\u00e1gi adatok<\/span><\/b><\/b><\/p>\n

Az acetofenon b\u0151rirrit\u00e1ci\u00f3t, s\u00falyos szemirrit\u00e1ci\u00f3t \u00e9s a GHS besorol\u00e1s szerint lenyelve vesz\u00e9lyeket okozhat. Megfelel\u0151 \u00f3vint\u00e9zked\u00e9seket kell tenni, p\u00e9ld\u00e1ul v\u00e9d\u0151szem\u00fcveget \u00e9s keszty\u0171t kell viselni.<\/span><\/p>\n

K\u00f6rnyezeti hat\u00e1sok<\/span><\/b><\/b><\/p>\n

Boml\u00e1sig hev\u00edtve irrit\u00e1l\u00f3 g\u0151z\u00f6ket \u00e9s g\u00e1zokat bocs\u00e1that ki.<\/span><\/p>\n

Orvosi tanulm\u00e1nyok<\/span><\/b><\/b><\/p>\n

Az acetofenon a gombatirozin\u00e1z potenci\u00e1lis g\u00e1tl\u00e1s\u00e1t mutatja, \u00e9s az \u00e9tv\u00e1gy fokoz\u00e1s\u00e1ban \u00e9s a testmozg\u00e1s cs\u00f6kkent\u00e9s\u00e9ben alkalmazhat\u00f3.<\/span><\/p>\n

Biztons\u00e1gi \u00e9s k\u00f6rnyezeti hat\u00e1sok<\/span><\/b><\/b><\/p>\n

Az acetofenon norm\u00e1l felhaszn\u00e1l\u00e1si k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt viszonylag biztons\u00e1gos az emberre n\u00e9zve, de a hosszan tart\u00f3 expoz\u00edci\u00f3 negat\u00edv eg\u00e9szs\u00e9g\u00fcgyi hat\u00e1sokkal j\u00e1rhat. A gy\u00e1rt\u00e1s \u00e9s a felhaszn\u00e1l\u00e1s sor\u00e1n megfelel\u0151 v\u00e9d\u0151int\u00e9zked\u00e9seket kell tenni a b\u0151rrel val\u00f3 \u00e9rintkez\u00e9s \u00e9s a g\u00e1z bel\u00e9legz\u00e9s\u00e9nek elker\u00fcl\u00e9se \u00e9rdek\u00e9ben. Ezenk\u00edv\u00fcl az acetofenon el\u0151\u00e1ll\u00edt\u00e1s\u00e1t \u00e9s kezel\u00e9s\u00e9t szigor\u00faan ellen\u0151rizni kell a k\u00f6rnyezetre gyakorolt hat\u00e1s minimaliz\u00e1l\u00e1sa \u00e9rdek\u00e9ben.<\/span><\/p>\n

Reakci\u00f3k<\/span><\/b><\/b><\/p>\n

A legt\u00f6bb metil-ketonvegy\u00fclethez hasonl\u00f3an a benzilid\u00e9n-aceton is enyh\u00e9n savas vegy\u00fclet az alfa-helyzetben, \u00e9s nagyon k\u00f6nnyen deproton\u00e1lhat\u00f3, \u00edgy a megfelel\u0151 enolvegy\u00fclet keletkezik. A vegy\u00fclet a k\u00f6vetkez\u0151 funkci\u00f3s csoportok jelenl\u00e9te miatt a k\u00f6vetkez\u0151 reakci\u00f3kat hajthatja v\u00e9gre, pl.: kett\u0151s k\u00f6t\u00e9sek add\u00edci\u00f3ja br\u00f3mmal; heterodi\u00e9nvegy\u00fcletek Diels-Alder-reakci\u00f3ja olefinekkel, \u00edgy dihidropir\u00e1nvegy\u00fcletek keletkeznek; a metilcsoportok benzaldehiddel tov\u00e1bb kondenz\u00e1lhat\u00f3k, \u00edgy dibenzilid\u00e9naceton keletkezik; a karbonilcsoportok pedig hidrazont k\u00e9pezhetnek. A vegy\u00fclet reag\u00e1lhat Fe2(CO)9-el is, \u00edgy (benzilid\u00e9naceton)Fe(CO)3 keletkezik, amely reagens k\u00e9pes Fe(CO)3-t sz\u00e1ll\u00edtani m\u00e1s szerves k\u00e9miai szubsztr\u00e1tokhoz.<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Benzilaceton: A benzilaceton 2550-26-7 A benzilaceton (IUPAC-n\u00e9v: 4-fenilbut\u00e1n-2-on) egy \u00e9des vir\u00e1gillat\u00fa folyad\u00e9k, amelyet a vir\u00e1gok (pl. a pr\u00e9rifarkas doh\u00e1ny, Nicotiana attenuata) legnagyobb mennyis\u00e9gben el\u0151fordul\u00f3 vonz\u00f3 vegy\u00fclet\u00e9nek tartanak, \u00e9s a kaka\u00f3 egyik ill\u00e9kony alkot\u00f3r\u00e9sz\u00e9nek. A dinnyel\u00e9gy (Bactrocera cucurbitae) csalogat\u00f3anyagak\u00e9nt haszn\u00e1lj\u00e1k [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nBenzylacetone: Properties, Applications, and Production Methods - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/benzylacetone-properties-applications-and-production-methods\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Benzylacetone: Properties, Applications, and Production Methods - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Benzylacetone: Properties, Applications, and Production Methods Benzylacetone\u00a02550-26-7 Benzylacetone (IUPAC name: 4-phenylbutan-2-one) is a liquid with a sweet floral odour and is considered to be the most abundant attractant compound in flowers (e.g., coyote tobacco, Nicotiana attenuata), and one of the volatile constituents of cocoa. 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