{"id":3264,"date":"2024-03-20T07:29:29","date_gmt":"2024-03-20T07:29:29","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=2980"},"modified":"2024-03-20T07:29:29","modified_gmt":"2024-03-20T07:29:29","slug":"what-is-the-effect-of-agitation-on-crystallization","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/mi-a-hatasa-a-keveresnek-a-kristalyosodasra\/","title":{"rendered":"Milyen hat\u00e1ssal van a kever\u00e9s a krist\u00e1lyosod\u00e1sra?"},"content":{"rendered":"

Milyen hat\u00e1ssal van a kever\u00e9s a krist\u00e1lyosod\u00e1sra?<\/strong><\/h1>\n

Az \u00e1ltal\u00e1nos krist\u00e1lyos\u00edt\u00f3 \u00fcstkever\u00e9s (kevert tart\u00e1lyos krist\u00e1lyos\u00edt\u00f3) az a. \u00e1br\u00e1n l\u00e1that\u00f3 axi\u00e1lis lap\u00e1tos t\u00edpus. a. Itt a szerz\u0151k egy horgonyszer\u0171, kapar\u00f3fal\u00fa kever\u0151 lap\u00e1tot terveztek (kapar\u00f3fel\u00fclet\u0171 krist\u00e1lyos\u00edt\u00f3), \u00e9s h\u00e1rom k\u00fcl\u00f6nb\u00f6z\u0151 t\u00edpus\u00fa API-t v\u00e1lasztottak ki a kever\u00e9s krist\u00e1lyosod\u00e1sra gyakorolt hat\u00e1s\u00e1nak vizsg\u00e1lat\u00e1hoz.<\/p>\n

\"\"<\/p>\n

A krist\u00e1lyos\u00edt\u00e1si technik\u00e1k \u00e1tfog\u00f3 \u00e1ttekint\u00e9se, ez a k\u00f6nyv igazi szemnyitogat\u00f3 volt!
\nAz els\u0151 az ibuprof\u00e9n (IBP) volt, amelyet \u00fagy krist\u00e1lyos\u00edtottunk, hogy az IBP 25 \u00b0C-os DMSO-ban oldott 25 \u00b0C-os oldat\u00e1hoz v\u00edzcseppet adtunk. A 60 fordulat\/perc ST tengelyes lap\u00e1tkever\u00e9ssel t\u00f6rt\u00e9n\u0151 krist\u00e1lyos\u00edt\u00e1s sor\u00e1n a kever\u00e9s nem volt j\u00f3, \u00e9s 25 percre a DMSO fels\u0151 r\u00e9teg\u00e9ben vizes f\u00e1zis jelent meg, ami a 30 perces mintav\u00e9tel \u00e9s elemz\u00e9s sor\u00e1n nagy hozamot eredm\u00e9nyezett. A kever\u00e9s \u00e9s a mintav\u00e9tel folytat\u00e1sa, a krist\u00e1lyos\u00edt\u00e1s ST axi\u00e1lis \u00e1raml\u00e1s\u00fa kever\u00e9ssel 200 rpm \u00e9s SS falkapar\u00f3 horgonykever\u00e9ssel 60 rpm fordulatsz\u00e1mon hasonl\u00f3 hozamot eredm\u00e9nyezett 30 percn\u00e9l \u00e9s 60 percn\u00e9l.<\/p>\n

\"\"<\/p>\n

Hogyan alkalmazhat\u00f3 a hat\u00e9kony, folyamatos \u00e1raml\u00e1s\u00fa gy\u00e1rt\u00e1si folyamat a biofarm\u00e1cia ter\u00fclet\u00e9n? Esetmegoszt\u00e1ssal!
\nA felsz\u00ednen l\u00e9v\u0151 kem\u00e9ny k\u00e9reg mag\u00e1nak a krist\u00e1lyos\u00edt\u00f3 API-nak a term\u00e9szet\u00e9vel, valamint a kever\u0151lap\u00e1t \u00e9s a krist\u00e1lyos\u00edt\u00f3 \u00fcst fel\u00fclet\u00e9nek simas\u00e1g\u00e1val \u00e9s kem\u00e9nys\u00e9g\u00e9vel f\u00fcgg \u00f6ssze. A rozsdamentes ac\u00e9l ST lap\u00e1t t\u00edpusn\u00e1l 200 rpm-n\u00e9l (c. \u00e1bra) er\u0151sebb fel\u00fcleti k\u00e9regk\u00e9pz\u0151d\u00e9s volt tapasztalhat\u00f3, de a PTFE-t haszn\u00e1l\u00f3 SS horgony t\u00edpusn\u00e1l 60 rpm-n\u00e9l kevesebb fel\u00fcleti k\u00e9regk\u00e9pz\u0151d\u00e9s volt tapasztalhat\u00f3.<\/p>\n

\"\"<\/p>\n

A difenhidramin-hidroklorid (DPH) egy lamell\u00e1s krist\u00e1ly, amely 60 \u00b0C-r\u00f3l 5 \u00b0C-ra t\u00f6rt\u00e9n\u0151 h\u0171t\u00e9ssel, majd tart\u00e1ssal csap\u00f3dik ki.Az SS Anchor 60 rpm krist\u00e1lyos\u00edt\u00e1si kinetika hasonl\u00f3 az ST 200 rpm-hez, \u00e9s mindkett\u0151 gyorsabban csap\u00f3dik ki, mint az ST Paddle 60 rpm.<\/p>\n

\"\"<\/p>\n

K\u00fcl\u00f6nbs\u00e9gek \u00e9s \u00f6sszef\u00fcgg\u00e9sek a kis \u00e9s nagym\u00e9ret\u0171 k\u00eds\u00e9rletek \u00e9s a k\u00eds\u00e9rleti gy\u00e1rt\u00e1s k\u00f6z\u00f6tt<\/p>\n

Az ST lap\u00e1tkever\u00e9ssel (b. \u00e1bra, 60 rpm; c, 200 rpm) kapott krist\u00e1lyokban t\u00f6bb volt a darabos szil\u00e1rd anyag (a. \u00e1bra).<\/p>\n

 <\/p>\n

\"\"<\/p>\n

A ki\u00fcr\u00edt\u00e9s mind az SS Anchor 60rpm, mind az ST Paddle 200rpm eset\u00e9ben k\u00f6nnyebb volt, \u00e9s nem maradtak darabos szil\u00e1rd anyagok, de az ST 60rpm eset\u00e9ben t\u00f6bb fel\u00fcleti k\u00e9rgesed\u00e9s \u00e9s darabos marad\u00e9k volt a ki\u00fcr\u00edt\u00e9skor.<\/p>\n

\"\"<\/p>\n

A szint\u00e9n leh\u0171t\u00f6tt \u00e9s dekrist\u00e1lyos\u00edtott, t\u0171 alak\u00fa fluoxetin-hidroklorid (FLU) eset\u00e9ben az SS Anchor 60rpm jelent\u0151sen gyorsabban dekrist\u00e1lyos\u00edtott, mint az ST Paddle.<\/p>\n

\"\"<\/p>\n

E h\u00e1rom krist\u00e1lyos\u00edt\u00e1si k\u00f6r\u00fclm\u00e9nyt alkalmazva hossz\u00fa, v\u00e9kony, t\u0171szer\u0171 FLU krist\u00e1lyokat kaptunk, az SS-horgony t\u00edpus hosszabb krist\u00e1lyokat eredm\u00e9nyezett (a. \u00e1bra), mint a t\u00f6bbi (a. \u00e1bra, ST, 60 rpm; c. \u00e1bra, ST, 200 rpm). (Sz\u00e1raz megoszt\u00e1s) Ipari krist\u00e1lyos\u00edt\u00e1si folyamat ellen\u0151rz\u00e9si pontjai \u00e9s alkalmaz\u00e1si esetek.<\/p>\n

\"\"<\/p>\n

A 60 fordulat\/perc sebess\u00e9ggel lehorgonyzott SS seg\u00edts\u00e9g\u00e9vel nem mer\u00fcltek fel ki\u00fcr\u00edt\u00e9si probl\u00e9m\u00e1k (a. \u00e1bra), de az ST-vel k\u00fcl\u00f6nb\u00f6z\u0151 sebess\u00e9ggel nyert krist\u00e1lyok rosszul mobilak voltak, \u00e9s nem lehetett k\u00f6zvetlen\u00fcl ki\u00f6nteni \u0151ket, csak az old\u00f3szer p\u00f3tl\u00e1sa ut\u00e1n (b. \u00e1bra).<\/p>\n

\"\"<\/p>\n

\u00c1tfog\u00f3 \u00f6sszehasonl\u00edt\u00e1s:
\n1. ST lap\u00e1tkever\u00e9s 200 fordulat\/perc el\u0151seg\u00edti a krist\u00e1lyt\u00f6r\u00e9st, az agglomer\u00e1ci\u00f3t \u00e9s a m\u00e1sodlagos nukle\u00e1ci\u00f3t, \u00edgy a krist\u00e1lym\u00e9ret-eloszl\u00e1s sz\u00e9lesebb.
\n2. ST lap\u00e1tkever\u00e9s 60 fordulat\/perc, a DPH krist\u00e1lyok egy bizonyos m\u00e9retre n\u0151nek, \u00e9s elkezdenek kicsap\u00f3dni \u00e9s agglomer\u00e1l\u00f3dni az \u00fcst alj\u00e1ra. A gyenge kever\u00e9s miatt a krist\u00e1lyn\u00f6veked\u00e9st befoly\u00e1solja az anyagmozg\u00e1s, ami lassabb krist\u00e1lykiv\u00e1l\u00e1st eredm\u00e9nyez.
\n3. SS horgony kever\u00e9s 60 rpm, mert a horgony \u00e9s a katlan fal k\u00f6z\u00f6tti r\u00e9s kisebb, a szil\u00e1rd szuszpenzi\u00f3 jobb, \u00e9s a CFD folyad\u00e9kszimul\u00e1ci\u00f3 azt mutatja, hogy a rendszer \u00e1tlagos ny\u00edr\u00e1sa kisebb. Kevesebb krist\u00e1lyt\u00f6r\u00e9s, p\u00e9ld\u00e1ul a FLU krist\u00e1lyosod\u00e1sa, mint m\u00e1s, finoman t\u00f6r\u00f6tt krist\u00e1lyokkal rendelkez\u0151 kever\u0151rendszerekn\u00e9l. Alacsony forg\u00e1si sebess\u00e9g \u00e9s alacsony ny\u00edr\u00e1s, \u00edgy kevesebb krist\u00e1ly-krist\u00e1ly \u00e9s krist\u00e1ly- \u00fcstfal k\u00f6lcs\u00f6nhat\u00e1s, \u00edgy kevesebb agglomer\u00e1ci\u00f3.<\/p>","protected":false},"excerpt":{"rendered":"

What is the effect of agitation on crystallization? The common crystallization kettle stirring (Stirred tank crystallizer) is the axial paddle type as shown in Fig. a. Here the authors designed an anchor-like scraped-wall stirring paddle (scraped surface crystallizer) and selected three different types of APIs to study the effect of stirring on crystallization. A comprehensive […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nWhat is the effect of agitation on crystallization? - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/mi-a-hatasa-a-keveresnek-a-kristalyosodasra\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is the effect of agitation on crystallization? - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"What is the effect of agitation on crystallization? The common crystallization kettle stirring (Stirred tank crystallizer) is the axial paddle type as shown in Fig. a. Here the authors designed an anchor-like scraped-wall stirring paddle (scraped surface crystallizer) and selected three different types of APIs to study the effect of stirring on crystallization. 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The common crystallization kettle stirring (Stirred tank crystallizer) is the axial paddle type as shown in Fig. a. Here the authors designed an anchor-like scraped-wall stirring paddle (scraped surface crystallizer) and selected three different types of APIs to study the effect of stirring on crystallization. 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