Coumalic Acid (CAS 500-05-0): A Comprehensive Guide to This Versatile Chemical Compound

What is Coumalic Acid?

Coumalic Acid (CAS 500-05-0), also known as cumalic acid or α-pyrone-5-carboxylic acid, is an organic compound with the molecular formula C₆H₄O₄ and molecular weight of 126.10 g/mol. This compound is a hydroxy acid derivative that serves as an important intermediate in various chemical syntheses and industrial applications.

Coumalic acid appears as a white to light yellow or light orange powder or crystal. It is characterized by its lactone structure, which contributes to its unique chemical properties and reactivity. The compound is also known by its systematic name 2-oxo-2H-pyran-5-carboxylic acid, reflecting its relationship to the pyrone family of compounds.

This versatile chemical is produced through various synthetic routes and is available in different purity grades to meet the requirements of different applications, from laboratory research to industrial manufacturing.

Chemical Properties and Specifications

Understanding the chemical properties of coumalic acid is essential for its proper handling and application:

Property	Érték
CAS-szám	500-05-0
Molekuláris képlet	C6H4O4
Molekulatömeg	126.10 g/mol
Megjelenés	White to light yellow or light orange powder or crystal
Tisztaság	≥97% (typical)
Olvadáspont	~210-215°C (decomposes)
Oldhatóság	Soluble in water and common organic solvents

Key Benefits and Advantages

1. Versatile Chemical Intermediate

Coumalic acid serves as a crucial building block in organic synthesis due to its reactive lactone ring and carboxylic acid group. This makes it valuable for:

• Synthesis of various heterocyclic compounds
• Production of pharmacologically active molecules
• Preparation of specialized dyes and pigments
• Development of novel polymer materials

2. Pharmaceutical Applications

In the pharmaceutical industry, coumalic acid is valued for its role as a scaffold in drug discovery and development:

• Anti-bronchial activity: Compounds derived from coumalic acid show promise in respiratory treatments
• Anti-malarial potential: Research has identified anti-malarial properties in certain coumalic acid derivatives
• Drug intermediate: Used in the synthesis of various pharmaceutical compounds

3. Flavor and Fragrance Industry

Coumalic acid finds applications in the flavors, fragrances, and cosmetics industries:

• Flavoring agent production
• Fragrance component synthesis
• Cosmetics formulation
• Enhancement of sensory profiles in consumer products

4. Polymer Chemistry

The compound’s reactive structure makes it useful in polymer applications:

• Polymer component development
• Specialized resin synthesis
• Material science research

Primary Applications and Uses

Pharmaceutical Applications

Coumalic acid is used in pharmaceutical research and manufacturing:

• Synthesis of anti-bronchial agents
• Development of anti-malarial compounds
• Drug intermediate for various therapeutic agents
• Research chemical in medicinal chemistry

Flavor and Fragrance Industry

The compound contributes to the flavor and fragrance industry:

• Natural flavoring agent production
• Fragrance compound synthesis
• Cosmetic additive formulation
• Sensory profile enhancement

Chemical Research and Manufacturing

In chemical research and industrial applications:

• Heterocyclic compound synthesis
• Dye and pigment intermediate production
• Polymer material development
• Laboratory reagent applications

Biztonság és kezelés

General Safety Information

When handling coumalic acid, standard safety precautions should be observed:

• Avoid contact with eyes, skin, and clothing
• Use appropriate personal protective equipment (PPE)
• Work in a well-ventilated area
• Follow proper laboratory safety procedures

Storage Requirements

• Store in a cool, dry place
• Keep away from heat and ignition sources
• Store in tightly closed containers
• Handle in accordance with safety data sheet (SDS) guidelines

First Aid Measures

• In case of skin contact: Wash thoroughly with soap and water
• In case of eye contact: Rinse immediately with plenty of water
• If swallowed: Seek medical attention if symptoms persist
• If inhaled: Move to fresh air if experiencing discomfort

Szabályozási státusz

Coumalic acid is available for use in various applications and is regulated according to:

• Industrial chemical regulations
• Pharmaceutical ingredient guidelines
• Food additive specifications (where applicable)
• Laboratory safety standards

Why Choose Our Coumalic Acid?

Quality Assurance

• High-purity grade (≥97%)
• Consistent batch-to-batch quality
• Comprehensive quality control testing
• Full documentation (COA, MSDS)

Competitive Advantages

• Reliable supply chain
• Technical support available
• Customized packaging options
• Competitive pricing for bulk orders

Applications Support

• Technical data and specifications
• Application guidance
• Regulatory documentation
• Responsive customer service

Frequently Asked Questions

Q: What is coumalic acid used for?

Coumalic acid is used as a chemical intermediate in pharmaceutical research, flavor and fragrance production, polymer chemistry, and various organic synthesis applications. It serves as a building block for creating more complex molecules.

Q: Is coumalic acid safe to handle?

When proper safety precautions are followed, coumalic acid can be handled safely. Always wear appropriate PPE and follow the safety data sheet (SDS) guidelines for handling this chemical.

Q: What is the purity of coumalic acid?

High-purity coumalic acid is typically available at ≥97% purity, suitable for most research and industrial applications. Specific purity requirements may vary based on the intended use.

Q: Can coumalic acid be used in pharmaceutical applications?

Yes, coumalic acid is used in pharmaceutical research as an intermediate for synthesizing various drug compounds, including those with anti-bronchial and anti-malarial properties.

Q: Where can I buy coumalic acid in bulk?

Longchang Chemical is a reliable supplier of coumalic acid (CAS 500-05-0) for pharmaceutical, flavor and fragrance, and chemical research applications. Contact us for competitive quotes and technical documentation.

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This article is for informational purposes only. For pharmaceutical and medical applications, please consult with qualified healthcare professionals.