{"id":6615,"date":"2024-08-06T12:45:17","date_gmt":"2024-08-06T12:45:17","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6615"},"modified":"2026-09-10T03:15:38","modified_gmt":"2026-09-10T03:15:38","slug":"using-response-surface-methodology","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/fr\/using-response-surface-methodology\/","title":{"rendered":"Optimisation du processus de fermentation du paraherquamide A \u00e0 l'aide de la m\u00e9thode de la surface de r\u00e9ponse"},"content":{"rendered":"<p>Optimisation du processus de fermentation du paraherquamide A \u00e0 l'aide de la m\u00e9thode de la surface de r\u00e9ponse<br \/>\nParasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. At present, avernectins are the most widely used antiparasitic drugs in veterinary clinical practice worldwide. However, due to the abuse of this drug, drug-resistant strains have emerged in many areas. In the late 1980s, China introduced and widely used this type of drug, and now domestic sheep gastrointestinal nematodes have developed varying degrees of resistance to avermectin drugs. Startect \u00ae is a new type of sheep oral short acting deworming drug developed by Zoetis, the world&#8217;s largest animal health drug and vaccine company, which can effectively prevent and solve livestock and poultry parasitic diseases and their drug resistance problems. <span data-no-translation lang=\"en\">The <a href=\"https:\/\/www.vmd.defra.gov.uk\/productinformationdatabase\/product\/A012504\" rel=\"noopener\">UK Veterinary Medicines Directorate record for Startect<\/a> identifies derquantel and abamectin as its active substances. The previous sentence confused a substance name and included an inappropriate administration calculation; that instruction has been removed. This fermentation article is not a veterinary dosing guide. Use the current authorized product information and veterinary guidance for the actual product.<\/span> According to the statistics of the Food and Agriculture Organization of the United Nations (FAO), the world&#8217;s sheep inventory has reached 1.2 billion. Therefore, the potential demand for Dequnt is in the hundreds of tons or even higher, and the market demand is huge.<\/p>\n<p>Le dextrant est un d\u00e9riv\u00e9 chimique du m\u00e9tabolite fongique Paraherquamide A (PA), qui est principalement obtenu par r\u00e9duction du carbonyle amide et d\u00e9soxyg\u00e9nation du PA (voir figure 1). Par cons\u00e9quent, l'approvisionnement en mati\u00e8res premi\u00e8res industrielles de la Dequnte est principalement affect\u00e9 par la production de PA. Cependant, la structure chimique des produits naturels tels que le paraherquamide est complexe. Bien qu'ils puissent \u00eatre synth\u00e9tis\u00e9s chimiquement \u00e0 partir de mati\u00e8res premi\u00e8res industrielles telles que l'isopr\u00e8ne ou les \u00e9poxydes d'isopr\u00e8ne, leurs \u00e9tapes de r\u00e9action chimique peuvent atteindre 46 \u00e9tapes, ce qui entra\u00eene des co\u00fbts \u00e9lev\u00e9s et des rendements extr\u00eamement faibles (2,5%), rendant difficile leur production \u00e0 l'\u00e9chelle industrielle. La production de PA par fermentation microbienne est actuellement un moyen efficace d'obtenir ce compos\u00e9 \u00e0 grande \u00e9chelle. L'AP a d'abord \u00e9t\u00e9 isol\u00e9 \u00e0 partir du produit de fermentation d'une souche de Penicillium paraherquei, un champignon appartenant au genre Penicillium. Cependant, la puissance de l'AP produit par le Penicillium de type sauvage n'\u00e9tait pas \u00e9lev\u00e9e, ce qui a entrav\u00e9 la poursuite de la recherche exp\u00e9rimentale et de l'application industrielle. Dans la recherche sur l'application des m\u00e9tabolites fongiques, le niveau d'activit\u00e9 du m\u00e9tabolite cible d\u00e9pend non seulement de la performance de la souche elle-m\u00eame, mais surtout de l'optimisation des conditions de fermentation et de culture afin d'utiliser pleinement sa capacit\u00e9 de production. La m\u00e9thodologie de la surface de r\u00e9ponse est actuellement largement utilis\u00e9e pour optimiser la culture de la fermentation microbienne. Cette m\u00e9thode combine la conception exp\u00e9rimentale et la mod\u00e9lisation math\u00e9matique et pr\u00e9sente les avantages suivants : moins d'exp\u00e9riences, des cycles plus courts, une plus grande pr\u00e9cision dans l'obtention des \u00e9quations de r\u00e9gression, une meilleure performance pr\u00e9dictive et l'\u00e9tude de l'interaction entre plusieurs facteurs.<\/p>\n<p>Lors des travaux pr\u00e9liminaires, notre groupe de recherche a d\u00e9couvert un champignon Penicillium KWF31 d'origine marine produisant beaucoup de PA. L'exploration initiale a montr\u00e9 que sa capacit\u00e9 de fermentation \u00e9tait de 55,8 \u00b1 3,7 mg\/L dans le milieu Chatelier, ce qui ne r\u00e9pondait pas aux exigences de la production industrielle. L'objectif de cette \u00e9tude est d'optimiser le milieu de fermentation de la souche KWF31 en utilisant des m\u00e9thodes de surface de r\u00e9ponse telles que le plan de Plackett Burman, le plan de mont\u00e9e la plus raide et le plan de Box Behnken, et d'\u00e9tablir un sch\u00e9ma technologique de production de PA stable et \u00e0 haut rendement.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6616\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png\" alt=\"\" width=\"784\" height=\"214\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243-768x210.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6617\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-203.png\" alt=\"\" width=\"785\" height=\"259\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-203.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-203-768x253.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6618\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-190.png\" alt=\"\" width=\"787\" height=\"157\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-190.png 787w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-190-768x153.png 768w\" sizes=\"(max-width: 787px) 100vw, 787px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6619\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-170.png\" alt=\"\" width=\"785\" height=\"373\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-170.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-170-768x365.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6620\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-153.png\" alt=\"\" width=\"780\" height=\"325\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-153.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-153-768x320.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6621\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-139.png\" alt=\"\" width=\"787\" height=\"240\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-139.png 787w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-139-768x234.png 768w\" sizes=\"(max-width: 787px) 100vw, 787px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6622\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-127.png\" alt=\"\" width=\"782\" height=\"477\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-127.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-127-768x468.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6623\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-115.png\" alt=\"\" width=\"785\" height=\"247\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-115.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-115-768x242.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6624\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-107.png\" alt=\"\" width=\"787\" height=\"145\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-107.png 787w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-107-768x141.png 768w\" sizes=\"(max-width: 787px) 100vw, 787px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6625\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-85.png\" alt=\"\" width=\"788\" height=\"617\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-85.png 788w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-85-768x601.png 768w\" sizes=\"(max-width: 788px) 100vw, 788px\" \/>Le PA est un alcalo\u00efde indole isopent\u00e9nyle dot\u00e9 d'une structure chimique unique et d'une excellente activit\u00e9 de r\u00e9sistance aux insectes. Il s'agit d'une mati\u00e8re premi\u00e8re pour la synth\u00e8se du Dextrant, un agent commercial r\u00e9sistant aux insectes, qui a une valeur marchande \u00e9lev\u00e9e et une \u00e9norme demande sur le march\u00e9. Cependant, la souche de Penicillium de type sauvage a un faible rendement en PA, avec de multiples \u00e9tapes de synth\u00e8se chimique et un faible rendement, ce qui fait qu'il est difficile de r\u00e9pondre \u00e0 la demande du march\u00e9. Cette \u00e9tude a utilis\u00e9 le plan de Plackett Burman pour s\u00e9lectionner trois composants du milieu qui affectent de mani\u00e8re significative la production de PA par fermentation horizontale de la souche sauvage KWF31 dans des flacons \u00e0 agitation \u00e0 partir de huit facteurs : amidon soluble, glucose et extrait de levure ; leurs concentrations ont \u00e9t\u00e9 progressivement optimis\u00e9es \u00e0 l'aide d'exp\u00e9riences d'escalade et du plan de Box Behnken. Les concentrations optimales sont les suivantes : amidon soluble 31,0 g\/l, glucose 1208 g\/l et extrait de levure 14,5 g\/l. Dans ce milieu, la souche de type sauvage KWF31 a montr\u00e9 une puissance \u00e9lev\u00e9e de 243,7 mg\/L pour la production d'AP pendant la fermentation horizontale en fiole agit\u00e9e, ce qui est 3,4 fois plus \u00e9lev\u00e9 qu'avant l'optimisation (55,8 mg\/L). Le processus \u00e9tabli dans cette \u00e9tude pour la production par fermentation d'AP par le champignon marin KWF31 pr\u00e9sente une bonne reproductibilit\u00e9, une bonne stabilit\u00e9 et une bonne contr\u00f4labilit\u00e9. Sur cette base, la poursuite du d\u00e9veloppement de processus de fermentation industrialis\u00e9s jette les bases du d\u00e9veloppement de nouveaux pesticides anti-n\u00e9matodes en Chine, ce qui a une importance th\u00e9orique et pratique importante pour la promotion d'un d\u00e9veloppement sain de l'\u00e9levage en Chine.<\/p>\n<p data-no-translation lang=\"en\"><em>Correction: 10 September 2026. Corrected the veterinary product identity and removed a dosing sentence that incorrectly named dexmedetomidine. This is a targeted claim correction; other historical statements still require their own supporting evidence.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology Parasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. At present, avernectins are the most widely used antiparasitic drugs in veterinary clinical practice worldwide. However, due to the abuse of this drug, drug-resistant strains have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/fr\/using-response-surface-methodology\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology Parasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. 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