{"id":5512,"date":"2024-08-04T19:31:38","date_gmt":"2024-08-04T19:31:38","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5512"},"modified":"2024-08-04T19:31:38","modified_gmt":"2024-08-04T19:31:38","slug":"uplc-q-orbitrap-hrms","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/fr\/uplc-q-orbitrap-hrms\/","title":{"rendered":"Empreinte UPLC-Q-Orbitrap HRMS et relation spectre-effet de l'activit\u00e9 antibact\u00e9rienne du Jinlongdeng"},"content":{"rendered":"

Empreinte UPLC-Q-Orbitrap HRMS et relation spectre-effet de l'activit\u00e9 antibact\u00e9rienne du Jinlongdeng
\nJin Deng Deng, \u00e9galement connu sous le nom de Suanjiang ou Red Maiden, est le calice s\u00e9ch\u00e9 ou fructifi\u00e9 de Physalis alkekengi L. var. franchetii (Mast.) Makino, une plante de la famille des Solanaceae. De saveur aigre et am\u00e8re, de nature froide, il appartient aux m\u00e9ridiens du poumon et de la rate. Elle a pour effet d'\u00e9liminer la chaleur et de d\u00e9sintoxiquer, de favoriser la gorge et d'\u00e9liminer les mucosit\u00e9s, la diur\u00e8se et de nettoyer le syst\u00e8me lymphatique. Il est utilis\u00e9 cliniquement pour traiter les maux de gorge, la toux due \u00e0 la chaleur du poumon et l'incontinence urinaire. La composition chimique du Jinlongdeng est vari\u00e9e et comprend principalement des compos\u00e9s tels que des amers, des flavono\u00efdes, des esters de saccharose, des ph\u00e9nylpropano\u00efdes, des alcalo\u00efdes, etc. Des \u00e9tudes pharmacologiques modernes ont montr\u00e9 que l'extrait d'alcool et l'extrait de dichlorom\u00e9thane de Jinlongdeng ont une bonne activit\u00e9 inhibitrice contre les bact\u00e9ries Gram positives, les bact\u00e9ries Gram n\u00e9gatives et Candida albicans. Il a \u00e9galement \u00e9t\u00e9 prouv\u00e9 que certains composants des amers acides ont des effets antibact\u00e9riens significatifs. \u00c0 l'heure actuelle, de nombreuses \u00e9tudes ont \u00e9t\u00e9 men\u00e9es sur l'activit\u00e9 antibact\u00e9rienne du Jinlongdeng, tant au niveau national qu'international, mais sa base mat\u00e9rielle n'est pas encore tr\u00e8s claire.<\/p>\n

La m\u00e9decine traditionnelle chinoise est elle-m\u00eame compos\u00e9e d'ingr\u00e9dients complexes et divers, et pr\u00e9sente les caract\u00e9ristiques d'une r\u00e9gulation multicible et globale lorsqu'elle exerce ses effets th\u00e9rapeutiques. La relation entre le spectre et l'efficacit\u00e9 de la m\u00e9decine traditionnelle chinoise repose sur l'\u00e9tude du spectre de l'empreinte digitale de la m\u00e9decine traditionnelle chinoise, sur le lien entre le spectre de l'empreinte digitale et les effets pharmacologiques, sur la recherche de la relation entre le spectre et l'efficacit\u00e9 et sur la clarification de la base mat\u00e9rielle de l'exercice des effets pharmacologiques. \u00c0 l'heure actuelle, il existe relativement peu de recherches sur le spectre d'empreintes digitales et la relation d'efficacit\u00e9 spectrale du Jinlongdeng. Par cons\u00e9quent, cette \u00e9tude vise \u00e0 explorer la base mat\u00e9rielle de l'activit\u00e9 antibact\u00e9rienne du Jinlongdeng \u00e0 partir de sa relation spectre-effet. En \u00e9tablissant les spectres d'empreintes digitales par spectrom\u00e9trie de masse de 16 lots de lanternes Jin Deng de trois origines diff\u00e9rentes et en d\u00e9terminant leur activit\u00e9 antibact\u00e9rienne contre Staphylococcus aureus et Escherichia coli, l'analyse de corr\u00e9lation grise a \u00e9t\u00e9 utilis\u00e9e pour explorer la corr\u00e9lation entre les pics caract\u00e9ristiques et leur activit\u00e9 antibact\u00e9rienne, afin de clarifier la base mat\u00e9rielle de leur activit\u00e9 antibact\u00e9rienne et de fournir une base pour le d\u00e9veloppement, l'utilisation et la recherche sur le contr\u00f4le de la qualit\u00e9 des lanternes Jin Deng.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Au d\u00e9but de cette exp\u00e9rience, l'effet de diff\u00e9rentes concentrations de m\u00e9thanol (50%, 70%, 100%) sur l'efficacit\u00e9 de l'extraction des mati\u00e8res m\u00e9dicinales de Jinlongdeng a \u00e9t\u00e9 \u00e9tudi\u00e9, et il a \u00e9t\u00e9 constat\u00e9 que le pic \u00e9tait le plus \u00e9lev\u00e9 lors de l'extraction de l'eau par le m\u00e9thanol \u00e0 70%. Parall\u00e8lement, lors de l'\u00e9tude des conditions de spectrom\u00e9trie de masse, il a \u00e9t\u00e9 constat\u00e9 que le chromatogramme de l'ion total en mode d'ion n\u00e9gatif \u00e9tait plus stable et que la forme du pic \u00e9tait plus attrayante. Par cons\u00e9quent, l'exp\u00e9rience a \u00e9t\u00e9 men\u00e9e en mode de balayage d'ions n\u00e9gatifs.<\/p>\n

Cette \u00e9tude a \u00e9tabli les spectres d'empreintes digitales de 16 lots d'herbes m\u00e9dicinales Jinlongdeng, extrait 38 pics communs, et la similarit\u00e9 \u00e9tait sup\u00e9rieure \u00e0 0,95, ce qui indique que la qualit\u00e9 des herbes m\u00e9dicinales Jinlongdeng de diff\u00e9rentes origines est relativement stable ; l'analyse en grappes et l'analyse PCA peuvent toutes deux regrouper les \u00e9chantillons en fonction des diff\u00e9rentes origines, ce qui indique que l'environnement de croissance des mati\u00e8res m\u00e9dicinales est un facteur majeur \u00e0 l'origine des diff\u00e9rences de qualit\u00e9.<\/p>\n

Parall\u00e8lement, cette \u00e9tude a d\u00e9termin\u00e9 l'activit\u00e9 antibact\u00e9rienne de 16 lots d'extraits de lanterne Jin Deng contre Staphylococcus aureus et Escherichia coli. Pour la premi\u00e8re fois, les spectres d'empreintes digitales ont \u00e9t\u00e9 combin\u00e9s \u00e0 des r\u00e9sultats pharmacologiques, et l'analyse de corr\u00e9lation grise a \u00e9t\u00e9 utilis\u00e9e pour \u00e9tudier la relation spectrale d'efficacit\u00e9 de la lanterne Jin Deng. Les r\u00e9sultats ont montr\u00e9 que l'activit\u00e9 antibact\u00e9rienne du Jinlongdeng peut \u00eatre le r\u00e9sultat de l'action combin\u00e9e de plusieurs composants. Parmi eux, les pics caract\u00e9ristiques qui contribuent de mani\u00e8re significative \u00e0 l'activit\u00e9 antibact\u00e9rienne (corr\u00e9lation \u2265 0,85) sont tous compos\u00e9s d'esters d'acide gras de saccharose, ce qui indique que ces composants contribuent de mani\u00e8re significative \u00e0 l'activit\u00e9 antibact\u00e9rienne du Jinlongdeng.<\/p>\n

Dans le pass\u00e9, les recherches sur le Jinlongdeng se sont principalement concentr\u00e9es sur la structure chimique complexe et l'activit\u00e9 biologique significative des compos\u00e9s amers acides, tout en n\u00e9gligeant l'\u00e9tude des esters d'acide gras de saccharose. Les caract\u00e9ristiques structurelles des esters d'acide gras de saccharose sont que le saccharose sert de noyau parent et est li\u00e9 \u00e0 un ou plusieurs fragments de cha\u00eene d'acide gras par des liaisons ester. La recherche pharmacologique moderne a montr\u00e9 que ce type de compos\u00e9 poss\u00e8de des activit\u00e9s antibact\u00e9riennes, anti-inflammatoires, hypoglyc\u00e9miques, antitumorales, insecticides et autres. Par ailleurs, les esters d'acide gras de saccharose ont une bonne biod\u00e9gradabilit\u00e9 et de bonnes propri\u00e9t\u00e9s toxicologiques, de sorte que leurs perspectives d'application sont vastes et m\u00e9ritent notre attention.<\/p>\n

En r\u00e9sum\u00e9, cette \u00e9tude a permis d'\u00e9tablir avec succ\u00e8s le spectre d'empreintes digitales de l'extrait de Lonicera japonica et d'\u00e9tudier pour la premi\u00e8re fois sa relation spectrale avec l'effet. Les r\u00e9sultats ont montr\u00e9 que les composants de l'ester d'acide gras du saccharose \u00e9taient \u00e9troitement li\u00e9s \u00e0 l'activit\u00e9 antibact\u00e9rienne de Lonicera japonica. Toutefois, en raison de sa structure unique, il n'a pas \u00e9t\u00e9 possible d'effectuer une analyse approfondie de sa structure par spectrom\u00e9trie de masse dans le cadre de cette exp\u00e9rience. \u00c0 l'avenir, ce type de composant du Jin Deng sera isol\u00e9 et purifi\u00e9 pour v\u00e9rifier son activit\u00e9 antibact\u00e9rienne. Sur cette base, la relation structure-activit\u00e9 sera r\u00e9sum\u00e9e pour servir de r\u00e9f\u00e9rence \u00e0 des recherches plus approfondies sur l'activit\u00e9 antibact\u00e9rienne et le m\u00e9canisme d'action du Jin Deng.<\/p>","protected":false},"excerpt":{"rendered":"

UPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng Jin Deng Deng, also known as Suanjiang or Red Maiden, is the dried or fruiting calyx of Physalis alkekengi L. var. franchetii (Mast.) Makino, a plant in the Solanaceae family. Sour and bitter in taste, cold in nature, belongs to the lung and […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nUPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/fr\/uplc-q-orbitrap-hrms\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"UPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng Jin Deng Deng, also known as Suanjiang or Red Maiden, is the dried or fruiting calyx of Physalis alkekengi L. var. franchetii (Mast.) Makino, a plant in the Solanaceae family. Sour and bitter in taste, cold in nature, belongs to the lung and […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/fr\/uplc-q-orbitrap-hrms\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T19:31:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-9.jpg\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/\",\"url\":\"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/\",\"name\":\"UPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-9.jpg\",\"datePublished\":\"2024-08-04T19:31:38+00:00\",\"dateModified\":\"2024-08-04T19:31:38+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-9.jpg\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-9.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"UPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Empreinte UPLC-Q-Orbitrap HRMS et relation spectre-effet de l'activit\u00e9 antibact\u00e9rienne de Jinlongdeng - China Chemical Manufacturer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/fr\/uplc-q-orbitrap-hrms\/","og_locale":"fr_FR","og_type":"article","og_title":"UPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng - China Chemical Manufacturer","og_description":"UPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng Jin Deng Deng, also known as Suanjiang or Red Maiden, is the dried or fruiting calyx of Physalis alkekengi L. var. franchetii (Mast.) Makino, a plant in the Solanaceae family. Sour and bitter in taste, cold in nature, belongs to the lung and […]","og_url":"https:\/\/longchangextracts.com\/fr\/uplc-q-orbitrap-hrms\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T19:31:38+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-9.jpg"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"longcha9","Dur\u00e9e de lecture estim\u00e9e":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/","url":"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/","name":"Empreinte UPLC-Q-Orbitrap HRMS et relation spectre-effet de l'activit\u00e9 antibact\u00e9rienne de Jinlongdeng - China Chemical Manufacturer","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-9.jpg","datePublished":"2024-08-04T19:31:38+00:00","dateModified":"2024-08-04T19:31:38+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-9.jpg","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-9.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/uplc-q-orbitrap-hrms\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"UPLC-Q-Orbitrap HRMS fingerprint and spectrum effect relationship of antibacterial activity of Jinlongdeng"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"Fabricant chinois de produits chimiques","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/posts\/5512"}],"collection":[{"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/comments?post=5512"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/posts\/5512\/revisions"}],"predecessor-version":[{"id":5523,"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/posts\/5512\/revisions\/5523"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/media?parent=5512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/categories?post=5512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/fr\/wp-json\/wp\/v2\/tags?post=5512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}