{"id":5435,"date":"2024-08-04T18:58:34","date_gmt":"2024-08-04T18:58:34","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5435"},"modified":"2024-08-04T18:58:34","modified_gmt":"2024-08-04T18:58:34","slug":"research-on-non-coumarin-components-in-bai-zhi","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/fr\/research-on-non-coumarin-components-in-bai-zhi\/","title":{"rendered":"Recherche sur les composants non coumariniques dans le Bai Zhi"},"content":{"rendered":"Recherche sur les composants non coumariniques dans le Bai Zhi
\nBai Zhi est une plante de la famille des ombellif\u00e8res, Angelica dahurica (Fisch. ex Hoffm.) Benth Et Hook. f. ou Hangbaizhi A dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan, racines s\u00e9ch\u00e9es. Go\u00fbt \u00e9pic\u00e9, nature chaude. Elle a pour effet de soulager les sympt\u00f4mes, de dissiper le froid, de chasser le vent et de soulager la douleur, de favoriser l'ouverture nasale, d'ass\u00e9cher l'humidit\u00e9 et d'arr\u00eater les ceintures, et de r\u00e9duire l'enflure et le pus. En pratique clinique, elle est utilis\u00e9e pour traiter les rhumes, les maux de t\u00eate, les douleurs sourcili\u00e8res, la congestion nasale, l'\u00e9coulement nasal, la congestion nasale, la sinusite nasale, les maux de dents, les pertes vaginales, les plaies douloureuses, etc. Angelica dahurica est l'une des substances m\u00e9dicinales en vrac les plus couramment utilis\u00e9es dans la pratique clinique. Selon les statistiques, jusqu'\u00e0 pr\u00e9sent, 565 vari\u00e9t\u00e9s de m\u00e9dicaments traditionnels chinois brevet\u00e9s et de pr\u00e9parations simples contenant de l'ang\u00e9lique dahurica ont \u00e9t\u00e9 incluses dans la base de donn\u00e9es des m\u00e9dicaments traditionnels chinois brevet\u00e9s et des pr\u00e9parations simples, et 1836 prescriptions contenant de l'ang\u00e9lique dahurica ont \u00e9t\u00e9 incluses dans la base de donn\u00e9es des prescriptions de la m\u00e9decine traditionnelle chinoise. Pour \u00e9lucider la base de sa substance pharmacologique, les chercheurs ont isol\u00e9 et identifi\u00e9 une s\u00e9rie de composants coumariniques dans le Bai Zhi. En outre, la litt\u00e9rature indique que le Bai Zhi contient d'abondants flavono\u00efdes, mais il n'existe actuellement aucun rapport pertinent sur l'isolement et la purification des monom\u00e8res de flavono\u00efdes du Bai Zhi. Lors de l'\u00e9tude syst\u00e9matique pr\u00e9liminaire de la composition chimique d'Angelica dahurica, l'\u00e9quipe de recherche a d\u00e9couvert qu'en plus d'une grande quantit\u00e9 de composants coumariniques, Angelica dahurica peut \u00e9galement contenir des composants non coumariniques tels que des alcalo\u00efdes et des flavono\u00efdes. En utilisant la technologie de s\u00e9paration guid\u00e9e par LC-MS, de multiples dim\u00e8res de coumarine structurellement nouveaux ont \u00e9t\u00e9 d\u00e9couverts avec succ\u00e8s dans l'Angelica dahurica, et les parties \u00e0 haute polarit\u00e9 de l'extrait d'\u00e9thanol de Hangbai dahurica ont \u00e9t\u00e9 \u00e9tudi\u00e9es. Seize alcalo\u00efdes pyrroliques ont \u00e9t\u00e9 isol\u00e9s et identifi\u00e9s avec succ\u00e8s. Cet article rapporte \u00e9galement l'isolement et l'identification de compos\u00e9s non coumariniques \u00e0 partir des parties solubles dans l'eau d'Angelica dahurica.<\/p>\n
![\"\"](\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-146.png\")
Dans la litt\u00e9rature sur la composition chimique d'Angelica dahurica, on pense g\u00e9n\u00e9ralement que les principaux composants chimiques d'Angelica dahurica sont des compos\u00e9s coumariniques, alors qu'il existe peu de rapports sur les compos\u00e9s non coumariniques d'Angelica dahurica. Lu et al. ont isol\u00e9 et identifi\u00e9 un alcalo\u00efde pyrrolique, la coumarine, \u00e0 partir d'Angelica dahurica. Dans notre \u00e9tude syst\u00e9matique de l'Angelica dahurica, notre groupe de recherche a non seulement isol\u00e9 une grande quantit\u00e9 de coumarines et de dim\u00e8res de coumarine, mais a \u00e9galement isol\u00e9 16 alcalo\u00efdes pyrroliques de l'Angelica dahurica, ce qui a permis d'enrichir notre compr\u00e9hension de sa composition chimique. En poursuivant les recherches sur la composition chimique du Bai Zhi, 18 composants non coumariniques mentionn\u00e9s dans cet article ont \u00e9t\u00e9 isol\u00e9s de mani\u00e8re inattendue. Outre l'alcalo\u00efde Jin Qian Cao signal\u00e9 pr\u00e9c\u00e9demment, les 17 autres composants non coumariniques, dont 9 flavono\u00efdes, 5 lignanes, 2 esters ph\u00e9noliques simples et la 1-H-imidazo [4,5-d] pyridazin-2-amine, ont tous \u00e9t\u00e9 isol\u00e9s de Bai Zhi pour la premi\u00e8re fois. Les compos\u00e9s 3 et 18 ont certains effets inhibiteurs sur la lib\u00e9ration de superoxyde des neutrophiles induite par le zymosan, tandis que les compos\u00e9s 1 et 18 ont des effets inhibiteurs sur la lib\u00e9ration de l'activit\u00e9 NO des cellules RAW 264.7. Il convient de noter que, bien qu'il y ait eu de nombreux rapports bibliographiques sur la pr\u00e9sence de flavono\u00efdes dans Angelica dahurica, il s'agit toujours de rapports pr\u00e9liminaires sur la d\u00e9termination de la teneur totale en flavono\u00efdes. Il n'existe actuellement aucun rapport sur l'isolement des flavono\u00efdes monom\u00e8res d'Angelica dahurica. Cependant, dans cette \u00e9tude, des flavono\u00efdes multiples et des glycosides flavono\u00efdes monom\u00e8res ont \u00e9t\u00e9 obtenus pour la premi\u00e8re fois \u00e0 partir d'Angelica dahurica, ce qui nous a beaucoup surpris. Nous avons dout\u00e9 qu'il s'agisse d'un probl\u00e8me avec les mat\u00e9riaux m\u00e9dicinaux, mais une analyse plus pouss\u00e9e des compos\u00e9s 1, 6, 7 et 8 isol\u00e9s et rapport\u00e9s dans cet article a \u00e9t\u00e9 trouv\u00e9e dans l'Angelica dahurica de trois origines diff\u00e9rentes, Hangbai, Chuanbai et Yubai, \u00e0 l'aide de la LC-MS. Cela indique que les compos\u00e9s 1, 6, 7 et 8 peuvent \u00eatre d\u00e9tect\u00e9s dans l'Angelica dahurica de diff\u00e9rentes origines. Le Bai Zhi peut effectivement contenir des flavono\u00efdes. Les r\u00e9sultats de la recherche ont permis de mieux comprendre la composition chimique de l'Angelica dahurica et ont fourni des r\u00e9f\u00e9rences importantes pour le contr\u00f4le de la qualit\u00e9, le d\u00e9veloppement et l'utilisation de cette plante.<\/p>","protected":false},"excerpt":{"rendered":"
Research on Non coumarin Components in Bai Zhi Bai Zhi is a plant in the Umbelliferae family, Angelica dahurica (Fisch. ex Hoffm.) Benth Et Hook. f. or Hangbaizhi A dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan’s dried roots. Spicy taste, warm nature. It has the effects of relieving […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\n
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Benth Et Hook. f. or Hangbaizhi A dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan’s dried roots. Spicy taste, warm nature. 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