{"id":5066,"date":"2024-08-04T17:08:27","date_gmt":"2024-08-04T17:08:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5066"},"modified":"2024-08-04T17:08:27","modified_gmt":"2024-08-04T17:08:27","slug":"a-new-amide-alkaloid-in-the-root-of-fake-konjac","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/fr\/a-new-amide-alkaloid-in-the-root-of-fake-konjac\/","title":{"rendered":"Un nouvel alcalo\u00efde amide dans la racine du faux konjac"},"content":{"rendered":"

Un nouvel alcalo\u00efde amide dans la racine du faux konjac
\nPiper sarmentosum est une herbe vivace, rampante, enracin\u00e9e n\u0153ud par n\u0153ud de la famille des Piperaceae, que l'on trouve commun\u00e9ment dans les zones humides de sous-bois ou de bord de route. Elle est principalement produite dans des provinces telles que le Yunnan, le Fujian et le Guizhou en Chine, et est \u00e9galement distribu\u00e9e en Inde, au Vi\u00eat Nam, aux Philippines et en Malaisie. Le faux konjac a non seulement une grande valeur m\u00e9dicinale, mais aussi une grande valeur ornementale, comestible et \u00e9conomique. Selon les classiques tels que \"Chinese Materia Medica\", le faux konjac a une nature chaude et un go\u00fbt amer et piquant. Ses racines, ses feuilles et ses fruits peuvent tous \u00eatre utilis\u00e9s comme m\u00e9dicaments et ont pour effet de r\u00e9chauffer le milieu et de disperser le froid, de dissiper le vent et l'humidit\u00e9, de r\u00e9duire les gonflements et les douleurs. Le konjac est couramment utilis\u00e9 dans le traitement des douleurs dues au froid de l'estomac, des douleurs dorsales rhumatismales, des \u0153d\u00e8mes de grossesse et des h\u00e9morragies traumatiques, avec des effets th\u00e9rapeutiques significatifs. Les fausses feuilles de konjac sont largement utilis\u00e9es et cultiv\u00e9es comme assaisonnement dans les r\u00e9gions de Jiangsu, Zhejiang et Guangdong, dans le sud de la Chine, en raison de leur ar\u00f4me piquant unique.
\nLes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les extraits de faux konjac ont un large \u00e9ventail d'activit\u00e9s biologiques, telles que des propri\u00e9t\u00e9s antioxydantes, anti-inflammatoires, antibact\u00e9riennes, insecticides, hypoglyc\u00e9miques et neuroprotectrices. \u00c0 l'heure actuelle, les recherches sur la composition chimique du faux konjac, tant au niveau national qu'international, se concentrent principalement sur les feuilles et les parties a\u00e9riennes, les recherches sur les racines souterraines \u00e9tant relativement peu nombreuses. Les composants chimiques isol\u00e9s et identifi\u00e9s \u00e0 partir du faux konjac comprennent des alcalo\u00efdes, des lignanes, des flavono\u00efdes et des st\u00e9rols. Notre groupe de recherche a isol\u00e9 7 compos\u00e9s alcalo\u00efdes \u00e0 partir des feuilles de faux konjac \u00e0 un stade pr\u00e9coce, dont certains ont montr\u00e9 une bonne activit\u00e9 antibact\u00e9rienne contre Staphylococcus aureus. Dans le cadre de recherches continues sur la composition chimique et l'activit\u00e9 biologique du faux konjac, il a \u00e9t\u00e9 constat\u00e9 que l'extrait \u00e9thanolique 95% de la racine de faux konjac peut att\u00e9nuer les sympt\u00f4mes de l'enflure du pied de la souris induite par la carrag\u00e9nine et a un effet d\u00e9pendant de la dose. On suppose donc que l'extrait contient des principes actifs anti-inflammatoires. Des \u00e9tudes connexes ont montr\u00e9 que les alcalo\u00efdes sont les principaux ingr\u00e9dients actifs de la racine du faux konjac. Cette exp\u00e9rience a permis d'\u00e9tudier la composition chimique de l'extrait \u00e9thanolique 95% de la racine de faux konjac et d'utiliser le mod\u00e8le d'inflammation cellulaire in vitro RAW264.7 induit par le LPS pour examiner l'activit\u00e9 anti-inflammatoire des compos\u00e9s monom\u00e8res obtenus. L'objectif est de clarifier la composition chimique et la base des substances pharmacologiques associ\u00e9es de la racine de faux konjac, afin de fournir des r\u00e9f\u00e9rences pour un d\u00e9veloppement et une utilisation plus rationnels des ressources v\u00e9g\u00e9tales de faux konjac.<\/p>\n

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\nCette exp\u00e9rience a utilis\u00e9 des techniques modernes de s\u00e9paration chromatographique et des m\u00e9thodes spectroscopiques pour isoler et identifier 10 compos\u00e9s alcalo\u00efdes de la racine du faux konjac. Parmi eux, le compos\u00e9 1 est un nouvel alcalo\u00efde amide, et tous les compos\u00e9s, \u00e0 l'exception du compos\u00e9 5, sont isol\u00e9s de cette plante pour la premi\u00e8re fois. L'activit\u00e9 anti-inflammatoire des compos\u00e9s isol\u00e9s a \u00e9t\u00e9 \u00e9valu\u00e9e \u00e0 l'aide d'un mod\u00e8le d'inflammation des macrophages RAW264.7 stimul\u00e9 par le LPS. Les r\u00e9sultats ont montr\u00e9 que les compos\u00e9s 1, 2, 4 et 10 avaient des effets inhibiteurs sur la production de NO et ne pr\u00e9sentaient pas de cytotoxicit\u00e9 significative aux concentrations test\u00e9es. Les r\u00e9sultats de cette \u00e9tude enrichissent la composition chimique de la racine de faux konjac et clarifient de mani\u00e8re pr\u00e9liminaire la base de certaines substances actives anti-inflammatoires dans la racine de faux konjac, fournissant une r\u00e9f\u00e9rence certaine et une base th\u00e9orique pour le d\u00e9veloppement et l'utilisation futurs de cette ressource v\u00e9g\u00e9tale.<\/p>","protected":false},"excerpt":{"rendered":"

A new amide alkaloid in the root of fake konjac Piper sarmentosum is a perennial, creeping, node by node rooted herb of the Piperaceae family, commonly found in understory or roadside wetlands. It is mainly produced in provinces such as Yunnan, Fujian, and Guizhou in China, and is also distributed in India, Vietnam, the Philippines, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nA new amide alkaloid in the root of fake konjac - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/fr\/a-new-amide-alkaloid-in-the-root-of-fake-konjac\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new amide alkaloid in the root of fake konjac - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"A new amide alkaloid in the root of fake konjac Piper sarmentosum is a perennial, creeping, node by node rooted herb of the Piperaceae family, commonly found in understory or roadside wetlands. 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