{"id":4588,"date":"2024-08-04T14:55:47","date_gmt":"2024-08-04T14:55:47","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4588"},"modified":"2024-08-04T14:55:47","modified_gmt":"2024-08-04T14:55:47","slug":"bairui-granules","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/fr\/bairui-granules\/","title":{"rendered":"\u00c9tude sur les composants sanguins des granul\u00e9s Bai Rui bas\u00e9e sur la technologie UHPLC-Q-TOF-MS\/MS"},"content":{"rendered":"

\u00c9tude sur les composants sanguins des granul\u00e9s Bai Rui bas\u00e9e sur la technologie UHPLC-Q-TOF-MS\/MS<\/p>\n

\u00c9tude sur les composants sanguins des granul\u00e9s Bai Rui bas\u00e9e sur la technologie UHPLC-Q-TOF-MS\/MS
\nLes granul\u00e9s Bairui sont une pr\u00e9paration granulaire compos\u00e9e d'une seule herbe, l'herbe Bairui, qui a des effets antibact\u00e9riens et anti-inflammatoires, qui \u00e9vacue la chaleur et d\u00e9toxifie, et qui soulage la toux. Ils sont couramment utilis\u00e9s dans la pratique clinique moderne pour traiter l'amygdalite p\u00e9diatrique, la bronchite et diverses infections respiratoires. Les principes actifs de la m\u00e9decine traditionnelle chinoise sont principalement transport\u00e9s vers la cible par le sang (\u00e0 l'exclusion de l'action directe dans l'intestin et de la m\u00e9dication externe) pour exercer leurs effets. Par cons\u00e9quent, l'analyse des ingr\u00e9dients actifs dans le corps apr\u00e8s l'administration orale de la m\u00e9decine traditionnelle chinoise est tr\u00e8s importante pour l'\u00e9tude de la base mat\u00e9rielle de l'efficacit\u00e9 de la m\u00e9decine traditionnelle chinoise. Notre groupe de recherche a d\u00e9j\u00e0 utilis\u00e9 la technologie de la chromatographie liquide et de la spectrom\u00e9trie de masse pour analyser syst\u00e9matiquement la composition chimique de l'extrait d'alcool d'Atractylodes macrocephala et a constat\u00e9 que l'Atractylodes macrocephala contenait de nombreux ingr\u00e9dients efficaces, tels que des flavono\u00efdes, des alcalo\u00efdes et d'autres compos\u00e9s. Les \u00e9tudes pr\u00e9c\u00e9dentes se sont principalement concentr\u00e9es sur la composition chimique et le contr\u00f4le de la qualit\u00e9 de plantes isol\u00e9es, sans recherche sur les composants sanguins et les processus m\u00e9taboliques des granules d'Atractylodes macrocephala in vivo, et la base de la substance pharmacologique n'est pas encore claire.<\/p>\n

La technologie de la spectrom\u00e9trie de masse \u00e0 temps de vol quadripolaire, gr\u00e2ce \u00e0 sa sensibilit\u00e9 et \u00e0 sa r\u00e9solution \u00e9lev\u00e9es, permet d'analyser rapidement et efficacement les composants chimiques de la m\u00e9decine traditionnelle chinoise et a \u00e9t\u00e9 largement utilis\u00e9e dans la recherche sur les substances \u00e0 l'origine de l'efficacit\u00e9 de la m\u00e9decine traditionnelle chinoise. Par cons\u00e9quent, sur la base des recherches pr\u00e9c\u00e9dentes, notre groupe de recherche continue d'utiliser la technologie de spectrom\u00e9trie de masse \u00e0 temps de vol quadripolaire par chromatographie liquide \u00e0 ultra-haute performance (UHPLC-Q-TOF-MS\/MS) pour analyser les composants entrant dans le sang et le processus m\u00e9tabolique du granul\u00e9 Baisui, ce qui fournit une base de r\u00e9f\u00e9rence pour la recherche fondamentale sur les substances efficaces et rev\u00eat une grande importance pour le contr\u00f4le de la qualit\u00e9, le d\u00e9veloppement et l'utilisation des m\u00e9dicaments chinois traditionnels brevet\u00e9s et des pr\u00e9parations simples.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nCette \u00e9tude a utilis\u00e9 la technologie UHPLC-Q-TOF-MS\/MS pour analyser les composants sanguins absorb\u00e9s des granules de Bairui. Au total, 20 composants prototypes et 10 m\u00e9tabolites ont \u00e9t\u00e9 d\u00e9tect\u00e9s dans le s\u00e9rum de rat. Les principaux composants analys\u00e9s dans l'organisme sont des alcalo\u00efdes tels que la querc\u00e9tine et la sophocarpine, ainsi que des flavono\u00efdes tels que le kaempf\u00e9rol et le resv\u00e9ratrol I. Les principaux produits m\u00e9taboliques dans l'organisme sont l'oxydation et la glucuronidation du kaempf\u00e9rol et l'oxydation et l'hydrolyse de la sophocarpine, ce qui indique que les alcalo\u00efdes et les flavono\u00efdes sont les principaux composants entrant dans l'organisme et qu'ils peuvent \u00e9galement \u00eatre des ingr\u00e9dients actifs potentiels pour l'efficacit\u00e9 des m\u00e9dicaments.<\/p>\n

La recherche pharmacologique moderne a montr\u00e9 que les flavono\u00efdes et les alcalo\u00efdes ont des fonctions pharmacologiques telles que l'anti-inflammation, l'antibact\u00e9rien, l'antiviral et l'antioxydant. Des \u00e9tudes ant\u00e9rieures ont rapport\u00e9 que l'effet anti-inflammatoire des d\u00e9riv\u00e9s du resv\u00e9ratrol dans le Bai Rui Cao est li\u00e9 \u00e0 leur inhibition efficace de la production intracellulaire d'esp\u00e8ces r\u00e9actives de l'oxyg\u00e8ne et \u00e0 l'activation de la MAPK p38 et de la prot\u00e9ine activatrice 1. En tant que flavonol naturel, le resv\u00e9ratrol a un effet important sur l'inhibition de la fonction des cellules inflammatoires et la suppression de l'expression des cytokines et des chimiokines pro-inflammatoires. Le Bairuicao I peut inhiber l'expression des cytokines inflammatoires TNF-\u03b1, IL-6, IL-1 \u03b2, etc. en agissant sur les voies NF- \u03ba B et MAPK, am\u00e9liorant ainsi l'\u0153d\u00e8me pulmonaire chez les souris infect\u00e9es par la pneumonie. Les alcalo\u00efdes peuvent inhiber de mani\u00e8re significative la croissance de micro-organismes tels qu'Escherichia coli et Staphylococcus aureus. La sophocarpine a de puissants effets anti-inflammatoires et analg\u00e9siques et peut r\u00e9duire l'inflammation en inhibant la voie de signalisation NF - \u03ba B. L'oxymatrine peut exercer des effets anti-inflammatoires en inhibant la voie de signalisation NF - \u03ba B et en r\u00e9duisant l'expression des facteurs inflammatoires IL-6 et IL-8.<\/p>\n

En r\u00e9sum\u00e9, cette \u00e9tude a \u00e9lucid\u00e9 les composants sanguins et les m\u00e9tabolites des granules de Bairui en utilisant la technologie UHPLC-Q-TOFMS\/MS. Ces compos\u00e9s peuvent \u00eatre \u00e9troitement li\u00e9s aux effets anti-inflammatoires et antibact\u00e9riens des granules de Bairui, ce qui est tr\u00e8s important pour clarifier la base mat\u00e9rielle de l'efficacit\u00e9 de la m\u00e9decine traditionnelle chinoise et am\u00e9liorer les normes de qualit\u00e9 de la m\u00e9decine traditionnelle chinoise. Elle fournit une base de r\u00e9f\u00e9rence pour mieux comprendre son m\u00e9canisme d'action et son application clinique.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Bairui granules are a granular preparation composed of single herb Bairui grass, which has the effects of antibacterial and anti-inflammatory, clearing heat and detoxifying, and relieving cough. They are […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/fr\/bairui-granules\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Bairui granules are a granular preparation composed of single herb Bairui grass, which has the effects of antibacterial and anti-inflammatory, clearing heat and detoxifying, and relieving cough. 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