{"id":3748,"date":"2024-08-03T07:42:11","date_gmt":"2024-08-03T07:42:11","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3748"},"modified":"2024-08-03T07:42:11","modified_gmt":"2024-08-03T07:42:11","slug":"trichothecium-roseum-diterpene","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/fr\/trichothecium-roseum-diterpene\/","title":{"rendered":"Diterp\u00e8nes \u00e0 activit\u00e9 cytotoxique dans les produits de fermentation de Trichoderma rose"},"content":{"rendered":"

Diterp\u00e8nes \u00e0 activit\u00e9 cytotoxique dans les produits de fermentation de Trichoderma rose
\nLe trichoth\u00e9cium roseum, qui appartient \u00e0 l'ordre des Hyphomyceales du sous-phylum des Deuteromycotina, a \u00e9t\u00e9 d\u00e9couvert et nomm\u00e9 en 2008. Ce champignon est facilement isol\u00e9 \u00e0 partir de corps v\u00e9g\u00e9taux en d\u00e9composition, du sol et de l'air, et est un champignon pathog\u00e8ne pour les plantes et les l\u00e9gumes largement r\u00e9pandu dans le monde. De nombreuses \u00e9tudes ont \u00e9t\u00e9 men\u00e9es sur les m\u00e9tabolites du trichoderma rose dans des conditions de culture en laboratoire, avec des structures repr\u00e9sentatives comprenant des sesquiterp\u00e8nes, des sesquiterp\u00e8nes, des diterp\u00e8nes et des peptides cycliques. Parmi eux, le trichoth\u00e9c\u00e8ne est le plus \u00e9tudi\u00e9. Tang et al. ont rapport\u00e9 que les compos\u00e9s du monotrichoth\u00e9c\u00e8ne peuvent provoquer la pourriture des trognons de pomme, tandis que les toxines du monotrichoth\u00e9c\u00e8ne inhibent et interf\u00e8rent avec la synth\u00e8se des prot\u00e9ines et des acides nucl\u00e9iques chez l'homme et l'animal, entra\u00eenant une suppression immunitaire de la sant\u00e9 humaine et animale. La consommation d'aliments et de produits contamin\u00e9s par ces toxines peut entra\u00eener des effets toxiques g\u00e9n\u00e9ralis\u00e9s chez l'homme et l'animal.<\/p>\n

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\nOutre les compos\u00e9s toxiniques, des compos\u00e9s \u00e0 activit\u00e9 cytotoxique ont \u00e9galement \u00e9t\u00e9 trouv\u00e9s dans ce bouillon de fermentation, comme le compos\u00e9 sesquiterp\u00e9nique cuspidatol trouv\u00e9 dans ce genre, qui a montr\u00e9 une forte activit\u00e9 immunosuppressive dans les essais MLR avec une valeur IC50 de 11 \u03bc g\/mL ; la monotrichoth\u00e9cine A a un fort effet inhibiteur sur la croissance des cellules HL-60, SMMC-7721, A549, MCF-7, et SW480, avec des valeurs IC50 de 0.022, 0,020, 0,015, 0,006 et 0.011 \u03bc mol\/L, respectivement, qui sont comparables au contr\u00f4le positif paclitaxel ; Le compos\u00e9 diterp\u00e9nique rosonolactone a de forts effets anti-prolif\u00e9ratifs et pro-apoptotiques sur les cellules HeLa du cancer du col de l'ut\u00e9rus humain ; La ros\u00e9ocarde, un compos\u00e9 peptidique ester cyclique, a un effet inotrope positif sur le myocarde de rat ; Le compos\u00e9 peptidique cyclique tricomide D a montr\u00e9 une cytotoxicit\u00e9 significative contre trois lign\u00e9es de cellules canc\u00e9reuses humaines (MCF-7, SW480, HL-6), avec des valeurs IC50 de 0.079, 0,107 et 0,149 \u03bc mol\/L, respectivement. Il s'agit du premier rapport sur l'activit\u00e9 cytotoxique de peptides cycliques. Afin de poursuivre la recherche de nouveaux compos\u00e9s ayant une activit\u00e9 cytotoxique, notre groupe de recherche a isol\u00e9 et identifi\u00e9 une souche de trichoth\u00e8que rose dans le sol o\u00f9 pousse le Ganoderma lucidum sauvage \u00e0 Baise (la ville d'origine du Ganoderma lucidum). Nous avons utilis\u00e9 un milieu de culture de riz pour \u00e9tendre le processus de fermentation, afin de d\u00e9couvrir des compos\u00e9s ayant des structures nouvelles et une bonne activit\u00e9 biologique, et de fournir des structures de m\u00e9dicaments de pointe.<\/p>\n

Dans cette \u00e9tude, cinq compos\u00e9s ont \u00e9t\u00e9 isol\u00e9s et identifi\u00e9s \u00e0 partir des produits de fermentation de T. roseum, tous \u00e9tant des diterp\u00e8nes. Parmi eux, le compos\u00e9 1 est un nouveau compos\u00e9 diterp\u00e9no\u00efde. Ce r\u00e9sultat enrichit la diversit\u00e9 des m\u00e9tabolites produits par le trichoderma rose. Cinq compos\u00e9s ont montr\u00e9 des degr\u00e9s variables d'effets inhibiteurs sur les cellules MCF-7, les compos\u00e9s 1 et 5 pr\u00e9sentant la meilleure activit\u00e9. On suppose que cela peut \u00eatre d\u00fb aux structures similaires des anneaux A et B des compos\u00e9s 1 et 5, tandis que le compos\u00e9 5, bien qu'il ressemble \u00e0 une cha\u00eene, a une conformation dominante avec une extension spatiale similaire au compos\u00e9 1. Les compos\u00e9s ayant cette caract\u00e9ristique structurelle ont montr\u00e9 une meilleure activit\u00e9 dans le mod\u00e8le de recherche d'activit\u00e9 s\u00e9lectionn\u00e9 dans cet article. Cette \u00e9tude enrichit la diversit\u00e9 des structures des m\u00e9tabolites secondaires des champignons Trichothecaum et fournit une r\u00e9f\u00e9rence pour le criblage de compos\u00e9s actifs anti-tumoraux.<\/p>","protected":false},"excerpt":{"rendered":"

Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. This fungus is easily isolated from decaying plant bodies, soil, and air, and is a widely distributed plant and vegetable pathogenic fungus worldwide. There have […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nDiterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/fr\/trichothecium-roseum-diterpene\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. This fungus is easily isolated from decaying plant bodies, soil, and air, and is a widely distributed plant and vegetable pathogenic fungus worldwide. 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