{"id":10644,"date":"2026-03-10T02:21:30","date_gmt":"2026-03-10T02:21:30","guid":{"rendered":"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/"},"modified":"2026-03-10T02:21:30","modified_gmt":"2026-03-10T02:21:30","slug":"esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/fr\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/","title":{"rendered":"Esomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor"},"content":{"rendered":"

<\/p>\n

What is Esomeprazole?<\/h2>\n

Esomeprazole is the S-enantiomer of omeprazole, belonging to the benzimidazole class of proton pump inhibitors. Chemically, it is designated as (S)-5-Methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl-1H-benzimidazole. The compound is a substituted benzimidazole with a molecular formula of C17H19N3O3S and a molecular weight of 345.42 g\/mol.<\/p>\n

Unlike its racemic parent compound omeprazole, esomeprazole consists specifically of the (S)-enantiomer, which demonstrates improved bioavailability and more consistent pharmacokinetic profiles compared to the racemic mixture.<\/p>\n

Chemical Properties of Esomeprazole<\/h2>\n\n\n\n\n\n\n\n\n
Num\u00e9ro CAS<\/strong><\/td>\n119141-88-7<\/td>\n<\/tr>\n
Formule mol\u00e9culaire<\/strong><\/td>\nC17H19N3O3S<\/td>\n<\/tr>\n
Poids mol\u00e9culaire<\/strong><\/td>\n345.42 g\/mol<\/td>\n<\/tr>\n
Apparence<\/strong><\/td>\nPoudre cristalline blanche \u00e0 blanc cass\u00e9<\/td>\n<\/tr>\n
Solubilit\u00e9<\/strong><\/td>\nSoluble in methanol and DMSO; slightly soluble in water<\/td>\n<\/tr>\n
pKa<\/strong><\/td>\n9.0 (benzimidazole nitrogen)<\/td>\n<\/tr>\n
Point de fusion<\/strong><\/td>\n155-160C<\/td>\n<\/tr>\n<\/table>\n

Structural Classification<\/h3>\n

Esomeprazole is classified as a substituted benzimidazole, a group of compounds characterized by a benzimidazole core structure with various substituents.<\/p>\n

M\u00e9canisme d'action<\/h2>\n

Esomeprazole works by irreversibly inhibiting the gastric H+\/K+-ATPase enzyme, which is responsible for the final step of gastric acid secretion in parietal cells of the stomach.<\/p>\n

    \n
  1. Pro-drug activation<\/strong>: Esomeprazole is a pro-drug that requires activation in the acidic environment of the parietal cell canaliculi.<\/li>\n
  2. Covalent binding<\/strong>: The activated form forms covalent disulfide bonds with cysteine residues on the H+\/K+-ATPase enzyme.<\/li>\n
  3. Prolonged inhibition<\/strong>: This irreversible binding inhibits acid secretion until new proton pumps are synthesized, providing up to 24 hours of acid suppression.<\/li>\n<\/ol>\n

    Therapeutic Uses and Benefits<\/h2>\n

    Esomeprazole is FDA-approved for the treatment of multiple gastrointestinal conditions:<\/p>\n

      \n
    • Gastroesophageal Reflux Disease (GERD)<\/strong>: Treatment of erosive esophagitis<\/li>\n
    • Duodenal Ulcer<\/strong>: Healing and prevention of recurrence<\/li>\n
    • Gastric Ulcer<\/strong>: Treatment of benign gastric ulcers<\/li>\n
    • NSAID-induced Ulcers<\/strong>: Prevention of gastric ulcers<\/li>\n
    • Zollinger-Ellison Syndrome<\/strong>: Management of gastric acid hypersecretion<\/li>\n
    • Helicobacter pylori Eradication<\/strong>: As part of combination therapy<\/li>\n<\/ul>\n

      Clinical Benefits<\/h3>\n
        \n
      • Rapid onset of action<\/strong>: Begins suppressing acid within 1 hour<\/li>\n
      • Long-lasting effect<\/strong>: Single daily dosing provides 24-hour acid control<\/li>\n
      • Superior efficacy<\/strong>: Better acid control than omeprazole<\/li>\n
      • Improved healing rates<\/strong>: Higher rates of erosive esophagitis healing<\/li>\n<\/ul>\n

        Dosage et administration<\/h2>\n\n\n\n\n\n\n
        Condition<\/th>\nRecommended Dose<\/th>\nDuration<\/th>\n<\/tr>\n
        GERD\/Erosive Esophagitis<\/td>\n20-40 mg once daily<\/td>\n4-8 weeks<\/td>\n<\/tr>\n
        Duodenal Ulcer<\/td>\n20 mg once daily<\/td>\n2-4 weeks<\/td>\n<\/tr>\n
        Gastric Ulcer<\/td>\n20-40 mg once daily<\/td>\n4-8 weeks<\/td>\n<\/tr>\n
        H. pylori Eradication<\/td>\n20-40 mg twice daily<\/td>\n10-14 days<\/td>\n<\/tr>\n<\/table>\n

        Administration Guidelines<\/h3>\n
          \n
        • Take esomeprazole at least 1 hour before meals<\/li>\n
        • Swallow tablets whole; do not crush or chew<\/li>\n
        • Can be administered via nasogastric tube if needed<\/li>\n<\/ul>\n

          Side Effects and Safety Profile<\/h2>\n

          Effets ind\u00e9sirables fr\u00e9quents<\/h3>\n
            \n
          • Headache<\/li>\n
          • Naus\u00e9e<\/li>\n
          • Diarrh\u00e9e<\/li>\n
          • Abdominal pain<\/li>\n
          • Constipation<\/li>\n
          • Flatulence<\/li>\n<\/ul>\n

            Less Common Side Effects<\/h3>\n
              \n
            • Dizziness<\/li>\n
            • Dry mouth<\/li>\n
            • Rash<\/li>\n
            • Pruritus (itching)<\/li>\n<\/ul>\n

              Rare but Serious Considerations<\/h3>\n
                \n
              • Long-term use risks<\/strong>: Increased risk of fractures, vitamin B12 deficiency<\/li>\n
              • Interactions m\u00e9dicamenteuses<\/strong>: Reduced absorption of ketoconazole, iron salts<\/li>\n
              • Hypersensitivity reactions<\/strong>: Rare cases of anaphylaxis<\/li>\n<\/ul>\n

                Contre-indications<\/h3>\n
                  \n
                • Known hypersensitivity to esomeprazole or omeprazole<\/li>\n
                • Concomitant use with rilpivirine<\/li>\n
                • Patients with severe hepatic impairment<\/li>\n<\/ul>\n

                  Drug Interactions<\/h2>\n\n\n\n\n\n\n
                  Interacting Drug<\/th>\nEffect<\/th>\n<\/tr>\n
                  Clopidogrel<\/td>\nReduced antiplatelet effect<\/td>\n<\/tr>\n
                  Atazanavir<\/td>\nDecreased atazanavir levels<\/td>\n<\/tr>\n
                  Ketoconazole<\/td>\nReduced antifungal absorption<\/td>\n<\/tr>\n
                  Iron salts<\/td>\nReduced iron absorption<\/td>\n<\/tr>\n<\/table>\n

                  Why Choose Esomeprazole?<\/h2>\n

                  Advantages Over Other PPIs<\/h3>\n
                    \n
                  1. Higher bioavailability<\/strong>: 50-70% higher plasma concentrations than omeprazole<\/li>\n
                  2. Better acid control<\/strong>: More consistent gastric pH elevation<\/li>\n
                  3. Improved healing rates<\/strong>: Superior healing of erosive esophagitis<\/li>\n
                  4. Faster symptom relief<\/strong>: Quicker resolution of heartburn<\/li>\n<\/ol>\n

                    Quality Considerations<\/h3>\n

                    For pharmaceutical manufacturing or research:<\/p>\n

                      \n
                    • Purity: 98% minimum for pharmaceutical applications<\/li>\n
                    • cGMP-compliant manufacturing<\/li>\n
                    • Complete COA available<\/li>\n
                    • Une cha\u00eene d'approvisionnement fiable<\/li>\n<\/ul>\n

                      Foire aux questions<\/h2>\n

                      Q: How does esomeprazole differ from omeprazole?<\/h3>\n

                      A:<\/strong> Esomeprazole is the S-isomer of omeprazole, providing better bioavailability and more consistent acid suppression.<\/p>\n

                      Q: Can I take esomeprazole with food?<\/h3>\n

                      A:<\/strong> Best taken 30-60 minutes before meals for optimal absorption.<\/p>\n

                      Q: How long can I take esomeprazole?<\/h3>\n

                      A:<\/strong> Treatment typically lasts 4-8 weeks for GERD. Long-term use requires medical supervision.<\/p>\n

                      Q: Is esomeprazole safe for long-term use?<\/h3>\n

                      A:<\/strong> Long-term use may have risks. Regular monitoring by healthcare provider is recommended.<\/p>\n

                      Conclusion<\/h2>\n

                      Esomeprazole (CAS 119141-88-7) represents a significant advancement in proton pump inhibitor therapy. Its superior pharmacokinetic properties and proven efficacy make it a preferred choice for treating acid-related gastrointestinal disorders.<\/p>\n

                      For pharmaceutical sourcing or bulk supply inquiries, contact us.<\/p>\n

                      \n

                      This article is for informational purposes only and does not constitute medical advice.<\/em><\/p>","protected":false},"excerpt":{"rendered":"What is Esomeprazole? Esomeprazole is the S-enantiomer of omeprazole, belonging to the benzimidazole class of proton pump inhibitors. Chemically, it is designated as (S)-5-Methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl-1H-benzimidazole. The compound is a substituted benzimidazole with a molecular formula of C17H19N3O3S and a molecular weight of 345.42 g\/mol. Unlike its racemic parent compound omeprazole, esomeprazole consists specifically of the (S)-enantiomer, [...]","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"yoast_head":"\nEsomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/fr\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Esomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor - China Chemical Manufacturer\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/fr\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-10T02:21:30+00:00\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Longchang Chemical\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\",\"url\":\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\",\"name\":\"Esomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"datePublished\":\"2026-03-10T02:21:30+00:00\",\"dateModified\":\"2026-03-10T02:21:30+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Esomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"description\":\"Longchang Chemical is the company publisher of chemical, ingredient and technical procurement information on longchangextracts.com. 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