{"id":7458,"date":"2024-08-06T19:58:27","date_gmt":"2024-08-06T19:58:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7458"},"modified":"2024-08-06T19:58:27","modified_gmt":"2024-08-06T19:58:27","slug":"jinlu","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/es\/jinlu\/","title":{"rendered":"Extracci\u00f3n, enriquecimiento y estudio de la actividad de un inhibidor de la alfa glucosidasa de la ciruela Jinlu"},"content":{"rendered":"

Extracci\u00f3n, enriquecimiento y estudio de la actividad de un inhibidor de la alfa glucosidasa de la ciruela Jinlu
\nLa \u03b1 - glucosidasa (AG) es una enzima estrechamente relacionada con la diabetes. Puede metabolizar los carbohidratos en glucosa, fructosa y galactosa que pueden ser absorbidos y utilizados por el cuerpo humano en el cuerpo. \u03b1 - inhibidor de la glucosidasa (AGI) puede bloquear la combinaci\u00f3n de AG y el az\u00facar y reducir el az\u00facar en la sangre en ayunas mediante la inhibici\u00f3n competitiva de la actividad de AG. En los \u00faltimos a\u00f1os, con el aumento de pacientes con diabetes, los ingredientes eficaces de los medicamentos chinos y tibetanos han aumentado gradualmente en la aplicaci\u00f3n cl\u00ednica del tratamiento de la diabetes. Los inhibidores naturales de \u03b1 - glucosidasa tienen las ventajas de eficacia estable, seguridad, peque\u00f1os efectos secundarios, etc., convirti\u00e9ndose en un punto caliente en el campo de investigaci\u00f3n de la medicina.
\nPotentilla fruticosa L. es una planta arbustiva caducifolia perteneciente a la familia Rosaceae y al g\u00e9nero Potentilla, distribuida principalmente en las regiones de gran altitud de la meseta tibetana de Qinghai. Las ra\u00edces, tallos, hojas, flores y ramas de Jin Lu Mei tienen una fuerte actividad farmacol\u00f3gica. Las hojas se utilizan com\u00fanmente como aditivos en alimentos y cosm\u00e9ticos, y los extractos de la ra\u00edz y el tallo tienen fuertes propiedades inmunorreguladoras, con un efecto m\u00e1s fuerte que el de Ci Wu Jia; El extracto de la rama es comestible, y los experimentos in vitro han demostrado que tiene una buena actividad en la reducci\u00f3n de los niveles de colesterol y glucosa en la sangre. Estudios anteriores de nuestro grupo de investigaci\u00f3n sobre la composici\u00f3n qu\u00edmica de Primulaceae mostraron que el compuesto flavonoide quercetina-7-O - \u03b2 - D-glucur\u00f3nido se aisl\u00f3 por primera vez en Primulaceae y tiene actividad inhibidora de la alfa glucosidasa.
\nLos m\u00e9todos de separaci\u00f3n y purificaci\u00f3n de los flavonoides vegetales incluyen principalmente la adsorci\u00f3n en resina, la cromatograf\u00eda l\u00edquida de alto rendimiento, etc. El m\u00e9todo de adsorci\u00f3n de resina es ampliamente utilizado para el enriquecimiento de flavonoides debido a sus ventajas de gran superficie, gran capacidad de adsorci\u00f3n, buena selectividad, larga vida \u00fatil de la resina, y bajo costo de operaci\u00f3n. Este estudio utiliz\u00f3 el m\u00e9todo de resina de adsorci\u00f3n macroporosa (AB-8) para enriquecer e inhibir la actividad AG del compuesto quercetina-7-O - \u03b2 - D-glucur\u00f3nido en Prunus mume, proporcionando una base te\u00f3rica para el desarrollo integral y la utilizaci\u00f3n de inhibidores naturales de \u03b1 - glucosidasa en Prunus mume.<\/p>\n

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\nEste art\u00edculo toma la medicina tibetana Jin Lu Mei como objeto de investigaci\u00f3n, y utiliza la cromatograf\u00eda l\u00edquida semipreparativa de alto rendimiento DAC-50 y la cromatograf\u00eda l\u00edquida de alto rendimiento para aislar por primera vez el compuesto hipoglucemiante diana con alta pureza a partir de Jin Lu Mei. Se establece un m\u00e9todo para separar los compuestos monom\u00e9ricos de quercetina-7-O - \u03b2 - D-glucur\u00f3nido de Jin Lu Mei. Extraer los componentes qu\u00edmicos presentes en Jinlu Mei utilizando etanol 75%. La soluci\u00f3n de extracci\u00f3n se separ\u00f3 y segment\u00f3 mediante cromatograf\u00eda en columna AB-8 con soluciones de etanol agua 0, 10%, 20%, 30%, 40% y 50%. Los compuestos se clasificaron preliminarmente en funci\u00f3n de su polaridad, y se aislaron y prepararon principalmente los compuestos monom\u00e9ricos en el eluyente AB-8 20% de Jinlumei.
\nA trav\u00e9s del an\u00e1lisis estructural del compuesto, se encontr\u00f3 que era un compuesto flavonoide. La detecci\u00f3n de la actividad y los resultados de la identificaci\u00f3n del tipo de inhibidor de este compuesto mostraron que la quercetina-7-O - \u03b2 - D-glucur\u00f3nido era un inhibidor competitivo, con la mayor tasa de inhibici\u00f3n de 94,67%. Esto indica que el compuesto tiene una fuerte competitividad en la uni\u00f3n a AG, reduciendo en gran medida la uni\u00f3n de AG a az\u00facares, lo que coincide con los resultados de investigaciones anteriores. Se estudi\u00f3 el posible modelo de uni\u00f3n entre el compuesto y el AG mediante el m\u00e9todo de acoplamiento molecular asistido por ordenador, y se explor\u00f3 el posible mecanismo de acci\u00f3n. Los tres anillos benc\u00e9nicos del n\u00facleo parental flavonoide del compuesto formaron un estado de uni\u00f3n estable con residuos de prote\u00edna AG a trav\u00e9s de enlaces conjugados \u03c0 - \u03c0, enlaces \u03c0 - alquilo, enlaces conjugados \u03c0 - \u03c3, enlaces de hidr\u00f3geno, etc., reduciendo as\u00ed la glucosa en sangre en ayunas. Este compuesto tiene una buena actividad inhibidora de la \u03b1 - glucosidasa, lo que indica que Jinlumei tiene potencial para desarrollar f\u00e1rmacos para el tratamiento de la diabetes, y proporciona una base te\u00f3rica cient\u00edfica para la investigaci\u00f3n y el desarrollo de ingredientes farmac\u00e9uticos hipoglucemiantes de Jinlumei.<\/p>","protected":false},"excerpt":{"rendered":"

Extraction, Enrichment, and Activity Study of an Alpha Glucosidase Inhibitor from Jinlu Plum \u03b1 – glucosidase (AG) is an enzyme closely related to diabetes. It can metabolize carbohydrates into glucose, fructose and galactose that can be absorbed and utilized by the human body in the body. \u03b1 – glucosidase inhibitor (AGI) can block the combination […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExtraction, Enrichment, and Activity Study of an Alpha Glucosidase Inhibitor from Jinlu Plum - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/es\/jinlu\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extraction, Enrichment, and Activity Study of an Alpha Glucosidase Inhibitor from Jinlu Plum - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Extraction, Enrichment, and Activity Study of an Alpha Glucosidase Inhibitor from Jinlu Plum \u03b1 – glucosidase (AG) is an enzyme closely related to diabetes. 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