{"id":6615,"date":"2024-08-06T12:45:17","date_gmt":"2024-08-06T12:45:17","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6615"},"modified":"2026-09-10T03:15:38","modified_gmt":"2026-09-10T03:15:38","slug":"using-response-surface-methodology","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/es\/using-response-surface-methodology\/","title":{"rendered":"Optimizaci\u00f3n del Proceso de Fermentaci\u00f3n de la Paraherquamida A Utilizando la Metodolog\u00eda de Superficie de Respuesta"},"content":{"rendered":"<p>Optimizaci\u00f3n del Proceso de Fermentaci\u00f3n de la Paraherquamida A Utilizando la Metodolog\u00eda de Superficie de Respuesta<br \/>\nParasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. At present, avernectins are the most widely used antiparasitic drugs in veterinary clinical practice worldwide. However, due to the abuse of this drug, drug-resistant strains have emerged in many areas. In the late 1980s, China introduced and widely used this type of drug, and now domestic sheep gastrointestinal nematodes have developed varying degrees of resistance to avermectin drugs. Startect \u00ae is a new type of sheep oral short acting deworming drug developed by Zoetis, the world&#8217;s largest animal health drug and vaccine company, which can effectively prevent and solve livestock and poultry parasitic diseases and their drug resistance problems. <span data-no-translation lang=\"en\">The <a href=\"https:\/\/www.vmd.defra.gov.uk\/productinformationdatabase\/product\/A012504\" rel=\"noopener\">UK Veterinary Medicines Directorate record for Startect<\/a> identifies derquantel and abamectin as its active substances. The previous sentence confused a substance name and included an inappropriate administration calculation; that instruction has been removed. This fermentation article is not a veterinary dosing guide. Use the current authorized product information and veterinary guidance for the actual product.<\/span> According to the statistics of the Food and Agriculture Organization of the United Nations (FAO), the world&#8217;s sheep inventory has reached 1.2 billion. Therefore, the potential demand for Dequnt is in the hundreds of tons or even higher, and the market demand is huge.<\/p>\n<p>El dextrante es un derivado qu\u00edmico del metabolito f\u00fangico Paraherquamida A (PA), que se obtiene principalmente mediante la reducci\u00f3n de amida carbonilo y la desoxigenaci\u00f3n de PA (v\u00e9ase la Figura 1). Por lo tanto, el suministro de materias primas industriales de Dequnte se ve afectado principalmente por la producci\u00f3n de PA. Sin embargo, la estructura qu\u00edmica de productos naturales como la paraherquamida es compleja. Aunque pueden sintetizarse qu\u00edmicamente a partir de materias primas industriales como el isopreno o los ep\u00f3xidos de isopreno, sus pasos de reacci\u00f3n qu\u00edmica pueden alcanzar hasta 46 pasos, lo que se traduce en costes elevados y rendimientos extremadamente bajos (2,5%), lo que dificulta su producci\u00f3n a escala industrial. La producci\u00f3n de PA mediante fermentaci\u00f3n microbiana es actualmente una forma eficaz de obtener este compuesto a gran escala. El PA se aisl\u00f3 por primera vez a partir del producto de fermentaci\u00f3n de una cepa de Penicillium paraherquei, un hongo perteneciente al g\u00e9nero Penicillium. Sin embargo, la potencia del PA producido por el Penicillium de tipo salvaje no era alta, lo que dificultaba su posterior investigaci\u00f3n experimental y su aplicaci\u00f3n industrial. En la investigaci\u00f3n de la aplicaci\u00f3n de metabolitos f\u00fangicos, el nivel de potencia del metabolito objetivo depende no s\u00f3lo del rendimiento de la propia cepa, sino, lo que es m\u00e1s importante, de la optimizaci\u00f3n de las condiciones de fermentaci\u00f3n y cultivo para aprovechar al m\u00e1ximo su capacidad de producci\u00f3n. En la actualidad, la metodolog\u00eda de superficie de respuesta se utiliza ampliamente para optimizar los cultivos de fermentaci\u00f3n microbiana. Este m\u00e9todo combina el dise\u00f1o experimental y la modelizaci\u00f3n matem\u00e1tica, y presenta las ventajas de un menor n\u00famero de experimentos, ciclos m\u00e1s cortos, mayor precisi\u00f3n en la obtenci\u00f3n de ecuaciones de regresi\u00f3n, mejor rendimiento predictivo y estudio de la interacci\u00f3n entre varios factores.<\/p>\n<p>En el trabajo preliminar, nuestro grupo de investigaci\u00f3n descubri\u00f3 un hongo Penicillium KWF31 derivado del mar con una elevada producci\u00f3n de PA. La exploraci\u00f3n inicial mostr\u00f3 que su potencia de fermentaci\u00f3n era de 55,8 \u00b1 3,7mg\/L en medio Chatelier, lo que no cumpl\u00eda los requisitos de la producci\u00f3n industrial. El objetivo de este estudio es optimizar el medio de fermentaci\u00f3n de la cepa KWF31 utilizando m\u00e9todos de superficie de respuesta como el dise\u00f1o de Plackett Burman, el dise\u00f1o de ascenso m\u00e1s pronunciado y el dise\u00f1o de Box Behnken, y establecer un esquema tecnol\u00f3gico de proceso de producci\u00f3n de PA estable y de alto rendimiento.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6616\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png\" alt=\"\" width=\"784\" height=\"214\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243-768x210.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6617\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-203.png\" alt=\"\" width=\"785\" height=\"259\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-203.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-203-768x253.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6618\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-190.png\" alt=\"\" width=\"787\" height=\"157\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-190.png 787w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-190-768x153.png 768w\" sizes=\"(max-width: 787px) 100vw, 787px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6619\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-170.png\" alt=\"\" width=\"785\" height=\"373\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-170.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-170-768x365.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6620\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-153.png\" alt=\"\" width=\"780\" height=\"325\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-153.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-153-768x320.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6621\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-139.png\" alt=\"\" width=\"787\" height=\"240\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-139.png 787w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-139-768x234.png 768w\" sizes=\"(max-width: 787px) 100vw, 787px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6622\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-127.png\" alt=\"\" width=\"782\" height=\"477\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-127.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-127-768x468.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6623\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-115.png\" alt=\"\" width=\"785\" height=\"247\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-115.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-115-768x242.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6624\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-107.png\" alt=\"\" width=\"787\" height=\"145\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-107.png 787w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-107-768x141.png 768w\" sizes=\"(max-width: 787px) 100vw, 787px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6625\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-85.png\" alt=\"\" width=\"788\" height=\"617\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-85.png 788w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-85-768x601.png 768w\" sizes=\"(max-width: 788px) 100vw, 788px\" \/>El PA es un alcaloide indol isopentenil con una estructura qu\u00edmica \u00fanica y una excelente actividad de resistencia a los insectos. Es una materia prima para la s\u00edntesis del agente comercial resistente a los insectos Dextrant y tiene un alto valor comercial y una enorme demanda en el mercado. Sin embargo, la cepa de Penicillium de tipo salvaje tiene un bajo rendimiento de PA, con m\u00faltiples pasos de s\u00edntesis qu\u00edmica y bajo rendimiento, lo que dificulta satisfacer la demanda del mercado. Este estudio utiliz\u00f3 el dise\u00f1o de Plackett Burman para seleccionar tres componentes del medio que afectan significativamente a la producci\u00f3n de PA por fermentaci\u00f3n horizontal de la cepa silvestre KWF31 en matraces agitados a partir de ocho factores: almid\u00f3n soluble, glucosa y extracto de levadura; sus concentraciones se optimizaron gradualmente utilizando experimentos de escalada y el dise\u00f1o Box Behnken. Las concentraciones \u00f3ptimas optimizadas son almid\u00f3n soluble 31.0g\/L, glucosa 1208g\/L, y extracto de levadura 14.5g\/L. En este medio, la cepa de tipo salvaje KWF31 mostr\u00f3 una alta potencia de 243,7 mg\/L para la producci\u00f3n de PA durante la fermentaci\u00f3n horizontal en matraz agitado, que fue 3,4 veces mayor que antes de la optimizaci\u00f3n (55,8 mg\/L). El proceso establecido en este estudio para la producci\u00f3n por fermentaci\u00f3n de PA por el hongo marino KWF31 tiene buena reproducibilidad, estabilidad y controlabilidad. Sobre esta base, el desarrollo ulterior de procesos de fermentaci\u00f3n industrializados sienta las bases para el desarrollo de nuevos plaguicidas contra nematodos en China, lo que tiene un importante significado te\u00f3rico y pr\u00e1ctico para promover el desarrollo saludable de la ganader\u00eda en China.<\/p>\n<p data-no-translation lang=\"en\"><em>Correction: 10 September 2026. Corrected the veterinary product identity and removed a dosing sentence that incorrectly named dexmedetomidine. This is a targeted claim correction; other historical statements still require their own supporting evidence.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology Parasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. At present, avernectins are the most widely used antiparasitic drugs in veterinary clinical practice worldwide. However, due to the abuse of this drug, drug-resistant strains have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/es\/utilizando-la-metodologia-de-superficie-de-respuesta\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology Parasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. 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