{"id":5099,"date":"2024-08-04T17:19:25","date_gmt":"2024-08-04T17:19:25","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5099"},"modified":"2024-08-04T17:19:25","modified_gmt":"2024-08-04T17:19:25","slug":"tumor-cell","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/es\/celula-tumoral\/","title":{"rendered":"Preparaci\u00f3n de fucoidan nano selenio y su inhibici\u00f3n de la proliferaci\u00f3n de c\u00e9lulas tumorales"},"content":{"rendered":"<p>Preparaci\u00f3n de fucoidan nano selenio y su inhibici\u00f3n de la proliferaci\u00f3n de c\u00e9lulas tumorales<br \/>\nEn la actualidad, adem\u00e1s de las enfermedades cardiovasculares, el c\u00e1ncer se ha convertido en la segunda causa de muerte humana. Debido a su dif\u00edcil tratamiento, su largo ciclo y su elevado coste, supone una pesada carga para la vida de las personas. La quimioterapia es uno de los principales m\u00e9todos de tratamiento del c\u00e1ncer en la medicina occidental moderna, pero debido a los graves efectos secundarios y a la resistencia de los f\u00e1rmacos quimioterap\u00e9uticos, el efecto del tratamiento no es el ideal. Por lo tanto, desarrollar un f\u00e1rmaco antitumoral de amplio espectro con gran eficacia y sin efectos secundarios t\u00f3xicos sigue siendo un problema urgente que hay que resolver.<br \/>\nEl selenio (Se) es un oligoelemento esencial para el cuerpo humano, que desempe\u00f1a un papel importante en la s\u00edntesis de glutati\u00f3n peroxidasa, tiorredoxina reductasa y otras enzimas. Participa en diversas actividades vitales y es de gran importancia para la salud humana. Al mismo tiempo, el selenio tambi\u00e9n tiene diversas actividades funcionales, como antioxidante y antitumoral. Las investigaciones han descubierto que los pacientes con c\u00e1ncer sufren una deficiencia de selenio en su organismo. Una ingesta adecuada de selenio puede proteger las c\u00e9lulas normales y reducir la aparici\u00f3n del c\u00e1ncer. Sin embargo, el rango de dosis segura de Se que puede utilizarse en los organismos es muy estrecho, y es f\u00e1cil causar intoxicaci\u00f3n debido a un uso excesivo. Por lo tanto, es crucial explorar y desarrollar formas seguras de Se para reducir su toxicidad. La investigaci\u00f3n ha descubierto que, en comparaci\u00f3n con las formas tradicionales de Se, las nanopart\u00edculas de selenio (SeNPs) tienen menor toxicidad y mejor biodisponibilidad debido a su tama\u00f1o y efectos superficiales \u00fanicos. Sin embargo, las SeNPs tienen una alta actividad debido a la falta de \u00e1tomos de coordinaci\u00f3n vecinos en su superficie, lo que las hace extremadamente inestables a temperatura ambiente y propensas a la agregaci\u00f3n para formar Se elemental m\u00e1s t\u00f3xico. Por lo tanto, en la preparaci\u00f3n de las SeNPs se suelen utilizar dispersantes para aumentar su dispersabilidad. Los polisac\u00e1ridos tienen grupos hidroxilo en su estructura molecular, que pueden unirse al Se mediante enlaces de hidr\u00f3geno intermoleculares para evitar la agregaci\u00f3n de las SeNPs. Por lo tanto, los polisac\u00e1ridos se utilizan a menudo para dispersar las SeNPs. En la actualidad, los polisac\u00e1ridos utilizados como modificadores de nano selenio de los que se tiene constancia incluyen polisac\u00e1ridos de astr\u00e1galo, glucomanano de konjac, etc.<br \/>\nEl fucoidan (FD) es un polisac\u00e1rido natural hidrosoluble derivado de algas pardas, compuesto de fucoidan sulfatado, manosa, arabinosa, \u00e1cido glucur\u00f3nico y otros monosac\u00e1ridos. Los investigadores han descubierto que el fucoidan tiene diversas actividades funcionales, como efectos antitumorales, antioxidantes y antiinflamatorios. Sin embargo, actualmente no existen informes sobre la modificaci\u00f3n del nano selenio con fucoidan. Por lo tanto, este art\u00edculo utiliza FD como estabilizador para preparar nanopart\u00edculas de selenio con fucoidan (FD SeNPs) mediante reacciones redox. Se utilizan experimentos de factor \u00fanico y de superficie de respuesta para optimizar los par\u00e1metros del proceso de preparaci\u00f3n, y se estudian adem\u00e1s la identificaci\u00f3n estructural y la inhibici\u00f3n de la proliferaci\u00f3n de c\u00e9lulas tumorales, proporcionando datos te\u00f3ricos que apoyan el desarrollo y la aplicaci\u00f3n de las FD SeNPs como inhibidores de c\u00e9lulas tumorales.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5100\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-118.png\" alt=\"\" width=\"783\" height=\"179\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-118.png 783w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-118-768x176.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5101\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-104.png\" alt=\"\" width=\"778\" height=\"338\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-104.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-104-768x334.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5102\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-98.png\" alt=\"\" width=\"782\" height=\"531\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-98.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-98-768x521.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5103\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-87.png\" alt=\"\" width=\"780\" height=\"355\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-87.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-87-768x350.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5104\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-80.png\" alt=\"\" width=\"782\" height=\"262\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-80.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-80-768x257.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5105\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-72.png\" alt=\"\" width=\"779\" height=\"198\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-72.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-72-768x195.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5106\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-65.png\" alt=\"\" width=\"780\" height=\"213\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-65.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-65-768x210.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5107\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-60.png\" alt=\"\" width=\"770\" height=\"250\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-60.png 770w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-60-768x249.png 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5108\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-54.png\" alt=\"\" width=\"367\" height=\"263\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5109\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-45.png\" alt=\"\" width=\"365\" height=\"244\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-45.png 365w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-45-325x217.png 325w\" sizes=\"(max-width: 365px) 100vw, 365px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5110\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-40.png\" alt=\"\" width=\"769\" height=\"231\" \/><br \/>\nEn este art\u00edculo se obtuvieron los par\u00e1metros \u00f3ptimos del proceso de preparaci\u00f3n de las SeNPs de FD mediante experimentos de optimizaci\u00f3n de un solo factor y de superficie de respuesta, que son una temperatura de reacci\u00f3n de 35 \u2103, un tiempo de reacci\u00f3n de 1 hora, una relaci\u00f3n molar de \u00e1cido asc\u00f3rbico y selenito s\u00f3dico de 14:1, y una concentraci\u00f3n de FD de 0,8 mg\/mL. En estas condiciones, el tama\u00f1o m\u00ednimo de part\u00edcula medido fue de (83,40 \u00b1 0,55) nm, el potencial fue de (-31,89 \u00b1 0,47) mV, y el contenido de selenio alcanz\u00f3 29,93%. La identificaci\u00f3n posterior de su estructura revel\u00f3 que el FD forma nanopart\u00edculas uniformemente esf\u00e9ricas en la superficie de las SeNPs mediante adsorci\u00f3n de hidroxilo, lo que indica que los grupos polares de los polisac\u00e1ridos pueden inhibir eficazmente la agregaci\u00f3n de las SeNPs.<\/p>\n<p>La investigaci\u00f3n actual ha descubierto que los mecanismos antitumorales incluyen principalmente la inhibici\u00f3n del crecimiento de c\u00e9lulas tumorales, la inhibici\u00f3n de la met\u00e1stasis o invasi\u00f3n de c\u00e9lulas tumorales y la mejora de la capacidad de regulaci\u00f3n inmunitaria del organismo para lograr efectos antitumorales. La investigaci\u00f3n ha demostrado que las SeNPs que utilizan polisac\u00e1ridos como plantillas pueden promover la expresi\u00f3n de prote\u00ednas apopt\u00f3ticas relacionadas y prote\u00ednas marcadoras de autofagia, induciendo as\u00ed la apoptosis y la autofagia de las c\u00e9lulas tumorales. El experimento antitumoral in vitro de este estudio descubri\u00f3 que las SeNPs modificadas con FD pueden mejorar significativamente la capacidad de las SeNPs para inhibir la proliferaci\u00f3n de c\u00e9lulas tumorales y tienen una buena selectividad celular, pero su mecanismo de acci\u00f3n espec\u00edfico debe estudiarse m\u00e1s a fondo.<\/p>","protected":false},"excerpt":{"rendered":"<p>Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation At present, besides cardiovascular disease, cancer has become the second leading cause of human death. Due to its difficult treatment, long treatment cycle, and high treatment cost, it brings a heavy burden to people&#8217;s lives. Chemotherapy is one of the main methods for [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/es\/celula-tumoral\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation At present, besides cardiovascular disease, cancer has become the second leading cause of human death. 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