{"id":3748,"date":"2024-08-03T07:42:11","date_gmt":"2024-08-03T07:42:11","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3748"},"modified":"2024-08-03T07:42:11","modified_gmt":"2024-08-03T07:42:11","slug":"trichothecium-roseum-diterpene","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/es\/trichothecium-roseum-diterpeno\/","title":{"rendered":"Diterpenos con actividad citot\u00f3xica en los productos de fermentaci\u00f3n de trichoderma rosa"},"content":{"rendered":"

Diterpenos con actividad citot\u00f3xica en los productos de fermentaci\u00f3n de trichoderma rosa
\nEl trichothecium roseum rosa, perteneciente al orden Hyphomyceales del subfilo Deuteromycotina, fue descubierto y bautizado en 2008. Este hongo se a\u00edsla f\u00e1cilmente de cuerpos vegetales en descomposici\u00f3n, suelo y aire, y es un hongo pat\u00f3geno de plantas y vegetales ampliamente distribuido por todo el mundo. Se han realizado muchos estudios sobre los metabolitos del trichoderma rosado en condiciones de cultivo de laboratorio, con estructuras representativas que incluyen sesquiterpenos, sesquiterpenos, diterpenos y p\u00e9ptidos c\u00edclicos. Entre ellos, el m\u00e1s ampliamente estudiado es el tricoteceno. Tang et al. informaron de que los compuestos de monotricoteceno pueden causar la descomposici\u00f3n de los corazones de las manzanas, mientras que las toxinas de monotricoteceno inhiben e interfieren en la s\u00edntesis de prote\u00ednas y \u00e1cidos nucleicos tanto en humanos como en animales, lo que conduce a la inmunosupresi\u00f3n de la salud humana y animal. El consumo de alimentos y productos contaminados con estas toxinas puede causar efectos t\u00f3xicos generalizados en humanos y animales.<\/p>\n

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\nAdem\u00e1s de los compuestos tox\u00ednicos, tambi\u00e9n se han encontrado compuestos con actividad citot\u00f3xica en este caldo de fermentaci\u00f3n, como el compuesto sesquiterp\u00e9nico cuspidatol encontrado en este g\u00e9nero, que mostr\u00f3 una fuerte actividad inmunosupresora en ensayos MLR con un valor IC50 de 11 \u03bc g\/mL; la monotricotequina A tiene un fuerte efecto inhibidor sobre el crecimiento de las c\u00e9lulas HL-60, SMMC-7721, A549, MCF-7 y SW480, con valores IC50 de 0.022, 0,020, 0,015, 0,006 y 0.011 \u03bc mol\/L, respectivamente, que son comparables a los del control positivo paclitaxel; El compuesto diterp\u00e9nico rosonolactona tiene fuertes efectos anti proliferativos y pro apopt\u00f3ticos en c\u00e9lulas HeLa de c\u00e1ncer cervical humano; La roseocardina, un compuesto p\u00e9ptido \u00e9ster c\u00edclico, tiene un efecto inotr\u00f3pico positivo en el miocardio de rata; El compuesto p\u00e9ptido c\u00edclico tricomida D mostr\u00f3 una citotoxicidad significativa contra tres l\u00edneas celulares de c\u00e1ncer humano (MCF-7, SW480, HL-6), con valores IC50 de 0.079, 0,107 y 0,149 \u03bc mol\/L, respectivamente. Este es el primer informe de la actividad citot\u00f3xica de p\u00e9ptidos c\u00edclicos. Con el fin de seguir buscando nuevos compuestos con actividad citot\u00f3xica, nuestro grupo de investigaci\u00f3n aisl\u00f3 e identific\u00f3 una cepa de trichothecus rosa del suelo donde crece el Ganoderma lucidum silvestre en Baise (la ciudad natal del Ganoderma lucidum). Utilizamos medio de cultivo de arroz para ampliar el proceso de fermentaci\u00f3n, con el fin de descubrir compuestos con estructuras novedosas y buena actividad biol\u00f3gica, y proporcionar estructuras de f\u00e1rmacos l\u00edderes.<\/p>\n

En este estudio, se aislaron e identificaron cinco compuestos a partir de los productos de fermentaci\u00f3n de T. roseum, todos ellos diterpenos. Entre ellos, el compuesto 1 es un nuevo compuesto diterpenoide. Este resultado enriquece la diversidad de metabolitos producidos por trichoderma roseum. Cinco compuestos mostraron diversos grados de efectos inhibitorios sobre las c\u00e9lulas MCF-7, siendo los compuestos 1 y 5 los que mostraron la mejor actividad. Se especula que esto puede deberse a las estructuras similares de los anillos A y B de los compuestos 1 y 5, mientras que el compuesto 5, aunque con aspecto de cadena, tiene una conformaci\u00f3n dominante con extensi\u00f3n espacial similar a la del compuesto 1. Los compuestos con esta caracter\u00edstica estructural mostraron mejor actividad en el modelo de investigaci\u00f3n de actividad seleccionado en este art\u00edculo. Este estudio enriquece la diversidad de estructuras de metabolitos secundarios en hongos Trichothecaum y proporciona una referencia para el cribado de compuestos activos antitumorales.<\/p>","protected":false},"excerpt":{"rendered":"

Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. This fungus is easily isolated from decaying plant bodies, soil, and air, and is a widely distributed plant and vegetable pathogenic fungus worldwide. There have […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nDiterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/es\/trichothecium-roseum-diterpeno\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. 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